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IDENTIFYINGDATAName:JosephLevitt,MD,MScAddress:300PasteurDrive,H3143Stanford,CA94305Phone:(650)723-6381Email:jlevitt@stanford.
eduB.
ACADEMICHISTORYCollegesandUniversitiesAttended1989-1993PomonaCollege,Claremont,CABachelorofArts,molecularbiologyJune19931994-1998UniversityofMinnesotaMedicalSchool,Minneapolis,MNDoctorofMedicineJune19982005-2006StanfordUniversity,Stanford,CAMastersofClinicalEpidemiologyInternship,ResidencyandFellowshipTraining1998-1999InterninInternalMedicineUniversityofArizonaHealthScienceCenter,Tucson,AZ1999-2001ResidentinInternalMedicineUniversityofChicagoHospitals,Chicago,IL2001-2002ChiefResidentinInternalMedicineCookCountyHospital,Chicago,IL2002-2004FellowinPulmonaryandCriticalCareUniversityofChicagoHospitals,Chicago,IL2004-2005FellowinPulmonaryandCriticalCareStanfordUniversityMedicalCenter,Stanford,CA2005-2006Post-doctoralFellowinPulmonaryandCriticalCareStanfordUniversityMedicalCenter,Stanford,CABoardCertification2001-2011InternalMedicine,AmericanBoardofInternalMedicine(ABIM)2005-currentPulmonaryMedicine,ABIM2006-currentCriticalCareMedicine,ABIMClinicalTrials&OtherResearchActivitiesPast:2005-2008FundingAgency:NIH/NHLBI(SCCOR)Title:RandomizedClinicalTrialofActivatedProteinCfortheTreatmentofAcuteLungInjuryRole:Site-Investigator(PI:Matthay)2011-2014FundingAgency:NIH/NHLBIARDSClinicalTrialsNetwork(NO1)Title:StatinsforAcutelyInjuredLungsfromSepsisRole:Site-PrincipalInvestigator(PI:Truwit)2009-2014FundingAgency:NIH/NHLBI(K23)Title:EarlyAcuteLungInjury(EALI):AProspectiveEvaluationPriortoRespiratoryFailureRole:PrincipalInvestigator2012-2015FundingAgency:NIH/NHLBI(UO1)andUnitedStatesCriticalIllnessandInvestigationTrials(USCIIT)groupTitle:LungInjuryPreventionStudywithAspirin(LIPS-A)Role:site-PrincipalInvestigator2012-12015FundingAgency:NIH/NHLBI(K23-LevittandKL2-Festic)andUnitedStatesCriticalIllnessandInvestigationTrials(USCIIT)groupTitle:RandomizedClinicalTrialofEarlyadministrationofaerosolizedbudesonideandformoterolinpatientsatriskofacutelunginjury(LIPS-B)Role:co-PrincipalInvestigator(Festicco-PI)Present:2012-presentFundingAgency:NIH/NHLBI(UO1)Title:HumanMesenchymalStemCellsforTreatmentofAcuteLungInjuryRole:Site-PrincipalInvestigator(PI:Matthay)2014-presentFundingAgency:NIH/NHLBI(UO1)TheEsophagealPressure-GuidedVentilation2(EPVent2)TrialRole:Site-PrincipalInvestigator(PI:Talmor)2015-presentFundingAgency:NIH/NHLBI(UO1)Title:PETAL-PreventionandEarlTreatmentofAcuteLungInjuryRole:Site-PrincipalInvestigator2016-presentFundingAgency:NIH/NHLBI(UO1)Title:ReevaluationofSystemicEarlyneuromuscularblockade(ROSE)aspartofNHLBIPETALNetworkRole:Site-PrincipalInvestigatorPending:2017FundingAgency:NIH/NHLBI(UO1)Title:VitaminDtoImproveOutcomesbyLeveragingEarlyTreatment(VIOLET)trialaspartofNHLBIPETALNetworkRole:ProtocolSubcommitteeandSite-PrincipalInvestigatorTeachingActivities2008-presentYearlyPulmonaryandCriticalCareCoreCurriculumLectures"IntrotoMechanicalVentilation""Hypoxemia:Shunt,Hypoventilation&V/QMismatch""HemodynamicsofShock:ImportanceoftheVasculatureinRegulatingVenousReturnandCardiacOutput""EvaluationofDiagnosticTests""AcuteLungInjury–Pathophysiology,DiagnosisandEvidenceBasedManagement""LungProtectiveVentilation""EarlyRecognitionandTreatmentofSepsis"2009-presentFacultyAdvisor,StanfordPulmonaryMedicineJointChestConferenceandChestRadiologyConference2008-presentFacultyAdvisor,StanfordPulmonaryMedicineJournalClub2005-2006Coordinator,StanfordUniversityMedicalStudentLungLab2006-presentFacultyVolunteer,StanfordUniversityMedicalStudentLungLabC.
