"NO.","工程和计算机科学综述文集(Synthesis)各系列",
www.00271 时间:2021-03-23 阅读:()
"1","AlgorithmsandSoftwareinEngineering","系列:工程算法与软件""2","Antennas","系列:天线""3","ArtificialIntelligenceandMachineLearning","系列:人工智能与机器学习""4","Assistive,Rehabilitative,andHealth-PreservingTechnologies","系列:辅助、复健及保健技术""5","Biomaterials","系列:生物材料""6","BiomedicalEngineering","系列:生物医学工程""7","CommunicationNetworks","系列:通信网络""8","Communications","系列:通信""9","ComputationalElectromagnetics","系列:计算电磁学""10","ComputerArchitecture","系列:计算机体系结构""11","ComputerGraphicsandAnimation","系列:CG动画""12","ComputerScience","系列:计算机科学""13","ComputerVision","系列:计算机视觉""14","ControlandMechatronics","系列:机电与控制""15","DataManagement","系列:数据管理""16","DataMiningandKnowledgeDiscovery","系列:数据挖掘和知识发现""17","DigitalCircuitsandSystems","系列:数字电路与系统""18","DistributedComputingTheory","系列:分布式计算理论""19","ElectricalEngineering","系列:电机工程""20","EnergyandtheEnvironment","系列:能源与环境""21","Engineering","系列:工程""22","Engineers,Technology,andSociety","系列:工程师、技术与社会""23","GlobalEngineering","系列:全局工程""24","Human-CenteredInformatics","系列:人本信息""25","HumanLanguageTechnologies","系列:人类语言技术""26","Image,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理""27","InformationConcepts,RetrievalandServices","系列:信息概念、获取与服务""28","InformationSecurity,Privacy,&Trust","系列:信息安全、隐秘与信任""29","Mathematics&Statistics","系列:数学与统计""30","MobileandPervasiveComputing","系列:移动计算与普适计算""31","NuclearTechnology&Society","系列:核技术与社会""32","PowerElectronics","系列:电力电子""33","QuantumComputing","系列:量子计算""34","RF/Microwaves","系列:射频/微波""35","SemanticWeb:TheoryandTechnology","系列:语义网""36","SignalProcessing","系列:信号处理""37","SolidStateMaterialsandDevices","系列:固态材料与设备""38","SpeechandAudioProcessing","系列:语音与音频处理""39","SyntheticBiology","系列:合成生物学""40","Technology,Management,andEntrepreneurship","系列:技术、管理与企业精神""41","TissueEngineering","系列:组织工程""42","Visualization","系列:可视化","生命科学综述文集(Colloquium)各系列","1","Biotechnology","系列:生物技术""2","CellBiologyofMedicine","系列:细胞生物学""3","TheDevelopingBrain","系列:脑发育""4","DevelopmentalBiology","系列:发育生物学""5","TheGeneticBasisofHumanDisease","系列:人类疾病的遗传基础""6","Genomic&MolecularMedicine","系列:基因及分子医学""7","IntegratedSystemsPhysiology:FromMoleculetoFunction","系列:综合生理系统""8","Neuropeptides","系列:神经肽""9","StemCellBiology","系列:干细胞生物学""文集","ISBN","文献名(英文)","文献名(中文)","出版年份","所属系列(英文)","所属系列(中文)","ISSNPRINT","ISSNELEC","URL""Collection1","1598291025","AntennaswithNon-FosterMatchingNetworks","不符合福斯特匹配网络的天线","2007","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00050ED1V01Y200609ANT002""Collection1","1598291823","ElectronicallyScannedArrays","电子扫描阵列","2007","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00081ED1V01Y200612ANT006""Collection1","1598290541","ImplantedAntennasinMedicalWirelessCommunications","医学无线通信中的嵌入式天线","2006","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00024ED1V01Y200605ANT001""Collection1","1598291769","IntroductiontoSmartAntennas","智能天线介绍","2007","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00079ED1V01Y200612ANT005""Collection1","1598290266","ReconfigurableAntennas","可重构天线","2007","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00067ED1V01Y200707ANT004""Collection1","1598295268","AConciseIntroductiontoMultiagentSystemsandDistributedArtificialIntelligence","多智能体系统和分布式人工智能简介","2007","SynthesisLecturesonArtificialIntelligenceandMachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00091ED1V01Y200705AIM002""Collection1","1598291262","IntelligentAutonomousRobotics:ARobotSoccerCaseStudy","智能型自治机器人技术:足球机器人案例学习","2007","SynthesisLecturesonArtificialIntelligenceandMachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00090ED1V01Y200705AIM001""Collection1","1598291505","AdvancedProbabilityTheoryforBiomedicalEngineers","面向生物医学工程师的高等概率论","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00063ED1V01Y200610BME011""Collection1","1598290487","ArtificialOrgans","人造器官","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00023ED1V01Y200604BME004""Collection1","1598290606","BasicProbabilityTheoryforBiomedicalEngineers","面向生物医学工程师的基础概率论","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00037ED1V01Y200606BME005""Collection1","1598291327","Bioinstrumentation","生物仪器","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00043ED1V01Y200608BME006""Collection1","1598291386","Bionanotechnology","生物纳米技术","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00051ED1V01Y200610BME007""Collection1","1598290347","Brain-MachineInterfaceEngineering","自动计算机接口工程","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00053ED1V01Y200710BME017""Collection1","1598292927","CapstoneDesignCourses:ProducingIndustry-ReadyBiomedicalEngineers","顶点设计教程:培养成熟的生物医学工程师","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00097ED1V01Y200709BME015""Collection1","1598295322","EstimationofCorticalConnectivityinHumans:AdvancedSignalProcessingTechniques","关于人类皮层链接的估计:高级信号处理技术","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00094ED1V01Y200708BME013""Collection1","1598290967","FundamentalsofRespiratorySoundsandAnalysis","呼吸音分析基础","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00054ED1V01Y200609BME008""Collection1","1598290363","ImageandSignalProcessingforNetworkedeHealthApplications","网络的电子健康应用程序的图像和信号处理","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00015ED1V01Y200602BME002""Collection1","1598291408","IntermediateProbabilityTheoryforBiomedicalEngineers","面向生物医学工程师的中级概率论","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00062ED1V01Y200610BME010""Collection1","1598291963","IntroductiontoStatisticsforBiomedicalEngineers","面向生物医学工程师的统计学介绍","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00095ED1V01Y200708BME014""Collection1","1598295500","MultimodalImaginginNeurology","神经学多峰成像","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00099ED1V01Y200710BME016""Collection1","1598290622","SensoryOrganReplacementandRepair","感知器官的代替和修复","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00022ED1V01Y200604BME003""Collection1","159829038X","SignalProcessingofRandomPhysiologicalSignals","随机生理学信号处理","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00012ED1V01Y200602BME001""Collection1","1598291106","NetworkSimulation","网络模拟仿真","2006","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00046ED1V01Y200609CNT001""Collection1","1598290401","CodeDivisionMultipleAccess(CDMA)","码分多址联接方式","2006","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00017ED1V01Y200508COM002""Collection1","1598292641","FundamentalsofSpreadSpectrumModulation","扩频调制基础","2007","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00096ED1V01Y200708COM003""Collection1","1598290169","GameTheoryforWirelessEngineers","无限工程师的博弈论","2006","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00014ED1V01Y200508COM001""Collection1","1598290789","AdaptiveMeshRefinementinTime-DomainNumericalElectromagnetics","时域数字电磁体中的自适应网格加密","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00052ED1V01Y200609CEM011""Collection1","1598290568","ComputationalElectronics","计算机电子学","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00026ED1V01Y200605CEM006""Collection1","1598295357","ElectromagneticScatteringusingtheIterativeMulti-RegionTechnique","基于重复多子域技术的电磁散射","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00055ED1V01Y200710CEM019""Collection1","1598295381","ElectromagneticsandAntennaOptimizationusingTaguchi'sMethod","基于Taguchi方法的电磁场和天线优化","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00083ED1V01Y200710CEM018""Collection1","1598290746","ExploitationofaShip'sMagneticFieldSignatures","舰艇磁特征的开发利用","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00034ED1V01Y200605CEM009""Collection1","1598290800","FrequencyDomainHybridFiniteElementMethodsinElectromagnetics","电磁学频域有限要素分析法","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00038ED1V01Y200606CEM010""Collection1","159829170X","FundamentalsofElectromagnetics1:InternalBehaviorofLumpedElements","电磁学基础1:集总元件的内部行为","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00077ED1V01Y200612CEM014""Collection1","1598291726","FundamentalsofElectromagnetics2:QuasistaticsandWaves","电磁学基础2:量子统计和波","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00078ED1V01Y200612CEM015""Collection1","1598290282","Higher-OrderFDTDSchemesforWaveguidesandAntennaStructures","波导和天线结构的高阶时域有限差分设计","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00018ED1V01Y200604CEM003""Collection1","1598290460","IntroductiontotheFiniteElementMethodinElectromagnetics","电磁学有限要素分析法介绍","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00019ED1V01Y200604CEM004""Collection1","1598290126","MappedVectorBasisFunctionsforElectromagneticIntegralEquations","电磁积分方程的映射向量基础工程","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00008ED1V01Y200508CEM001""Collection1","159829184X","MellinTransformMethodforIntegralEvaluation","梅林变换积分求值","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00076ED1V01Y200612CEM013""Collection1","1598292501","ModelingaShip'sFerromagneticSignatures","船舶磁性特征建模","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00092ED1V01Y200706CEM016""Collection1","1598290142","MRTD(MultiResolutionTimeDomain)MethodinElectromagnetics","电磁学中的时域多分辨分析","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00009ED1V01Y200508CEM002""Collection1","1598290827","PerfectlyMatchedLayer(PML)forComputationalElectromagnetics","计算机电磁学的完全匹配层","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00030ED1V01Y200605CEM008""Collection1","159829024X","SupportVectorMachinesforAntennaArrayProcessingandElectromagnetics","天线阵列处理和电磁学的支持向量机","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00020ED1V01Y200604CEM005""Collection1","1598290509","TheTransmission-LineModeling(TLM)MethodinElectromagnetics","电磁学传输线矩阵法","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00027ED1V01Y200605CEM007""Collection1","1598292447","Three-DimensionalIntegrationandModeling:ARevolutioninRFandWirelessPackaging","三维集成和建模:RF和无线封装的变革","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00080ED1V01Y200710CEM017""Collection1","159829122X","ChipMultiprocessorArchitecture:TechniquestoImproveThroughputandLatency","芯片多处理器结构","2007","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00093ED1V01Y200707CAC003""Collection1","1598291181","QuantumComputingforComputerArchitects","计算机结构的量子计算","2006","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00066ED1V01Y200610CAC001""Collection1","1598291246","TransactionalMemory","事务型存储器","2007","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00070ED1V01Y200611CAC002""Collection1","1598291165","ABlossomingDevelopmentofSplines","样条线的迅速发展","2006","SynthesisLecturesonComputerGraphicsandAnimation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00041ED1V01200607CGR001""Collection1","1598291149","HighFidelityHapticRendering","高保真触觉渲染","2006","SynthesisLecturesonComputerGraphicsandAnimation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00045ED1V01Y200609CGR002""Collection1","159829010X","TheTheoryofTimedI/OAutomata","时间输入/输出自动机理论","2006","SynthesisLecturesonComputerScience","系列:计算机科学","1932-1228","1932-1686","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00006ED1V01Y200508CSL001""Collection1","1598291947","TheReactionWheelPendulum","反作用轮摆","2007","SynthesisLecturesonControlandMechatronics","系列:机电与控制","1939-0564","1939-0572","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00085ED1V01Y200702CRM001""Collection1","1598295411","AtmelAVRMicrocontrollerPrimer:ProgrammingandInterfacing","AtmelAVR单片机入门:编程和接口","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00100ED1V01Y200712DCS015""Collection1","1598295292","FiniteStateMachine-DatapathDesign,Optimization,andImplementation","有限状态机—数据通道设计,优化和植入","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00087ED1V01Y200702DCS014""Collection1","1598291343","High-SpeedDigitalSystemDesign","高速数字系统设计","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00044ED1V01Y200609DCS005""Collection1","1598291068","IntroductiontoLogicSynthesisusingVerilogHDL","使用VerilogHDL的逻辑合成介绍","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00060ED1V01Y200610DCS006""Collection1","1598290584","MicrocontrollersFundamentalsforEngineersandScientists","面向工程师和科学家的微控制器基础","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00025ED1V01Y200605DCS001""Collection1","1598291904","Multiple-ValuedLogic:ConceptsandRepresentations","多值逻辑:概念和表示","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00065ED1V01Y200709DCS012""Collection1","1598290681","PragmaticCircuits:D-CandTimeDomain","实用电路:D-C和时域","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00031ED1V01Y200605DCS002""Collection1","1598290703","PragmaticCircuits:FrequencyDomain","实用电路:频域","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00032ED1V01Y200605DCS003""Collection1","159829072X","PragmaticCircuits:SignalsandFilters","实用电路:信号和滤波器","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00033ED1V01Y200605DCS004""Collection1","1598291920","PragmaticLogic","实用逻辑","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00084ED1V01Y200702DCS013""Collection1","1598291602","PSpiceforAnalogCommunicationsEngineering","模拟通信工程的PSpice设计","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00071ED1V01Y200612DCS009""Collection1","1598291564","PSpiceforCircuitTheoryandElectronicDevices","电路理论和电子设备的Pspice设计","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00068ED1V01Y200611DCS007""Collection1","1598291629","PSpiceforDigitalCommunicationsEngineering","数字通信工程的PSpice设计","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00072ED1V01Y200612DCS010""Collection1","1598291645","PSpiceforDigitalSignalProcessing","数字信号处理的PSpice设计","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00073ED1V01Y200612DCS011""Collection1","1598291580","PSpiceforFiltersandTransmissionLines","滤波器和传输线的PSpice设计","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00069ED1V01Y200611DCS008""Collection1","1598291424","LearningProgrammingUsingMatlab","学用Matlab编程","2006","SynthesisLecturesonElectricalEngineering","系列:电机工程","1559-811X","1559-8128","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00051ED1V01Y200609EEL003""Collection1","1598290029","UnderstandingCircuits","了解电路","2005","SynthesisLecturesonElectricalEngineering","系列:电机工程","1559-811X","1559-8128","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00003ED1V01Y200508EEL001""Collection1","1598293400","GlobalWarmingandtheFutureoftheEarth","全球变暖与地球的未来","2007","SynthesisLecturesonEnergyandtheEnvironment:Technology,Science,andSociety","系列:能源与环境","1940-851X","1942-4361","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00098ED1V01Y200709EGY001""Collection1","1598291866","EssentialsofAppliedMathematicsforScientistsandEngineers","面向科学家和工程师的应用数学要素","2007","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00082ED1V01Y200612ENG003""Collection1","1598291742","ProjectManagementforEngineeringDesign","工程设计项目管理","2007","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00075ED1V01Y200612ENG002""Collection1","1598291300","RelativisticFlightMechanicsandSpaceTravel","相对飞行力学和宇宙航行","2006","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00042ED1V01Y200611ENG001""Collection1","1598293486","TensorPropertiesofSolids,PartOne","固体张力特质,第一部分","2007","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00057ED1V01Y200712ENG04""Collection1","1598293486","TensorPropertiesofSolids,PartTwo","固体张力特质,第二部分","2007","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00058ED1V01Y200712ENG05""Collection1","1598290908","EngineeringEthics:Peace,Justice,andtheEarth","工程学伦理:和平,正义和地球","2006","SynthesisLecturesonEngineers,Technology,andSociety","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00039ED1V01Y200606ETS001""Collection1","1598292188","Engineering,Poverty,andtheEarth","工程学,贫困和地球","2007","SynthesisLecturesonEngineers,Technology,andSociety","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00088ED1V01Y200704ETS004""Collection1","159829136X","EngineerswithinaLocalandGlobalSociety","地方和全球社会中的工程师","2006","SynthesisLecturesonEngineers,Technology,andSociety","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00059ED1V01Y200609ETS002""Collection1","1598291521","Globalization,Engineering,andCreativity","全球化,工程和创造","2007","SynthesisLecturesonEngineers,Technology,andSociety","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00064ED1V01Y200610ETS003""Collection1","1598290185","BiomedicalImageAnalysis:Tracking","生物医学影像分析:追踪","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00002ED1V01Y200508IVM002""Collection1","1598290444","JointSource-ChannelVideoTransmission","联合信源信道视频传输","2007","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00061ED1V01Y200707IVM010""Collection1","1598290762","LightFieldSampling","光场采样","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00035ED1V01Y200606IVM006""Collection1","1598290223","ModernImageQualityAssessment","现代影像质量评估","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00010ED1V01Y200508IVM003""Collection1","1598290428","MPEG-4BeyondConventionalVideoCoding","MPEG4——超乎寻常的视频编码","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00011ED1V01Y200508IVM004""Collection1","1598290525","Real-TimeImageandVideoProcessing","实时影像和视频处理","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00021ED1V01Y200604IVM005""Collection1","1598290061","RecognitionofHumansandTheirActivitiesUsingVideo","人和行为的视频识别","2005","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00002ED1V01Y200508IVM001""Collection1","1598290843","SuperResolutionofImagesandVideo","影像和视频的超级解决方案","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00036ED1V01Y200606IVM007""Collection1","1598291009","TensorVoting","TensorVoting技术","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00049ED1V01Y200609IVM008""Collection1","1598291289","ControllingEnergyDemandinMobileComputingSystems","移动计算系统中的控制能量需求","2007","SynthesisLecturesonMobileandPervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00089ED1V01Y200704MPC002""Collection1","1598291084","RFIDExplained","RFID解释","2006","SynthesisLecturesonMobileandPervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00040ED1V01Y200602MPC001""Collection1","1598291122","DigitalControlinPowerElectronics","电源设备中的数字控制","2006","SynthesisLecturesonPowerElectronics","系列:电力电子","1931-9525","1931-9533","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00047ED1V01Y200609PEL002""Collection1","1598290320","PowerElectronicsforModernWindTurbines","现代风能发电的电源电子","2006","SynthesisLecturesonPowerElectronics","系列:电力电子","1931-9525","1931-9533","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00014ED1V01Y200602PEL001""Collection1","1598290304","NonlinearSourceSeparation","非线性信源的分离","2006","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00016ED1V01Y200602SPR002""Collection1","1598290002","SpectralAnalysisofSignals","信号光谱分析","2005","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00001ED1V01Y200508SPR001""Collection1","1598295756","TheTheoryofLinearPrediction","线性预测理论","2007","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00086ED1V01Y200712SPR003""Collection1","1598290045","Hf-BasedHigh-kDielectrics","基于HF的高K值电解质","2005","SynthesisLecturesonSolidStateMaterialsandDevices","系列:固态材料与设备","1932-1260","1932-1724","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00005ED1V01Y200508SSM001""Collection1","1598290665","OpticalInterconnects","光学互联","2007","SynthesisLecturesonSolidStateMaterialsandDevices","系列:固态材料与设备","1932-1260","1932-1724","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00029ED1V01Y200605SSM002""Collection1","1598290088","ArticulationandIntelligibility","音和清晰度","2005","SynthesisLecturesonSpeechandAudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00004ED1V01Y200508SAP001""Collection1","1598290649","DynamicSpeechModels","动态演讲模型","2006","SynthesisLecturesonSpeechandAudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00028ED1V01Y200605SAP002""Collection1","1598291041","LatentSemanticMapping:PrinciplesandApplications","潜在语义描绘:原理和应用","2007","SynthesisLecturesonSpeechandAudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00048ED1V01Y200609SAP003""Collection1","1598291688","UnderstandingtheFinancialScore","财务分数理解","2007","SynthesisLecturesonTechnology,Management,andEntrepreneurship","系列:技术、管理与企业精神","1933-978X","1933-9798","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00074ED1V01Y200612TME001""文集","ISBN","文献名(英文)","文献名(中文)","出版年份","所属系列(英文)","所属系列(中文)","ISSNPRINT","ISSNELEC","URL""Collection2","9781598296723","AdvancesinWaveform-AgileSensingforTracking","基于追踪的灵敏波形感应高级技巧","2008","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00168ED1V01Y200812ASE002""Collection2","9781598296211","DespeckleFilteringAlgorithmsandSoftwareforUltrasoundImaging","超声影像滤波算法和软件","2008","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00116ED1V01Y200805ASE001""Collection2","9781598298147","GeneralizedTransmissionLineMethodtoStudytheFar-zoneRadiationofAntennasunderaMultilayerStructure","研究多层结构下天线远区场辐射的普遍化传输线方法","2009","SynthesisLecturesonAntennas","系列:天线","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00156ED1V01Y200810ANT009""Collection2","1-59829-088-6","MultiantennaSystemsforMIMOCommunications","MIMO通信的多天线系统","2008","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00104ED1V01Y200803ANT007""Collection2","9781598296518","NarrowbandDirectionofArrivalEstimationforAntennaArrays","天线阵列窄带波达方向估计","2008","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00118ED1V01Y200805ANT008""Collection2","1-59829-593-4","EssentialsofGameTheory","博弈论类要","2008","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00108ED1V01Y200802AIM003""Collection2","9781598296600","RepresentationDiscoveryusingHarmonicAnalysis","使用谐波分析的表示法发现","2008","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00130ED1V01Y200806AIM004""Collection