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THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
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441thermofisher.
com/contactusTauMonoclonalAntibody(TAU-5)CatalogNumberAHB0042ProductdatasheetDetailsSize100gHost/IsotopeMouse/IgG1ClassMonoclonalTypeAntibodyCloneTAU-5ImmunogenPurifiedbovinemicrotubule-associatedproteins.
ConjugateUnconjugatedFormLiquidConcentration0.
5mg/mLPurificationpurifiedStoragebufferPBS,pH7.
4Contains15mMsodiumazideStorageConditions-20°CSpeciesReactivitySpeciesreactivityBovine,Human,Mouse,Sheep,RatPublishedspeciesRat,Non-humanprimate,Bovine,Mouse,Human,NotApplicableTestedApplicationsDilution*Immunocytochemistry(ICC)AssayDependentImmunohistochemistry(Paraffin)(IHC(P))1:20-1:200Immunoprecipitation(IP)AssayDependentWesternBlot(WB)1:500PublishedApplicationsImmunohistochemistry(IHC)See8publicationsbelowWesternBlot(WB)See66publicationsbelowImmunocytochemistry(ICC)See3publicationsbelowImmunofluorescence(IF)See5publicationsbelowImmunoprecipitation(IP)See4publicationsbelowImmunohistochemistry(Frozen)(IHC(F))See3publicationsbelowMiscellaneousPubMed(Misc)See5publicationsbelowELISA(ELISA)See2publicationsbelowSuggestedworkingdilutionsaregivenasaguideonly.
Itisrecommendedthattheusertitratetheproductforuseintheirownexperiment*usingappropriatenegativeandpositivecontrols.
Background/TargetInformationTauisaneuronalmicrotubule-associatedproteinfoundpredominantlyonaxons.
ThefunctionofTauistopromotetubulinpolymerizationandstabilizemicrotubules.
TheC-terminusbindsaxonalmicrotubuleswhiletheN-terminusbindsneuralplasmamembranecomponents,suggestingthattaufunctionsasalinkerproteinbetweenboth.
AxonalpolarityispredeterminedbyTAU/MAPTlocalization(intheneuronalcell)inthedomainofthecellbodydefinedbythecentrosome.
Theshortisoformsallowplasticityofthecytoskeletonwhilethelongerisoformsmaypreferentiallyplayaroleinitsstabilization.
Initshyper-phosphorylatedform,Tauisthemajorcomponentofpairedhelicalfilaments(PHF),thebuildingblockofneurofibrillarylesionsinAlzheimer'sdiseases(AD)brain.
Hyper-phosphorylationimpairsthemicrotubulebindingfunctionofTau,resultinginthedestabilizationofmicrotubulesinADbrains,ultimatelyleadingtothedegenerationoftheaffectedneurons.
Numerousserine/threoninekinasesphosphorylateTau,includingGSK-3beta,proteinkinaseA(PKA),cyclin-dependentkinase5(cdk5)andcaseinkinaseII.
Hyper-phosphorylatedTauisfoundinneurofibrillarylesionsinarangeandothercentralnervoussystemdisorderssuchasPick'sdisease,frontotemporaldementia,cortico-basaldegenerationandprogressivesupranuclearpalsy.
ForResearchUseOnly.
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thermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
AdvancedVerificationDataTauAntibody(AHB0042)AntibodyspecificitywasdemonstratedbydetectionofdifferentialbasalexpressionofthetargetacrossMouseBrain,RatBrain,MouseKidney,MouseLung,RatLungowingtotheirinherentgeneticconstitution.
RelativeexpressionofTauwasobservedinMouseandRatBrainascomparedtoKidneyandLungtissuesusingAnti-TauMonoclonalAntibody(TAU-5)(Product#AHB0042)inWesternBlot.
Relativeexpressionvalidationinfo.
ProductImagesForTauMonoclonalAntibody(TAU-5)TauAntibody(AHB0042)inIFImmunofluorescentanalysisofTau(Tau-5)wasdoneon70%confluentlogphaseSHSY5Ycells.
Thecellswerefixedwith4%paraformaldehydefor15minutes,permeabilizedwith0.
25%TritonX-100for10minutes,andblockedwith5%BSAfor1houratroomtemperature.
ThecellswerelabeledwithTau(Tau-5)MouseMonoclonalAntibody(Product#AHB0042)at1g/mLin1%BSAandincubatedfor3hoursatroomtemperatureandthenlabeledwithAlexaFluor488RabbitAnti-MouseIgGSecondaryAntibody(Product#A-11059)atadilutionof1:400for30minutesatroomtemperature(Panela:green).
Nuclei(Panelb:blue)werestainedwithSlowFadeGoldAntifadeMountantwithDAPI(Product#S36938).
F-actin(Panelc:red)wasstainedwithAlexaFluor594Phalloidin(Product#A12381).
Paneldisamergedimageshowingcytoplasmiclocalizationandpaneleisanoprimaryantibodycontrol.
Theimageswerecapturedat20Xmagnification.
TauAntibody(AHB0042)inIHC(P)ImmunohistochemistryanalysisofTaushowingstaininginthecytoplasmandweaknuclearstainingofparaffin-embeddedhumanbraintissue(right)comparedtoanegativecontrolwithoutprimaryantibody(left).
Toexposetargetproteins,antigenretrievalwasperformedusing10mMsodiumcitrate(pH6.
0),microwavedfor8-15min.
Followingantigenretrieval,tissueswereblockedin3%H2O2-methanolfor15minatroomtemperature,washedwithddH2OandPBS,andthenprobedwithaTau(Product#AHB0042)dilutedin3%BSA-PBSatadilutionof1:200overnightat4°Cinahumidifiedchamber.
TissueswerewashedextensivelyinPBSTanddetectionwasperformedusinganHRP-conjugatedsecondaryantibodyfollowedbycolorimetricdetectionusingaDABkit.
Tissueswerecounterstainedwithhematoxylinanddehydratedwithethanolandxylenetoprepformounting.
thermofisher.
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MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
TauAntibody(AHB0042)inIHC(P)ImmunohistochemistryanalysisofTaushowingstaininginthecytoplasmofparaffin-embeddedmousebraintissue(right)comparedtoanegativecontrolwithoutprimaryantibody(left).
Toexposetargetproteins,antigenretrievalwasperformedusing10mMsodiumcitrate(pH6.
0),microwavedfor8-15min.
Followingantigenretrieval,tissueswereblockedin3%H2O2-methanolfor15minatroomtemperature,washedwithddH2OandPBS,andthenprobedwithaTau(Product#AHB0042)dilutedin3%BSA-PBSatadilutionof1:20overnightat4°Cinahumidifiedchamber.
TissueswerewashedextensivelyinPBSTanddetectionwasperformedusinganHRP-conjugatedsecondaryantibodyfollowedbycolorimetricdetectionusingaDABkit.
Tissueswerecounterstainedwithhematoxylinanddehydratedwithethanolandxylenetoprepformounting.
TauAntibody(AHB0042)inIHC(P)ImmunohistochemistryanalysisofTaushowingstaininginthecytoplasmofparaffin-embeddedhumanastroglioma(right)comparedtoanegativecontrolwithoutprimaryantibody(left).
Toexposetargetproteins,antigenretrievalwasperformedusing10mMsodiumcitrate(pH6.
0),microwavedfor8-15min.
Followingantigenretrieval,tissueswereblockedin3%H2O2-methanolfor15minatroomtemperature,washedwithddH2OandPBS,andthenprobedwithaTau(Product#AHB0042)dilutedin3%BSA-PBSatadilutionof1:50overnightat4°Cinahumidifiedchamber.
TissueswerewashedextensivelyinPBSTanddetectionwasperformedusinganHRP-conjugatedsecondaryantibodyfollowedbycolorimetricdetectionusingaDABkit.
Tissueswerecounterstainedwithhematoxylinanddehydratedwithethanolandxylenetoprepformounting.
TauAntibody(AHB0042)inIHC(F)Immunofluorescentanalysisofp-Tau(S396)andTauinhumaniPSC-derivedforebrainorganoidsderivedatDay40.
Theorganoidswerefixedwith4%PFAfor1houratroomtemperature,followedbyincubationwith30%sucrosesolutionovernightat4°C.
TheorganoidswerethenembeddedinOCTandcryosectionedat5m,permeabilizedwith0.
2%TritonX-100for20min,andblockedwith10%donkeyseruminPBSfor30minatroomtemperature.
OrganoidsliceswerestainedwithaMouseTau(TAU-5)monoclonalantibody(green;Product#AHB0042)atadilutionof1:500andaRabbitp-Tau(Ser396)polyclonalantibody(red;Product#44-752G)atadilutionof1:500inblockingbufferovernightat4°C,andthenincubatedwithDonkeyanti-MouseAlexaFluor488(Product#R37114),Donkeyanti-RabbitAlexaFluor568(Product#A10042)atadilutionof1:1000aswellasDAPI(blue;1:25000)inblockingsolutionatroomtemperaturefor1hour.