EMPLOYMENTHISTORYAcademicAppointments2015-presentProgramDirector,PulmonaryandCriticalCareMedicineStanfordUniversitySchoolofMedicineStanford,California2013-presentAssistantProfessorofMedicineDivisionofPulmonaryandCriticalCareMedicineStanfordUniversitySchoolofMedicineStanford,California2010-2015AssociateProgramDirector,PulmonaryandCriticalCareMedicineStanfordUniversitySchoolofMedicineStanford,California2005-presentInstructorofMedicineDivisionofPulmonaryandCriticalCareMedicineStanfordUniversitySchoolofMedicineStanford,CaliforniaOtherAppointments2005-2009StaffPhysician,SanFranciscoCriticalCareMedicalGroupCaliforniaPacificMedicalCenter,SanFrancisco,CA2003-2004StaffPhysician,KindredHospital,Chicago,IllinoisD.
PUBLICANDPROFESSIONALSERVICEStanfordUniversityMedicalCenter2008-presentIntensiveCareUnitContinuingQualityImprovementCommitteeLeadfacultymemberfordevelopment,institutionandtrainingofrespiratorytherapistandnursingstaffforlungprotectivemechanicalventilationandsedationprotocols2011-presentFacultyevaluator,InternalMedicineResidencyTranslationalInvestigatorProgram(TIP)candidates2012-presentAntibioticSubcommitteeFacultyrepresentativefortheIntensiveCareUnitNational2016Peerreviewpanel,DepartmentofDefensePeer-ReviewedMedicalResearchProgram–ClinicalTrialsinLungDiseaseandInjury2016PanelMember,DepartmentofDefensePeer-ReviewedMedicalResearchProgram–AcuteLungInjury2015-presentMember,AmericanThoracicSocietyProgramReviewSubcommittee2015-presentProtocolCommittee,VIOLETTrial(VitDforcriticallyill),NIH/NHLBIPreventionandEarlyTreatmentofAcuteLungInjury(PETAL)Network2015Member,AmericanThoracicSocietyCriticalCareAssemblyProgramCommittee2014-presentSite-PrincipleInvestigator,NIH/NHLBIPreventionandEarlyTreatmentofAcuteLungInjury(PETAL)Network2014Member,WorkingGroupforObservationalStudies,NIH/NHLBINetworkforthePreventionandEarlyTreatmentofAcuteLungInjury(PETAL)2014-presentMentor,YoungAcademiciansCommittee,AmericanThoracicSocietyCriticalCareAssembly2012-presentFacilitator,InternationalConferenceoftheAmericanThoracicSociety2012-2014Member,YoungAcademiciansCommittee,AmericanThoracicSocietyCriticalCareAssembly2011-2014Site-PrincipleInvestigator,NIH/NHLBIAcuteRespiratoryDistressSyndromeClinicalTrialsNetwork2008-presentAdHocReviewer:AmericanJournalofRespiratoryandCriticalCareMedicineChestLancetRespiratoryMedicineCriticalCareMedicineCriticalCareBMCPulmonaryMedicine2004-presentMember,AmericanThoracicSocietyE.
BIBLIOGRAPHYPeer-reviewedArticles–OriginalWorkFesticE,CarrGE,Cartin–CebaR,HindsRF,Banner–GoodspeedV,BansalV,AsuniAT,TalmorD,RajagopalanR,FrankRD,GajicO,MatthayMA,LevittJE.