2","9781598295450","ActionProgrammingLanguages","Action编程语言","2008","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00143ED1V01Y200807AIM005""Collection2","9781598295481","IntroductiontoSemi-SupervisedLearning","半监督学习介绍","2009","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00196ED1V01Y200906AIM006""Collection2","9781598296938","MarkovLogic:AnInterfaceLayerforArtificialIntelligence","马尔科夫逻辑:人工智能接口层","2009","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00206ED1V01Y200907AIM007""Collection2","9781598296181","IntroductiontoContinuumBiomechanics","连续介质生物力学介绍","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00121ED1V01Y200805BME019""Collection2","1-59829-294-3","ABiosystemsApproachtoIndustrialPatientMonitoringandDiagnosticDevices","病人监测与诊断仪器的生物系统研究","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00101ED1V01Y200702BME012""Collection2","9781598298284","AnOutlineofInformationalGenetics","信息遗传学概述","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00151ED1V01Y200809BME023""Collection2","9781598299519","BasicFeedbackControlsinBiomedicine","生物医学基本反馈控制","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00157ED1V01Y200812BME027""Collection2","9781598298451","IntroductiontoBiomedicalEngineering:BiomechanicsandBioelectricity,PartI","生物医学工程介绍:生物医学和生物电第1部分","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00182ED1V01Y200903BME028""Collection2","9781598296129","IntroductoryMedicalImaging","医疗成像介绍","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00165ED1V01Y200811BME026""Collection2","9781598292855","LandmarkingandSegmentationof3DCTImages","3DCT影像标志和分割","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1932-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00185ED1V01Y200903BME030""Collection2","9781598297119","LungSounds:AnAdvancedSignalProcessingPerspective","肺音:高级信号处理展望","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00127ED1V01Y200811BME009""Collection2","9781598296815","NeuralInterfacing:ForgingtheHuman-MachineConnection","神经接口:打造人机接口","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00148ED1V01Y200809BME022""Collection2","9781598296754","QuantitativeNeurophysiology","定量神经生理学","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00125ED1V01Y200808BME021""Collection2","1-59829-578-0","TheEffectsofHypergravityandMicrogravityonBiomedicalExperiments","超微重力生物医学影响实验","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00105ED1V01Y200801BME018""Collection2","9781598292978","UnderstandingAtrialFibrillation,PartI","理解心房纤颤,第1部分","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00152ED1V01Y200809BME024""Collection2","9781598298376","UnderstandingAtrialFibrillation,PartII","理解心房纤颤,第2部分","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00153ED1V01Y200809BME025""Collection2","9781598298468","IntroductiontoBiomedicalEngineering:BiomechanicsandBioelectricity,PartII","生物医学工程介绍:生物医学和生物电第2部分","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00183ED1V01Y200903BME029""Collection2","9781598299762","PhonocardiographySignalProcessing","心音图描记法信号处理","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00187ED1V01Y200904BME031""Collection2","9781608451258","StrategicHealthTechnologyIncorporation","战略卫生技术团体","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00216ED1V01Y200908BME032""Collection2","9781598296396","Tremor:FromPathogenesistoTreatment","颤动:从发病机理到治疗手段","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00129ED1V01Y200807BME020""Collection2","9781608451494","JointSourceChannelCodingusingArithmeticCodes","基于算术码的联合信源信道编码","2009","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00222ED1V01Y200911COM004""Collection2","9781608453009","AnIntroductiontoLocallyCorrectedNystromMethod","高阶局部修正的Nystrom方法介绍","2009","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00217ED1V01Y200910CEM025""Collection2","1-59829-318-0","ModernEMCAnalysisTechniquesVolumeI:Time-DomainComputationalSchemes","现代EMC分析技术卷1:时域计算方案","2008","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00113ED1V01Y200804CEM021""Collection2","1-59829-3203","ModernEMCAnalysisTechniquesVolumeII:ModelsandApplications","现代EMC分析技术卷2:模型和应用","2008","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00114ED1V01Y200804CEM022""Collection2","9781598292480","ReductionofaShip'sMagneticFieldSignatures","船体磁特征的减少","2008","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00150ED1V01Y200809CEM023""Collection2","9781598291490","IntegralEquationMethodsforElectromagneticandElasticWaves","电磁波与弹性波的积分方程方法","2008","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00102ED1V01Y200807CEM012""Collection2","1-59829-614-3","ParticleSwarmOptimization:APhysics-BasedApproach","颗粒群优化:基于物理的方法","2008","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00110ED1V01Y200804CEM020""Collection2","9781598298260","TransientSignalsonTransmissionLines","传输线上的瞬变信号","2009","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00155ED1V01Y200812CEM024""Collection2","9781598292084","ComputerArchitectureTechniquesforPower-Efficiency","基于节能的计算机结构技术","2008","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00119ED1V01Y200805CAC004""Collection2","9781598299540","FaultTolerantComputerArchitecture","可容错计算机结构","2009","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00192ED1V01Y200904CAC005""Collection2","9781598295856","On-ChipNetworks","芯片网络","2009","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00209ED1V01Y200907CAC008""Collection2","9781598295573","TheDatacenterasaComputer:AnIntroductiontotheDesignofWarehouse-ScaleMachines","计算机数据中心:库房机器设计介绍","2009","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00193ED1V01Y200905CAC006""Collection2","9781598295887","TheMemorySystem","存储器系统","2009","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00201ED1V01Y200907CAC007""Collection2","9781598292152","HighDynamicRangeVideo","高动态范围视频","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00109ED1V01Y200806CGR005""Collection2","9781598292114","InteractiveShapeDesign","交互式形状设计","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00122ED1V01Y200806CGR006""Collection2","9781608450183","IntroductoryTilingTheoryforComputerGraphics","计算机图形Tiling理论介绍","2009","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00207ED1V01Y200907CGR011""Collection2","9781598296457","PracticalGlobalIlluminationwithIrradianceCaching","使用辐照缓存的全局照明实践","2009","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00180ED1V01Y200903CGR010""Collection2","9781598297935","Real-TimeMassiveModelRendering","实时大规模模型利用","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00131ED1V01Y200807CGR007""Collection2","1-59829-559-4","GPU-BasedTechniquesforGlobalIlluminationEffects","基于GPU的全局光照效果技术","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00107ED1V01Y200801CGR004""Collection2","1-59829-562-4","HighDynamicRangeImageReconstruction","高动态范围图像重构","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00103ED1V01Y200711CGR003""Collection2","9781598299304","InformationTheoryToolsforComputerGraphics","计算机图形信息论工具","2009","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00208ED1V01Y200909CGR012""Collection2","9781598296419","VirtualCrowds:Methods,Simulation,andControl","虚拟人群:方法,仿真和控制","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00123ED1V01Y200808CGR008""Collection2","9781598299663","WangTilesinComputerGraphics","计算机图形中基于WangTiles的纹理合成","2009","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S000179ED1V01Y200903CGR009""Collection2","9781608452453","Image-BasedModelingofPlantsandTrees","植物和树的影像建模","2009","SynthesisLecturesonComputerVision","系列:计算机视觉","2153-1056","2153-1064","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00205ED1V01Y200911COV001""Collection2","9781598299090","ModelingandDataMininginBlogosphere","博客世界中的建模和数据挖掘","2009","SynthesisLecturesonDataMiningandKnowledgeDiscovery","系列:数据挖掘和知识发现","2151-0067","2151-0075","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00213ED1V01Y200907DMK001""Collection2","9781598293517","AnIntroductiontoLogicCircuitTesting","逻辑电路测试介绍","2008","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00149ED1V01Y200808DCS017""Collection2","9781598299823","DesigningAsynchronousCircuitsusingNULLConventionLogic(NCL)","基于非传统逻辑的异步电路设计","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00202ED1V01Y200907DCS023""Collection2","9781608451289","EmbeddedSystemsDesignwiththeAtmelAVRMicrocontrollerPartI","AtmelAVR微控制器嵌入式系统设计第1部分","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00138ED1V01Y200910DCS024""Collection2","9781608453320","EmbeddedSystemsDesignwiththeAtmelAVRMicrocontrollerPartII","AtmelAVR微控制器嵌入式系统设计第2部分","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00225ED1V01Y200910DCS025""Collection2","9781598299427","MismatchandNoiseinModernICProcesses","现代IC处理中的失陪和噪音","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00171ED1V01Y200901DCS019""Collection2","9781598296907","AsynchronousSequentialMachineDesignandAnalysis","异步时序机的设计和分析","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00160ED1V01Y200811DCS018""Collection2","9781598299793","DevelopingEmbeddedSoftwareusingDaVinciandOMAPTechnology","DaVinci和OMAP技术嵌入式软件开发","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00189ED1V01Y200904DCS021""Collection2","9781608450091","EmbeddedSystemsInterfacingforEngineersusingtheFreescaleHCS08MicrocontrollerII:DigitalandAnalogHardwareInterfacing","基于FreescaleHCS08微控制器的工程嵌入式系统接口技术:数字和模拟硬件接口","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00199ED1V01Y200906DCS022""Collection2","9781608450060","EmbeddedSystemsInterfacingforEngineersusingtheFreescaleHCS08MicrocontrollerPartI:AssemblyLanguageProgramming","基于FreescaleHCS08微控制器的工程嵌入式系统接口技术:汇编语言编程","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00188ED1V01Y200906DCS020""Collection2","9781598297980","PragmaticPower","实用电源","2008","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00145ED1V01Y200808DCS016""Collection2","9781598293357","HittingtheWall:AVisionofaSecureEnergyFuture","撞墙效应:安全能源未来视界","2008","SynthesisLecturesonEnergyandtheEnvironment","系列:能源与环境","1940-851X","1942-4361","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00124ED1V01Y200805EGY003""Collection2","9781598293302","NonimagingOpticsinSolarEnergy","太阳能非成像光学","2008","SynthesisLecturesonEnergyandtheEnvironment","系列:能源与环境","1940-851X","1940-851X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00120ED1V01Y200807EGY002""Collection2","9781598297669","CAD/CAMofSculpturedSurfacesonMulti-AxisNCMachine","复杂曲面多轴数控机床的CAD/CAM设计","2008","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00141ED1V01Y200806ENG008""Collection2","9781598297607","IntroductiontoEngineering:AStarter'sGuidewithHands-OnAnalogMultimediaExplorations","工程技术介绍:实用模拟媒体探索新手指南","2008","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00139ED1V01Y200806ENG006""Collection2","9781598297638","IntroductiontoEngineering:AStarter'sGuidewithHands-OnDigitalMultimediaandRoboticsExplorations","工程技术介绍:实用数字媒体和机器人技术探索新手指南","2008","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00140ED1V01Y200806ENG007""Collection2","9781598292992","StyleandEthicsofCommunicationinScienceandEngineering","科学工程通信的道德风气","2009","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00128ED1V01Y200809ENG009""Collection2","9781608452637","GeometricProgrammingforDesignandCostOptimization","基于设计和成本优化的几何设计","2009","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00221ED1V01Y200909ENG010""Collection2","9781598296693","Engineering:WomenandLeadership","工程技术:女性与领导力","2008","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00111ED1V01Y200804ETS005""Collection2","1-59829-623-5","BridgingtheGapBetweenEngineeringandtheGlobalWorld","架连工程技术与世界","2008","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00112ED1V01Y200804ETS006""Collection2","1-59829-626-4","EngineeringandSocialJustice","工程技术与社会正义","2008","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00117ED1V01Y200805ETS007""Collection2","9781598296631","EngineeringandSociety:WorkingTowardsSocialJusticePartI","工程技术与社会:为了社会正义工作第1部分","2009","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00136ED1V01Y200905ETS008""Collection2","9781598296655","EngineeringandSociety:WorkingTowardsSocialJusticePartII","工程技术与社会:为了社会正义工作第2部分","2009","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00137ED1V01Y200905ETS009""Collection2","9781598296662","EngineeringandSociety:WorkingTowardsSocialJusticePartIII","工程技术与社会:为了社会正义工作第3部分","2009","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00195ED1V01Y200905ETS010""Collection2","9781598295979","DependencyParsing","依存分析","2009","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00169ED1V01Y200901HLT002""Collection2","9781598296006","SpokenDialogueSystems","口头对话系统","2009","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00204ED1V01Y200910HLT005""Collection2","9781598299335","IntroductiontoChineseNaturalLanguageProcessing","中文处理介绍","2009","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00211ED1V01Y200909HLT004""Collection2","9781598297393","IntroductiontoLinguisticAnnotationandTextAnalytics","语言注释和文字分析介绍","2009","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00194ED1V01Y200905HLT003""Collection2","9781598295917","StatisticalLanguageModelsforInformationRetrieval","信息检索的统计语言模型","2009","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00158ED1V01Y200811HLT001""Collection2","9781598299458","SemioticEngineeringMethodsforScientificResearchinHCI","HCI中科学研究的符号工程学方法","2009","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00173ED1V01Y200901HCI002""Collection2","9781598298581","CommonGroundinElectronicallyMediatedConversation","电子调解对话的共性","2009","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00154ED1V01Y200810HCI001""Collection2","9781598299915","Context-AwareMobileComputing","上下为文感知型移动计算技术","2009","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00135ED1V01Y200905HCI004""Collection2","9781608450244","DesigningforUserEngagement:AestheticandAttractiveUserInterfaces","用户参与设计:美观有吸引力的人机界面","2009","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00210ED1V01Y200910HCI005""Collection2","9781598299885","StudiesofWorkandtheWorkplaceinHCI:ConceptsandTechniques","HCI中工作和工作点的研究:概念和技术","2009","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00177ED1V01Y200903HCI003""Collection2","9781598290219","BiomedicalImageAnalysis:Segmentation","生物医学影像分析:分割","2009","SynthesisLecturesonImage,Video,&MultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00133ED1V01Y200807IVM009""Collection2","9781598292336","TheStructureandPropertiesofColorSpacesandtheRepresentationofColorImages","色彩空间和色彩影像表现的结构和特质","2009","SynthesisLecturesonImage,Video,&MultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00224ED1V01Y200910IVM011""Collection2","9781598297720","AutomatedMetadatainMultimediaInformationSystems","多媒体信息系统的自动化元数据","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00167ED1V01Y200812ICR002""Collection2","9781598297843","ExploratorySearch:BeyondtheQuery-ResponseParadigm","探索:超越应答系统模板","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00174ED1V01Y200901ICR003""Collection2","9781598297454","NewConceptsinDigitalReference","数字引用的新概念","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00166ED1V01Y200812ICR001""Collection2","9781598299069","ReadingandWritingtheElectronicBook","读写电子书","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00215ED1V01Y200907ICR009""Collection2","9781608450008","FacetedSearch","面搜索","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00190ED1V01Y200904ICR005""Collection2","9781608450923","HypermediaGenes:AnEvolutionaryPerspectiveofConcepts,ModelsandArchitecture","超媒体基因:概念,模型和结构的革命","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00223ED1V01Y200910ICR011""Collection2","9781598299601","InformationArchitecture:TheDesignandIntegrationofInformationSpaces","信息结构:信息空间的设计与整合","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00214ED1V01Y200910ICR008""Collection2","9781598299946","IntroductiontoWebometrics","网络计量学介绍","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00176ED1V01Y200903ICR004""Collection2","9781598298529","UnderstandingUser-WebInteractionsviaWebAnalytics","基于网站分析上人机界面交互的理解","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00191ED1V01Y200904ICR006""Collection2","9781598297874","XMLRetrieval","XML检索","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00203ED1V01Y200907ICR007""Collection2","9781598292121","OperatingSystemSecurity","操作系统安全","2008","SynthesisLecturesonInformationSecurity,Privacy,andTrust","系列:信息安全、隐秘与信任","1945-9742","1945-9750","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00126ED1V01Y200808SPT001""Collection2","9781598298857","FundamentalsofPlasticsThermoforming","塑料热压成型基础","2009","SynthesisLecturesonMaterialsEngineering","系列:材料工程","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00184ED1V01Y200904MRE001""Collection2","9781598298239","AGyrovectorSpaceApproachtoHyperbolicGeometry","双曲几何GyrovectorSpace研究","2008","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00175ED1V01Y200901MAS004""Collection2","9781598298024","AnIntroductiontoMultivariableMathematics","多元数学介绍","2008","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00147ED1V01Y200808MAS003""Collection2","9781598298055","JordanCanonicalForm:ApplicationtoDifferentialEquations","Jordan表准形:微分方程上的应用","2008","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00146ED1V01Y200808MAS002""Collection2","9781608452514","JordanCanonicalForm:TheoryandPractice","Jordan表准形:理论与实践","2009","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00218ED1V01Y200908MAS006""Collection2","9781598297782","StatisticsisEasy!
","统计学很简单!
","2008","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00142ED1V01Y200807MAS001""Collection2","9781598298208","TheGeometryofWalkerManifolds","WalkerManifolds几何学","2009","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00197ED1V01Y200906MAS005""Collection2","1-59829-202-2","ReplicatedDataManagementforMobileComputing","基于移动计算的重复数据管理","2008","SynthesisLecturesonMobile&PervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00132ED1V01Y200807MPC005""Collection2","9781608452545","APracticalGuidetoTestingWirelessSmartphoneApplications","智能机应用程序测试实验指南","2009","SynthesisLecturesonMobile&PervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00219ED1V01Y200909MPC006""Collection2","1-59829-120-3","ApplicationDesignforWearableComputing","便携计算机应用程序设计","2008","SynthesisLecturesonMobile&PervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00106ED1V01Y200801MPC003""Collection2","1-59829-581-8","LocationSystems:AnIntroductiontotheTechnologyBehindLocationAwareness","定位系统:位置侦测以后的技术介绍","2008","SynthesisLecturesonMobile&PervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00115ED1V01Y200804MPC004""Collection2","9781598299854","India'sNuclearFuelCycle:UnravelingtheImpactoftheUS-IndiaNuclearAccord","印度核燃料循环:揭示美印核能合作的影响","2009","SynthesisLecturesonNuclearTechnology&Society","系列:核技术与社会","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S000181ED1V01Y200908NTS001""Collection2","9781598297331","QuantumComputerScience","量子计算机科学","2009","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00159ED1V01Y200810QMC002""Collection2","9781598296563","QuantumWalksforComputerScientists","计算机科学家们的量子步伐","2008","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00144ED1V01Y200808QMC001""Collection2","9781598298611","DesignandDevelopmentofRFIDandRFID-EnabledSensorsonFlexibleLowCostSubstrates","RFID和灵活低成本电路板上RFID感应器的设计开发","2009","SynthesisLecturesonRF/Microwaves","系列:射频/微波","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00172ED1V01Y200905MRF001""Collection2","9781598298420","AdvancedRadarDetectionSchemesunderMismatchedSignalModels","不匹配信号模型的高级雷达检测技术","2009","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00170ED1V01Y200902SPR008""Collection2","9781598298918","DSPforMATLABandLabVIEWI:FundamentalsofDiscreteSignalProcessing","基于Matlab和Labview的DSP设计:离散信号处理基础","2008","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S000161ED1V01Y200811SPR004""Collection2","9781598298949","DSPforMATLABandLabVIEWII:DiscreteFrequencyTransforms","基于Matlab和Labview的DSP设计:离散频率变换","2008","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S000162ED1V01Y200811SPR005""Collection2","9781598298970","DSPforMATLABandLabVIEWIII:DigitalFilterDesign","基于Matlab和Labview的DSP设计:数字滤波器设计","2008","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S000163ED1V01Y200811SPR006""Collection2","9781598299007","DSPforMATLABandLabVIEWIV:LMSAdaptiveFiltering","基于Matlab和Labview的DSP设计:LMS自适应滤波器","2009","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00164ED1V01Y200811SPR007""Collection2","9781598292596","Fixed-PointSignalProcessors","定点信号处理器","2009","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00220ED1V01Y200909SPR009""Collection2","9781598293098","DiscriminativeLearningforSpeechRecognition","语音识别的判别学习","2008","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00134ED1V01Y200807SAP004""Collection2","9781598298390","Multi-PitchEstimation","多音高估计","2009","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00178ED1V01Y200903SAP005""Collection2","9781598299489","GenomeRefactoring","基因组重组","2009","SynthesisLecturesonSyntheticBiology","系列:合成生物学","2151-0008","2151-0016","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00200ED1V01Y200906SBI001""Collection2","9781598298765","ArticularCartilageTissueEngineering","关节软骨组织工程","2009","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00212ED1V01Y200910TIS003""Collection2","9781598298734","EngineeringtheKneeMeniscus","膝盖半月板工程","2009","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00186ED1V01Y200903TIS001""Collection2","9781598299977","TissueEngineeringofTemporomandibularJointCartilage","人工颞下颌软骨的组织工程.