Imagesweretakenat20Xmagnification.
Scalebar:50m.
DatacourtesyofDr.
ZhexingWenatEmoryUniversity.
TauAntibody(AHB0042)inIHC(F)ImmunofluorescentanalysisofTauinhumaniPSC-derivedforebrainorganoidsderivedatDay40.
Theorganoidswerefixedwith4%PFAfor1houratroomtemperature,followedbyincubationwith30%sucrosesolutionovernightat4°C.
TheorganoidswerethenembeddedinOCTandcryosectionedat5m,permeabilizedwith0.
2%TritonX-100for20min,andblockedwith10%donkeyseruminPBSfor30minatroomtemperature.
OrganoidsliceswerestainedwithaMouseTaumonoclonalantibody(green;Product#AHB0042)atadilutionof1:500inblockingbufferovernightat4°C,andthenincubatedwithDonkeyanti-MouseAlexaFluor488(Product#R37114)atadilutionof1:1000aswellasDAPI(blue;1:25000)inblockingsolutionatroomtemperaturefor1hour.
Imagesweretakenat20Xmagnification.
DatacourtesyofDr.
ZhexingWenatEmoryUniversity.
thermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
TauAntibody(AHB0042)inWBWesternblotwasperformedusingAnti-TauMonoclonalAntibody(TAU-5)(Product#AHB0042)and40-80kDabandscorrespondingtoTauwereobservedinMouseandRatBrainbutnotinMouseKidneyorMouseandRatLung.
Tissueextracts(30glysate)ofMouseBrain(Lane1),RatBrain(Lane2),MouseKidney(Lane3),MouseLung(Lane4)orRatLung(Lane5)wereelectrophoresedusingNuPAGE10%Bis-TrisProteinGel(Product#NP0301BOX).
ResolvedproteinswerethentransferredontoaNitrocellulosemembrane(Product#IB23001)byiBlot2DryBlottingSystem(Product#IB21001).
Theblotwasprobedwiththeprimaryantibody(1:500)anddetectedbychemiluminescencewithGoatanti-MouseIgG(H+L)SuperclonalRecombinantSecondaryAntibody,HRP(Product#A28177,1:4000)usingtheiBrightFL1000(Product#A32752).
ChemiluminescentdetectionwasperformedusingNovexECLChemiluminescentSubstrateReagentKit(Product#WP20005).
Additionalbandat25kDacorrespondstotissueIgGandhasbeenmarkedwithanasterisk.
TauAntibody(AHB0042)inWBWesternblotanalysisofTau-5wasperformedbyloading20gofMousebraintissuelysatesusingNovexNuPAGE4-12%Bis-Trisgel(Product#NP0321BOX),XCellSureLockElectrophoresisSystem(Product#EI0002),NovexSharpPre-StainedProteinStandard(Product#LC5800),andiBlotDryBlottingSystem(Product#IB21001).
Proteinsweretransferredtoanitrocellulosemembraneandblockedwith5%skimmilkfor1houratroomtemperature.
Tau-5wasdetectedat~50kDausingTau-5MouseMonoclonalAntibody(Product#AHB0042)at0.
5-1g/mLin2.
5%skimmilkat4°Covernightonarockingplatform.
Goatanti-MouseHRPSecondaryAntibody(Product#62-6520)at1:4000dilutionwasusedandchemiluminescentdetectionwasperformedusingPierceECLWesternblottingSubstrate(Product#32106).
thermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
PubMedReferencesForTauMonoclonalAntibody(TAU-5)8ImmunohistochemistryReferencesSpecies/DilutionSummaryRat/1:400AHB0042wasusedinImmunohistochemistrytostudythepathologicalassociationoftaudynamicsinbothcerebralischemiaandAlzheimer'sdisease.
Journalofcerebralbloodflowandmetabolism:officialjournaloftheInternationalSocietyofCerebralBloodFlowandMetabolism(Jul2017;37:2441)"ModificationsoftauproteinaftercerebralischemiaandreperfusioninratsaresimilartothoseoccurringinAlzheimer'sdisease-Hyperphosphorylationandcleavageof4-and3-repeattau.
"Author(s):FujiiH,TakahashiT,MukaiT,TanakaS,HosomiN,MaruyamaH,SakaiN,MatsumotoMPubMedArticleURL:http://dx.
doi.
org/10.
1177/0271678X16668889Rat/1:400AHB0042wasusedinImmunohistochemistrytodeterminehowfluxthroughspecificionchannelscontributestothevariouspathologies,usingpartialopticnervetransectioninadultfemaleratstomodelsecondarydegenerationfollowingneurotrauma.
BMCneuroscience(Aug2017;18:null)"Specificionchannelscontributetokeyelementsofpathologyduringsecondarydegenerationfollowingneurotrauma.
"Author(s):O'HareDoigRL,ChihaW,GiacciMK,YatesNJ,BartlettCA,SmithNM,HodgettsSI,HarveyAR,FitzgeraldMPubMedArticleURL:http://dx.
doi.
org/10.
1186/s12868-017-0380-1Rat/1:5000PloSone(Aug2012;7:null)"Transientfocalcerebralischemia/reperfusioninducesearlyandchronicaxonalchangesinrats:itsimportancefortheriskofAlzheimer'sdisease.
"Author(s):ZhangQ,GaoT,LuoY,ChenX,GaoG,GaoX,ZhouY,DaiJPubMedArticleURL:http://dx.
doi.
org/10.
1371/journal.
pone.
0033722Mouse/1:3000AHB0042wasusedinimmunohistochemistrytoassessiftaureductionbenefitsintractablegeneticepilepsiesAnnalsofneurology(Sep2014;76:443)"TaureductionpreventsdiseaseinamousemodelofDravetsyndrome.
"Author(s):GheyaraAL,PonnusamyR,DjukicB,CraftRJ,HoK,GuoW,FinucaneMM,SanchezPE,MuckeLPubMedArticleURL:http://dx.
doi.
org/10.
1002/ana.
24230NotApplicable/NotCitedAHB0042wasusedinimmunohistochemistrytodeterminethedistributionoftauopathyindifferentregionsofthebrainusingthealpha-SynoverexpressingmousemodelBMCneuroscience(Aug2011;12:null)"Region-specifictauopathyandsynucleinopathyinbrainofthealpha-synucleinoverexpressingmousemodelofParkinson'sdisease.
"Author(s):KaulT,CredleJ,HaggertyT,OaksAW,MasliahE,SidhuAPubMedArticleURL:http://dx.
doi.
org/10.
1186/1471-2202-12-79Human/NotCitedActaneuropathologica(Jun2002;103:599)"Ubiquitin-positiveneuronalandtau2-positiveglialinclusionsinfrontotemporaldementiaofmotorneurontype.
"Author(s):FornoLS,LangstonJW,HerrickMK,WilsonJD,MurayamaSPubMedArticleURL:http://dx.
doi.
org/10.
1007/s00401-001-0509-1Mouse/1:250AHB0042wasusedinImmunohistochemistrytodevelopamodeloforganotypicbrainslicesinwhichtheinteractionsbetweenamyloid-betaandtauinbothplaqueandtaupathologycanbeexamined.
Frontiersinagingneuroscience(Sep2020;10:null)"DifferentialHyperphosphorylationofTau-S199,-T231and-S396inOrganotypicBrainSlicesofAlzheimerMice.
AModeltoStudyEarlyTauHyperphosphorylationUsingOkadaicAcid.
"Author(s):FoidlBM,HumpelCPubMedArticleURL:http://dx.
doi.
org/10.
3389/fnagi.
2018.
00113NotApplicable/1:2000AHB0042wasusedinimmunohistochemistrytoexaminethebrainsof6-month-oldratstreatedneonatallywiththeglutamatergicbeta-N-methylamino-L-alanineToxicologicalsciences:anofficialjournaloftheSocietyofToxicology(Dec2012;130:391)"NeonatalexposuretothecyanobacterialtoxinBMAAinduceschangesinproteinexpressionandneurodegenerationinadulthippocampus.
"Author(s):KarlssonO,BergAL,LindstrmAK,HanriederJ,ArnerupG,RomanE,BergquistJ,LindquistNG,BritteboEB,AnderssonMPubMedArticleURL:http://dx.
doi.
org/10.
1093/toxsci/kfs24166WesternBlotReferencesthermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
Species/DilutionSummaryMouse/1:1000AHB0042wasusedinwesternblottofindnofunctionalormorphologicaldeficitsupontaureductionordepletioninagedmicePloSone(May2017;11:null)"NoOvertDeficitsinAgedTau-DeficientC57Bl/6.
Mapttm1(EGFP)KitGFPKnockinMice.
"Author(s):vanHummelA,BiM,IppatiS,vanderHovenJ,VolkerlingA,LeeWS,TanDC,BongersA,IttnerA,KeYD,IttnerLMPubMedArticleURL:http://dx.
doi.
org/10.
1371/journal.
pone.