RandomizedClinicalTrialofaCombinationofanInhaledCorticosteroidandBetaAgonistinPatientsatRiskofDevelopingtheAcuteRespiratoryDistressSyndrome.
CritCareMedicne(inpress)MaxwellBG,MooneyJJ,LeePH,LevittJE,ChhatwaniL,NicollsMR,ZamoraMR,ValentineV,WeillD,DhillonGS.
Increasedresourceuseinlungtransplantadmissionsinthelungallocationscoreera.
AmJRespirCritCareMed.
2015Feb1;191(3):302-8.
PMCID:PMC4351576.
WilsonJG,LiuKD,ZhuoH,CaballeroL,McMillanM,FangX,CosgroveK,VojnikR,CalfeeCS,LeeJW,RogersAJ,LevittJ,Wiener-KronishJ,BajwaEK,LeavittA,McKennaD,ThompsonBT,MatthayMA.
;Mesenchymalstem(stromal)cellsfortreatmentofARDS:aphase1clinicaltrial.
LancetRespirMed.
2015Jan;3(1):24-32LiuKD,WilsonJG,ZhuoH,CaballeroL,McMillanML,FangX,CosgroveK,CalfeeCS,LeeJW,KangelarisKN,GottsJE,RogersAJ,LevittJE,Wiener-KronishJP,DelucchiKL,LeavittAD,McKennaDH,ThompsonBT,MatthayMA.
;DesignandimplementationoftheSTART(STemcellsforARDSTreatment)trial,aphase1/2trialofhumanmesenchymalstem/stromalcellsforthetreatmentofmoderate-severeacuterespiratorydistresssyndrome.
AnnIntensiveCare.
2014Jul3;4:22LevittJE/MaxwellBG,GoldsteinBA,MooneyJJ,NicollsMR,ZamoraM,ValentineV,Weill,DhillonGS;ImpactoftheLungAllocationScoreonSurvivalbeyondOneYearpostLungTransplantation.
AmJTransplant.
2014Oct;2288-94FesticE,Ortiz-DiazE,LeeA,LiG,KorDJ,AdebolaA,AkcaO,HothJ,LevittJE,CarterR,GajicO;UnitedStatesCriticalIllnessandInjuryTrialsGroup:LungInjuryPreventionStudyInvestigators(USCIITG-LIPS).
Prehospitaluseofinhaledsteroidsandincidenceofacutelunginjuryamongpatientsatrisk.
JCritCare.
2013Dec;28(6):985-91.
LevittJE,CalfeeCS,GoldsteinBA,VojnikR,MatthayMA.
Earlyacutelunginjury:CriteriaforidentifyinglungInjurypriortotheneedformechanicalventilation.
CritCareMed2013Aug;41(8);1929-37.
AgrawalA,ZhuoH,BradyS,LevittJ,SteingrubJ,SiegelMD,SotoG,PetersonMW,ChesnuttMS,MatthayMA,LiuKD.
PathogeneticandpredictivevalueofbiomarkersinpatientswithALIandlowerseverityofillness:resultsfromtwoclinicaltrials.
AmJPhysiolLungCellMolPhysiol2012;303(8):L634-9.
RackleyCR,LevittJE,ZhuoH,MatthayMA,CalfeeCS.
ClinicalEvidenceofEarlyAcuteLungInjuryOftenPrecedestheDiagnosisofALI.
JIntensiveCareMed.
2012,inpressDhillonGS,ValentineVG,LevittJE,MallidiH,PatelP,GuptaMR,SeoaneL,WeillD.
Clarithromycinforpreventionofbronchiolitisobliteranssyndromeinlungallograftrecipients.
ClinTransplant2012;26(1):105-10GehlbachBK,SalamancaVR,LevittJE,SachsGA,SweeneyMK,PohlmanAS,CharbeneauJ,KrishnanJA,HallJB.
Patient-relatedfactorsassociatedwithhospitaldischargetoacarefacilityaftercriticalillness.
AmJCritCare2011;20:378-86:DhillonGS,LevittJE,MallidiH,ValentineVG,GuptaMR,Sista,WeillD.