","2009","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00198ED1V01Y200906TIS002""文集","ISBN","文献名(英文)","文献名(中文)","出版年份","所属系列(英文)","所属系列(中文)","ISSNPRINT","ISSNELEC","URL""Collection3","9781608455775","AdaptiveHigh-ResolutionSensorWaveformDesignforTracking","用于追踪的自适应高分辨率传感波形设计","2010","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00311ED1V01Y201011ASE004""Collection3","9781608453887","AlgorithmsandSoftwareforPredictiveandPerceptualModelingofSpeech","语音预测和感知建模的算法和软件","2011","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00333ED1V01Y201102ASE007""Collection3","9781608453856","MATLABSoftwarefortheCodeExcitedLinearPredictionAlgorithm:TheFederalStandard-1016","基于码激励线性预测算法的Matlab软件:联邦标准-1016","2010","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00252ED1V01Y201001ASE003""Collection3","9781598297027","OFDMSystemsforWirelessCommunications","基于无线通信的OFDM系统","2010","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00255ED1V01Y201002ASE005""Collection3","9781608451074","AdvancesinModernBlindSignalSeparationAlgorithms:TheoryandApplications","现代盲信号分离:理论和应用","2010","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00258ED1V01Y201003ASE006""Collection3","9781608455812","Meta-SmithChartsandTheirPotentialApplications","Meta-Smith图表和潜在应用","2010","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00276ED1V01Y201009ANT010""Collection3","9781608456178","LearningwithSupportVectorMachines","使用支持向量机的学习","2011","SynthesisLecturesonArtificalIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00324ED1V01Y201102AIM010""Collection3","9781608454938","AlgorithmsforReinforcementLearning","强化学习算法","2010","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00268ED1V01Y201005AIM009""Collection3","9781598297423","DataIntegration:TheRelationalLogicApproach","数据整合:相关逻辑实现","2010","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00226ED1V01Y200911AIM008""Collection3","9781598299694","VisualObjectRecognition","视觉目标认知","2011","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00332ED1V01Y201103AIM011""Collection3","9781608450305","AnalysisofOrientedTexturewithApplicationtotheDetectionofArchitecturalDistortioninMammorgrams","有取向性组织分析—乳房结构扭曲检测应用","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00301ED1V01Y201010BME038""Collection3","9781608456321","DigitalImageProcessingforOphthalmology:DetectionoftheOpticNerveHead","眼科学数字影像处理:视神经头检测","2011","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00335ED1V01Y201102BME040""Collection3","9781598298673","FundamentalsofBiomedicalTransportProcesses","生物医学传递过程基础","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00288ED1V01Y201007BME037""Collection3","9781608454501","TheGraphTheoreticalApproachinBrainFunctionalNetworks","脑功能网络中的图形理论探索","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00279ED1V01Y201004BME036""Collection3","9781608452330","ModelsofHorizontalEyeMovements,PartI:EarlyModelsofSaccadesandSmoothPursuit","水平眼动模型第1部分:早期扫视和平稳跟踪","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00263ED1V01Y201003BME034""Collection3","9781608454471","ModelsofHorizontalEyeMovements,PartII:A3rdOrderLinearSaccadeModel","水平眼动模型第2部分:3阶线性扫视模型","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00264ED1V01Y201003BME035""Collection3","9781608450336","ModelingandAnalysisofShapewithApplicationsinComputer-AidedDiagnosisofBreastCancer","基于计算机辅助诊断乳腺癌应用程序的建模和分析","2011","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00325ED1V01Y201012BME039""Collection3","9781608451616","BiomedicalTechnologyAssessment:The3QMethod","生物医学技术评价:3Q方法","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00256ED1V01Y201002BME033""Collection3","9781608450954","CommunicationNetworks:AConciseIntroduction","通信网络:简述","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00254ED1V01Y201002CNT004""Collection3","9781608454099","NetworkGames:Theory,Models,andDynamics","网络游戏:理论、方法和动态","2011","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00330ED1V01Y201101CNT009""Collection3","9781598299243","PathProblemsinNetworks","网络路径问题","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00245ED1V01Y201001CNT003""Collection3","9781598299182","PerformanceModelingofCommunicationNetworkswithMarkovChains","马尔科夫链通信网络的性能建模","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00269ED1V01Y201004CNT005""Collection3","9781608450770","PerformanceModeling,LossNetworks,andStatisticalMultiplexing","性能建模,损耗网络和统计复用","2009","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00241ED1V01Y200911CNT002""Collection3","9781608454624","SchedulingandCongestionControlforWirelessandProcessingNetworks","无线和处理网络的计划和阻塞控制","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00270ED1V01Y201008CNT006""Collection3","9781608454563","StochasticNetworkOptimizationwithApplicationtoCommunicationandQueueingSystems","应用通信和排队系统的随机网络优化","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00271ED1V01Y201006CNT007""Collection3","9781608450800","AnIntroductiontoModelsofOnlinePeer-to-PeerSocialNetworking","P2P社交网络模型介绍","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00313ED1V01Y201011CNT008""Collection3","9781608452606","BasicSimulationModelsofPhaseTrackingDevicesusingMATLAB","基于Matlab的相位跟踪设备的基础仿真模型","2010","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00245ED1V01Y201009COM005""Collection3","9781598299038","AnalysisandDesignofSubstrateIntegratedWaveguideUsingEfficient2DHybridMethod","基于高效2D混合方法的基片集成波导的分析和设计","2010","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00259ED1V01Y201003CEM026""Collection3","9781608455232","IntroductiontotheFinite-DifferenceTime-Domain(FDTD)MethodforElectromagnetics","电磁学有限差分时域法介绍","2011","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00316ED1V01Y201012CEM027""Collection3","9781608454686","ComputerArchitecturePerformanceEvaluationStandards","计算机结构性能评估标准","2010","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00273ED1V01Y201006CAC010""Collection3","9781608454594","DynamicBinaryModification:Tools,Techniques,andApplications","动态二元修正:工具、技术和应用","2011","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1932-3235","1932-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00345ED1V01Y201104CAC015""Collection3","9781608454037","HighPerformanceDatacenterNetworks:Architectures,Algorithms,andOpportunities","高性能数据中心网络:结构、算法和机会","2011","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00341ED1V01Y201103CAC014""Collection3","9781608453375","IntroductiontoReconfigurableSupercomputing","超级计算重构介绍","2009","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00238ED1V01Y200911CAC009""Collection3","9781608455652","APrimeronMemoryConsistencyandCacheCoherence","存储一致性和Cache一致性初探","2011","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00346ED1V01Y201104CAC016""Collection3","9781608456208","QuantumComputingforComputerArchitects,SecondEdition","计算机结构的量子计算,第二版","2011","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00331ED1V01Y201101CAC013""Collection3","9781608452361","TransactionalMemory,2ndEdition","事务存储器,第二版","2010","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00272ED1V01Y201006CAC011""Collection3","9781608454532","ProcessorMicroarchitecture:AnImplementationPerspective","处理器微体系结构:执行视角","2010","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00309ED1V01Y201011CAC012""Collection3","9781608454211","RethinkingQuaternions","四元数的再思考","2010","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00292ED1V01Y201008CGR013""Collection3","9781608454419","AnalyticalPerformanceModelingforComputerSystems","计算机系统分析性能模型","2010","SynthesisLecturesonComputerScience","系列:计算机科学","1932-1228","1932-1686","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00282ED1V01Y201005CSL002""Collection3","9781608456963","StoringClockedProgramsInsideDNA:ASimplifyingFrameworkforNanocomputing","储藏于DNA中的定时程序:纳米计算的单一框架","2011","SynthesisLecturesonComputerScience","系列:计算机科学","1932-1228","1932-1686","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00343ED1V01Y201103CSL004""Collection3","9781608456567","ScienceFictionPrototyping:DesigningtheFuturewithScienceFiction","科幻小说原型:用科幻小说设计未来","2011","SynthesisLecturesonComputerScience","系列:计算机科学","1932-1228","1932-1686","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00336ED1V01Y201102CSL003""Collection3","9781608451340","Boosting-BasedFaceDetectionandAdaptation","基于Boosting算法的脸部检测和视觉调整","2010","SynthesisLecturesonComputerVision","系列:计算机视觉","2153-1056","2153-1064","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00300ED1V01Y201009COV002""Collection3","9781608455843","DeformableSurface3DReconstructionfromMonocularImages","基于单目图像的可变形表面3D重建","2010","SynthesisLecturesonComputerVision","系列:计算机视觉","2153-1056","2153-1064","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00319ED1V01Y201012COV003""Collection3","9781608453764","AccessControlinDataManagementSystems","数据管理系统的入口控制","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00281ED1V01Y201005DTM004""Collection3","9781608451937","AdvancedMetasearchEngineTechnology","高级搜索引擎技术","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00307ED1V01Y201011DTM011""Collection3","9781608452736","DataStreamManagement","数据流管理","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00284ED1V01Y201006DTM005""Collection3","9781608453825","DatabaseReplication","数据库复制","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00296ED1V01Y201008DTM007""Collection3","9781608452217","AnIntroductiontoDuplicateDetection","重复检测介绍","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00262ED1V01Y201003DTM003""Collection3","9781608451968","KeywordSearchinDatabases","数据库中的关键词检索","2009","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00231ED1V01Y200912DTM001""Collection3","9781608455386","MultidimensionalDatabasesandDataWarehousing","多维数据库和数据仓储","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00299ED1V01Y201009DTM009""Collection3","9781608457205","Peer-to-PeerDataManagement","P2P数据管理","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00338ED1V01Y201104DTM015""Collection3","9781608455683","ProbabilisticRankingTechniquesinRelationalDatabases","关系数据库中的概率排序技术","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00344ED1V01Y201103DTM014""Collection3","9781608454129","RelationalandXMLDataExchange","XML和关系数据交换","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00297ED1V01Y201008DTM008""Collection3","9781608452828","User-CenteredDataManagement","以用户为中心的数据管理","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00285ED1V01Y201006DTM006""Collection3","9781608452484","WebPageRecommendationModels:TheoryandAlgorithms","网络页面推荐模型:理论和算法","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00305ED1V01Y201010DTM010""Collection3","9781608454778","FundamentalsofObjectDatabases:Object-OrientedandObject-RelationalDesign","目标数据库基础:目标导向和目标相关设计","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00315ED1V01Y201012DTM012""Collection3","9781608454341","UncertainSchemaMatching","不确定模式匹配","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00337ED1V01Y201102DTM013""Collection3","9781608452170","Privacy-PreservingDataPublishing:AnOverview","隐私保护数据的出版:概况","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00237ED1V01Y201003DTM002""Collection3","9781608453559","CommunityDetectionandMininginSocialMedia","社会媒体中社团的寻找和挖掘","2010","SynthesisLecturesonDataMiningandKnowledgeDiscovery","系列:数据挖掘和知识发现","2151-0067","2151-0075","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00298ED1V01Y201009DMK003""Collection3","9781608452859","EnsembleMethodsinDataMining:ImprovingAccuracyThroughCombiningPredictions","数据挖掘中的集合方法","2010","SynthesisLecturesonDataMiningandKnowledgeDiscovery","系列:数据挖掘和知识发现","2151-0067","2151-0075","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00240ED1V01Y200912DMK002""Collection3","9781608454389","ArduinoMicrocontrollerProcessingforEveryone,PartI","Arduino微控制器处理第1部分","2010","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00280ED1V01Y201005DCS028""Collection3","9781608454884","ArduinoMicrocontrollerProcessingforEveryone,PartII","Arduino微控制器处理第2部分","2010","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00283ED1V01Y201005DCS029""Collection3","9781608451791","DigitalSystemVerification:ACombinedFormalMethodsandSimulationFramework","数字系统验证:一种组合形式方法和仿真框架","2010","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00257ED1V01Y201002DCS027""Collection3","9781608454990","IntroductiontoEmbeddedSystems:UsingANSICandtheArduinoDevelopmentEnvironment","嵌入式系统介绍:使用ANSIC和Arduino开发环境","2010","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00291ED1V01Y201007DCS030""Collection3","9781608457144","MicrocontrollerProgrammingandInterfacing:TexasInstrumentsMSP430PARTI","微处理器编程和界面连接:德州仪器MSP430第一部分","2011","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00317ED1V01Y201105DCS032""Collection3","9781608457526","MicrocontrollerProgrammingandInterfacing:TexasInstrumentsMSP430PARTII","微处理器编程和界面连接:德州仪器MSP430第二部分","2011","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00340ED1V01Y201105DCS033""Collection3","9781608456697","PragmaticElectricalEngineering:Fundamentals","语用电机工程:基本原理","2011","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00242ED1V01Y201105DCS031""Collection3","9781608451821","ProgressinApplicationsofBooleanFunctions","应用程序和布尔功能的进步","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00243ED1V01Y200912DCS026""Collection3","9781608452941","CommunicationandAgreementAbstractionsforFault-TolerantAsynchronousDistributedSystems","可容错异步分布式系统的通信和协议抽象系统","2010","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00236ED1V01Y201004DCT002""Collection3","9781608451371","TheMobileAgentRendezvousProblemintheRing","Ring中移动主体汇聚问题","2010","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00278ED1V01Y201004DCT001""Collection3","9781608455904","NewModelsforPopulationProtocols","PopulationProtocols的新模式","2011","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00328ED1V01Y201101DCT006""Collection3","9781608450121","PrinciplesofTransactionalMemory","事务存储原理","2010","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00253ED1V01Y201009DCT004""Collection3","9781608450039","TheTheoryofTimedI/OAutomata,SecondEdition","时间输入/输出自动机理论,第二版","2010","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00310ED1V01Y201011DCT005""Collection3","9781608455263","Fault-TolerantAgreementinSynchronousMessage-PassingSystems","同步消息传递系统的容错协议","2010","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00294ED1V01Y201009DCT003""Collection3","9781608456086","FinShapeThermalOptimizationUsingBejan'sConstructalTheory","使用Bejan构造理论的鳍状热优化","2011","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00318ED1V01Y201102ENG013""Collection3","9781608456116","GeometricProgrammingforDesignandCostOptimization,SecondEdition","基于设计和预算优化的几何图形编程,第二版","2010","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00314ED1V01Y201011ENG012""Collection3","9781608455140","SurviveandThrive:AGuideforUntenuredFaculty","生存与发展:非长期员工导引","2010","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00234ED1V01Y201009ENG011""Collection3","9781608457021","SystemsEngineering:BuildingSuccessfulSystems","系统工程:构建成功的系统","2011","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00349ED1V01Y201104ENG014""Collection3","9781608455997","APhilosophyofTechnology:FromTechnicalArtefactstoSociotechnicalSystems","技术哲学:从技术人工物到社会技术系统","2011","SynthesisLecturesonEngineers,TechnologyandSociety","系列:工程师、技术与社会","1933-3633","1933-3641","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00321ED1V01Y201012ETS014""Collection3","9781608450718","EngineeringandSustainableCommunityDevelopment","工程技术和可持续社区的发展","2010","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00247ED1V01Y201001ETS011""Collection3","9781608451524","HumanitarianEngineering","人道主义工程技术","2010","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3641","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00248ED1V01Y201006ETS012""Collection3","9781608451647","NeedsandFeasibility:AGuideforEngineersDoingCommunityProjects","需要和可行性:给做社区项目工程师的导航","2010","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1947-3633","1947-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00249ED1V01Y201001ETS013""Collection3","9781608456291","TragedyintheGulfofMexico:TheNeedforaNewEngineeringEthic","墨西哥湾的悲剧:对新工程道德的需求","2010","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1947-3633","1947-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00322ED1V01Y201012ETS015""Collection3","9781608457380","AHybridImagination:ScienceandTechnologyinCulturalPerspective","一种混合想象:文化透视中的科学与技术","2011","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3641","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00339ED1V01Y201104ETS016""Collection3","9781608455799","WhatisGlobalEngineeringEducationForTheMakingofInternationalEducators,Part1","全球工程教育为了什么创造国际教育者,第一部分","2010","SynthesisLecturesonGlobalEngineering","系列:全局工程","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00302ED1V01Y201010GES001""Collection3","9781608455447","WhatisGlobalEngineeringEducationForTheMakingofInternationalEducators,Part2","全球工程教育为了什么创造国际教育者,第二部分","2010","SynthesisLecturesonGlobalEngineering","系列:全局工程","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00303ED1V01Y201010GES002""Collection3","9781608454716","AutomatedGrammaticalErrorDetectionforLanguageLearners","为语言学习者的自动语法错误检测","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00275ED1V01Y201006HLT009""Collection3","9781608453405","ComputationalModelingofHumanLanguageAcquisition","人类语言获取的计算机建模","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00304ED1V01Y201010HLT011""Collection3","9781598298642","Cross-LanguageInformationRetrieval","跨语言信息检索","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00266ED1V01Y201005HLT008""Collection3","9781608453436","Data-IntensiveTextProcessingwithMapReduce","基于MapReduce的数据密集型文章处理","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00274ED1V01Y201006HLT007""Collection3","9781598297966","IntroductiontoArabicNaturalLanguageProcessing","阿拉伯语处理介绍","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00277ED1V01Y201008HLT010""Collection3","9781598298321","SemanticRoleLabeling","语义角色标注","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00239ED1V01Y200912HLT006""Collection3","9781608457083","LearningtoRankforInformationRetrievalandNaturalLanguageProcessing","信息获取和自然语言处理","2011","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00348ED1V01Y201104HLT012""Collection3","9781608450541","DesigningandEvaluatingUsableTechnologyinIndustrialResearch:ThreeCaseStudies","工业研究中可用技术的设计和评估:三个案例研究","2010","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00228ED1V01Y200911HCR007""Collection3","9781608450459","Experience-CenteredDesign:Designers,Users,andCommunitiesinDialogue","经验设计:对话中的设计者、用户和社区","2010","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00229ED1V01Y201003HCI009""Collection3","9781608450480","ExperienceDesign:TechnologyforAlltheRightReasons","经验设计:为了所有正确原因的技术","2010","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00261ED1V01Y201003HCI008""Collection3","9781608455966","GeographicalDesign:SpatialCognitionandGeographicalInformationScience","地理学设计:空间认知和地理信息科学","2011","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00342ED1V01Y201103HCI011""Collection3","9781608450275","InteractingwithInformation","信息交互","2010","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00227ED1V01Y200911HCI006""Collection3","9781608453733","User-CenteredAgileMethods","以用户为中心的便捷方法","2010","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00286ED1V01Y201002HCI010""Collection3","9781608453580","EstimatingtheQueryDifficultyforInformationRetrieval","信息检索中查询难易度的估计","2010","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00235ED1V01Y201004ICR015""Collection3","9781598299632","InformationConcepts:FromBookstoCyberspaceIdentities","信息概念:从书到赛博空间","2010","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00306ED1V01Y201010ICR016""Collection3","9781608453344","iRODSPrimer:IntegratedRule-OrientedDataSystem","iRODS入门:完整规则导向数据系统","2010","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00233ED1V01Y200912ICR012""Collection3","9781598299571","KnowledgeManagement(KM)inOrganizations:TheoreticalFoundationsandPractice","组织中的知识管理:理论基础和实践","2011","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00323ED1V01Y201012ICR018""Collection3","9781608450985","MultimediaInformationRetrieval","多媒体信息搜索","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00244ED1V01Y200912ICR010""Collection3","9781608451432","OnlineMultiplayerGames","在线多人游戏","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00232ED1V01Y200912ICR013""Collection3","9781608451227","CollaborativeSearch:Who,What,Where,When,andWhy","协同搜索:谁,什么,哪里,何时,为什么","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00230ED1V01Y200912ICR014""Collection3","9781608455089","Search-BasedApplications:AttheConfluenceofSearchandDatabaseTechnologies","基于检索的应用:检索汇合及数据库技术","2010","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00320ED1V01Y201012ICR017""Collection3","9781598296303","AnalysisTechniquesforInformationSecurity","信息安全分析技术","2010","SynthesisLecturesonInformationSecurity,Privacy,andTrust","系列:信息安全、隐秘与信任","1945-9742","1945-9750","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00260ED1V01Y201003SPT002""Collection3","9781608456147","TheIntegral:ACruxforAnalysis","积分:分析症结","2011","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00327ED1V01Y201101MAS009""Collection3","9781608454969","LecturesonFinancialMathematics:DiscreteAssetPricing","金融数学讲座:离散资产定价","2010","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00293ED1V01Y201008MAS007""Collection3","9781608455713","StatisticsisEasy!
SecondEdition","统计学很简单!