0163236NotApplicable/1:1000AHB0042wasusedinwesternblottoevaluateifOVX/stressaffectslevelsofAlzheimer'sdisease-relatedmoleculesinthemousehippocampusNeuroscienceletters(Mar2008;433:141)"EnhancedactivityofhippocampalBACE1inamousemodelofpostmenopausalmemorydeficits.
"Author(s):FukuzakiE,TakumaK,HimenoY,YoshidaS,FunatsuY,KitaharaY,MizoguchiH,IbiD,KoikeK,InoueM,YamadaKPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
neulet.
2007.
12.
060NotApplicable/1:1000AHB0042wasusedinimmunocytochemistryandwesternblottodeterminemodulationofcellularreleaseoftaubyFRMD4A-cytohesinsignalingJournalofcellscience(May2016;129:2003)"FRMD4A-cytohesinsignalingmodulatesthecellularreleaseoftau.
"Author(s):YanX,NyknenNP,BrunelloCA,HaapasaloA,HiltunenM,UronenRL,HuttunenHJPubMedArticleURL:http://dx.
doi.
org/10.
1242/jcs.
180745Human/1:1,000AHB0042wasusedinWesternBlottingtodemonstratethataberranttauinFTDpatient-derivedneuronsisamenabletotargeteddegradation,representinganimportantadvancefortherapeutics.
eLife(Mar2019;8:null)"Targeteddegradationofaberranttauinfrontotemporaldementiapatient-derivedneuronalcellmodels.
"Author(s):SilvaMC,FergusonFM,CaiQ,DonovanKA,NandiG,PatnaikD,ZhangT,HuangHT,LucenteDE,DickersonBC,MitchisonTJ,FischerES,GrayNS,HaggartySJPubMedArticleURL:http://dx.
doi.
org/10.
7554/eLife.
45457Mouse/NotCitedJournalofneuroscienceresearch(Jan2010;88:102)"Deletionoftauattenuatesheatshock-inducedinjuryinculturedcorticalneurons.
"Author(s):MiaoY,ChenJ,ZhangQ,SunAPubMedArticleURL:http://dx.
doi.
org/10.
1002/jnr.
22188Mouse/NotCitedAHB0042wasusedinWesternBlottingtoshowreduced,behaviourallydriven,gammaoscillationsbeforetheonsetofplaqueformationorcognitivedeclineinamousemodelofAlzheimer'sdisease.
Nature(Dec2016;540:230)"Gammafrequencyentrainmentattenuatesamyloidloadandmodifiesmicroglia.
"Author(s):IaccarinoHF,SingerAC,MartorellAJ,RudenkoA,GaoF,GillinghamTZ,MathysH,SeoJ,KritskiyO,AbdurrobF,AdaikkanC,CanterRG,RuedaR,BrownEN,BoydenES,TsaiLHPubMedArticleURL:http://dx.
doi.
org/10.
1038/nature20587Human/1:1000AHB0042wasusedinwesternblottotestifneuriteretractionintheSH-SY5Ymodelisassociatedwithchangesinothertauhyperphosphorylableresidues.
Journalofneuroscienceresearch(Sep2011;89:1489)"Inhibitionofcyclin-dependentkinase5butnotofglycogensynthasekinase3-preventsneuriteretractionandtauhyperphosphorylationcausedbysecretableproductsofhumanT-cellleukemiavirustypeI-infectedlymphocytes.
"Author(s):MaldonadoH,RamírezE,UtrerasE,PandoME,KettlunAM,ChiongM,KulkarniAB,ColladosL,PuenteJ,CartierL,ValenzuelaMAPubMedArticleURL:http://dx.
doi.
org/10.
1002/jnr.
22678Mouse/NotCitedAHB0042wasusedinwesternblotidentifyandinvestigateReelin-regulatedsignalingpathwaysinthebrainMolecularandcellularbiology(Oct2007;27:7113)"Reelinsignalsthroughphosphatidylinositol3-kinaseandAkttocontrolcorticaldevelopmentandthroughmTortoregulatedendriticgrowth.
"Author(s):JossinY,GoffinetAMPubMedArticleURL:http://dx.
doi.
org/10.
1128/MCB.
00928-07thermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
Rat/1:200AHB0042wasusedinWesternBlottingtoprovideanovelmechanismofthehyperphosphorylationoftauandidentifybothPKAandGSK-3aspromisingtherapeutictargetsforADandothertauopathies.
TheJournalofbiologicalchemistry(Nov2004;279:50078)"TaubecomesamorefavorablesubstrateforGSK-3whenitisprephosphorylatedbyPKAinratbrain.
"Author(s):LiuSJ,ZhangJY,LiHL,FangZY,WangQ,DengHM,GongCX,Grundke-IqbalI,IqbalK,WangJZPubMedArticleURL:http://dx.
doi.
org/10.
1074/jbc.
M406109200Mouse/NotCitedAHB0042wasusedinwesternblottotesttheeffectsofhighfatdietusingamousemodeloffamilialAlzheimerdisease.
Biochimicaetbiophysicaacta(Sep2015;1852:1687)"High-fatdiet-inducedderegulationofhippocampalinsulinsignalingandmitochondrialhomeostasisdeficiencescontributetoAlzheimerdiseasepathologyinrodents.
"Author(s):PetrovD,PedrósI,ArtiachG,SuredaFX,BarrosoE,PallàsM,CasadesúsG,Beas-ZarateC,CarroE,FerrerI,Vazquez-CarreraM,FolchJ,CaminsAPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
bbadis.
2015.
05.
004Human/NotCitedAHB0042wasusedinWesternBlottingtostudywhetherHS3ST2andits3-O-sulphatedheparansulphateproductsareinvolvedinthemechanismsleadingtotheabnormalphosphorylationoftauinAlzheimer'sdiseaseandrelatedtauopathies.
Brain:ajournalofneurology(May2015;138:1339)"HS3ST2expressioniscriticalfortheabnormalphosphorylationoftauinAlzheimer'sdisease-relatedtaupathology.
"Author(s):Sepulveda-DiazJE,AlaviNainiSM,HuynhMB,OuidjaMO,YanicostasC,ChantepieS,VillaresJ,LamariF,JospinE,vanKuppeveltTH,Mensah-NyaganAG,Raisman-VozariR,Soussi-YanicostasN,Papy-GarciaDPubMedArticleURL:http://dx.
doi.
org/10.
1093/brain/awv056Mouse/1:20,000AHB0042wasusedinwesternblottoinvestigatetheroleofmembrane-anchoredversussolubleCX3CL1inregulatingthemicroglia-mediatedameliorationofAbetapathologyTheJournalofneuroscience:theofficialjournaloftheSocietyforNeuroscience(Sep2014;34:12538)"Opposingeffectsofmembrane-anchoredCX3CL1onamyloidandtaupathologiesviathep38MAPKpathway.
"Author(s):LeeS,XuG,JayTR,BhattaS,KimKW,JungS,LandrethGE,RansohoffRM,LambBTPubMedArticleURL:http://dx.
doi.
org/10.
1523/JNEUROSCI.
0853-14.
2014Mouse/1:1000AHB0042wasusedinWesternBlottingtodeterminewhetherovarianhormonesinfluencetheeffectofdietonthebrain.
Frontiersincellularneuroscience(Sep2020;12:null)"OvarianFunctionModulatestheEffectsofLong-ChainPolyunsaturatedFattyAcidsontheMouseCerebralCortex.
"Author(s):HerreraJL,Ordoez-GutierrezL,FabriasG,CasasJ,MoralesA,HernandezG,AcostaNG,RodriguezC,Prieto-ValienteL,Garcia-SeguraLM,AlonsoR,WandosellFGPubMedArticleURL:http://dx.
doi.
org/10.
3389/fncel.
2018.
00103NotApplicable/1:1000AHB0042wasusedinwesternblottoelucidatehowtheremovalofassembledneurofilamentsfromaxonsormisaccumulatingneurofilamentsinmotorneuroncellbodiesslowsdiseaseinamousemodelofamyotrophiclateralsclerosisProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica(Jul2005;102:10351)"Alteredaxonalarchitecturebyremovaloftheheavilyphosphorylatedneurofilamenttaildomainsstronglyslowssuperoxidedismutase1mutant-mediatedALS.
"Author(s):LobsigerCS,GarciaML,WardCM,ClevelandDWPubMedArticleURL:http://dx.
doi.
org/10.
1073/pnas.
0503862102NotApplicable/1:1000AHB0042wasusedinwesternblottodeterminethatAbetadepositionoroestrogendeficiencyincreasesPP2AphosphorylationtocompromisetaudephosphorylationandcauseneurofibrillarytangleformationinAlzheimer'sdiseaseJournalofcellularandmolecularmedicine(Jul2008;12:241)"PhosphorylatedPP2A(tyrosine307)isassociatedwithAlzheimerneurofibrillarypathology.
"Author(s):LiuR,ZhouXW,TanilaH,BjorkdahlC,WangJZ,GuanZZ,CaoY,GustafssonJA,WinbladB,PeiJJPubMedArticleURL:http://dx.
doi.
org/10.