ImpactofHepatitisBCoreAntibodyPositiveDonorsinLungandHeart-LungTransplantation:AnAnalysisoftheUnitedNetworkforOrganSharingDatabase.
Transplantation2009Sep27;88(6):842-6.
LevittJE,Bedi,HCalfeeC,GouldMK,MatthayMA.
IdentificationofEarlyAcuteLungInjuryatInitialEvaluationinanAcuteCareSettingPriortotheOnsetofRespiratoryFailure.
Chest2009;135(4):936-43Liu,KD,LevittJE,ZhuoH,KalletRH,BradyS,SteingrubJ,TidswellM,SiegelMD,SotoG,PetersonMW,ChestnuttMS,PhillipsC,WeinackerA,ThompsonBT,EisnerMD,andMatthayMA.
RandomizedClinicalTrialofActivatedProteinCfortheTreatmentofAcuteLungInjury.
AmJRespirCritCareMed.
2008;178(6):618-23LevittJE/VinayakAG,GehlbachB,PohlmanA,VanCleveW,HallJB,andKressJP.
DiagnosticUtilityofB-typeNatriureticPeptideinCriticallyIllPatientswithPulmonaryEdema:AProspectiveCohortStudy.
CriticalCare2008;12(1):R3KressJP,VinayakAG,LevittJ,SchweickertWD,GehlbachBK,ZimmermanF,PohlmanAS,HallJB.
Dailysedativeinterruptioninmechanicallyventilatedpatientsatriskforcoronaryarterydisease.
CritCareMed.
2007;35(2):365-71VinayakAG,LevittJ,GehlbachB,PohlmanAS,HallJB,KressJP.
Usefulnessoftheexternaljugularveinexaminationindetectingabnormalcentralvenouspressureincriticallyillpatients.
ArchInternMed.
2006Oct23;166(19):2132-7.
CarsonSS,KressJP,RodgersJE,VinayakA,Campbell-BrightS,LevittJ,BourdetS,IvanovaA,HendersonAG,PohlmanA,ChangL,RichPB,HallJ.
Arandomizedtrialofintermittentlorazepamversuspropofolwithdailyinterruptioninmechanicallyventilatedpatients.
CritCareMed.
2006May;34(5):1326-32.
Peer-ReviewedArticles–ReviewsLevittJE,RogersAJ.
;Proteomicstudyofacuterespiratorydistresssyndrome:currentknowledgeandimplicationsfordrugdevelopment.
ExpertRevProteomics.
2016May;13(5):457-69SweattAJandLevittJE.
EvolvingEpidemiologyandDefinitionsoftheAcuteRespiratoryDistressSyndromeandEarlyAcuteLungInjury.
ClinChestMed35(2014)609–624.
ReviewOrtiz-DiazE,FesticE,GajicO,LevittJE.
EmergingPharmacologicTherapiesforPreventionandEarlyTreatmentofAcuteLungInjury.
SeminRespirCritCareMed2013Aug:34(4);2448-58.
ReviewLevittJE.
Designingabetter"nest":applicabletopreventinghospitalexposurestoriskfactorsforacuterespiratorydistresssyndromeorjustretrospectivestudydesignCritCareMed.
2014Jan;42(1):197-8.
EditorialLevittJE,MatthayMA.
EarlyTreatmentofAcuteLungInjury:ParadigmShifttowardPreventionandTreatmentPriortoRespiratoryFailure.
CritCare2012,16:223.
ReviewLevittJE,MatthayMA.
TheUtilityofClinicalPredictorsofAcuteLungInjury:TowardPreventionandEarlierRecognition.
ExpertRevRespirMed2010;4(6):785-97.
ReviewLevittJE,GouldMK,WareLB,MatthayMA.
PathogeneticandPrognosticValueofBiomarkersinAcuteLungInjury.
JIntensiveCareMed2009;24(3):151-67.
ReviewLevittJ,MatthayMA.
Treatmentofacutelunginjury:historicalperspectiveandpotentialfuturetherapies.
SeminRespirCritCareMed.
2006;27(4):426-37.
ReviewChaptersandLetters1.
LevittJ.
E.