第二版","2010","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00295ED1V01Y201009MAS008""Collection3","9781598299274","TheLandscapeofPervasiveComputingStandards","普适计算标准远景","2010","SynthesisLecturesonMobile&PervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00267ED1V01Y201004MPC007""Collection3","9781608450602","BroadbandQuantumCryptography","宽带量子密码学","2010","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00265ED1V01Y201004QMC003""Collection3","9781608454907","TheComplexityofNoise:APhilosophicalOutlookonQuantumErrorCorrection","噪声复杂度:量子错误更正的学术观点","2010","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00290ED1V01Y201007QMC004""Collection3","9781608456994","APerspectiveonSingle-ChannelFrequency-DomainSpeechEnhancement","单通道频率域语音增强透视","2011","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00344ED1V01Y201104SAP008""Collection3","9781598293074","SparseAdaptiveFiltersforEchoCancellation","用于回声消除的自适应滤波器研+C53究","2010","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00289ED1V01Y201006SAP006""Collection3","9781608456055","SpeechEnhancementintheKarhunen-LoeveExpansionDomain","Karhunen-Loeve展开域内的语音加强","2011","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00326ED1V01Y201101SAP007""Collection3","9781598299120","BacterialSensors:SyntheticDesignandApplicationPrinciples","细菌感应器:合成设计和应用原理","2010","SynthesisLecturesonSyntheticBiology","系列:合成生物学","2151-0008","2151-0016","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00312ED1V01Y201011SBI002""Collection3","9781608451760","OutoftheComfortZone:NewWaystoTeach,Learn,andAssessEssentialProfessionalSkills","非适宜温度:教,学和获取专业技能的新方法","2010","SynthesisLecturesonTechnology,Management,andEntrepreneurship","系列:技术、管理与企业精神","1933-978X","1933-9798","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00251ED1V01Y201001TME002""Collection3","9781608454310","LinkedData:EvolvingtheWebintoaGlobalDataSpace","关联数据:Web进化为全局数据空间","2011","SynthesisLecturesontheSemanticWeb","系列:语义网","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00334ED1V01Y201102WBE001""Collection3","9781608451739","BiologicFoundationsforSkeletalTissueEngineering","骨骼组织工程中的生物学原理","2011","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00329ED1V01Y201101TIS007""Collection3","9781608451708","FundamentalBiomechanicsinBoneTissueEngineering","骨骼组织工程中的基础生物力学","2010","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00246ED1V01Y200912TIS004""Collection3","9781608452149","RegenerativeDentistry","再生牙科医学技术","2010","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00287ED1V01Y201006TIS006""Collection3","9781608454655","CellsandBiomaterialsforIntervertebralDiscRegeneration","脊椎盘再生细胞和生物材料","2010","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00250ED1V01Y201006TIS005""Collection3","9781608455935","AGuidetoVisualMulti-LevelInterfaceDesignfromSynthesisofEmpiricalStudyEvidence","综合实例研究证明中视觉多层界面导引","2010","SynthesisLecturesonVisualization","系列:可视化","2159-516X","2159-5178","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00308ED1V01Y201011VIS001""文集","ISBN","文献名(英文)","出版年份","所属系列(英文)","所属系列(中文)","ISSNPRINT","ISSNELEC","URL""Collection4","9781608458028","AnalysisoftheMPEG-1LayerIII(MP3)AlgorithmUsingMATLAB","2012","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00382ED1V01Y201110ASE009""Collection4","9781608457540","TheoryandApplicationsofGaussianQuadratureMethods","2011","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00366ED1V01Y201105ASE008""Collection4","pending","ActiveLearning","2012","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00429ED1V01Y201207AIM018""Collection4","9781608456536","ComputationalAspectsofCooperativeGameTheory","2011","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00355ED1V01Y201107AIM016""Collection4","9781608455171","HumanComputation","2011","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00371ED1V01Y201107AIM013""Collection4","pending","PlanningwithMarkovDecisionProcesses:AnAIPerspective","2012","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00426ED1V01Y201206AIM017""Collection4","9781608455874","AShortIntroductiontoPreferences:BetweenAIandSocialChoice","2011","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00372ED1V01Y201107AIM014""Collection4","9781598296068","TradingAgents","2011","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00370ED1V01Y201107AIM012""Collection4","9781608457298","RepresentationsandTechniquesfor3DObjectRecognitionandSceneInterpretation","2011","SynthesisLecturesonArtificialIntelligenceandMachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00370ED1V01Y201107AIM015""Collection4","9781608457410","DesignandtheDigitalDivide:Insightsfrom40YearsinComputerSupportforOlderandDisabledPeople","2011","SynthesisLecturesonAssistive,Rehabilitative,andHealth-PreservingTechnologies","系列:辅助、复健及保健技术","2162-7258","2162-7266","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00369ED1V01Y201106ARH001""Collection4","9781608455201","Zero-EffortTechnologies:Considerations,Challenges,andUseinHealth,Wellness,andRehabilitation","2011","SynthesisLecturesonAssistive,Rehabilitative,andHealth-PreservingTechnologies","系列:辅助、复健及保健技术","2162-7258","2162-7266","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00380ED1V01Y201108ARH002""Collection4","9781608451463","ComputationalGenomicSignatures","2011","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00360ED1V01Y201105BME041""Collection4","9781608453702","EthicsforBioengineers","2012","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00393ED1V01Y201111BME042""Collection4","9781608456932","NSSimulatorforBeginners","2012","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00397ED1V01Y201112CNT010""Collection4","pending","BlockTransceivers:OFDMandBeyond","2012","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00424ED1V01Y201206COM007""Collection4","pending","ScatteringAnalysisofPeriodicStructuresUsingFinite-DifferenceTime-DomainMethod","2012","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00415ED1V01Y201204CEM028""Collection4","9781608458424","AutomaticParallelization:AnOverviewofFundamentalCompilerTechniques","2012","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00340ED1V01Y201201CAC019""Collection4","9781598297546","Multi-CoreCacheHierarchies","2011","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00365ED1V01Y201105CAC017""Collection4","9781608456666","PhaseChangeMemory:FromDevicestoSystems","2012","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00381ED1V01Y201109CAC018""Collection4","9781608456505","GazingatGames:AnIntroductiontoEyeTrackingControl","2012","SynthesisLecturesonComputerGraphicsandAnimation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00395ED1V01Y201111CGR014""Collection4","9781608456758","CameraNetworks:TheAcquisitionandAnalysisofVideosoverWideAreas","2012","SynthesisLecturesonComputerVision","系列:计算机视觉","2153-1056","2153-1064","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00400ED1V01Y201201COV004""Collection4","9781608456628","ControlSystemsSynthesis:AFactorizationApproach,PartI","2011","SynthesisLecturesonControl&Mechatronics","系列:机电与控制","1939-0564","1939-0572","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00351ED1V01Y201105CRM002""Collection4","9781608456635","ControlSystemsSynthesis:AFactorizationApproach,PartII","2011","SynthesisLecturesonControl&Mechatronics","系列:机电与控制","1939-0564","1939-0572","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00358ED1V01Y201105CRM003""Collection4","pending","MobileRoboticsforMultidisciplinaryStudy","2012","SynthesisLecturesonControl&Mechatronics","系列:机电与控制","1939-0564","1939-0572","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00407ED1V01Y201203CRM004""Collection4","pending","BusinessProcesses:ADatabasePerspective","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00430ED1V01Y201206DTM027""Collection4","9781608457632","DatabaseRepairsandConsistentQueryAnswering","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00379ED1V01Y201108DTM020""Collection4","pending","DataProtectionfromInsiderThreats","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00431ED1V01Y201207DTM028""Collection4","9781608456024","DeclarativeNetworking","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00403ED1V01Y201202DTM023""Collection4","pending","DeepWebQueryInterfaceUnderstandingandIntegration","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00419ED1V01Y201205DTM026""Collection4","9781608457960","Full-Text(Substring)IndexesinExternalMemory","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00396ED1V01Y201111DTM022""Collection4","9781608452798","FundamentalsofPhysicalDesignandQueryCompilation","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00363ED1V01Y201105DTM018""Collection4","9781608453528","ManagingEventInformation:Modeling,Retrieval,andApplications","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00374ED1V01Y201107DTM019""Collection4","9781608453917","MethodsforMiningandSummarizingTextConversations","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00363ED1V01Y201105DTM017""Collection4","pending","P2PTechniquesforDecentralizedApplications","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00414ED1V01Y201204DTM025""Collection4","9781608456819","ProbabilisticDatabases","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00362ED1V01Y201105DTM016""Collection4","9781608457663","QueryAnswerAuthentication","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00405ED1V01Y201202DTM024""Collection4","9781608458332","SpatialDataManagement","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00394ED1V01Y201111DTM021""Collection4","pending","MiningHeterogeneousInformationNetworks:PrinciplesandMethodologies","2012","SynthesisLecturesonDataMiningandKnowledgeDiscovery","系列:数据挖掘和知识发现","2151-0067","2151-0075","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00433ED1V01Y201207DMK005""Collection4","pending","PrivacyinSocialNetworks","2012","SynthesisLecturesonDataMiningandKnowledgeDiscovery","系列:数据挖掘和知识发现","2151-0067","2151-0075","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00408ED1V01Y201203DMK004""Collection4","9781608458059","AdvancedCircuitSimulationUsingMultisimWorkbench","2012","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00399ED1V01Y201112DCS036""Collection4","pending","ArduinoMicrocontroller:ProcessingforEveryone!
SecondEdition","2012","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00421ED1V01Y201205DCS038""Collection4","pending","AtmelAVRMicrocontrollerPrimer:ProgrammingandInterfacing,SecondEdition","2012","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00427ED1V01Y201206DCS039""Collection4","9781608457571","CircuitAnalysiswithMultisim","2011","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00386ED1V01Y201109DCS035""Collection4","9781608456727","PragmaticElectricalEngineering:Signals&Systems","2011","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00353ED1V01Y201105DCS034""Collection4","pending","RepresentationofMultiple-ValuedLogicFunctions","2012","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00420ED1V01Y201205DCS037""Collection4","9781608456840","QuorumSystems:WithApplicationstoStorageandConsensus","2012","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00402ED1V01Y201202DCT009""Collection4","9781608452880","CooperativeTask-OrientedComputing:AlgorithmsandComplexity","2011","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00376ED1V01Y201108DCT007""Collection4","9781608450428","LinkReversalAlgorithms","2011","SynthesisLecturesonDstributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00389ED1V01Y201111DCT008""Collection4","pending","CraftingYourResearchFuture:AGuidetoSuccessfulMaster'sandPh.
D.
DegreesinScience&Engineering","2012","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00412ED1V01Y201203ENG018""Collection4","9781608453641","EngineeringThermodynamicsand21stCenturyEnergyProblems","2011","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00387ED1V01Y201110ENG016""Collection4","pending","FundamentalsofEngineeringEconomicsandDecisionAnalysis","2012","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00410ED1V01Y201203ENG018""Collection4","9781608458681","ALittleBookonTeaching:ABeginner'sGuideforEducatorsofEngineeringandAppliedScience","2012","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00406ED1V01Y201203ENG017""Collection4","9781608457113","MATLABforEngineeringandtheLifeSciences","2011","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00375ED1V01Y201107ENG015""Collection4","9781608457908","Engineers,Society,andSustainability","2011","SynthesisLecturesonEngineers,Technology,andSociety","系列:工程师、技术与社会","1933-3633","1933-3633","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00378ED1V01Y201108ETS017""Collection4","pending","ActivityTheoryinHCI:FundamentalsandReflections","2012","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00413ED1V01Y201203HCI013""Collection4","9781608457502","ConceptualModels:CoretoGoodDesign","2012","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00391ED1V01Y201111HCI012""Collection4","pending","HCITheory:Classical,Modern,andContemporary","2012","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00418ED1V01Y201205HCI014""Collection4","pending","MakingClaims:KnowledgeDesign,Capture,andSharinginHCI","2012","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00423ED1V01Y201205HCI015""Collection4","9781608455119","BitextAlignment","2011","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00367ED1V01Y201106HLT014""Collection4","9781608457359","DiscourseProcessing","2012","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00354ED1V01Y201111HLT015""Collection4","9781608454068","LinguisticStructurePrediction","2011","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00361ED1V01Y201105HLT013""Collection4","pending","SentimentAnalysisandOpinionMining","2012","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00416ED1V01Y201204HLT016""Collection4","9781608458202","RemoteSensingImageProcessing","2012","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00392ED1V01Y201107IVM012""Collection4","9781598299724","InformationRetrievalEvaluation","2011","SynthesisLecturesonInformationConcepts,Retrieval&Services","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00368ED1V01Y201105ICR019""Collection4","pending","TheFutureofPersonalInformationManagement","2012","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00411ED1V01Y201203ICR021""Collection4","9781608456901","SearchUserInterfaceDesign","2011","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00371ED1V01Y201111ICR020""Collection4","pending","EnhancingInformationSecurityandPrivacybyCombiningBiometricswithCryptography","2012","SynthesisLecturesonInformationSecurity,Privacy,andTrust","系列:信息安全、隐秘与信任","1945-9742","1945-9750","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00417ED1V01Y201205SPT003""Collection4","9781608456598","MatricesinEngineeringProblems","2011","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00352ED1V01Y201105MAS010""Collection4","9781598299151","ChaoticMaps:Dynamics,Fractals,andRapidFluctuations","2011","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00373ED1V01Y201107MAS011""Collection4","9781608457816","EssentialsofAppliedMathematicsforEngineersandScientists,SecondEdition","2012","SynthesisLecturesonMathematicsandStatistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00377ED1V01Y201202MAS012""Collection4","9781608458677","MobilePlatformsandDevelopmentEnvironments","2012","SynthesisLecturesonMobileandPervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00404ED1V01Y201202MPC009""Collection4","9781608457328","QualityofServiceinWirelessNetworksOverUnlicensedSpectrum","2012","SynthesisLecturesonMobileandPervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00383ED1V01Y201109MPC008""Collection4","9781608458172","TheSmartGrid:AdaptingthePowerSystemtoNewChallenges","2011","SynthesisLecturesonPowerElectronics","系列:电力电子","1931-9525","1931-9533","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00385ED1V01Y201109PEL003""Collection4","pending","High-levelStructuresforQuantumComputing","2012","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00422ED1V01Y201205QMC006""Collection4","9781608458271","QuantumRadar","2011","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00384ED1V01Y201110QMC005""Collection4","9781608457939","ProcessingofSeismicReflectionDatausingMATLAB","2011","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00384ED1V01Y201109SPR010""Collection4","pending","ArticulatorySpeechSynthesisfromtheFluidDynamicsoftheVocalApparatus","2012","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00398ED1V01Y201112SAP009""Collection4","9781608457472","SustainableInnovation","2011","SynthesisLecturesonTechnology,Management,&Entrepreneurship","系列:技术、管理与企业精神","1933-978X","1933-9798","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00359ED1V01Y201105TME003""Collection4","9781608457878","CentralNervousSystemTissueEngineering:CurrentConsiderationsandStrategies","2012","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00390ED1V01Y201111TIS008""Collection4","9781608456260","DataRepresentations,Transformations,andStatisticsforVisualReasoning","2011","SynthesisLecturesonVisualization","系列:可视化","pending","pending","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00357ED1V01Y201105VIS002",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"Collection","PaperbackISBN","eBookISBN","Title","所属系列","Pages","Year","Author1","A1Affiliation","Author2","A2Affiliation","Author3","A3Affiliation","Author4","A4Affiliation","ISSNprint","ISSNelec","URL","DOI","Description""1","9781615041145","9781615041152","ProcessMonitoringandQualitybyDesignforBiotechnologyProducts","ColloquiumSeriesonBiotechnology","38","2010","NeslihanDelacruz"2159-2969","2159-2950","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00019ED1V01Y201011BTY001","10.
4199/C00019ED1V01Y201011BTY001","TraditionalpharmaceuticaldevelopmentisanunwieldyprocessrequiringextensiveexperimentationandlongleadtimesbeforeprocessscientistscanfullyunderstandtheeffectthatprocessparameterssuchaspH,temperature,cellviability,orprocessyieldmayhaveontheproductacceptability.
Implementationofqualitybydesignisascience-basedapproachthatallowstheoperatingrangesandtheacceptancecriteriatobeestablishedbasedontheimpactonproductqualityattributes.
Duringmanufacturing,processmonitoringbecomespartofacontinuousverificationeffortandstatisticalcontrollimitscanbeusedtosignalpotentialtrendsordriftsintheprocess.
Singlemanufacturingbatchesthatareaberrantarereadilyidentified.
Themeldingofscientificunderstanding,informationsystemsarchitecture,instrumentation,software,andpersonneltrainingprovidesalargereturnoninvestmentbyensuringthatthemanufacturingprocessproducesaconsistentpharmaceuticalproductthatmeetsacceptablereleasestandardsforhumanuse.
TableofContents:Abbreviations/Introduction/FromtheTraditionalDevelopmentPathtoQualitybyDesign/ContinuousProcessVerificationandProcessMonitoring/ProcessMonitoringandStatisticalControlLimits/MultivariateAnalysis:AMatureStateofStatisticalProcessMonitoring/Conclusion/Bibliography""1","9781615040636","9781615040643","FGFSignallinginVertebrateDevelopment","ColloquiumSeriesonDevelopmentalBiology","75","2010","MaryElizabethPownall","UniversityofYork","HarryIsaacs","UniversityofYork",,,,,"2155-3521","2155-353X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00011ED1V01Y201004DEB002","10.
4199/C00011ED1V01Y201004DEB002","Thefibroblastgrowthfactors(FGFs)representoneoftherelativelyfewfamiliesofextracellularsignallingpeptidesthathavebeenshowninrecentdecadestobekeyregulatorsofmetazoandevelopment.
FGFsarerequiredformultipleprocessesinbothprotostomeanddeuterostomegroups.
GiventhewiderangeofregulatoryrolesattributedtotheFGFs,itisperhapsnotsurprisingthatmisregulationofthissignallingpathwayhasbeenimplicatedinanumberofhumandiseaseconditions.
ThefocusofthepresentreviewistolookatthefundamentalcomponentsoftheFGFpathwayandillustratehowthishighlyconservedregulatorycassettehasbeendeployedtoregulatemultiple,diverseprocessesduringvertebratedevelopment.
ThisreviewwillexploreexamplesfromseveralvertebratemodelorganismsandincludediscussionsoftheroleofFGFsignallinginregulatingtheestablishmentofthemesoderm,neuralpatterning,morphogenesis,myogenesis,limbdevelopment,andtheestablishmentofright–leftasymmetry.
TableofContents:Introduction/FGFLigands/FGFReceptors/HeparanSulphateProteoglycans/FGFSignalTransduction/Regulators/IntegrationwithOtherSignallingPathways/MesodermInduction/NeuralInduction/FGFSignallingandPosteriorNeuralPatterning/FGFSignallingattheIsthmicOrganizer/FGFSignallingattheAnteriorNeuralRidge/Morphogenesis/Somitogenesis/FGFandMyogenesis/LimbDevelopment/FGFandLeft-RightAsymmetry/Perspectives/References/AbouttheAuthors""1","9781615041022","9781615041039","InductionandSegregationoftheVertebrateCranialPlacodes","ColloquiumSeriesonDevelopmentalBiology","83","2010","Byung-YongPark","ChonbukNationalUniversity,CollegeofVeterinaryMedicine","Jean-PierreSaint-Jeannet","UniversityofPennsylvania,SchoolofVeterinaryMedicine",,,,,"2155-3521","2155-353X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00014ED1V01Y201007DEB003","10.
4199/C00014ED1V01Y201007DEB003","Duringevolutionthevertebrateheadhasacquiredanumberofuniquefeaturesincludingspecializedpairedsenseorgansandcranialsensoryganglia.
Theseevolutionarynoveltiesarisefromdiscretethickeningsoftheheadectodermknownascranialplacodes.
Theyincludetheadenohypophyseal,olfactory,lens,trigeminal,profundal,otic,epibranchialandlaterallineplacodes.
Whiledistinctinthederivativesandcelltypestheywillform,allcranialplacodesoriginatefromacommonpreplacodaldomainsurroundingtheanteriorneuralplate.
Recentevidencesuggeststhattheinductionofthispre-placodaldomainanditssubsequentsubdivisionintoindividualplacodeswithspecificidentitiesisamulti-stepprocess.
Herewedescribethedevelopmentoftheseplacodesandtheirderivativesandsummarizerecentadvancesinthecharacterizationoftherepertoireoftranscriptionfactorsunderlyingtheirdevelopment.
Wealsoreviewrecentstudiesthathavestartedtoaddresstheroleofseveralclassesofsignalingmoleculesinplacodeinductionandsegregation,includingBoneMorphogeneticProteins,FibroblastGrowthFactorsandWntmolecules.
TableofContents:Introduction/CranialPlacodesandTheirDerivatives/MolecularIdentityofCranialPlacodes/InductionandSegregationoftheCranialPlacodes/Conclusion/Acknowledgments/References/AuthorBiographies""1","9781615040513","9781615040520","MaternalControlofDevelopmentinVertebrates","ColloquiumSeriesonDevelopmentalBiology","196","2010","FlorenceMarlow","AlbertEinsteinCollegeofMedicine"2155-3521","2155-353X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00023ED1V01Y201012DEB005","10.
4199/C00023ED1V01Y201012DEB005","EggsofallanimalscontainmRNAsandproteinsthataresuppliedtoordepositedintheeggasitdevelopsduringoogenesis.
Thesematernalgeneproductsregulateallaspectsofoocytedevelopment,andanembryofullyreliesonthesematernalgeneproductsforallaspectsofitsearlydevelopment,includingfertilization,transitionsbetweenmeioticandmitoticcellcycles,andactivationofitsowngenome.
Giventhediverseprocessesrequiredtoproduceadevelopmentallycompetenteggandembryo,itisnotsurprisingthatmaternalgeneproductsarenotonlyessentialfornormalembryonicdevelopmentbutalsoforfertility.
Thisreviewprovidesanoverviewoffundamentalaspectsofoocyteandearlyembryonicdevelopmentandtheinterferenceandgeneticapproachesthathaveprovidedaccesstomaternallyregulatedaspectsofvertebratedevelopment.
Someofthepathwaysandmoleculeshighlightedinthisreview,inparticular,Bmps,Wnts,smallGTPases,cytoskeletalcomponents,andcellcycleregulators,arewellknownandareessentialregulatorsofmultipleaspectsofanimaldevelopment,includingoogenesis,earlyembryogenesis,organogenesis,andreproductivefitnessoftheadultanimal.