1111/j.
1582-4934.
2008.
00249.
xMouse/NotCitedAHB0042wasusedinWesternBlottingtoinvestigatethefunctionofmiR-128asatumoursuppressoringlioma.
Oncogene(Apr2012;31:1884)"Pro-neuralmiR-128isagliomatumorsuppressorthattargetsmitogenickinases.
"Author(s):PapagiannakopoulosT,Friedmann-MorvinskiD,NeveuP,DugasJC,GillRM,HuillardE,LiuC,ZongH,RowitchDH,BarresBA,VermaIM,KosikKSPubMedArticleURL:http://dx.
doi.
org/10.
1038/onc.
2011.
380Rat/NotCitedTheEMBOjournal(Jan2005;24:209)"ACdk5inhibitorypeptidereducestauhyperphosphorylationandapoptosisinneurons.
"Author(s):ZhengYL,KesavapanyS,GravellM,HamiltonRS,SchubertM,AminN,AlbersW,GrantP,PantHCPubMedArticleURL:http://dx.
doi.
org/10.
1038/sj.
emboj.
7600441thermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
NotApplicable/1mg/mlAHB0042wasusedinwesternblottocharacterizechronictraumaticencephalopathytodetermineifphosphorylatedtauisuniqueinepilepticbrainandchronictraumaticencephalopathyBrainresearch(Jan2016;1630:225)"IsphosphorylatedtauuniquetochronictraumaticencephalopathyPhosphorylatedtauinepilepticbrainandchronictraumaticencephalopathy.
"Author(s):PuvennaV,EngelerM,BanjaraM,BrennanC,SchreiberP,DadasA,BahramiA,SolankiJ,BandyopadhyayA,MorrisJK,BernickC,GhoshC,RappE,BazarianJJ,JanigroDPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
brainres.
2015.
11.
007Mouse/1:2,500AHB0042wasusedinWesternBlottingtoconcludethattheroleofERstressinADpathogenesisneedstobecarefullyaddressedinfuturestudies.
TheJournalofbiologicalchemistry(Mar2018;293:3118)"EndoplasmicreticulumstressresponsesinmousemodelsofAlzheimer'sdisease:Overexpressionparadigmversusknockinparadigm.
"Author(s):HashimotoS,IshiiA,KamanoN,WatamuraN,SaitoT,OhshimaT,YokosukaM,SaidoTCPubMedArticleURL:http://dx.
doi.
org/10.
1074/jbc.
M117.
811315NotApplicable/1:1000AHB0042wasusedinimmunohistochemistry-paraffinsectionandwesternblottoevaluatemotorfunctionandtaupathologyofP301StautransgenicmiceMolecularneurodegeneration(Nov2014;9:null)"Long-termtreadmillexerciseattenuatestaupathologyinP301Stautransgenicmice.
"Author(s):Ohia-NwokoO,MontazariS,LauYS,EriksenJLPubMedArticleURL:http://dx.
doi.
org/10.
1186/1750-1326-9-54NotApplicable/1:10,000AHB0042wasusedinimmunohistochemistry-paraffinsectionandwesternblottocharacterizeanewmousemodelofAlzheimer'sdiseaseTheAmericanjournalofpathology(Aug2006;169:599)"Alzheimer'sdisease-liketauneuropathologyleadstomemorydeficitsandlossoffunctionalsynapsesinanovelmutatedtautransgenicmousewithoutanymotordeficits.
"Author(s):SchindowskiK,BrettevilleA,LeroyK,BégardS,BrionJP,HamdaneM,BuéeLPubMedArticleURL:http://dx.
doi.
org/10.
2353/ajpath.
2006.
060002Mouse/1:2000Scientificreports(Sep2017;7:null)"ThetyrosinephosphatasePTPN13/FAP-1linkscalpain-2,TBIandtautyrosinephosphorylation.
"Author(s):WangY,HallRA,LeeM,Kamgar-ParsiA,BiX,BaudryMPubMedArticleURL:http://dx.
doi.
org/10.
1038/s41598-017-12236-3Human/NotCitedAHB0042wasusedinWesternBlottingtostudyUPS14aptamersfordegradingproteotoxicproteinstoprotectcellsfromneurodegenerativestressors.
Scientificreports(Jun2015;5:null)"FacilitatedTauDegradationbyUSP14AptamersviaEnhancedProteasomeActivity.
"Author(s):LeeJH,ShinSK,JiangY,ChoiWH,HongC,KimDE,LeeMJPubMedArticleURL:http://dx.
doi.
org/10.
1038/srep10757Mouse/NotCitedAHB0042wasusedinWesternBlottingtosuggestthatMECP2isapotentialnovelregulatoroftaupathologyrelevanttoADandtauopathies.
Frontiersinmolecularneuroscience(Sep2020;10:null)"WholeGenomeExpressionAnalysisinaMouseModelofTauopathyIdentifiesMECP2asaPossibleRegulatorofTauPathology.
"Author(s):MaphisNM,JiangS,BinderJ,WrightC,GopalanB,LambBT,BhaskarKPubMedArticleURL:http://dx.
doi.
org/10.
3389/fnmol.
2017.
00069NotApplicable/NotCitedAHB0042wasusedinWesternBlottingtoshowthatnon-lethalreductionsinaxonaltransport,andperhapsothertypesofminoraxonalstress,aresufficienttoinduceand/oraccelerateabnormaltaubehaviourcharacteristicofAlzheimer'sdiseaseandotherneurodegenerativetauopathies.
Humanmoleculargenetics(Nov2010;19:4399)"Kinesin-1transportreductionsenhancehumantauhyperphosphorylation,aggregationandneurodegenerationinanimalmodelsoftauopathies.
"Author(s):FalzoneTL,GunawardenaS,McClearyD,ReisGF,GoldsteinLSPubMedArticleURL:http://dx.
doi.
org/10.
1093/hmg/ddq363thermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
Human/1:2000AHB0042wasusedinwesternblottoseethatthegranulinAlzheimer'sdiseaseriskvarianthasnosignificanteffectsonflorbetapirpositronemissiontomographicamyloidimagingandcerebrospinalfluidAbetalevelsActaneuropathologica(May2017;133:785)"OpposingeffectsofprogranulindeficiencyonamyloidandtaupathologiesviamicroglialTYROBPnetwork.
"Author(s):TakahashiH,KleinZA,BhagatSM,KaufmanAC,KostylevMA,IkezuT,StrittmatterSMPubMedArticleURL:http://dx.
doi.
org/10.
1007/s00401-017-1668-zBovine/NotCitedTheJournalofbiologicalchemistry(Apr2012;287:14984)"TheproteinphosphatasePP2A/Bbindstothemicrotubule-associatedproteinsTauandMAP2atamotifalsorecognizedbythekinaseFyn:implicationsfortauopathies.
"Author(s):SontagJM,Nunbhakdi-CraigV,WhiteCL,HalpainS,SontagEPubMedArticleURL:http://dx.
doi.
org/10.
1074/jbc.
M111.
338681NotApplicable/1:1000AHB0042wasusedinwesternblottoassesstheneuroprotectiveeffectsofdelphinidinagainstAbeta-inducedtoxicityBioscience,biotechnology,andbiochemistry(Jul2009;73:1685)"Delphinidinamelioratesbeta-amyloid-inducedneurotoxicitybyinhibitingcalciuminfluxandtauhyperphosphorylation.
"Author(s):KimHS,SulD,LimJY,LeeD,JooSS,HwangKW,ParkSYPubMedArticleURL:http://dx.
doi.
org/10.
1271/bbb.
90032NotApplicable/1:5000AHB0042wasusedinwesternblottoassessthedeletionofCcr2andcavitysizeandtaupathologyaftermildtraumaticbraininjuryJournalofneuroinflammation(Dec2015;12:null)"Ccr2deletiondissociatescavitysizeandtaupathologyaftermildtraumaticbraininjury.
"Author(s):GyonevaS,KimD,KatsumotoA,Kokiko-CochranON,LambBT,RansohoffRMPubMedArticleURL:http://dx.
doi.
org/10.
1186/s12974-015-0443-0NotApplicable/1:1000AHB0042wasusedinwesternblottoinvestigatethepotentialneuroprotectiveeffectsofcaffeicacidagainstAbeta-inducedtoxicityLifesciences(Feb2009;84:257)"Protectiveeffectofcaffeicacidagainstbeta-amyloid-inducedneurotoxicitybytheinhibitionofcalciuminfluxandtauphosphorylation.
"Author(s):SulD,KimHS,LeeD,JooSS,HwangKW,ParkSYPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
lfs.
2008.
12.
001NotApplicable/1:500AHB0042wasusedinwesternblottostudythetauopathicchangesinthestriatumofthealpha-synucleinA53TmutantmousePloSone(Mar2011;6:null)"TauopathicchangesinthestriatumofA53T-synucleinmutantmousemodelofParkinson'sdisease.