(2014)TreatmentoftheAcuteRespiratoryDistressSyndrome.
B.
M.
White&R.
Litchkofski(Eds),PulmonaryDiseaseBoardReviewManual(pp1-23);Vol15,part3;HospitalPhysician;www.
tuner-white.
com2.
KhazeniN,LevittJE.
DoesitraconazoleimprovequalityoflifeinsevereasthmawithfungalsensitizationAmJRespirCritCareMed.
2009Jul15;180(2):191-2.
Letter3.
LevittJ,GouldMK.
PoorchoiceofprimaryoutcomeinaclinicaltrialofpirfenidoneinpatientswithIPF.
AmJRespirCritCareMed.
2005Nov1;172(9):1228-9.
Letter4.
LevittJ,HallJB.
Abstracts&Analysis:Acriticalanalysisoftheviewthatrightatrialpressuredeterminesvenousreturn[ClinicalInsights].
MDConsultRespiratory&CriticalCareMedicine.
July15,2003.
Availableat:http://www.
mdconsult.
com5.
LevittJ,SchmidtGA.
Vasopressin:Newrolesforanolddrug[ClinicalInsights,ContemporaryTopics].
MDConsultRespiratory&CriticalCareMedicine.
June17,2003.
Availableat:http://www.
mdconsult.
com6.
LevittJ.
CrystalDepositionDiseases.
InHalasyamaniLK,LucasBP.
EdsPocketPrimaryCare.
Lippincott,William&Wilkins,July,20017.
LevittJ,RizakT.
ChronicRenalFailure.
InHalasyamaniLK,LucasBP.
EdsPocketPrimaryCare.
Lippincott,William&Wilkins,July,2001Abstracts(notpublishedinotherforms)LinMY,LiuKD,GoldsteinBA,TruwitJD,LevittJE.
AssociationBetweenAcuteKidneyInjury(AKI)andMortalityDiffersbyFluidBalancePriortoOnsetofAKIinPatientswithAcuteRespiratoryDistressSyndrome.
AmJRespirCritCareMed.
May2015:A5394LinMY,LiuKD,GoldsteinBA,TruwitJD,LevittJE.
IncreasedCentralVenousPressureReducesRenalPerfusionPressureandIncreasesRiskofAcuteKidneyInjuryinPatientswithAcuteRespiratoryDistressSyndrome.
AmJRespirCritCareMed.
May2015:A3993LevittJE,VazquezGuillametR,CalfeeCS,MatthayMA.
PlasmaTNF-AlphaLevelsareElevatedEarlyinAcuteLungInjuryPriortoOnsetofRespiratoryFailure.
AmJRespirCritCareMed.
May2011:A145LevittJE,LeungA,GouldMK,MatthayMA.
ComparisonofTwoChestRadiographScoringSystemsinNon-IntubatedPatientsatRiskforAcuteLungInjury.
AmJRespirCritCareMed.
May2008LevittJ,VinayakA,PohlmanA,MohanM,HemmannS,GehlbachB,KressJ,HallJ.
ImpactofCompliancewithACGMEMandatedDutyHoursonResidentEducationduringRotationsintheMedicalIntensiveCareUnit.
AmJRespirCritCareMed.
Apr12004;169(7):A41VinayakA,LevittJ,PohlmanA,Engel-HallA,McCallisterK,HemmannS,KressJ,GehlbachB,HallJ.
ImpactofCompliancewithACGMEMandatedDutyHoursonPatientCareinaMedicalIntensiveCareUnit.
AmJRespirCritCareMed.
Apr12004;169(7):A39VinayakA,LevittJ,PohlmanA,HemmannS,McCallisterK,WestringJ,KressJ,GehlbachB,HallJ.
ImpactofCompliancewithACGMEMandatedDutyHoursonResidentWell-beingandPatientSatisfactioninaMedicalIntensiveCareUnit.
AmJRespirCritCareMed.