Specificexamplesofdevelopmentalprocessesundermaternalcontrolandtheessentialproteinswillbeexploredineachchapter,andwhereknownconservedaspectsordivergentrolesforthesematernalregulatorsofearlyvertebratedevelopmentwillbediscussedthroughoutthisreview.
TableofContents:Introduction/Oogenesis:FromGermlineStemCellstoGermlineCysts/OocytePolarityandtheEmbryonicAxes:TheBalbianiBody,anAncientOocyteAsymmetry/PreparingDevelopmentallyCompetentEggs/EggActivation/BlockingPolyspermy/Cleavage/Mitosis:GoingMulticellular/Maternal–ZygoticTransition/Reprogramming:EpigeneticModificationsandZygoticGenomeActivation/Dorsal–VentralAxisFormationbeforeZygoticGenomeActivationinZebrafishandFrogs/MaternalTGF-βandtheDorsal–VentralEmbryonicAxis/MaternalControlAfterZygoticGenomeActivation/CompensationbyStableMaternalProteins/MaternalContributionstoGermlineEstablishmentorMaintenance/Perspective/Acknowledgments/References""1","9781615040483","9781615040490","TranscriptionalControlofNeuralCrestDevelopment","ColloquiumSeriesonDevelopmentalBiology","227","2010","BrianNelms","VanderbiltUniversity","PatriciaLabosky","VanderbiltUniversity",,,,,"2155-3521","2155-353X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00010ED1V01Y201003DEB001","10.
4199/C00010ED1V01Y201003DEB001","Theneuralcrestisaremarkableembryonicpopulationofcellsfoundonlyinvertebratesandhasthepotentialtogiverisetomanydifferentcelltypescontributingthroughoutthebody.
Thesederivativesrangefromthemesenchymalboneandcartilagecomprisingthefacialskeleton,toneuronalderivativesoftheperipheralsensoryandautonomicnervoussystems,tomelanocytesthroughoutthebody,andtosmoothmuscleofthegreatarteriesoftheheart.
Forthesecellstocorrectlyprogressfromanunspecified,nonmigratorypopulationtoawidearrayofdynamic,differentiatedcelltypes—someofwhichretainstemcellcharacteristicspresumablytoreplenishthesederivatives—requiresacomplexnetworkofmolecularswitchestocontrolthegeneprogramsgivingthesecellstheirdefiningstructural,enzymatic,migratory,andsignalingcapacities.
Thisreviewwillbringtogethercurrentknowledgeofneuralcrest-specifictranscriptionfactorsgoverningtheseprogressionsthroughoutthecourseofdevelopment.
Amorethoroughunderstandingofthemechanismsoftranscriptionalcontrolindifferentiationwillaidinstrategiesdesignedtopushundifferentiatedcellstowardaparticularlineage,andunravelingtheseprocesseswillhelptowardreprogrammingcellsfromadifferentiatedtoamorenaivestate.
TableofContents:Introduction/APGenes/bHLHGenes/ETSGenes/FoxGenes/HomeoboxGenes/HoxGenes/LimGenes/PaxGenes/POUDomainGenes/RAR/RXRGenes/SmadGenes/SoxGenes/ZincFingerGenes/OtherMiscellaneousGenes/References/AuthorBiographies""1","9781615040544","9781615040551","Wnt/β-cateninSignalinginVertebratePosteriorNeuralDevelopment","ColloquiumSeriesonDevelopmentalBiology","79","2010","YanivM.
Elkouby","DepartmentofBiochemistry,TheRappaportFamilyInstituteforResearchintheMedicalSciences,FacultyofMedicine,Technion-IsraelInstituteofTechnology","DaleFrank","DepartmentofBiochemistry,TheRappaportFamilyInstituteforResearchintheMedicalSciences,FacultyofMedicine,Technion-IsraelInstituteofTechnology",,,,,"2155-3521","2155-353X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00015ED1V01Y201007DEB004","10.
4199/C00015ED1V01Y201007DEB004","TheWnt/β-cateninsignalingpathwayisakeyregulatorofcellfatespecification,differentiation,andgrowthinmultiplesystemsthroughouttheanimalkingdom.
Invertebrateposteriorneuraldevelopment,Wnt/β-cateninsignalingcontrolsthiscomplexmultistepprocess.
Itinitiallyinducestheposteriorregionsofthenervoussystem,includingthemid-hindbrainborder,hindbrain,spinalcordandneuralcrest,andthensubsequentlyfine-tunesthepatternofeachregionanddeterminesthedifferentcellfateswithinthem.
Inthisreview,weexplorethefunctionoftheWnt/β-cateninpathwayduringtheformationofthesespecificposteriorneuralregions.
WehaveexaminedtheimportanttranscriptionaltargetsoftheWnt/β-cateninpathwayactingdownstreamtomediateitsmorphogeneticactivity.
Differentregulatorynetworksareactivatedindifferentposteriorneuralregions,andthesenetworksinducespecificneuralcelltypesineachregion.
EludidatinghoweachofthesenetworksspecifydifferentcellfatesiscrucialforunderstandingthebasictenetsofhowWntmorphogeneticactivityinducestheposteriornervoussystemduringtheearlieststagesofvertebratedevelopment.
TableofContents:Introduction/MakingtheNeuralRear/WntMorphogeneticActivityinNeuralPosteriorInduction/InductionoftheMidbrain–HindbrainBorder/InductionoftheHindbrain/InductionoftheSpinalCord/DownstreamofWnt:HindbrainorSpinalCord/NeuralCrestInduction/Anti-WntAnteriorDeterminants/TheRoleofMesodermandSpecificWntLigandsinNeuralPatterning/ConcludingRemarks/References""1","9781615043309","9781615043316","Angiogenesis","ColloquiumSeriesonIntegratedSystemsPhysiology","84","2010","ThomasAdair","UniversityofMississippiMedicalCenter","Jean-PierreMontani","UniversityofMississippiMedicalCenter",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00017ED1V01Y201009ISP010","10.
4199/C00017ED1V01Y201009ISP010","Angiogenesisisthegrowthofbloodvesselsfromtheexistingvasculature.
Thefieldofangiogenesishasgrownenormouslyinthepast30years,withonly40paperspublishedin1980andnearly6000in2010.
WhyhastherebeenthisexplosivegrowthinangiogenesisresearchAngiogenictherapiesprovideapotentialtoconquercancer,heartdiseases,andmorethan70oflife'smostthreateningmedicalconditions.
Thelivesofatleast1billionpeopleworldwidecouldbeimprovedwithangiogenictherapy,accordingtotheAngiogenesisFoundation.
Inthislittlebook,weprovideasimpleapproachtounderstandtheessentialelementsoftheangiogenicprocess,wecritiquethemostpowerfulangiogenesisassaysthatareusedtodiscoverproangiogenicandantiangiogenicsubstances,andweprovideanin-depthphysiologicalperspectiveonhowangiogenesisisregulatedinnormal,healthytissuesofthehumanbody.
Alltissuesofthebodyrequireacontinuoussupplyofoxygentoburnmetabolicsubstratesthatareneededforenergy.
Oxygenisconductedtothesetissuesbybloodcapillaries:morecapillariescanimprovetissueoxygenationandthusenhanceenergyproduction;fewercapillariescanleadtohypoxiaandevenanoxiainthetissues.
Thismeansthatangiogenictherapiesdesignedtocontrolthegrowthandregressionofbloodcapillariescanbeusedtoimprovethesurvivalofpoorlyperfusedtissuesthatareessentialtothebody(heart,brain,skeletalmuscle,etc.
)andtoridthebodyofunwantedtissues(tumors).
TableofContents:OverviewofAngiogenesis/AngiogenesisAssays/Regulation:MetabolicFactors/Regulation:MechanicalFactors/Glossary/References/AuthorBiographies""1","9781615040667","9781615040674","CapillaryFluidExchange:Regulation,Functions,andPathology","ColloquiumSeriesonIntegratedSystemsPhysiology","94","2010","JoshuaScallan","UniversityofMissouri-Columbia","VirginiaHuxley","UniversityofMissouri-Columbia","RonaldKorthuis","UniversityofMissouri-Columbia",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00006ED1V01Y201002ISP003","10.
4199/C00006ED1V01Y201002ISP003","Thepartitionoffluidbetweenthevascularandinterstitialcompartmentsisregulatedbyforces(hydrostaticandoncotic)operatingacrossthemicrovascularwallsandthesurfaceareasofpermeablestructurescomprisingtheendothelialbarriertofluidandsoluteexchange,aswellaswithintheextracellularmatrixandlymphatics.
Inadditiontoitsroleintheregulationofvascularvolume,transcapillaryfluidfiltrationalsoallowsforcontinuousturnoverofwaterbathingtissuecells,providingthemediumfordiffusionalfluxofoxygenandnutrientsrequiredforcellularmetabolismandremovalofmetabolicbyproducts.
Transendothelialvolumeflowhasalsobeenshowntoinfluencevascularsmoothmuscletoneinarterioles,hydraulicconductivityincapillaries,andneutrophiltransmigrationacrosspostcapillaryvenules,whiletheflowofthisfiltratethroughtheinterstitialspacesfunctionstomodifytheactivitiesofparenchymal,residenttissue,andmetastasizingtumorcells.
Likewise,theflowoflymph,whichisdrivenbycapillaryfiltration,isimportantforthetransportofimmuneandtumorcells,antigendeliverytolymphnodes,andforreturnoffilteredfluidandextravasatedproteinstotheblood.
Giventhisbackground,theaimsofthistreatisearetosummarizeourcurrentunderstandingofthefactorsinvolvedintheregulationoftranscapillaryfluidmovement,howfluidmovementsacrosstheendothelialbarrierandthroughtheinterstitiumandlymphaticvesselsinfluencecellfunctionandbehavior,andthepathophysiologyofedemaformation.
TableofContents:FluidMovementAcrosstheEndothelialBarrier/TheInterstitium/TheLymphaticVasculature/PathophysiologyofEdemaFormation""1","9781615041503","9781615041510","ColonicMotility","ColloquiumSeriesonIntegratedSystemsPhysiology","157","2010","SushilSarna","UniversityofTexasMedicalBranch"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00020ED1V01Y201011ISP011","10.
4199/C00020ED1V01Y201011ISP011","Threedistincttypesofcontractionsperformcolonicmotilityfunctions.
Rhythmicphasiccontractions(RPCs)causeslownetdistalpropulsionwithextensivemixing/turningover.
Infrequentlyoccurringgiantmigratingcontractions(GMCs)producemassmovements.
ToniccontractionsaidRPCsintheirmotorfunction.
Thespatiotemporalpatternsofthesecontractionsdiffermarkedly.
TheamplitudeanddistanceofpropagationofaGMCareseveral-foldlargerthanthoseofanRPC.
Theentericneuronsandsmoothmusclecellsarethecoreregulatorsofallthreetypesofcontractions.
Theregulationofcontractionsbythesemechanismsismodifiablebyextrinsicfactors:CNS,autonomicneurons,hormones,inflammatorymediators,andstressmediators.
OnlytheGMCsproducedescendinginhibition,whichaccommodatesthelargebolusbeingpropelledwithoutincreasingmuscletone.
Thestrongcompressionofthecolonwallgeneratesafferentsignalsthatarebelownociceptivethresholdinhealthysubjects.
However,thesesignalsbecomenociceptive;iftheamplitudesofGMCsincrease,afferentnervesbecomehypersensitive,ordescendinginhibitionisimpaired.
TheGMCsalsoprovidetheforceforrapidpropulsionoffecesanddescendinginhibitiontorelaxtheinternalanalsphincterduringdefecation.
ThedysregulationofGMCsisamajorfactorincolonicmotilitydisorders:irritablebowelsyndrome(IBS),inflammatoryboweldisease(IBD),anddiverticulardisease(DD).
FrequentmassmovementsbyGMCscausediarrheaindiarrheapredominantIBS,IBD,andDD,whileadecreaseinthefrequencyofGMCscausesconstipation.
TheGMCsgeneratetheafferentsignalsforintermittentshort-livedepisodesofabdominalcrampinginthesedisorders.
EpigeneticdysregulationduetoadverseeventsinearlylifeisoneofthemajorfactorsingeneratingthesymptomsofIBSinadulthood.
TableofContents:Introduction/RegulatoryMechanisms/ColonicMotilityinHealth/ColonicMotilityDysfunction/References""1","9781615040216","9781615040223","ControlofCardiacOutput","ColloquiumSeriesonIntegratedSystemsPhysiology","97","2010","DavidYoung","UniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00008ED1V01Y201002ISP006","10.
4199/C00008ED1V01Y201002ISP006","Althoughcardiacoutputismeasuredastheflowofbloodfromtheleftventricleintotheaorta,thesystemthatcontrolscardiacoutputincludesmanyothercomponentsbesidestheheartitself.
Theheart'srateofoutputcannotexceedtherateofvenousreturntoit,andtherefore,thefactorsgoverningvenousreturnareprimarilyresponsibleforcontrolofoutputfromtheheart.
Venousreturnisaffectedbyitspressuregradientandresistancetoflowthroughoutthevascularsystem.
Thepressuregradientforvenousreturnisafunctionofseveralfactorsincludingthebloodvolumeflowingthroughthesystem,theunstressedvascularvolumeofthecirculatorysystem,itscapacitance,meansystemicpressure,andrightatrialpressure.
Resistancetovenousreturnisthesumoftotalvascularresistancefromtheaorticvalvetotherightatrium.
Thesympatheticnervoussystemandvasoactivecirculatinghormonesaffectshort-termresistance,whereaslocaltissuebloodflowautoregulatorymechanismsarethedominantdeterminantsoflong-termresistancetovenousreturn.
Thestrengthofcontractionoftheheartrespondstochangesinatrialpressuredrivenbychangesinvenousreturn,withsmallchangesinatrialpressureelicitinglargechangesinstrengthofcontraction,asdescribedbytheFrank–Starlingmechanism.
Inaddition,theautonomicnervoussysteminputtotheheartaltersmyocardialpumpingabilityinresponsetocardiovascularchallenges.
Thefunctionofthecardiovascularsystemisstronglyaffectedbytheoperationoftherenalsodiumexcretion–bodyfluidvolume–arterialpressurenegativefeedbacksystemthatmaintainsarterialbloodpressureatacontrolledvalueoverlongperiods.
Theintentofthisvolumeistointegratethebasicknowledgeofthesecardiovascularsystemcomponentsintoanunderstandingofcardiacoutputregulation.
TableofContents:Introduction/VenousReturn/CardiacFunction/IntegratedAnalysisofCardiacOutputControl/AnalysisofCardiacOutputRegulationbyComputerSimulation/AnalysisofCardiacOutputControlinResponsetoChallenges/Conclusion/References/AuthorBiography""1","9781615040094","9781615040100","HepaticCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","174","2010","W.
WayneLautt","UniversityofManitoba"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00004ED1V01Y200910ISP001","10.
4199/C00004ED1V01Y200910ISP001","TheHepaticcirculationisuniqueamongvascularbeds.
Themostobviousuniquefeaturesincludethedualvascularsupply;themechanismofintrinsicregulationofthehepaticartery(thehepaticarterialbufferresponse);thefactthatportalbloodflow,supplyingtwothirdsofliverbloodflow,isnotcontrolleddirectlybytheliver;thefactthat20%ofthecardiacoutputrushesthroughthemostvascularizedorganinthebody,drivenbyapressuregradientofonlyafewmillimetersofmercury;theextremelydistensiblecapacitanceandvenousresistancesites;theunidirectionalacinarbloodflowthatregulatesparenchymalcellmetabolicspecialization;andthehighconcentrationofmacrophagic(Kupffer)cellsfilteringtheblood.
Theliveristheonlyorganreportedtohaveregionalbloodflowmonitoredbytheautonomicnervoussystem.
Thismechanism,whendysfunctional,accountsforthehepatorenalsyndromeandoffersamechanistictherapeutictargettotreatthissyndrome.
Thetriggerforliverregenerationisdependentonhepatichemodynamicssothatchronicliverbloodflowregulateslivercellmass.
Insevereliverdisease,thewholebodycirculationisreorganized,byformingportacavalshunts,toaccommodatetheincreasedintrahepaticvenousresistance.
Theseshuntsprotectthevenousdrainageofthesplanchnicorgansbutleadtolossofmajorregulatoryrolesoftheliver.
Thedevelopmentofknowledgeofthehepaticvasculatureispresentedfromahistoricalperspectivewithmodernconceptssummarizedbasedontheperspectiveoftheauthor'sfourdecadesofdevotiontothismostmarvelousoforgans.
TableofContents:Acknowledgements/HistoricalPerspectives/Overview/FluidExchange/Capacitance/ResistanceintheHepaticArtery/ResistanceintheVenousSystem/FetalandNeonatalHepaticCirculation/InVivoPharmacodynamicApproaches/NitricOxide/Adenosine/HepaticNerves/HepaticCirculationandToxicology/HepatorenalSyndrome/IntegrativeHepaticResponsetoHemorrhage/BloodFlowRegulationofHepatocyteProliferation/MultipleMechanismsMaintainingaConstantHepaticBloodFlowtoLiverMassRatio/PathopharmacologyandRepurposingDrugsasaResearchStrategy/References""1","9781615041657","9781615041664","InflammationandtheMicrocirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","87","2010","D.
NeilGranger","LouisianaStateUniversity","ElenaSenchenkova","LouisianaStateUniversity",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00013ED1V01Y201006ISP008","10.
4199/C00013ED1V01Y201006ISP008","Themicrocirculationishighlyresponsiveto,andavitalparticipantin,theinflammatoryresponse.
Allsegmentsofthemicrovasculature(arterioles,capillaries,andvenules)exhibitcharacteristicphenotypicchangesduringinflammationthatappeartobedirectedtowardenhancingthedeliveryofinflammatorycellstotheinjured/infectedtissue,isolatingtheregionfromhealthytissueandthesystemiccirculation,andsettingthestagefortissuerepairandregeneration.
Thebestcharacterizedresponsesofthemicrocirculationtoinflammationincludeimpairedvasomotorfunction,reducedcapillaryperfusion,adhesionofleukocytesandplatelets,activationofthecoagulationcascade,andenhancedthrombosis,increasedvascularpermeability,andanincreaseintherateofproliferationofbloodandlymphaticvessels.
Avarietyofcellsthatnormallycirculateinblood(leukocytes,platelets)orresidewithinthevesselwall(endothelialcells,pericytes)orintheperivascularspace(mastcells,macrophages)areactivatedinresponsetoinflammation.
Theactivationproductsandchemicalmediatorsreleasedfromthesecellsactthroughdifferentwell-characterizedsignalingpathwaystoinducethephenotypicchangesinmicrovesselfunctionthataccompanyinflammation.
Drugsthattargetaspecificmicrovascularresponsetoinflammation,suchasleukocyte-endothelialcelladhesionorangiogenesis,haveshownpromiseinboththepreclinicalandclinicalstudiesofinflammatorydisease.
Futureresearcheffortsinthisareawilllikelyidentifynewavenuesfortherapeuticinterventionininflammation.
TableofContents:Introduction/HistoricalPerspectives/AnatomicalConsiderations/ImpairedVasomotorResponses/CapillaryPerfusion/Angiogenesis/Leukocyte–EndothelialCellAdhesion/Platelet–VesselWallInteractions/CoagulationandThrombosis/EndothelialBarrierDysfunction/Epilogue/References""1","9781615040391","9781615040407","Platelet-VesselWallInteractionsinHemostasisandThrombosis","ColloquiumSeriesonIntegratedSystemsPhysiology","75","2010","RolandoRumbaut","MichaelE.
DeBakeyVAMedicalCenterandBaylorCollegeofMedicine","PerumalThiagarajan","MichaelE.
DeBakeyVAMedicalCenterandBaylorCollegeofMedicine",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00007ED1V01Y201002ISP004","10.
4199/C00007ED1V01Y201002ISP004","Plateletsareessentialmediatorsofthephysiologicprocessofhemostasisandpathologicthrombosis.
Whileplateletsdonotinteractwithvascularwallsundernormalconditions,vascularinjuryorinflammationresultinacoordinatedseriesofeventsincludingplateletadhesion,aggregation,andpromotionofcoagulation.
Inthisreview,wedescribetheprimarymechanismsinvolvedintheseresponsesinvariousvascularbedsofbothmacro-andmicrovessels,andoutlinekeyunresolvedaspectsoftheseimportantinteractions.
TableofContents:Introduction/GeneralCharacteristicsofPlatelets/PlateletAdhesiontoVascularWalls/PlateletAggregation/PlateletRecruitmentandBloodCoagulation/Arterial,Venous,andMicrovascularHemostasis/Thrombosis/Summary""1","9781615041800","9781615041817","RegulationofVascularSmoothMuscleFunction","ColloquiumSeriesonIntegratedSystemsPhysiology","62","2010","RaoufKhalil","BrighamandWomen'sHospitalandHarvardMedicalSchoolBoston,Massachusetts"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00012ED1V01Y201005ISP007","10.
4199/C00012ED1V01Y201005ISP007","Vascularsmoothmuscle(VSM)constitutesmostofthetunicamediainbloodvesselsandplaysanimportantroleinthecontrolofvasculartone.
Ca2+isamajorregulatorofVSMcontractionandisstrictlyregulatedbyanintricatesystemofCa2+mobilizationandCa2+homeostaticmechanisms.