"Author(s):WillsJ,CredleJ,HaggertyT,LeeJH,OaksAW,SidhuAPubMedArticleURL:http://dx.
doi.
org/10.
1371/journal.
pone.
0017953Mouse/1:1000AHB0042wasusedinwesternblottoinvestigatethemurinetauisoformsinbrainandperipheralorgansPloSone(Feb2015;8:null)"Profilingmurinetauwith0N,1Nand2Nisoform-specificantibodiesinbrainandperipheralorgansrevealsdistinctsubcellularlocalization,withthe1Nisoformbeingenrichedinthenucleus.
"Author(s):LiuC,GtzJPubMedArticleURL:http://dx.
doi.
org/10.
1371/journal.
pone.
0084849NotApplicable/1:5000AHB0042wasusedinwesternblottoevaluatefiveglycogensynthasekinase-3betainhibitorsandlithiuminloweringphosphorylatedtauandglycogensynthasekinase-3betaenzymeactivitylevelsin12-dayoldpostnatalratsBritishjournalofpharmacology(Nov2007;152:959)"Efficacyofsmall-moleculeglycogensynthasekinase-3inhibitorsinthepostnatalratmodeloftauhyperphosphorylation.
"Author(s):SelenicaML,JensenHS,LarsenAK,PedersenML,HelboeL,LeistM,LothariusJPubMedArticleURL:http://dx.
doi.
org/10.
1038/sj.
bjp.
0707471Human/NotCitedAHB0042wasusedinwesternblottoinvestigatetheroleofApaf1inaxonogenesisCellularandmolecularlifesciences:CMLS(Nov2015;72:4173)"Apaf1-deficientcorticalneuronsexhibitdefectsinaxonaloutgrowth.
"Author(s):DeZioD,MolinariF,RizzaS,GattaL,CiottiMT,SalvatoreAM,MathiassenSG,CwetschAW,FilomeniG,RosanoG,FerraroEPubMedArticleURL:http://dx.
doi.
org/10.
1007/s00018-015-1927-xthermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
NotApplicable/1:1000AHB0042wasusedinwesternblottotestifsexhormonespreventtaucleavageandAbetatoxicityNeuroscience(Jan2007;144:119)"Caspase-3-andcalpain-mediatedtaucleavagearedifferentiallypreventedbyestrogenandtestosteroneinbeta-amyloid-treatedhippocampalneurons.
"Author(s):ParkSY,TournellC,SinjoanuRC,FerreiraAPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
neuroscience.
2006.
09.
012Mouse/NotCitedRat/NotCitedAHB0042wasusedinWesternBlottingtoidentifyapotentUSP14inhibitorthatretainsspecificityforUSP14.
TheJournalofbiologicalchemistry(Nov2017;292:19209)"AninhibitoroftheproteasomaldeubiquitinatingenzymeUSP14inducestaueliminationinculturedneurons.
"Author(s):BoselliM,LeeBH,RobertJ,PradoMA,MinSW,ChengC,SilvaMC,SeongC,ElsasserS,HatleKM,GahmanTC,GygiSP,HaggartySJ,GanL,KingRW,FinleyDPubMedArticleURL:http://dx.
doi.
org/10.
1074/jbc.
M117.
815126Human/NotCitedAHB0042wasusedinwesternblottoinvestigatetheaxoninitialsegmentinneurologicaldisordersMolecularneurodegeneration(Jun2016;11:null)"Acetylatedtaudestabilizesthecytoskeletonintheaxoninitialsegmentandismislocalizedtothesomatodendriticcompartment.
"Author(s):SohnPD,TracyTE,SonHI,ZhouY,LeiteRE,MillerBL,SeeleyWW,GrinbergLT,GanLPubMedArticleURL:http://dx.
doi.
org/10.
1186/s13024-016-0109-0Human/NotCitedAHB0042wasusedinWesternBlottingtoproposethatdysregulationofneuralgenenetworksmaysetinmotionthepathologiccascadethatleadstoAD.
Cellreports(Jan2019;26:1112)"RESTandNeuralGeneNetworkDysregulationiniPSCModelsofAlzheimer'sDisease.
"Author(s):MeyerK,FeldmanHM,LuT,DrakeD,LimET,LingKH,BishopNA,PanY,SeoJ,LinYT,SuSC,ChurchGM,TsaiLH,YanknerBAPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
celrep.
2019.
01.
023Mouse/NotCitedAHB0042wasusedinIP/WesternBlottingtoidentifymoleculeswhichmayprovidenewtoolstostudyaneuronalmigrationandcorticalplatedevelopment.
Cerebralcortex(NewYork,N.
Y.
:1991)(Jan2007;17:211)"Identificationofsmallmoleculesthatinterferewithradialneuronalmigrationandearlycorticalplatedevelopment.
"Author(s):ZhouL,JossinY,GoffinetAMPubMedArticleURL:http://dx.
doi.
org/10.
1093/cercor/bhj139NotApplicable/NotCitedAHB0042wasusedinwesternblottostudyenhanceddegradationofproteasomalsubstratesthatareassociatedwithneurodegenerativediseaseandtheeffectofinactivationofUSP14F1000Research(May2016;5:null)"DoesinactivationofUSP14enhancedegradationofproteasomalsubstratesthatareassociatedwithneurodegenerativediseases"Author(s):OrtunoD,CarlisleHJ,MillerSPubMedArticleURL:http://dx.
doi.
org/10.
12688/f1000research.
7800.
2Mouse/NotCitedTheJournalofbiologicalchemistry(Mar2003;278:10506)"Tauphosphorylationbycyclin-dependentkinase5/p39duringbraindevelopmentreducesitsaffinityformicrotubules.
"Author(s):TakahashiS,SaitoT,HisanagaS,PantHC,KulkarniABPubMedArticleURL:http://dx.
doi.
org/10.
1074/jbc.
M211964200Mouse/1:5000AHB0042wasusedinwesternblottoreportthatdocosahexaenoicacidisaninducerofcellularproteinaggregatesExperimentalandmolecularmedicine(Jan2017;49:null)"Docosahexaenoicacid-mediatedproteinaggregatesmayreduceproteasomeactivityanddelaymyotubedegradationduringmuscleatrophyinvitro.
"Author(s):ShinSK,KimJH,LeeJH,SonYH,LeeMW,KimHJ,NohSA,KimKP,KimIG,LeeMJPubMedArticleURL:http://dx.
doi.
org/10.
1038/emm.
2016.
133thermofisher.
com/contactusThermoFisherScientific3747N.
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NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
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UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
Rat/1:1000AHB0042wasusedinwesternblottoinvestigatetheinvolvementofmicroRNA-195intheeffectofchronicbrainhypoperfusiononrodentCdk5/p25andtauphosphorylationJournalofneurochemistry(Sep2015;134:1139)"ActivationofCdk5/p25andtauphosphorylationfollowingchronicbrainhypoperfusioninratsinvolvesmicroRNA-195down-regulation.
"Author(s):SunLH,BanT,LiuCD,ChenQX,WangX,YanML,HuXL,SuXL,BaoYN,SunLL,ZhaoLJ,PeiSC,JiangXM,ZongDK,AiJPubMedArticleURL:http://dx.
doi.
org/10.
1111/jnc.
13212Human/NotCitedChemistryandbiology(Jul2005;12:811)"DefiningCdk5ligandchemicalspacewithsmallmoleculeinhibitorsoftauphosphorylation.
"Author(s):AhnJS,RadhakrishnanML,MapelliM,ChoiS,TidorB,CunyGD,MusacchioA,YehLA,KosikKSPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
chembiol.
2005.
05.
011Human/NotCitedMouse/NotCitedAHB0042wasusedinWesternBlottingtoinvestigatetowhatextenttaucleavageandthegenerationoftheneurotoxictau45-230fragmentisassociatedwithamyotrophiclateralsclerosis.
Molecularmedicine(Cambridge,Mass.
)(Oct2016;22:477)"TheNeurotoxicTAU45-230FragmentAccumulatesinUpperandLowerMotorNeuronsinAmyotrophicLateralSclerosisSubjects.
"Author(s):VintilescuCR,AfreenS,RubinoAE,FerreiraAPubMedArticleURL:http://dx.
doi.
org/10.
2119/molmed.
2016.
00095NotApplicable/NotCitedAHB0042wasusedinwesternblottosurveytheactivationofasynapseweakeningpathwaybyhumanVal66,notMet66inproBDNFPharmacologicalresearch(Feb2016;104:97)"ActivationofasynapseweakeningpathwaybyhumanVal66butnotMet66pro-brain-derivedneurotrophicfactor(proBDNF).
"Author(s):KailainathanS,PiersTM,YiJH,ChoiS,FaheyMS,BorgerE,Gunn-MooreFJ,O'NeillL,LeverM,WhitcombDJ,ChoK,AllenSJPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
phrs.
2015.
12.
008Mouse/1:1000AHB0042wasusedinwesternblottoelucidatetheroleofdietaryresveratrolinSAMP8mice.