Apr12004;169(7):A39InvitedPresentationsInternationalPending:Nov20176thInternationalARDS/ECMOSymposium;Marburg,GermanyOralPresentation,"MesenchymalStemCellsforTreatmentofARDS"National/RegionalPending:Mar2017FromAirwaytoVentilation,CaliforniaSocietyofRespiratoryCareTahoeConference(Tahoe,CA),"3P'sofLungProtectiveVentilation:PEEP,Proning,andParalysis"Past:201434thAnnualPulmonary,InfectiousDiseaseandCriticalCareSymposium(Sacramento,CA)1.
"StrategiesforPrevention,EarlyIdentificationandTreatmentofAcuteLungInjury"2.
"LungProtectiveVentilation"DameronHospitalAssociationCMEProgram(Stockton,CA),"UpdatesinDiagnosisandTreatmentofSepsis"2010RegionalMedicalCenterCMEProgram(SanJose,CA),"EarlyRecognitionandTreatmentofSepsis"Local2016StanfordUniversityPulmonaryGrandRounds,"ClinicalTrialsinLungInjuryPrevention:LessonsfromLIPS-AandLIPS-B"2015RespiratoryCareWeekSymposium,"3P'sofLungProtectiveVentilation:PEEP,Proning,andParalysis"2014RespiratoryCareWeekSymposium,"StrategiesforLungProtective"Ventilation"2012StanfordUniversityPulmonaryGrandRounds,"EarlyAcuteLungInjury:ParadigmShiftTowardPreventionandTreatmentPriortoRespiratoryFailure"StanfordUniversityDepartmentofMedicineGrandRounds,"EarlyAcuteLungInjury:ParadigmShiftTowardPreventionandTreatmentPriortoRespiratoryFailure"2011-presentStanfordHealthCareContinuingEducationProgram,AdultCriticalCare:PulmonaryDysfunction,"StrategiesforLungProtectiveVentilation"PresentationsatNationalMeetings2016AmericanThoracicSocietyInternationalConference(SanFrancisco,CA)MiniSymposium(OralPresentation),"LungInjuryPreventionStudywithBudesonideandBetaAgonist,Formoterol(LIPS-B):AMulticenterRandomizedClinicalTrial"2015AmericanThoracicSocietyInternationalConference(SanDiego,CA)MiniSymposium(OralPresentation),"AssociationBetweenAcuteKidneyInjury(AKI)andMortalityDiffersbyFluidBalancePriortoOnsetofAKIinPatientswithAcuteRespiratoryDistressSyndrome"AmericanThoracicSocietyInternationalConferencePosterDiscussionSession,"IncreasedCentralVenousPressureReducesRenalPerfusionPressureandIncreasesRiskofAcuteKidneyInjuryinPatientswithAcuteRespiratoryDistressSyndrome"2013Chair,ScientificSymposium,"ParadigmShift:PreventionandEarlyTreatmentofAcuteLungInjury",AmericanThoracicSocietyInternationalConference(Philadelphia,PA)OralPresentation,ScientificSymposium,"StrategiesforPreventionandEarlyIdentificationandTreatmentofAcuteLungInjury",AmericanThoracicSocietyInternationalConference(Philadelphia,PA)2011AmericanThoracicSocietyInternationalConferencePosterPresentation"PlasmaTNF-AlphaLevelsareElevatedEarlyinAcuteLungInjuryPriortoOnsetofRespiratoryFailure"AmericanThoracicSocietyInternationalConference–SunriseSeminar"EarlyAcuteLungInjury:ParadigmShiftTowardRecognitionPriortoRespiratoryFailure"2009AmericanThoracicSocietyInternationalConferencePosterPresentation"IdentificationofEarlyAcuteLungInjuryatInitialEvaluationinanAcuteCareSettingPriortotheOnsetofRespiratoryFailure"2008AmericanThoracicSocietyInternationalConferencePosterPresentation"ComparisonofTwoChestRadiographScoringSystemsinNon-IntubatedPatientsatRiskforAcuteLungInjury"2007AmericanThoracicSocietyInternationalConferencePosterPresentation"EarlyAcuteLungInjury(EALI):AProspectiveEvaluationPriortoRespiratoyFailure"2004AmericanThoracicSocietyInternationalConferencePosterPresentation"ImpactofCompliancewithACGMEMandatedDutyHoursonResidentEducationintheMedicalIntensiveCareUnit"F.