Theinteractionofaphysiologicalagonistwithitsplasmamembranereceptorstimulatesthehydrolysisofmembranephospholipidsandincreasesthegenerationofinositol1,4,5-trisphosphate(IP3)anddiacylglycerol(DAG).
IP3stimulatesCa2+releasefromtheintracellularstoresinthesarcoplasmicreticulum.
AgonistsalsostimulateCa2+influxfromtheextracellularspaceviavoltage-gated,receptor-operated,andstore-operatedchannels.
Ca2+homeostaticmechanismstendtodecreasetheintracellularfreeCa2+concentration([Ca2+]i)byactivatingCa2+extrusionviatheplasmalemmalCa2+pumpandtheNa+/Ca2+exchangerandtheuptakeofexcessCa2+bythesarcoplasmicreticulumandpossiblythemitochondria.
Athresholdincreasein[Ca2+]iactivatesCa2+-dependentmyosinlightchain(MLC)phosphorylation,stimulatesactin–myosininteraction,andinitiatesVSMcontraction.
Theagonist-inducedmaintainedincreaseinDAGalsoactivatesspecificproteinkinaseC(PKC)isoforms,whichinturncausephosphorylationofcytoplasmicsubstratesthatincreasethecontractilemyofilamentsforcesensitivitytoCa2+andtherebyenhanceVSMcontraction.
AgonistscouldalsoactivateRhokinase(ROCK),leadingtoinhibitionofMLCphosphataseandfurtherenhancementofthemyofilamentsforcesensitivitytoCa2+.
Thecombinedincreasesin[Ca2+]i,PKCandROCKactivitycausesignificantvasoconstrictionandcouldalsostimulateVSMhypertrophyandhyperplasia.
Theprotractedandprogressiveactivationoftheseprocessescouldleadtopathologicalvascularremodelingandvasculardisease.
TableofContents:Acknowledgments/Introduction/Ca2+ReleasefromtheIntracellularStores/Ca2+EntryfromtheExtracellularSpace/MechanismsofCa2+Homeostasis/Ca2+-DependentMyosinLightChainPhosphorylation/ProteinKinaseC/RhoKinaseinVascularSmoothMuscle/VascularSmoothMuscleDysfunctionandVascularDisease/Summary/References/AuthorBiography""1","9781615040124","9781615040131","TheCerebralCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","59","2010","MarilynCipolla","UniversityofVermontCollegeofMedicine"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00005ED1V01Y200912ISP002","10.
4199/C00005ED1V01Y200912ISP002","Thispresentationdescribesstructuralandfunctionalpropertiesofthecerebralcirculationthatareuniquetothebrain,anorganwithhighmetabolicdemands,andtheneedfortightwaterandionhomeostasis.
Autoregulationispronouncedinthebrain,withmyogenic,metabolic,andneurogenicmechanismscontributingtomaintainrelativelyconstantbloodflowduringbothincreasesanddecreasesinpressure.
Inaddition,unlikeperipheralorganswherethemajorityofvascularresistanceresidesinsmallarteriesandarterioles,largeextracranialandintracranialarteriescontributesignificantlytovascularresistanceinthebrain.
Theprominentroleoflargearteriesincerebrovascularresistancehelpsmaintainbloodflowandprotectdownstreamvesselsduringchangesinperfusionpressure.
Thecerebralendotheliumisalsouniqueinthatitsbarrierpropertiesareinsomewaymorelikeepitheliumthanendotheliumintheperiphery.
Thecerebralendothelium,knownastheblood-brainbarrier,hasspecializedtightjunctionsthatdonotallowionstopassfreelyandhasverylowhydraulicconductivityandtranscellulartransport.
ThisspecialconfigurationmodifiesStarling'sforcesinthebrainsuchthationsretainedinthevascularlumenopposewatermovementduetohydrostaticpressure.
Tightwaterregulationisnecessaryinthebrainbecauseithaslimitedcapacityforexpansionwithintheskull.
Increasedintracranialpressureduetovasogenicedemacancausesevereneurologiccomplicationsanddeath.
Thischapterwillreviewthesespecialfeaturesofthecerebralcirculationandhowtheycontributetothephysiologyofthebrain.
TableofContents:Introduction/AnatomyandUltrastructure/PerivascularInnervation/RegulationofCerebrovascularTone/ControlofCerebralBloodFlow/BarriersoftheCNS/Summary/References""1","9781615041176","9781615041183","TheGastrointestinalCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","127","2010","PeterKvietys","LondonHealthSciencesCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00009ED1V01Y201002ISP005","10.
4199/C00009ED1V01Y201002ISP005","Themicrocirculationofthegastrointestinaltractisunderthecontrolofbothmyogenicandmetabolicregulatorysystems.
Themyogenicmechanismcontributestobasalvasculartoneandtheregulationoftransmuralpressure,whilethemetabolicmechanismisresponsibleformaintaininganappropriatebalancebetweenO2demandandO2delivery.
Inthepostprandialstate,hydrolyticproductsoffooddigestionelicitahyperemia,whichservestomeettheincreasedO2demandofnutrientassimilation.
Metabolicallylinkedfactors(e.
g.
,tissuepO2,adenosine)areprimarilyresponsibleforthisfunctionalhyperemia.
Thefenestratedcapillariesofthegastrointestinalmucosaarerelativelypermeabletosmallhydrolyticproductsoffooddigestion(e.
g.
,glucose),yetrestrictthetranscapillarymovementoflargermolecules(e.
g.
,albumin).
Thisallowsfortheabsorptionofhydrolyticproductsoffooddigestionwithoutcompromisingtheoncoticpressuregradientgoverningtranscapillaryfluidmovementandedemaformation.
Thegastrointestinalmicrocirculationisalsoanimportantcomponentofthemucosaldefensesystemwhosefunctionistoprevent(andrapidlyrepair)inadvertentepithelialinjurybypotentiallynoxiousconstituentsofchyme.
Twopathologicalconditionsinwhichthegastrointestinalcirculationplaysanimportantroleareischemia/reperfusionandchronicportalhypertension.
Ischemia/reperfusionresultsinmucosaledemaanddisruptionoftheepitheliumdue,inpart,toaninflammatoryresponse(e.
g.
,increaseincapillarypermeabilitytomacromoleculesandneutrophilinfiltration).
Chronicportalhypertensionresultsinanincreaseingastrointestinalbloodflowduetoanimbalanceinvasodilatorandvasoconstrictorinfluencesonthemicrocirculation.
TableofContents:Introduction/Anatomy/RegulationofVascularToneandOxygenation/ExtrinsicVasoregulation:NeuralandHumoral/PostprandialHyperemia/TranscapillarySoluteExchange/TranscapillaryFluidExchange/InteractionofCapillaryandInterstitialForces/GastrointestinalCirculationandMucosalDefense/GastrointestinalCirculationandMucosalPathologyI:Ischemia/Reperfusion/GastrointestinalCirculationandMucosalPathologyII:ChronicPortalHypertension/SummaryandConclusions/References/AuthorBiography""1","9781615040452","9781615040469","VascularBiologyofthePlacenta","ColloquiumSeriesonIntegratedSystemsPhysiology","98","2010","YupingWang","LouisianaStateUniversity"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00016ED1V01Y201008ISP009","10.
4199/C00016ED1V01Y201008ISP009","Theplacentaisanorganthatconnectsthedevelopingfetustotheuterinewall,therebyallowingnutrientuptake,wasteelimination,andgasexchangeviathemother'sbloodsupply.
Propervasculardevelopmentintheplacentaisfundamentaltoensuringahealthyfetusandsuccessfulpregnancy.
Thisbookprovidesanup-to-datesummaryandsynthesisofknowledgeregardingplacentalvascularbiologyanddiscussestherelevanceofthisvascularbedtothefunctionsofthehumanplacenta.
TableofContents:Introduction/PlacentalBloodCirculation/StructureofthePlacenta/CellTypesofthePlacenta/OxygenTensionandPlacentalVascularDevelopment/VasculogenesisandAngiogenesisofHumanPlacenta/AngiogenicFactors/VasoactivatorsandPlacentalVasoactivity/LymphaticPhenotypicCharacteristicsoftheHumanPlacenta/PlacentalTissueandCordBloodStemCells/Summary/Acknowledgment/References""1","9781615042678","9781615042685","CellOrigin,Structure,andFunction:HowCellsMakeaLiving","ColloquiumSeriesontheCellBiologyofMedicine","48","2010","JoelPardee","CEO,NeuralEssenceLLC"2153-0513","2153-0521","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00022ED1V01Y201012CBM005","10.
4199/C00022ED1V01Y201012CBM005","Inthislecture,wewillbrieflyreviewtheprinciplesofphysics,centralmetabolism,andcellbiologythatmakehealthpossible.
Thisexerciseisappropriateforthoseofuswhohavesetbeforeourselvestheproblemofunderstandingandpreservinglifeprocesses,becauseitisthroughthemediumofacellthatenergycreateslife.
Weareawarethatlifeprocessesrequireacomplexsetofbiochemicalreactions.
Butthatisnotenough.
Notonlyarecomplexreactionsnecessary,butsuperimposedonthisessentialrequirementisthenecessitytobuildandmaintainadynamiccellularstructure.
Chemicalenergybuildscells.
Inthislecture,wewillseehowcellsextractenergyfromtheentropicdissolutionoftheuniverse,howtheextractedenergyisusedtobuildcellstructure,andhowcellstructuredeterminescellfunction.
TableofContents:OriginandEnergyofLife/HowCellsMakeaLiving/OrderFromChaos:EntropyandTheRiverofTime/CapturingEntropy/CellArchitecture/WhyCellsareCompartmentalized.
TheFunctionofOrganelles/CellFunction/TheSecretoryPathway/TheGolgiApparatus/Mitochondria/TheCytoskeleton:HowOrganellesareOrganized/VesicleTransport/Mitosis/EnergyandMetabolism/References""1","9781615040001","9781615040018","HowtheHeartDevelops","ColloquiumSeriesontheCellBiologyofMedicine","68","2010","DonaldFischman","WeillCornellMedicalCollege"2153-0513","2153-0521","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00001ED1V01Y200904CBM001","10.
4199/C00001ED1V01Y200904CBM001","Withpossibleexceptionoftheatomicclock,theheartmaybethemostperfectmachineeverdevised.
Howitdevelopsfromasimpleembryonictubeisafascinatingstoryofbiologyandlendsagreatdealofinsightintothesourceofheartdefectsthataffectchildrenandadultsalike.
Centraltothisentirelectureisthefactthatthefetusresidesinanaquaticenvironment.
Oxygenatedbloodarrivesfromtheplacentaanddeoxygenatedreturnstotheplacenta.
Thelungsplaynoroleindeliveringoxygenorremovingcarbondioxidetoorfromthecirculation.
Thus,thefetusmainly(butnotexclusively)requiresathree-chamberedheartratherthanthefourchamberedheartthatweareallfamiliarwith.
Thisresemblesfishcirculationinwhichbloodleavestheheartintoanaorticsacfromwhichemanatetheaorticarchesthatdeliverbloodtothegills,whereitisoxygenatedandCO2isremoved.
Bloodthengoestothedorsalaortaefornourishingthebodytissues.
Inafishthereisnoneedforafour-chamberedheart,sincefishdonotuselungstoaeratethebloodorremoveCO2.
Althoughthefetuslacksgillsandstilldevelopsafour-chamberedheart,muchoffetalcirculatoryphysiologydependsona""quasi-three-chamberedcirculation""thatbypassesthepulmonarycirculation.
Uponbirth,this""aquatic""circulationmustchangewithinminutestopermitlungfunction.
Thetopicstofollowtracehowthiscirculationdevelopsandhowitchangesuponbirth.
TableofContents:FetalandEmbryonicHematopoiesis/FormationofthePrecardiacMesodermandFateMappingDuringGastrulation/TubularHeart/CardiacLooping/PericardialCavity/EndocardialCushions/AtrialSeptation/VentricularSeptation/PartitioningoftheBulbusCordisandTruncusArteriosus/ConductingSystem/CellLineagesDuringHeartDevelopment/CirculationatTermandChangesuponBirth/RecommendedReadings""1","9781615040032","9781615040049","SkeletalMuscle&MuscularDystrophy:AVisualApproach","ColloquiumSeriesontheCellBiologyofMedicine","56","2010","DonaldFischman","WeillCornellMedicalCollege"2153-0513","2153-0521","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00002ED1V01Y200904CBM002","10.
4199/C00002ED1V01Y200904CBM002","Histologically,muscleisconvenientlydividedintotwogroups,striatedandnonstriated,basedonwhetherthecellsexhibitcross-striationsinthelightmicroscope(Figure3).
Smoothmuscleisinvoluntary:itscontractioniscontrolledbytheautonomicnervoussystem.
Striatedmuscleincludesbothcardiac(involuntary)andskeletal(voluntary).
Theformerisinnervatedbyvisceralefferentfibersoftheautonomicnervoussystem,whereasthelatterisinnervatedbysomaticefferentfibers,mostofwhichhavetheircellbodiesintheventral,motorhornofthespinalcord.
Smoothmuscleisdesignedtohaveslow,relativelysustainedcontractions,whilestriatedmusclecontractsrapidlyandusuallyphasically.
Bothcardiacandsmoothmusclecellsaremononucleated,whereasskeletalmusclecells(fibers)aremultinucleated.
[Inagingheartsorhypertrophiedhearts,cardiacmusclecellsareoftenbinucleated.
]Multinucleationofskeletalmusclearisesduringdevelopmentbythecytoplasmicfusionofmuscleprecursorcells,myoblasts.
Adultskeletalmusclecellsdonotdivide;thatisalsotrueofmostcardiacmyocytes.
However,skeletalmuscleexhibitsaconsiderableamountofregenerationafterinjury.
Thisisbecauseadultskeletalmusclecontainsastemcell,thesatellitecell,whichliesbeneaththebasementmembranesurroundingthemusclefibers.
[Themultinucleationofcardiacmusclearisesfromkaryokinesiswithoutcytokinesis.
]AdiagrammaticseriesofenlargementsofskeletalmuscleareshowninFigure4.
Abundleofmusclefibers(fasciculus)iscutfromthedeltoidmuscle.
Eachmusclecellistermedamyofiberormusclefiber.
Eachmusclefibercontainscontractileorganellestermedmyofibrils,whichcontainthecontractileunitsofmuscletermedsarcomeres.
Thesarcomeresarecomposedofmyofilaments,whichinturnarecomposedofcontractileproteins.
Muscleconnectivetissuelayersareorganizedinconcentriclayersthatareimportantintheentryandexitofvesselsandnervestoandfromthetissue.
TheseareshowninFigure5.
Theoutermostlayeristheepimysiumormusclesheath.
Connectivetissueseptae(perimysium)runradiallyintothemuscletissue,dividingitintomusclefascicles.
Thedeepestlayer,surroundingeachofthemusclefibersistheendomysium.
Theendomysiumisindirectcontactwithabasallaminathatensheatheseachmusclefiber.
Itsurroundstheplasmamembraneofthemusclefibertermedthesarcolemma.
TableofContents:TheMuscleCell(Myofiber)/TheSarcomere/TheMyosinMolecule/RegulationofMuscleContraction/TheSarcoplasmicReticulum/MuscleFiberTypes/TheMyotendonJunction/TheSatelliteCell/MuscularDystrophy/RecommendedReadings""1","9781615040063","9781615040070","TheActinCytoskeletoninCellMotility,Cancer,andInfection","ColloquiumSeriesontheCellBiologyofMedicine","57","2010","JoelPardee","President,NeuralEssence,formerlyfacultyandDeanforGraduateResearch,WeillCornellSchoolofMedicine"2153-0513","2153-0521","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00003ED1V01Y200907CBM003","10.
4199/C00003ED1V01Y200907CBM003","Bynowitisabundantlyclearthatthecellsofourbodieshavetheabilitytomovebecauseoftheiractincytoskeleton.
Fromtheearliestcellmigrationsintheembryothatservetoformtheprimordialtissuelayerstotheoutgrowthofneurons,thecontractionsofourheartandskeletalmuscles,andthemetastasisofcancercells,itistheregulatedactionoftheactincytoskeletonthatpropelsourvariousmotions.
Inthischapterwewillexaminethebiochemicalandcellbiologicalmechanismsthatcontrolactin-basedcellmotility.
Wewillseethatcellmigrationalongasubstratumoccursinthreefundamentalphasesthatareexquisitelyorchestratedinsequence.
Cellmigrationoccursbyaninitialextensionofthefrontedgeofthecell,followedcloselybycontractionofthecell'srearendtopushcytoplasmintothenewlyformedextension.
Asthecell'snewleadingedgeextends,attachmentsitesareassembledonthecellfloor,andextendthroughtheplasmamembranetocouplethemigratingcelltotheunderlyingsurface.
Howthecellknowswheretogo,whentodetachandreattachduringthemigration,andhowtokeepeachprocessunderstrictcontrolisastorywellworthhearing,becauseitismotilityandadhesionthatmakeamulticellularlifesuchasourspossible.
TableofContents:TheCytoskeleton/HowCellsMove/RegulationoftheActinCytoskeleton/TheRoleofMyosininCellMotility/TheRoleofCellAdhesioninCellMotility/RecommendedReadings""1","9781615040759","9781615040766","UnderstandingBreastCancer:CellBiologyandTherapy","ColloquiumSeriesontheCellBiologyofMedicine","52","2010","JoelPardee","CEO,NeuralEssenceLLCandformerlyAssociateDean,WeillCornellMedicalCollege"2153-0513","2153-0521","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00021ED1V01Y201012CBM004","10.
4199/C00021ED1V01Y201012CBM004","Themysteriousdiseaseofcancer,includingbreastcancer,hasplaguedmankindsincethedawnofrecordedhistory.
Regardingtheelusivecauseofthedisease,the""FatherofMedicine,""HippocratesofAthens(460–377BC),wrotethat,""Forinstabilityischaracteristicofthehumoursandsotheymaybeeasilyalteredbynatureandbychance.
""Theenigmahaspersisteduntiltoday.
In1971,thenPresidentRichardNixonsignedtheNationalCancerActanddeclareda""WaronCancer.
""Hebelievedthecounselofscientistsandphysiciansthatifsufficientresourceswerecommittedtothefight,cancercouldbevirtuallyeliminatedwithin5years.
Theprophesyfailed.
Althoughmortalityfromafewcancers,mostnotablyleukemias,hasbeensignificantlyreduced,carcinomas,cancersoftheepithelium,whichaccountfor80%ofcancerdeaths,remainunchanged.
Whiletremendousadvanceshavetakenplaceinourunderstandingofthemolecularandcellularmechanismsoperantincancer,ithasprovenexceedinglydifficulttopreventtheoccurrenceortohalttheprogressofthedisease.
Theverybesttherapyremainsearlydetectionwhiletheprimarytumorissmallandlocalizedtoasinglesite,followedbyremovaloftheoffendinggrowthbysurgeryand/orradiation.
Thegreatchallengeoffindingacureconfrontsusyet,anditiseffectiveinterventionatthemolecularlevelthatoffersourbesthope.
Westillmustfindthe""magicbullet.
""TableofContents:TheProblemofCancer/HowCarcinomasBecomeLethal/BreastCancer/BreastCancerandEstrogen/TreatingBreastCancer/Conclusion/References""1","9781615040605","9781615040612","SexandtheDevelopingBrain","ColloquiumSeriesontheDevelopingBrain","110","2010","MargaretMcCarthy","UniversityofMaryland"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00018ED1V01Y201010DBR001","10.
4199/C00018ED1V01Y201010DBR001","Thebrainsofmalesandfemales,menandwomen,aredifferent—thatisafact.
Whatisdebatedishowdifferentandhowimportantthosedifferencesare.
Sexdifferencesinthebrainaredeterminedbygenetics,hormones,andexperience,whichinhumansincludesculture,society,andparentalandpeerexpectations.
Theimportanceofnonbiologicalvariablestosexdifferencesinhumansisparamount,makingitdifficultifnotimpossibletoparseoutthosecontributionsthataretrulybiological.
Thestudyofanimalsprovidesustheopportunitytounderstandthemagnitudeandscopeofbiologicallybasedsexdifferencesinthebrainandunderstandingthecellularmechanismsprovidesusinsightintonovelsourcesofbrainplasticity.
Manysexdifferencesareestablishedduringadevelopmentalsensitivewindowbydifferencesinthehormonalmilieuofmalesversusfemales.
Theneonataltestisproduceslargeamountsoftestosterone,whichgainsaccesstothebrainandisfurthermetabolizedintoactiveandrogensandestrogens,whichmodifybraindevelopment.
Majorparametersthatareinfluencedbyhormonesincludeneurogenesis,celldeath,neurochemicalphenotype,axonalanddendriticgrowth,andsynaptogenesis.
Varianceintheseparametersresultsinsexdifferencesinthesizeofparticularbrainregions,theprojectionsbetweenbrainregions,andthenumberandtypeofsynapseswithinparticularbrainregions.
Thecellularmechanismsarebothregionandendpointspecificandinvokemanysurprisingsystemssuchasprostaglandins,endocannabinoids,andcelldeathproteins.
Byunderstandingwhen,why,andhowsexdifferencesinthebrainareestablished,wemayalsolearnthesourceofstronggenderbiasesintherelativeriskandseverityofnumerousneurologicaldiseasesanddisordersofmentalhealth,includingbutnotlimitedtoautism,dyslexia,attentiondeficitdisorder,schizophrenia,Alzheimer's,multiplesclerosis,Parkinson's,andmajordepressivedisorder.