Age(Dordrecht,Netherlands)(Oct2013;35:1851)"DietaryresveratrolpreventsAlzheimer'smarkersandincreaseslifespaninSAMP8.
"Author(s):PorquetD,CasadesúsG,BayodS,VicenteA,CanudasAM,VilaplanaJ,PelegríC,SanfeliuC,CaminsA,PallàsM,delValleJPubMedArticleURL:http://dx.
doi.
org/10.
1007/s11357-012-9489-4Rat/NotCitedToxicologicalsciences:anofficialjournaloftheSocietyofToxicology(Apr2012;126:506)"Differingeffectsoftoxicants(methylmercury,inorganicmercury,lead,amyloid,androtenone)onculturedratcerebrocorticalneurons:differentialexpressionofrhoproteinsassociatedwithneurotoxicity.
"Author(s):FujimuraM,UsukiFPubMedArticleURL:http://dx.
doi.
org/10.
1093/toxsci/kfr352Human/NotCitedAHB0042wasusedinWesternBlottingtoinvestigatetheeffects,innormothermicconditions,ofacuteorrepeatedexposuretosevofluraneonhippocampaltauphosphorylationandspatialmemoryinadultmice.
Anesthesiology(Apr2012;116:779)"Tauphosphorylationandsevofluraneanesthesia:anassociationtopostoperativecognitiveimpairment.
"Author(s):LeFrecheH,BrouilletteJ,Fernandez-GomezFJ,PatinP,CaillierezR,ZommerN,SergeantN,Buée-ScherrerV,LebuffeG,BlumD,BuéeLPubMedArticleURL:http://dx.
doi.
org/10.
1097/ALN.
0b013e31824be8c7Human/NotCitedAHB0042wasusedinwesternblottotestifBAG2mediatesthecold-inducedaccumulationofphosphorylatedtauprotein.
Cellularandmolecularneurobiology(May2016;36:593)"TheCo-chaperoneBAG2MediatesCold-InducedAccumulationofPhosphorylatedTauinSH-SY5YCells.
"Author(s):dePaulaCA,SantiagoFE,deOliveiraAS,OliveiraFA,AlmeidaMC,CarrettieroDCPubMedArticleURL:http://dx.
doi.
org/10.
1007/s10571-015-0239-xNotApplicable/1:1000AHB0042wasusedinwesternblottostudyAlzheimer'sdiseasebyuseofadomesticcatanimalmodelActaneuropathologicacommunications(Dec2015;3:null)"ThedomesticcatasanaturalanimalmodelofAlzheimer'sdisease.
"Author(s):ChambersJK,TokudaT,UchidaK,IshiiR,TatebeH,TakahashiE,TomiyamaT,UneY,NakayamaHPubMedArticleURL:http://dx.
doi.
org/10.
1186/s40478-015-0258-3thermofisher.
com/contactusThermoFisherScientific3747N.
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ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
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AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
Mouse/NotCitedAHB0042wasusedinwesternblottotestif-amyloidaccumulationaffectsprioninfectivityandifdifferentamountsofPrPaffect-amyloidaccumulation.
Neurobiologyofaging(Dec2013;34:2793)"Cellularprionproteinmodulates-amyloiddepositioninagedAPP/PS1transgenicmice.
"Author(s):Ordóez-GutiérrezL,TorresJM,GavínR,AntónM,Arroba-EspinosaAI,EspinosaJC,VergaraC,DelRíoJA,WandosellFPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
neurobiolaging.
2013.
05.
019NotApplicable/NotCitedAHB0042wasusedinwesternblottoassesstheeffectslithiumchlorideoncoldwaterstress-inducedchangesintauphosphorylationinthemousehippocampusJournalofneuraltransmission(Vienna,Austria:1996)(Nov2006;113:1803)"Lithiuminhibitsstress-inducedchangesintauphosphorylationinthemousehippocampus.
"Author(s):YoshidaS,MaedaM,KakuS,IkeyaH,YamadaK,NakaikeSPubMedArticleURL:http://dx.
doi.
org/10.
1007/s00702-006-0528-0Human/NotCitedJournalofcellscience(Jan2005;118:433)"Neuriteextensionincentralneurons:anovelroleforthereceptortyrosinekinasesRor1andRor2.
"Author(s):PaganoniS,FerreiraAPubMedArticleURL:http://dx.
doi.
org/10.
1242/jcs.
01622Mouse/1:1000AHB0042wasusedinwesternblottoelucidatehowliraglutideaffectsdiseaseandcognitivefunctioninamousemodelofAlzheimerdiseaseNeurochemicalresearch(Aug2017;42:2326)"LiraglutideImprovesWaterMazeLearningandMemoryPerformanceWhileReducesHyperphosphorylationofTauandNeurofilamentsinAPP/PS1/TauTripleTransgenicMice.
"Author(s):ChenS,SunJ,ZhaoG,GuoA,ChenY,FuR,DengYPubMedArticleURL:http://dx.
doi.
org/10.
1007/s11064-017-2250-8Human/1:500AHB0042wasusedinwesternblottoexaminetauopathyinmicethatoverexpresshumanalpha-synucleinasamodelofParkinson'sdisease.
TheEuropeanjournalofneuroscience(May2011;33:1598)"HyperphosphorylatedTauinan-synuclein-overexpressingtransgenicmodelofParkinson'sdisease.
"Author(s):HaggertyT,CredleJ,RodriguezO,WillsJ,OaksAW,MasliahE,SidhuAPubMedArticleURL:http://dx.
doi.
org/10.
1111/j.
1460-9568.
2011.
07660.
xNotApplicable/1:1000AHB0042wasusedinwesternblottoelucidatethebetweentauaggregationandtheunfoldedproteinresponseinneurodegenerativedisordersJournalofneuroscienceresearch(Jul2010;88:1951)"Transgenicmouseandcellculturemodelsdemonstratealackofmechanisticconnectionbetweenendoplasmicreticulumstressandtaudysfunction.
"Author(s):SpataraML,RobinsonASPubMedArticleURL:http://dx.
doi.
org/10.
1002/jnr.
22359NotApplicable/1:1000AHB0042wasusedinwesternblottoinvestigatetheneurotoxicityof2,3,7,8-tetrachlorodibenzo-p-dioxinToxicology(Jan2009;255:65)"2,3,7,8-TCDDneurotoxicityinneuroblastomacellsiscausedbyincreasedoxidativestress,intracellularcalciumlevels,andtauphosphorylation.
"Author(s):SulD,KimHS,ChoEK,LeeM,KimHS,JungWW,HwangKW,ParkSYPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
tox.
2008.
10.
006Mouse/NotCitedAHB0042wasusedinwesternblottoinvestigatetheabnormalitesinhippocampalenergymetabolisminthepathogenesisofAlzheimerdiseaseBiochimicaetbiophysicaacta(Sep2014;1842:1556)"EarlyalterationsinenergymetabolisminthehippocampusofAPPswe/PS1dE9mousemodelofAlzheimer'sdisease.
"Author(s):PedrósI,PetrovD,AllgaierM,SuredaF,BarrosoE,Beas-ZarateC,AuladellC,PallàsM,Vázquez-CarreraM,CasadesúsG,FolchJ,CaminsAPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
bbadis.
2014.
05.
025thermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
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ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
Mouse/1:500AHB0042wasusedinWesternBlottingtostudythesynapticroleofTau.
PhilosophicaltransactionsoftheRoyalSocietyofLondon.
SeriesB,Biologicalsciences(Jan2014;369:null)"Microtubule-associatedproteintauisessentialforlong-termdepressioninthehippocampus.
"Author(s):KimuraT,WhitcombDJ,JoJ,ReganP,PiersT,HeoS,BrownC,HashikawaT,MurayamaM,SeokH,SotiropoulosI,KimE,CollingridgeGL,TakashimaA,ChoKPubMedArticleURL:http://dx.
doi.
org/10.
1098/rstb.
2013.
0144NotApplicable/1:1000AHB0042wasusedinwesternblottostudyreductionofhyperphosphorilatedTaubybeta-secretase1'stargetingimplyingautophagyactorsin3xTg-ADmiceFrontiersincellularneuroscience(Jan2016;9:null)"-Secretase1'sTargetingReducesHyperphosphorilatedTau,ImplyingAutophagyActorsin3xTg-ADMice.
"Author(s):PiedrahitaD,Castro-AlvarezJF,BoudreauRL,Villegas-LanauA,KosikKS,Gallego-GomezJC,Cardona-GómezGPPubMedArticleURL:http://dx.
doi.
org/10.
3389/fncel.
2015.
00498NotApplicable/NotCitedAHB0042wasusedinwesternblottoinvestigatesurvivalandneuronaldifferentiationofhumanBM-MSCsbypulsedelectromagneticfieldsLifesciences(Apr2016;151:130)"PulsedelectromagneticfieldspromotesurvivalandneuronaldifferentiationofhumanBM-MSCs.