GRANTSUPPORTACTIVEW81XWH15105049/15/2015-9/14/20200.
72calendarPrimeSponsor:DepartmentofDefense$62,780SubcontractfromUnivofColorado(AlbertsPI)SighVentilationtoReducetheIncidenceand/ortheSeverityoftheAcuteRespiratoryDistressSyndromeRole:Site-PIPhaseIIclinicaltrialtoassessifaddingsighbreathstousualinvasivemechanicalventilationwillreducetheriskofdevelopingARDSanddecreasethenumberofdaysofmechanicalventilationinintubatedtraumapatients5U01HL123004-025/01/2015-4/30/20210.
48calendarPrimeSponsor:NIH/NHLBI$29,448SubcontractfromUCSF(MatthayPI)PETAL-PreventionandEarlTreatmentofAcuteLungInjuryRole:Site-PISupportforcoreefforttosupportscreeningandmaintenanceofregulatorycomplianceofforclinicaltrialsperformedwithinthePETALNetwork5U01HL123004-0211/01/2015-04/30/20190.
84calendarPrimeSponsor:NIH/NHLBI$114,605SubcontractfromUCSF(MatthayPI)ReevaluationofSystemicEarlyneuromuscularblockade(ROSE)Role:Site-PIPhaseIIIclinicaltrialwithinPETALNetworkofearlyuseofneuromuscularblockadeforthetreatmentofmoderatetosevereARDSU01HL1087137/01/2013-present1.
20calendarPrimeSponsor:NIH/NHLBI$107,595SubcontractfromUCSF(MatthayPI)HumanMesenchymalStemCellsforTreatmentofAcuteLungInjuryRole:Site-PIPhaseIIclinicaltrialevaluatingsafetyandefficacyofmesenchymalstemcellsforthetreatmentofmoderatetosevereARDS(capitatedreimbursementforeffortdirectlyrelatedtopatientenrollment)U01-HL1087245/11/2014–present0.
36CMNIH/NHLBISubcontractfromBethIsraelMedicalCenter(TalmorPI)TheEsophagealPressure-GuidedVentilation2(EPVent2)TrialRole:Site-PIPhaseIIbclinicaltrialofuseofesophagealpressuremeasuredbyesophagealballoontotitratepositiveend-expiratorypressure(PEEP)inpatientswithmoderatetosevereacuterespiratorydistresssyndrome(ARDS)PASTU01HL1087137/01/2013–6/30/20160.
6CMNIH/NHLBI$84,666SubcontractfromUCSF(MatthayPI)AllogeneicHumanMesenchymalStemCellsfortheTreatmentofAcuteLungInjuryRole:Site-PICoresupportformesenchymalstemcellsforthetreatmentofmoderatetosevereacuterespiratorydistresssyndrome(ARDS)inhumanstrial.
N01HR056166(Levitt,SitePI)7/1/2010–6/30/2014NIH/NHLBIClinicalResearchNetworkfortheTreatmentofAcuteLungInjury(ALI)andAcuteRespiratoryDistressSyndrome(ARDS)(contractfromNHLBI)(N01)TotestnewtherapeuticstrategiesforARDSinPhaseIItrialsinmultiplemedicalcenters.
K23HL091334Levitt(PI)7/01/2009–11/30/2014NIH/NHLBIEarlyAcuteLungInjury(EALI):AProspectiveEvaluationPriortoRespiratoryFailureThegoalistoidentifyAcuteLungInjurypriortoneedformechanicalventilationandestablishevidence-basedcriteriaforadefinitionofEarlyAcuteLungInjurytoallowenrollmentofsubjectsinarandomizedcontroltrialofaerosolizedalbuterolpriortoprogressiontoacutelunginjury.
Role:PI(Mentor:Matthay)U01HL1087127/01/2013–8/31/20141.
2CMNIH/NHLBISubcontractfromMayoClinic–Rochester(GajicPI)LungInjuryPreventionStudywithAspirin(LIPS-A)Role:Site-PINovelphaseIImulticenterclinicaltrialtargetingthepreventionofAcuteLungInjuryinhigh-riskpatientswithaspirin.

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