TableofContents:Introduction/SexDeterminationversusSexDifferentiation/Masculinization,Feminization,andDefeminization/SteroidHormonesArePotentModulatorsofBrainDevelopment/SexDifferencesintheBrainAreEstablishedDuringaDevelopmentalSensitiveWindow/SexDifferencesinPhysiologyandBehaviorAreCoordinated/KnockoutsoftheRule:MicewithNullMutationsofSteroidReceptors,SteroidogenicEnzymes,andBindingProteins/SteroidsInfluenceMultipleEndpointstoOrganizetheBrain/CellularMechanismsofSteroid-MediatedOrganizationoftheBrain/WingedMessengers:LessonsfromBirdsandFlies/SexualDifferentiationofthePrimateBrain/SexualDifferentiationoftheHumanBrain/OvercomingtheHegemonyofHormones:GenesMatterToo/TheValueofUnderstandingtheEffectofSexontheDevelopingBrain/References""1","9781615043453","9781615043460","CardiovascularResponsestoExercise","ColloquiumSeriesonIntegratedSystemsPhysiology","124","2011","LushaXiang","UniversityofMississippiMedicalCenter","RobertHester","UniversityofMississippiMedicalCenter",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00040ED1V01Y201109ISP027","10.
4199/C00040ED1V01Y201109ISP027","Exerciseistheactofincreasingmetabolicrateforthepurposeofenhancingphysicalfitness.
Exercisecanbeoneofthemoststressfulphysiologicalresponsesthatthebodyundertakes.
Withexercise,thereareincreasesinmetabolicrate,heartrate,bloodflow(hyperemia),respiration,andheatproduction.
Theincreasedmetabolicrequirementduringexerciseiswellmetbyanincreasedbloodflow(functionalhyperemia)andoxygensupplytotheexercisingtissue,whichisregulatedbymultiplelocalandsystemicmechanisms.
Thelocalmechanisms(factors)areresponsibleformediatingthemusclehomeostasisandvascularconductancetomatchtheincreasedmetabolicrequirement,whereasthesystemicmechanismsareresponsibleforthemaintenanceofbloodpressureandglobalcardiovascularhomeostasis,includingtheincreaseinandredistributionofcardiacoutput,whichismainlymediatedbysympatheticactivation.
Forinstance,thesubstantialdecreasesinvascularresistanceandresultantlargeincreaseinbloodflowduringexerciserequirehigherbloodpressureandmorecardiacoutput,suchthatthemetabolicallyactivemusclecanbeperfusedwithadequatebloodflow.
Thisbookwillprovideanoverviewofthecardiovascularresponsestoexerciseunderphysiologicalconditionsaswellassomepathologicalcircumstances.
TableofContents:CapillaryPerfusioninSkeletalMuscleDuringExercise/LocalControlofArteriolarDiameterandBloodFlowDuringExercise/SystemicControlofCardiovascularResponsetoExercise/CardiovascularResponsetoExerciseunderPathologicalConditions/References/AuthorBiography""1","9781615042104","9781615042111","EndothelinintheKidney","ColloquiumSeriesonIntegratedSystemsPhysiology","88","2011","DavidPollock","GeorgiaHealthSciencesUniversity","ErikaBoesen","GeorgiaHealthSciencesUniversity",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00042ED1V01Y201110ISP028","10.
4199/C00042ED1V01Y201110ISP028","Thediscoveryofapotentvasoconstrictor,endothelin(ET)-1,derivedfromvascularendothelialcellswasamongavarietyofkeylinesofinvestigationthathelpedtofuelamajorexplosionofstudiesrelatedtoendothelialcellbiology.
Thiswasparticularlyevidentwithinthepharmaceuticalindustrywherereceptorantagonistswerequicklydevelopedandarenowonthemarketfortreatmentofpulmonaryhypertensionandindevelopmentforotherdiseasessuchasdiabeticnephropathyandcancer.
Importantly,weknowthatthekidneycontainsthehighestlevelofET-1productionandreceptorexpressioninthebodywhereithasbeendemonstratedtofunctionasapro-natriureticautocrineandparacrinefactorthatisactivatedinconditionsofhighsaltintake.
ThiseBookprovidesareviewofthevariousmechanismswherebyET-1hasbeenshowntofunctionwithinthekidneythroughawiderangeofactionsthatincludedirecteffectsontubulartransport,intrarenalhemodynamics,aswellasneuralandendocrinefunctions.
Muchhasyettobediscerned,butitisclearthattheETsystemisamajorphysiologicalregulatoroffluid-electrolytebalanceandbloodpressurethroughtheserenalactions.
TableofContents:DiscoveryofEndothelin/BasicBiologyoftheEndothelinSystem/RenalLocalization/RenalHemodynamics/RenalTubularActionsofEndothelin/EndothelininNeuralModulationofRenalFunction/PhysiologicalRoleofEndothelin/EndothelininRenalPathology/References/AuthorBiographies""1","9781615043392","9781615043408","EntericNervousSystem:TheBrain-in-the-Gut","ColloquiumSeriesonIntegratedSystemsPhysiology","172","2011","JackieD.
Wood","OhioStateUniversity"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00039ED1V01Y201107ISP026","10.
4199/C00039ED1V01Y201107ISP026","Minute-to-minutebehaviorofthealimentarytractreflectstheintegratedfunctioningofthegut'smusculature,secretoryglandsandblood–lymphaticvasculature.
Activityofthethreeeffectorsystemstogeneratefunctionallyeffectivepatternsofbehavior,whichareadaptivefordifferingdigestivestates,isorganizedandcoordinatedbytheentericnervoussystem(i.
e.
,thebrain-in-the-gut).
Theheuristicmodelfortheentericnervoussystem(ENS)isthesameasforallintegrativenervoussystems,whetherinvertebrateorinvertebrateanimals.
Likeotherintegrativenervoussystems,suchasthespinalcordandbrainstem,theENSfunctionswithsensoryneurons,interneuronsandmotorneurons.
ThatthegutdoesnotworkwithouttheENScanbemadeasanabsolutestatement.
ThisisapparentinitsabsenceinterminalregionsofthelargeintestineinHirschsprung'sdiseaseinhumansandanimalswhereitisreflectedbydysfunctionalmotility,failureofdefecationandproximalfecalcompactionwithinaproximalmegacolon.
AutoimmuneablationoftheENSintheloweresophagealsphincterunderliesthepathophysiologyofachalasia.
Furthermore,neuropathicdegenerationofENSneuronsinirritablebowelsyndrome,otherfunctionalgastrointestinaldisorders,intestinalpseudoobstruction,Chagasdisease,paraneoplasticsyndromeandentericganglionitis,underliesthemorbidityassociatedwiththesedisorders.
TheimpactoftheseclinicaldisordersonqualityoflifeandcostofhealthcareisareminderoftheimportanceoftheENSforanormallyfunctioninggut.
Moreover,ourincompleteunderstandingofthepathobiologyofthesedisordershighlightsaneedforresearchdirectedtoexpansionofcurrentknowledgeoftheneurobiologyoftheENSatalllevelsoforganizationfromthecellularbiologyofindividualneuronstothebiophysicsofintegratednetworkstowholeorganbehavior.
InvestigationofthenormalanddisorderedENSanditsinteractionswiththecentralnervoussystemisabranchofneurogastroenterology.
Neurogastroenterologyisascientificandclinicalsubspecialtyofgastroenterologythatdealswiththeneuralmechanismsthatinfluencefunctionofthedigestivetractandthatunderlieprojectionofconscioussensationstothegut.
TableofContents:Introduction/HistoricalPerspective/HeuisticModel/Microanatomy/SensoryNeurophysiology/Interneurons/EntericMotorNeurons/DisinhibitoryMotorDisorders/NeuronalElectricalBehavior/SynapticTransmission/OrganLevelIntegration/GastricMotorIntegration/IntegratedControloftheSmallandLargeIntestines/PlasticityintheENS/SmallIntestineMotility/Defecation/References""1","9781615042135","9781615042142","HemeOxygenaseandtheKidney","ColloquiumSeriesonIntegratedSystemsPhysiology","80","2011","DavidStec","UniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00036ED1V01Y201107ISP024","10.
4199/C00036ED1V01Y201107ISP024","Hemeoxygenases(HOs)aretheenzymesresponsibleforthebreakdownofhemeandthegenerationofbiliverdin/bilirubinandcarbonmonoxide(CO).
Thekidneyisacomplexorganconsistingofmanydifferentcelltypesallworkingtogetherforthesinglepurposeoffilteringthebloodtoeliminatewasteproductsandconservingions,minerals,andwaternecessaryforlife.
HOenzymesandtheirproductsplayacriticalroleinthenormalfunctionofthekidneyaswellasprotectingthekidneyfromvariousinsultsincludingischemiaandexposuretonephrotoxins.
Forexample,theHOmetabolite,bilirubin,isapotentantioxidantwhichcanlimitdamagetorenaltubularepithelialcellsfollowingexposuretonephrotoxinsassociatedwithchemotherapyortraumaticinjury.
AnotherHOmetabolite,CO,isanimportantvasodilatorofrenalbloodvesselsandhelpsprotectagainstseveredecreasesinrenalbloodflowinconditionsasdiverseasexposuretoradiocontrastagentsandinhypertension-inducedkidneydisease.
HOanditsmetabolitesalsoplayanimportantroleinthesurvivalofkidneycellsafteracuteandchronicinjuriesbyregulatingimportantcellgrowthandprogrammedcelldeathpathways.
TheintentofthisvolumeistohighlighttheimportantrolethatHOenzymesandtheirrelatedmetabolites,bilirubinandCO,playintheregulationofrenalfunctionandintheresponseofthekidneytobothacuteandchronicpathologies.
TableofContents:IntroductiontotheHOSystem/HOandRenalVascularFunction/HOandRenalTubuleFunction/HOandAcuteKidneyInjury/HOandChronicKidneyInjury/FutureofRenalHOResearch/References""1","9781615041626","9781615041633","HemorheologyandHemodynamics","ColloquiumSeriesonIntegratedSystemsPhysiology","140","2011","GilesCokelet","MontanaStateUniversity"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00033ED1V01Y201106ISP021","10.
4199/C00033ED1V01Y201106ISP021","Fromtheperspectiveofbloodflow,bloodhassomeunusualproperties:itisasuspensionofbloodcellsofwhichtheredbloodcellsaremostnumerousandarebothdeformable(atmoderateandhighflowrates)andwillaggregateunderconditionsofslowflow.
Also,thecellularvolumeconcentrationishigh(about40-45%).
Thesefeaturescausebloodtohavevariableviscosity,dependentonflowconditions,andcausebothredbloodcellsedimentationandsyneresiseffectsunderslowflowconditions(whichcanleadtorheologicalartifacts).
Theseeffectsalsocauseunusualflowphenomenawhenbloodflowsinsystemsofsmalldiametervessels(especiallyfordiametersofabout500μmorless).
Thesephenomenaareseeninnon-uniformcelldistributionsinvesselcrosssections,acell-poorlayerofmostlybloodplasmaatvesselswalls,non-proportionatecellulardistributionduringbloodflowthroughvascularbifurcations,whichleadstoaverywidedistributionofvesselcellularconcentrations(fromzerotosystemicvalues)inthesmallervesselsofthemicrocirculation,etc.
Allthesephenomenaarediscussedinthisbook,aswellasthedifficultiespresentedbyinvivomicrovesselshavingnon-idealgeometries.
TableofContents:Introduction/TheCompositionofBlood/Viscometers/ConstitutiveEquations/AtLast,ExperimentalData!
/SomeInVitroBloodFlows/TheFahraeusEffect/TheFahreus-LindqvistEffect/InVitroArterial-TypeBifurcationExperimentalData/InVivoExperimentalBifurcationData/FlowinMicrovascularNetworks/Optimization/ConcludingStatement/References""1","9781615041442","9781615041459","IntestinalImmuneSystem","ColloquiumSeriesonIntegratedSystemsPhysiology","122","2011","SoichiroMiura","NationalDefenseMedicalCollege","RyotaHokari","NationalDefenseMedicalCollege","ShunsukeKomoto","NationalDefenseMedicalCollege",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00037ED1V01Y201107ISP025","10.
4199/C00037ED1V01Y201107ISP025","Intheintestine,auniqueimmunologicalsystemthatisdifferentfromthesystemicimmunesystemexiststoprovideadaptiveimmunityinresponsetoluminalbacteriaanddietaryantigens.
Therearemanylymphoidcellaggregatescalledgut-associatedlymphoidtissue(GALT)includingPeyer'spatches(PPs),whichfunctionasimportantinductionsitesforthemucosalimmuneresponse.
M-cellsarepresentintheepitheliumofPPs,havingaspecializedstructureforuptakeofmacromoleculessuchasbacteria.
InadditiontoGALT,thereareabundantlymphoidcellsintheintestinallaminapropria,wheretheymainlyplayaroleasimmuneeffectorcells.
Astronginnateimmunesystemthatmainlyconsistsofdendriticcells,macrophages,andγδTlymphocytesalsoexistsintheintestinalmucosatoassistthebarrierfunctionofintestinalepithelialcells.
Theintestinalmucosathusshowsauniquemorphologicalstructurewithmanyimmunecellsbeingpresentunderphysiologicalconditions.
Thisconditionisknownas""controlledinflammation.
""Theseabundantimmunecellsalsohavecharacteristicfunctions:theyare""negativelyregulated""andhavebeeneducatednottooverreactunnecessarilytotheintestinalluminalmilieu.
MainplayersthatcontrolinflammationoftheintestinalmucosaincluderegulatorycytokinesandregulatoryTcellswhichinduceoraltolerancetointestinalbacteriaandfoodantigens,andthesecretoryIgAsystem.
Themaintenanceofuniqueimmunologicalactivityintheintestineisalsorelatedtoanorganized,orchestratedlymphocytemigratorymechanismcalledthe""commonmucosalimmunesystem.
""Thesenegativeregulatorymechanismsoftheintestinalimmunesystemaredisturbedincertaindiseaseconditions,causingtheimmunocompetentcellstorespondtofoodcomponentsandcommensalbacteriabybecomingactivatedandtooverproduceinflammatorycytokinesandchemokines.
Thesediseaseconditionsincludefoodallergies,suchasceliacdisease,andtheinflammatoryboweldiseases,suchasulcerativecolitisandCrohn'sdisease,althoughtheirexactetiologicalmechanismsremaintoberevealed.
TableofContents:Introduction/GALT:ItsStructureandFormation/IntestinalEpithelialCellsandTheirImmuneFunction/InnateImmunityintheIntestinalMucosa/IntraepithelialLymphocytes(IELs)/LymphoidCellTraffickinginIntestinalImmunology/SiteofInductionofMucosalImmunityandAntigenPresentationbyDendriticCells/ProductionofSecretoryIgA(SIgA)/EffectorSiteofAcquiredImmunityandTHelperCellSubpopulation/ImmuneRegulatorySystemandOralTolerance/FoodAllergyandCeliacDisease/InflammatoryBowelDiseases/EntericInfectionwithPathogenicMicrobesandMucosalImmunity/References""1","9781615043330","9781615043347","MotorFunctionofthePharynx,Esophagus,anditsSphincters","ColloquiumSeriesonIntegratedSystemsPhysiology","84","2011","RaviMittal","UniversityofCalifornia,SanDiego"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00030ED1V01Y201104ISP018","10.
4199/C00030ED1V01Y201104ISP018","Deglutitionoraswallowbeginsasavoluntaryactintheoralcavitybutproceedsautonomouslyinthepharynxandesophagus.
Bilateralsequencedactivationandinhibitionofmorethan25pairsofmusclesofmouth,pharynx,larynx,andesophagusisrequiredduringaswallow.
Asingleswallowelicitsperistalsisinthepharynxandesophagusalongwithrelaxationofupperandloweresophagealsphincters.
Multipleswallows,atcloselyspacedtimeintervals,demonstratedeglutitiveinhibition;sphinctersremainrelaxedduringtheentireperiod,butonlythelastswallowelicitsperistalsis.
Laryngealinletclosureorairwayprotectionisveryimportantduringswallow.
Upperpartoftheesophagusthatincludesupperesophagealsphincteriscomposedofskeletalmuscles,middleesophagusiscomposedofamixtureofskeletalandsmoothmuscles,andloweresophagus,includingloweresophagealsphincter,iscomposedofsmoothmuscles.
Peristalsisprogressesinseamlessfashion,despiteseparatecontrolmechanism,fromtheskeletaltosmoothmuscleesophagus.
Theesophagus'scircularandlongitudinalmusclelayerscontractsynchronouslyduringperistalsis.
Sphinctersmaintaincontinuoustone;neuromuscularmechanismsfortonicclosureintheupperandloweresophagealsphinctersaredifferent.
Loweresophagealsphinctertransientrelaxation,belchingmechanism,regurgitation,vomiting,andrefluxaremediatedviathebrainstem.
TableofContents:Introduction/CentralProgramGeneratorandBrainStem/Pharynx-Anatomy,NeuralInnervation,andMotorPattern/UpperEsophagealSphincter/NeuromuscularAnatomyofEsophagusandLowerEsophagealSphincter/ExtrinsicInnervation:ParasympatheticandSympathetic/InterstitialCellsofCajal/RecordingTechniques/MotorPatternsoftheEsophagus-AboralandOralTransport/DeglutitiveInhibitionandMuscleRefractoriness/PeristalsisintheCircularandLongitudinalMusclesoftheEsophagus/NeuralandMyogenicMechanismofPeristalsis/CentralMechanismofPeristalsis-CorticalandBrainStemControl/PeripheralMechanismsofPeristalsis/CentralVersusPeripheralMechanismofDeglutitiveInhibition/NeuralControlofLongitudinalMuscleContraction/ModulationofPrimaryandSecondaryPeristalsis/NeuralControlofLowerEsophagealSphincterandCruralDiaphragm/LowerEsophagealSphincter/Swallow-InducedLESRelaxation/CruralDiaphragmContributiontoEGJandNeuralControl/TransientLESRelaxationandPharmacologicalInhibition/ComplianceoftheEGJ/References""1","9781615042319","9781615042326","NeuralControlofRenalFunction","ColloquiumSeriesonIntegratedSystemsPhysiology","96","2011","UllaKopp","UniversityofIowaCarverCollegeofMedicineandDepartmentofVeteransAffairsMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00034ED1V01Y201106ISP022","10.
4199/C00034ED1V01Y201106ISP022","Thekidneyisinnervatedwithefferentsympatheticnervefibersreachingtherenalvasculature,thetubules,thejuxtaglomerulargranularcells,andtherenalpelvicwall.
Therenalsensorynervesaremainlyfoundintherenalpelvicwall.
Increasesinefferentrenalsympatheticnerveactivityreducerenalbloodflowandurinarysodiumexcretionbyactivationofα1-adrenoceptorsandincreasereninsecretionratebyactivationofβ1-adrenoceptors.
Inresponsetonormalphysiologicalstimulation,changesinefferentrenalsympatheticnerveactivitycontributeimportantlytohomeostaticregulationofsodiumandwaterbalance.
Therenalmechanosensorynervesareactivatedbystretchoftherenalpelvictissueproducedbyincreasesinrenalpelvicpressureofamagnitudethatmayoccurduringincreasedurineflowrate.
Activationofthesensorynerveselicitsaninhibitoryrenorenalreflexresponseconsistingofdecreasesinefferentrenalsympatheticnerveactivityleadingtonatriuresis.
Increasingefferentsympatheticnerveactivityincreasesafferentrenalnerveactivitywhich,inturn,decreasesefferentrenalsympatheticnerveactivitybyactivationoftherenorenalreflexes.
Thus,activationoftheafferentrenalnervesbufferschangesinefferentrenalsympatheticnerveactivityintheoverallgoalofmaintainingsodiumbalance.
Inpathologicalconditionsofsodiumretention,impairmentoftheinhibitoryrenorenalreflexescontributestoaninappropriatelyincreasedefferentrenalsympatheticnerveactivityinthepresenceofsodiumretention.
Instatesofrenaldiseaseorinjury,thereisashiftfrominhibitorytoexcitatoryreflexesoriginatinginthekidney.
Studiesinessentialhypertensivepatientshaveshownthatrenaldenervationresultsinlong-termreductioninarterialpressure,suggestinganimportantrolefortheefferentandafferentrenalnervesinhypertension.
TableofContents:PartI:EfferentRenalSympatheticNerves/Introduction/Neuroanatomy/NeuralControlofRenalHemodynamics/NeuralControlofRenalTubularFunction/NeuralControlofReninSecretionRate/PartII:AfferentRenalSensoryNerves/Introduction/Neuroanatomy/RenorenalReflexes/MechanismsInvolvedintheActivationofAfferentRenalSensoryNerves/PartIII:PathophysiologicalStates/EfferentRenalSympatheticNerves/AfferentRenalSensoryNerves/Conclusions/References""1","9781615043620","9781615043637","ReactiveOxygenSpeciesandtheCardiovascularSystem","ColloquiumSeriesonIntegratedSystemsPhysiology","102","2011","AugustoMontezano","UniversityofOttawaandUniversityofGlasgow","Touyz,Rhian","UniversityofOttawaandUniversityofGlasgow",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00043ED1V01Y201112ISP032","10.