"Author(s):UrnukhsaikhanE,ChoH,Mishig-OchirT,SeoYK,ParkJKPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
lfs.
2016.
02.
066NotApplicable/1:500AHB0042wasusedinwesternblottostudyhowinductionofCalyculinAinN2acellscanattenuateaxonaltransportimpairmentandaxonopathybyBerberinePloSone(Jan2015;9:null)"BerberineattenuatesaxonaltransportimpairmentandaxonopathyinducedbyCalyculinAinN2acells.
"Author(s):LiuX,ZhouJ,AbidMD,YanH,HuangH,WanL,FengZ,ChenJPubMedArticleURL:http://dx.
doi.
org/10.
1371/journal.
pone.
0093974NotApplicable/1:5000AHB0042wasusedinwesternblottoelucidatehowmethyleneblueinhibitstauaggregationScientificreports(Jun2015;5:null)"Nontoxicsingletoxygengeneratorasatherapeuticcandidatefortreatingtauopathies.
"Author(s):SheikMohideenS,YamasakiY,OmataY,TsudaL,YoshiikeYPubMedArticleURL:http://dx.
doi.
org/10.
1038/srep10821NotApplicable/NotCitedAHB0042wasusedinwesternblottousetripletransgenicAlzhemier'smicetostudyshort-andlong-termCDK5knockdownandpreventionofspatialmemorydysfunctionandtaupathologyFrontiersinagingneuroscience(Oct2014;6:null)"Long-andshort-termCDK5knockdownpreventsspatialmemorydysfunctionandtaupathologyoftripletransgenicAlzheimer'smice.
"Author(s):Castro-AlvarezJF,Uribe-AriasSA,KosikKS,Cardona-GómezGPPubMedArticleURL:http://dx.
doi.
org/10.
3389/fnagi.
2014.
00243NotApplicable/1:1000AHB0042wasusedinwesternblottoelucidatetheneuroprotectivemechanismsbywhichcurcuminprotectsagainstAbeta-inducedtoxicityFoodandchemicaltoxicology:aninternationaljournalpublishedfortheBritishIndustrialBiologicalResearchAssociation(Aug2008;46:2881)"CurcuminprotectedPC12cellsagainstbeta-amyloid-inducedtoxicitythroughtheinhibitionofoxidativedamageandtauhyperphosphorylation.
"Author(s):ParkSY,KimHS,ChoEK,KwonBY,PharkS,HwangKW,SulDPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
fct.
2008.
05.
0303ImmunocytochemistryReferencesSpecies/DilutionSummaryHuman/NotCitedAHB0042wasusedinimmunocytochemistrytosuggestthatTauregulatesneuronalpericentromericheterochromatinintegrityScientificreports(Sep2016;6:null)"LossofTauproteinaffectsthestructure,transcriptionandrepairofneuronalpericentromericheterochromatin.
"Author(s):MansurogluZ,Benhelli-MokraniH,MarcatoV,SultanA,VioletM,ChauderlierA,DelattreL,LoyensA,TalahariS,BégardS,NesslanyF,ColinM,SouèsS,LefebvreB,BuéeL,GalasMC,BonnefoyEPubMedArticleURL:http://dx.
doi.
org/10.
1038/srep33047thermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
Rat/1:1,000AHB0042wasusedinImmunocytochemistry-immunoflourescencetoprovidefurtherinsightsintothepotentialmolecularmechanismsunderlyingtheeffectsofagrinonneuriteoutgrowthinratcentralneurons.
Neuroscience(Nov2007;149:527)"Agrininducedmorphologicalandstructuralchangesingrowthconesofculturedhippocampalneurons.
"Author(s):BergstromRA,SinjoanuRC,FerreiraAPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
neuroscience.
2007.
08.
017Mouse/NotCitedAHB0042wasusedinImmunoprecipitationtoshowthatRac1levelsdecreasedinthefrontalcortexofAlzheimer'sdiseasepatientscomparedtonon-dementedcontrols.
Actaneuropathologicacommunications(Jul2018;6:null)"Rac1activationlinkstauhyperphosphorylationandAdysmetabolisminAlzheimer'sdisease.
"Author(s):BorinM,SaracenoC,CataniaM,LorenzettoE,PontelliV,PaterliniA,FostinelliS,AvesaniA,DiFedeG,ZanussoG,BenussiL,BinettiG,ZorzanS,GhidoniR,BuffelliM,BologninSPubMedArticleURL:http://dx.
doi.
org/10.
1186/s40478-018-0567-45ImmunofluorescenceReferencesSpecies/DilutionSummaryRat/1:1,000AHB0042wasusedinImmunocytochemistry-immunoflourescencetoprovidefurtherinsightsintothepotentialmolecularmechanismsunderlyingtheeffectsofagrinonneuriteoutgrowthinratcentralneurons.
Neuroscience(Nov2007;149:527)"Agrininducedmorphologicalandstructuralchangesingrowthconesofculturedhippocampalneurons.
"Author(s):BergstromRA,SinjoanuRC,FerreiraAPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
neuroscience.
2007.
08.
017Non-humanprimate/NotCitedHuman/NotCitedToxicologicpathology(Dec2007;35:972)"Expressionofserine/threonineprotein-kinasesandrelatedfactorsinnormalmonkeyandhumanretinas:themechanisticunderstandingofaCDK2inhibitorinducedretinaltoxicity.
"Author(s):SaturnoG,PesentiM,CavazzoliC,RossiA,GiustiAM,GierkeB,PawlakM,VenturiMPubMedArticleURL:http://dx.
doi.
org/10.
1080/01926230701748271Mouse/NotCitedAHB0042wasusedinImmunoprecipitationtoshowthatRac1levelsdecreasedinthefrontalcortexofAlzheimer'sdiseasepatientscomparedtonon-dementedcontrols.
Actaneuropathologicacommunications(Jul2018;6:null)"Rac1activationlinkstauhyperphosphorylationandAdysmetabolisminAlzheimer'sdisease.
"Author(s):BorinM,SaracenoC,CataniaM,LorenzettoE,PontelliV,PaterliniA,FostinelliS,AvesaniA,DiFedeG,ZanussoG,BenussiL,BinettiG,ZorzanS,GhidoniR,BuffelliM,BologninSPubMedArticleURL:http://dx.
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org/10.
1186/s40478-018-0567-4Human/NotCitedMolecularbiologyofthecell(Jun2004;15:2720)"Modulationofmicrotubuledynamicsbytauinlivingcells:implicationsfordevelopmentandneurodegeneration.
"Author(s):BunkerJM,WilsonL,JordanMA,FeinsteinSCPubMedArticleURL:http://dx.
doi.
org/10.
1091/mbc.
e04-01-0062Rat/NotCitedTheEMBOjournal(Jan2005;24:209)"ACdk5inhibitorypeptidereducestauhyperphosphorylationandapoptosisinneurons.
"Author(s):ZhengYL,KesavapanyS,GravellM,HamiltonRS,SchubertM,AminN,AlbersW,GrantP,PantHCPubMedArticleURL:http://dx.
doi.
org/10.
1038/sj.
emboj.
76004414ImmunoprecipitationReferencesSpecies/DilutionSummaryMouse/NotCitedAHB0042wasusedinIP/WesternBlottingtoidentifymoleculeswhichmayprovidenewtoolstostudyaneuronalmigrationandcorticalplatedevelopment.
Cerebralcortex(NewYork,N.
Y.
:1991)(Jan2007;17:211)"Identificationofsmallmoleculesthatinterferewithradialneuronalmigrationandearlycorticalplatedevelopment.
"Author(s):ZhouL,JossinY,GoffinetAMPubMedArticleURL:http://dx.
doi.
org/10.
1093/cercor/bhj139NotApplicable/NotCitedAHB0042wasusedinimmunoprecipitationandwesternblottoinvestigatetheeffectsoftauacetylationatLys174Naturemedicine(Oct2015;21:1154)"Criticalroleofacetylationintau-mediatedneurodegenerationandcognitivedeficits.
"Author(s):MinSW,ChenX,TracyTE,LiY,ZhouY,WangC,ShirakawaK,MinamiSS,DefensorE,MokSA,SohnPD,SchillingB,CongX,EllerbyL,GibsonBW,JohnsonJ,KroganN,ShamlooM,GestwickiJ,MasliahE,VerdinE,GanLPubMedArticleURL:http://dx.
doi.
org/10.
1038/nm.
3951thermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
Mouse/1:1,000AHB0042wasusedinImmunoprecipitationtoshowthatRac1levelsdecreasedinthefrontalcortexofAlzheimer'sdiseasepatientscomparedtonon-dementedcontrols.
Actaneuropathologicacommunications(Jul2018;6:null)"Rac1activationlinkstauhyperphosphorylationandAdysmetabolisminAlzheimer'sdisease.
"Author(s):BorinM,SaracenoC,CataniaM,LorenzettoE,PontelliV,PaterliniA,FostinelliS,AvesaniA,DiFedeG,ZanussoG,BenussiL,BinettiG,ZorzanS,GhidoniR,BuffelliM,BologninSPubMedArticleURL:http://dx.
doi.
org/10.
1186/s40478-018-0567-4Human/NotCitedAHB0042wasusedinImmunoprecipitationtoidentifysalivaryTauspeciesaspotentialbiomarkersofAlzheimer'sdisease.
JournalofAlzheimer'sdisease:JAD(Aug2012;27:299)"SalivarytauspeciesarepotentialbiomarkersofAlzheimer'sdisease.
"Author(s):ShiM,SuiYT,PeskindER,LiG,HwangH,DevicI,GinghinaC,EdgarJS,PanC,GoodlettDR,FurayAR,Gonzalez-CuyarLF,ZhangJPubMedArticleURL:http://dx.
doi.
org/10.
3233/JAD-2011-1107313Immunohistochemistry(Frozen)ReferencesSpecies/DilutionSummaryNotApplicable/1:500AHB0042wasusedinimmunohistochemistry-frozensectionandwesternblottoutilizeatimecoursestudyofsciaticnervesfromagingmicetogainaneurogenicperspectiveofsarcopeniaJournalofneuropathologyandexperimentalneurology(May2016;75:464)"ANeurogenicPerspectiveofSarcopenia:TimeCourseStudyofSciaticNervesFromAgingMice.
"Author(s):KrishnanVS,WhiteZ,McMahonCD,HodgettsSI,FitzgeraldM,ShavlakadzeT,HarveyAR,GroundsMDPubMedArticleURL:http://dx.
doi.
org/10.
1093/jnen/nlw019NotApplicable/1:500AHB0042wasusedinimmunohistochemistry-frozensectionandwesternblottoisolatecis-actingregulatoryelementsforthegenerationoftransgeniczebrafishmodelsofneurodegenerationNucleicacidsresearch(Dec2007;35:6501)"GenerationofatransgeniczebrafishmodelofTauopathyusinganovelpromoterelementderivedfromthezebrafisheno2gene.
"Author(s):BaiQ,GarverJA,HukriedeNA,BurtonEAPubMedArticleURL:http://dx.
doi.
org/10.
1093/nar/gkm608Mouse/1:100AHB0042wasusedinimmunohistochemistry-frozensectiontoinvestigatetheexpressionpatternsofHAsynthasesinthemurinecentralnervoussystemJournalofAlzheimer'sdisease:JAD(Feb2018;57:395)"TauPathologyPromotestheReorganizationoftheExtracellularMatrixandInhibitstheFormationofPerineuronalNetsbyRegulatingtheExpressionandtheDistributionofHyaluronicAcidSynthases.
"Author(s):LiY,LiZX,JinT,WangZY,ZhaoPPubMedArticleURL:http://dx.
doi.
org/10.
3233/JAD-1608045MiscellaneousPubMedReferencesSpecies/DilutionSummaryHuman/1:10,000AHB0042wasusedinwesternblottoinvestigatetheroleofchannelgatinginmammalianproteasomesNaturecommunications(Mar2016;7:null)"Open-gatemutantsofthemammalianproteasomeshowenhancedubiquitin-conjugatedegradation.
"Author(s):ChoiWH,dePootSA,LeeJH,KimJH,HanDH,KimYK,FinleyD,LeeMJPubMedArticleURL:http://dx.
doi.
org/10.
1038/ncomms10963Rat/1:1000AHB0042wasusedinimmunohistochemistry-paraffinsectionandwesternblottoelucidatethemolecularmechanismsofischemictoleranceNeurologicalsciences:officialjournaloftheItalianNeurologicalSocietyandoftheItalianSocietyofClinicalNeurophysiology(Apr2011;32:229)"Ischemicpreconditioningattenuatesofischemia-induceddegradationofspectrinandtau:implicationsforischemictolerance.
"Author(s):NakajimaT,OchiS,OdaC,IshiiM,OgawaKPubMedArticleURL:http://dx.
doi.
org/10.
1007/s10072-010-0359-5thermofisher.
com/contactusThermoFisherScientific3747N.
MeridianRoadRockford,IL61105USAForResearchUseOnly.
Notforuseindiagnosticprocedures.
Notforresalewithoutexpressauthorization.
ProductsarewarrantedtooperateorperformsubstantiallyinconformancewithpublishedProductspecificationsineffectatthetimeofsale,assetforthintheProductiondocumentation,specificationsand/oraccompanyingpackageinserts("Documentation").
NoclaimofsuitabilityforuseinapplicationsregulatedbyFDAismade.
Thewarrantyprovidedhereinisvalidonlywhenusedbyproperlytrainedindividuals.
UnlessotherwisestatedintheDocumentation,thiswarrantyislimitedtooneyearfromdateofshipmentwhentheProductissubjectedtonormal,properandintendedusage.
ThiswarrantydoesnotextendtoanyoneotherthantheBuyer.
AnymodelorsamplefurnishedtoBuyerismerelyillustrativeofthegeneraltypeandqualityofgoodsanddoesnotrepresentthatanyProductwillconformtosuchmodelorsample.
NOOTHERWARRANTIES,EXPRESSORIMPLED,AREGRANTEDINCLUDINGWITHOUTLIMITATION,IMPLIEDWARRANTIESOFMERCHANTABILITY,FITNESSFORANYPARTICULARPURPOSE,ORNONINFRINGEMENT.
BUYER'SEXCLUSIVEREMEDYFORNON-CONFORMINGPRODUCTSDURINGTHEWARRANTYPERIODISLIMITEDTOREPAIR,REPLACEMENTOFORREFUNDFORTHENON-CONFORMINGPRODUCT(S)ATSELLER'SSOLEOPTION.
THEREISNOOBLIGATIONTOREPAIR,REPLACEORREFUNDFORPRODUCTSASTHERESULTOF(I)ACCIDENT,DISASTEROREVENTOFFORCEMAJEURE,(II)MISUSE,FAULTORNEGLIGENCEOFORBYBUYER,(III)USEOFTHEPRODUCTSINAMANNERFORWHICHTHEYWERENOTDESIGNED,OR(IV)IMPROPERSTORAGEANDHANDLINGOFTHEPRODUCTS.
UnlessotherwiseexpresslystatedontheProductorinthedocumentationaccompanyingtheProduct,theProductisintendedforresearchonlyandisnottobeusedforanyotherpurpose,includingwithoutlimitation,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticuses,oranytypeofconsumptionbyorapplicationtohumanoranimals.
Rat/NotCitedAHB0042wasusedinwesternblottotestifcalpaincleavethecyclin-dependentkinase5activatorp35toap25fragmentandresultsintauhyperphosphorylation.
Biochemicalandbiophysicalresearchcommunications(Nov2002;298:693)"Cleavageofthecyclin-dependentkinase5activatorp35top25doesnotinducetauhyperphosphorylation.
"Author(s):KerokoskiP,SuuronenT,SalminenA,SoininenH,PirttilTPubMedArticleURL:http://dx.
doi.
org/10.
1016/s0006-291x(02)02543-3Mouse/NotCitedAHB0042wasusedinwesternblottoinvestigatethecontributionofAngIItoAlzheimerdisease.
FEBSletters(Oct2012;586:3737)"CentralangiotensinII-inducedAlzheimer-liketauphosphorylationinnormalratbrains.
"Author(s):TianM,ZhuD,XieW,ShiJPubMedArticleURL:http://dx.
doi.
org/10.
1016/j.
febslet.
2012.
09.
004Mouse/NotCitedAHB0042wasusedinimmunohistochemistry(frozen)tostudythecompositionofpathologicalgranulesthatappearindegenerativebraindiseases.
Age(Dordrecht,Netherlands)(Feb2014;36:151)"Presenceofaneo-epitopeandabsenceofamyloidbetaandtauproteinindegenerativehippocampalgranulesofagedmice.
"Author(s):ManichG,delValleJ,CabezónI,CaminsA,PallàsM,PelegríC,VilaplanaJPubMedArticleURL:http://dx.
doi.
org/10.
1007/s11357-013-9560-92ELISAReferencesSpecies/DilutionSummaryNotApplicable/NotCitedAHB0042wasusedinELISAtotestifHFEpolymorphismsareassociatedwithalterationsintauphosphorylationinahumanneuroblastomacelllineNeurobiologyofaging(Aug2011;32:1409)"ExpressionoftheHFEallelicvariantH63DinSH-SY5Ycellsaffectstauphosphorylationatserineresidues.
"Author(s):HallEC,LeeSY,MairuaeN,SimmonsZ,ConnorJRPubMedArticleURL:http://dx.
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org/10.
1016/j.
neurobiolaging.
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08.
012Human/NotCitedJournalofbiomolecularscreening(Mar2004;9:122)"Developmentofanassaytoscreenforinhibitorsoftauphosphorylationbycdk5.
"Author(s):AhnJS,MusacchioA,MapelliM,NiJ,ScintoL,SteinR,KosikKS,YehLAPubMedArticleURL:http://dx.
doi.
org/10.
1177/1087057103260594