4199/C00043ED1V01Y201112ISP032","Reactiveoxygenspecies(ROS)influencevariousphysiologicalprocessesincludinghostdefense,hormonebiosynthesis,andcellularsignaling.
IncreasedROSproduction(oxidativestress)isimplicatedinmanydiseasesofthecardiovascularsystem,includinghypertension,atherosclerosis,cardiacfailure,stroke,diabetes,andkidneydisease.
ROSareproducedthroughoutthecardiovascularsystem,inthekidneyandcentralandperipheralnervoussystem.
Amajorsourceforcardiovascular,renal,andneuralROSisafamilyofnon-phagocyticNAD(P)Hoxidases,includingtheprototypicNox2homologue-basedNAD(P)Hoxidase,aswellasotherNAD(P)Hoxidases,suchasNox1andNox4.
Otherpossiblesourcesincludemitochondrialelectrontransportenzymes,xanthineoxidase,cyclooxygenase,lipoxygenase,anduncouplednitricoxidesynthase(NOS).
NAD(P)Hoxidase-derivedROSisimportantinregulatingendothelialfunctionandvasculartoneandoxidativestressisimplicatedinendothelialdysfunction,inflammation,hypertrophy,apoptosis,migration,fibrosis,angiogenesisandrarefaction,importantprocessesinvolvedinvascularremodelingincardiovasculardisease.
Thesefindingshaveevokedconsiderableinterestbecauseofthepossibilitiesthattherapiestargetedagainstnon-phagocyticNAD(P)HoxidasetodecreaseROSgenerationand/orstrategiestoincreasenitricoxide(NO)availabilityandantioxidantsmaybeusefulinminimizingvascularinjuryandtherebypreventorregresstargetorgandamageassociatedwithhypertensionandothercardiovasculardiseases.
""1","9781615041749","9781615041756","RegulationofCardiacContractility","ColloquiumSeriesonIntegratedSystemsPhysiology","50","2011","R.
JohnSolaro","UniversityofIllinoisatChicago"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00030ED1V01Y201104ISP018","10.
4199/C00030ED1V01Y201104ISP018","Contractilitydescribestherelativeabilityofthehearttoejectastrokevolume(SV)atagivenprevailingafterload(arterialpressure)andpreload(end-diastolicvolume;EDV).
VariousmeasuresofcontractilityarerelatedtothefractionastheSV/EDVortheejectionfraction,andthedynamicsofejectionasdeterminedfrommaximumpressureriseintheventriclesorarteriesorfromaorticflowvelocitiesdeterminedbyechocardiography.
Atthecellularlevel,theultimatedeterminantofcontractilityistherelativetensiongenerationandshorteningcapabilityofthemolecularmotors(myosincross-bridges)ofthesarcomeresasdeterminedbytheratesandextentofCaactivation,theturnoverkineticsofthecross-bridges,andtherelativeCaresponsivenessofthesarcomeres.
Engagementoftheregulatorysignalingcascadescontrollingcontractilityoccurswithoccupancyandsignaltransductionbyreceptorsforneurohumorsoftheautonomicnervoussystemaswellasgrowthandstresssignalingpathways.
ContractilityisalsodeterminedbytheprevailingconditionsofpH,temperature,andredoxstate.
Short-termcontrolofcontractilityisfullyexpressedduringexercise.
Inlong-termresponsestostressesontheheart,contractilityismodifiedbycellularremodelingandalteredsignalingthatmaycompensateforatimebutwhichultimatelymayfail,leadingtodisorders.
TableofContents:Introduction:ContractilityandtheIntegrativeBiologyoftheMyocardium/ControlofContractilityIsattheCellularLevelofOrganization/LeftVentricularDiastolicandSystolicPressure,Ejection,andRelaxationReflectSarcomericMechanicalProperties/IntegrationofSarcomereMechanicswithCardiacFunctionClarifiestheMeaningofPreload,Afterload,andContractility/PressureVolumeLoopsProvideaQuantificationofContractility/PhosphorylationsofRegulatoryProteinsinExcitationContractionCouplingModifyContractilitybyControllingCellularCa+Fluxes,theResponseoftheMyofilamentstoCa+,andtheKineticsoftheCross-BridgeCycle/ContractilityMayBeAlteredbyaVarietyofMechanismsNotInvolvingaProminentRolefortheAutonomicNervousSystem/CardiacFunctionCurvesProvideaCompactGraphicalRepresentationofRegulationofCOandSV/HeartFailureasaFailureofContractility/References""1","9781615041206","9781615041213","RegulationofEndothelialBarrierFunction","ColloquiumSeriesonIntegratedSystemsPhysiology","146","2011","SarahYuan","UniversityofCalifornia,Davis","RobertRigor","UniversityofCalifornia,Davis",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00025ED1V01Y201101ISP013","10.
4199/C00025ED1V01Y201101ISP013","Thevascularendotheliumliningtheinnersurfaceofbloodvesselsservesasthefirstinterfaceforcirculatingbloodcomponentstointeractwithcellsofthevascularwallandsurroundingextravasculartissues.
Inadditiontoregulatingblooddeliveryandperfusion,amajorfunctionofvascularendothelia,especiallythoseinexchangemicrovessels(capillariesandpostcapillaryvenules),istoprovideasemipermeablebarrierthatcontrolsblood–tissueexchangeoffluids,nutrients,andmetabolicwasteswhilepreventingpathogensorharmfulmaterialsinthecirculationfromenteringintotissues.
Duringhostdefenseagainstinfectionortissueinjury,endothelialbarrierdysfunctionoccursasaconsequenceaswellascauseofinflammatoryresponses.
Plasmaleakagedisturbsfluidhomeostasisandimpairstissueoxygenation,apathophysiologicalprocesscontributingtomultipleorgandysfunctionassociatedwithtrauma,infection,metabolicdisorder,andotherformsofdisease.
Inthisbook,weprovideanupdatedoverviewofmicrovascularendothelialbarrierstructureandfunctioninhealthanddisease.
Thediscussionisinitiatedwiththebasicphysiologicalprinciplesoffluidandsolutetransportacrossmicrovascularendothelium,followedbydetailedinformationonendothelialcell–cellandcell–matrixinteractionsandtheexperimentaltechniquesthatareemployedtomeasureendothelialpermeability.
Furtherdiscussionfocusesonthesignalingandmolecularmechanismsofendothelialbarrierresponsestovariousstimulationsordrugs,aswellastheirrelevancetoseveralcommonclinicalconditions.
Takentogether,thisbookprovidesacomprehensiveanalysisofmicrovascularendothelialcellandmolecularpathophysiology.
Suchinformationwillassistscientistsandcliniciansinadvancedbasicandclinicalresearchforimprovedhealthcare.
TableofContents:Acknowledgments/Introduction/StructureandFunctionofExchangeMicrovessels/MethodsforMeasuringPermeability/TheEndothelialBarrier/SignalingMechanismsintheRegulationofEndothelialPermeability/EndothelialBarrierProtectors/PathophysiologyandClinicalRelevance/Conclusion/References""1","9781615041329","9781615041336","RegulationofGastrointestinalMucosalGrowth","ColloquiumSeriesonIntegratedSystemsPhysiology","114","2011","Jian-YingWang","UniversityofMarylandSchoolofMedicineandBaltimoreVeteransAffairsMedicalCenter","RaoN.
Jaladanki","UniversityofMarylandSchoolofMedicineandBaltimoreVeteransAffairsMedicalCenter",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00028ED1V01Y201103ISP015","10.
4199/C00028ED1V01Y201103ISP015","Themammaliangastrointestinalmucosaisarapidlyself-renewingtissueinthebody,anditshomeostasisispreservedthroughthestrictregulationofepithelialcellproliferation,growtharrest,andapoptosis.
Thecontrolofthegrowthofgastrointestinalmucosaisuniqueand,comparedwithmostothertissueinthebody,complex.
Mucosalgrowthisregulatedbythesamehormonesthataltermetabolisminothertissues,butthegastrointestinalmucosaalsorespondstoahostofeventstriggeredbytheingestionandpresenceoffoodwithinthedigestivetract.
Theseguthormonesandpeptidesregulatethegrowthoftheexocrinepancreas,gallbladderepithelium,andthemucosaoftheoxynticglandregionofthestomachandthesmallandlargeintestines.
Luminalfactors(nutrientsorotherdietaryfactors,secretions,andmicrobes),whichoccurwithinthelumenanddistributeoveraproximal-to-distalgradient,arealsocrucialforthemaintenanceofthenormalgutmucosalgrowthandcouldexplainthevillousheight–cryptdepthgradientandvarietyofadaptationssincethesefactorsarediluted,absorbed,anddestroyedastheypassdownthedigestivetract.
Recently,intestinalstemcellsandpolyaminesareshowntoplayanimportantroleintheregulationofgastrointestinalmucosalgrowthunderphysiologicalandvariouspathologicalconditions.
Inthischapter,wehighlightkeyissuesandfactorsthatcontrolgastrointestinalmucosalgrowth,withspecialemphasisonthemechanismsthroughwhichepithelialrenewalisregulatedbypolyaminesatthecellularandmolecularlevels.
TableofContents:Introduction/IntestinalArchitectureandDevelopment/CharacteristicsofGutMucosalGrowth/IntestinalStemCells/RoleofGIHormonesontheGutMucosalGrowth/PeptideGrowthFactorsinGIMucosalGrowth/LuminalNutrientsandMicrobesinGutMucosalGrowth/PolyaminesintheRegulationofMucosalGrowth/SummaryandConclusions/Acknowledgments/References""1","9781615041770","9781615041787","RegulationofTissueOxygenation","ColloquiumSeriesonIntegratedSystemsPhysiology","100","2011","RolandPittman","VirginiaCommonwealthUniversity"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00029ED1V01Y201103ISP017","10.
4199/C00029ED1V01Y201103ISP017","Thispresentationdescribesvariousaspectsoftheregulationoftissueoxygenation,includingtherolesofthecirculatorysystem,respiratorysystem,andblood,thecarrierofoxygenwithinthesecomponentsofthecardiorespiratorysystem.
Therespiratorysystemtakesoxygenfromtheatmosphereandtransportsitbydiffusionfromtheairinthealveolitothebloodflowingthroughthepulmonarycapillaries.
Thecardiovascularsystemthenmovestheoxygenatedbloodfromthehearttothemicrocirculationofthevariousorgansbyconvection,whereoxygenisreleasedfromhemoglobinintheredbloodcellsandmovestotheparenchymalcellsofeachtissuebydiffusion.
Oxygenthathasdiffusedintocellsisthenutilizedinthemitochondriatoproduceadenosinetriphosphate(ATP),theenergycurrencyofallcells.
ThemitochondriaareabletoproduceATPuntiltheoxygentensionorPOintheirvicinityfallstoacriticallevelofabout1mmHg.
Thus,inordertomeettheenergeticneedsofcells,itisimportanttomaintainacontinuoussupplyofoxygentothemitochondriaatorabovethecriticalPO.
Inordertoaccomplishthisdesiredoutcome,thecardiorespiratorysystem,includingtheblood,mustbecapableofregulationtoensuresurvivalofalltissuesunderawiderangeofcircumstances.
Thepurposeofthispresentationistoprovidebasicinformationabouttheoperationandregulationofthecardiovascularandrespiratorysystems,aswellasthepropertiesofthebloodandparenchymalcells,sothatafundamentalunderstandingoftheregulationoftissueoxygenationisachieved.
TableofContents:Introduction/TheCirculatorySystemandOxygenTransport/TheRespiratorySystemandOxygenTransport/OxygenTransport/ChemicalRegulationofRespiration/TissueGasTransport/OxygenTransportinNormalandPathologicalSituations:DefectsandCompensations/MatchingOxygenSupplytoOxygenDemand/ExerciseandHemorrhage/MeasurementofOxygen/Summary/References/Biography""1","9781615041831","9781615041848","SkeletalMuscleCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","144","2011","RonaldKorthuis","UniversityofMissouriSchoolofMedicine"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00035ED1V01Y201106ISP023","10.
4199/C00035ED1V01Y201106ISP023","Theaimofthistreatiseistosummarizethecurrentunderstandingofthemechanismsforbloodflowcontroltoskeletalmuscleunderrestingconditions,howperfusioniselevated(exercisehyperemia)tomeettheincreaseddemandforoxygenandothersubstratesduringexercise,mechanismsunderlyingthebeneficialeffectsofregularphysicalactivityoncardiovascularhealth,theregulationoftranscapillaryfluidfiltrationandproteinfluxacrossthemicrovascularexchangevessels,andtheroleofchangesintheskeletalmusclecirculationinpathologicstates.
Skeletalmuscleisuniqueamongorgansinthatitsbloodflowcanchangeoveraremarkablylargerange.
Comparedtobloodflowatrest,musclebloodflowcanincreasebymorethan20-foldonaverageduringintenseexercise,whileperfusionofcertainindividualwhitemusclesorportionsofthosemusclescanincreasebyasmuchas80-fold.
Thisiscomparedtomaximalincreasesof4-to6-foldinthecoronarycirculationduringexercise.
Theseincreasesinmuscleperfusionarerequiredtomeettheenormousdemandsforoxygenandnutrientsbytheactivemuscles.
Becauseofitslargemassandthefactthatskeletalmusclesreceive25%ofthecardiacoutputatrest,sympatheticallymediatedvasoconstrictioninvesselssupplyingthistissueallowscentralhemodynamicvariables(e.
g.
,bloodpressure)tobesparedduringstressessuchashypovolemicshock.
Sympatheticvasoconstrictioninskeletalmuscleinsuchpathologicconditionsalsoeffectivelyshuntsbloodflowawayfrommusclestotissuesthataremoresensitivetoreductionsintheirbloodsupplythatmightotherwiseoccur.
Again,becauseofitslargemassandpercentageofcardiacoutputdirectedtoskeletalmuscle,alterationsinbloodvesselstructureandfunctionwithchronicdisease(e.
g.
,hypertension)contributesignificantlytothepathologyofsuchdisorders.
Alterationsinskeletalmusclevascularresistanceand/orintheexchangepropertiesofthisvascularbedalsomodifytranscapillaryfluidfiltrationandsolutemovementacrossthemicrovascularbarriertoinfluencemusclefunctionandcontributetodiseasepathology.
Finally,itisclearthatexercisetraininginducesanadaptivetransformationtoaprotectedphenotypeinthevasculaturesupplyingskeletalmuscleandothertissuestopromoteoverallcardiovascularhealth.
TableofContents:Introduction/AnatomyofSkeletalMuscleandItsVascularSupply/RegulationofVascularToneinSkeletalMuscle/ExerciseHyperemiaandRegulationofTissueOxygenationDuringMuscularActivity/MicrovascularFluidandSoluteExchangeinSkeletalMuscle/SkeletalMuscleCirculationinAgingandDiseaseStates:ProtectiveEffectsofExercise/References""1","9781615041237","9781615041244","TheEndothelium,PartI:MultipleFunctionsoftheEndothelialCells--FocusonEndothelium-DerivedVasoactiveMediators","ColloquiumSeriesonIntegratedSystemsPhysiology","306","2011","MichelFélétou","InstitutdeRecherchesServier"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00031ED1V01Y201105ISP019","10.
4199/C00031ED1V01Y201105ISP019","Theendothelium,amonolayerofendothelialcells,constitutestheinnercellularliningofthebloodvessels(arteries,veinsandcapillaries)andthelymphaticsystem,andthereforeisindirectcontactwiththeblood/lymphandthecirculatingcells.
Theendotheliumisamajorplayerinthecontrolofbloodfluidity,plateletaggregationandvasculartone,amajoractorintheregulationofimmunology,inflammationandangiogenesis,andanimportantmetabolizingandanendocrineorgan.
Endothelialcellscontrolsvasculartone,andtherebybloodflow,bysynthesizingandreleasingrelaxingandcontractingfactorssuchasnitricoxide,metabolitesofarachidonicacidviathecyclooxygenases,lipoxygenasesandcytochromeP450pathways,variouspeptides(endothelin,urotensin,CNP,adrenomedullin,etc.
),adenosine,purines,reactiveoxygenspeciesandsoon.
Additionally,endothelialectoenzymesarerequiredstepsinthegenerationofvasoactivehormonessuchasangiotensinII.
Anendothelialdysfunctionlinkedtoanimbalanceinthesynthesisand/orthereleaseofthesevariousendothelialfactorsmayexplaintheinitiationofcardiovascularpathologies(fromhypertensiontoatherosclerosis)ortheirdevelopmentandperpetuation.
TableofContents:Introduction/MultipleFunctionsoftheEndothelialCells/CalciumSignalinginVascularCellsandCell-to-CellCommunications/Endothelium-DependentRegulationofVascularTone/Conclusion/References""1","9781615043378","9781615043361","TheEndothelium,PartII:EDHF-MediatedResponses""TheClassicalPathway""","ColloquiumSeriesonIntegratedSystemsPhysiology","306","2011","MichelFélétou","InstitutdeRecherchesServier"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00032ED1V01Y201105ISP020","10.
4199/C00032ED1V01Y201105ISP020","Theendotheliumcontrolsvasculartonebyreleasingvariousvasoactivesubstances.
Additionally,anotherpathwayassociatedwiththehyperpolarizationofbothendothelialandvascularsmoothmusclecellscontributesalsotoendothelium-dependentrelaxations(EDHF-mediatedresponses).
TheseresponsesinvolveanincreaseintheintracellularCaconcentrationoftheendothelialcellsfollowedbytheopeningofCa-activatedKchannelsofsmallandintermediateconductances(SKCaandIKCa).
Thesechannelsshowadistinctsubcellulardistribution,suggestingthattheiractivationcouldbeelicitedbydistinctstimuli.
FollowingKCaactivation,theendothelialhyperpolarizationcanbeconductedtotheunderlyingsmoothmusclecellsbyelectricalcouplingthroughmyo-endothelialgapjunctions.
Inaddition,thepotassiumeffluxcanleadtotheaccumulationofpotassiumionsintheintercellularspaceandthesubsequentactivationofsmoothmuscleKir2.
1and/orNa/K-ATPase.
Thehyperpolarizationofthesmoothmusclecellsproducesvascularrelaxation,predominantlybyclosingvoltage-gatedcalciumchannels,andvasodilatation.
EDHFmediatedresponsesarealteredinvariouspathologiesor,conversely,actasacompensatingmechanismwhenotherendothelialpathwaysareimpaired.
AbettercharacterizationofEDHF-mediatedresponsesshouldallowdeterminingwhetherornotnewdrugabletargetscanbeidentifiedwithinthisendothelialpathwayforthetreatmentofcardiovasculardiseases.
TableofContents:Endothelium-DependentHyperpolarizations:TheClassical""EDHF""Pathway/Conclusion/References""1","9781615041985","9781615041992","TheEntericMicrobiota","ColloquiumSeriesonIntegratedSystemsPhysiology","88","2011","FranciscoGuarner","DigestiveSystemResearchUnit,UniversityHospitalValld'Hebron,Spain"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00047ED1V01Y201110ISP029","10.
4199/C00047ED1V01Y201110ISP029","Thehumangutisthenaturalhabitatforadiverseanddynamicmicrobialecosystemhavinganimportantimpactonhealthanddisease.
Bacteriahavelivedinandonanimalhostssincemulticellularlifeevolvedabout1billionyearsago.
Hostsprovidehabitatandnutritiontothemicrobialcommunitiesandderivemanybenefitsfromtheirgueststhatcontributewithmetabolic(recoveryofenergyandnutrients),defensive(barriereffectagainstinvaders)andtrophic(immuneregulation,neuro-endocrinedevelopment)functions.
Severaldiseasestatesordisordershavebeenassociatedwithchangesinthecompositionorfunctionoftheentericmicrobiota,includinginflammatoryboweldiseases,obesityandthemetabolicsyndrome.
Probioticsandprebioticscanbeusedtoimprovesymbiosisbetweenentericmicrobiotaandhost,orcorrectstatesofdysbiosis.
TableofContents:MicrobialCommunities/Host-MicrobeInteractionsintheGut/CompositionoftheHumanEntericMicrobiota/AcquisitionoftheEntericMicrobiota/DysfunctionoftheEntericMicrobiota/TherapeuticManipulationoftheEntericMicrobiota/References/AuthorBiography""1","9781615041381","9781615041398","TheExocrinePancreas","ColloquiumSeriesonIntegratedSystemsPhysiology","64","2011","StephenPandol","UniversityofCalifornia,DepartmentofVeteransAffairs"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00026ED1V01Y201102ISP014","10.
4199/C00026ED1V01Y201102ISP014","Thesecretionsoftheexocrinepancreasprovidefordigestionofamealintocomponentsthatarethenavailableforprocessingandabsorptionbytheintestinalepithelium.
Withouttheexocrinepancreas,malabsorptionandmalnutritionresult.
Thischapterdescribesthecellularparticipantsresponsibleforthesecretionofdigestiveenzymesandfluidthatincombinationprovideapancreaticsecretionthataccomplishesthedigestivefunctionsofthegland.
Keycellularparticipants,theacinarcellandtheductcell,areresponsiblefordigestiveenzymeandfluidsecretion,respectively,oftheexocrinepancreas.
Thischapterdescribestheneurohumoralpathwaysthatmediatethepancreaticresponsetoamealaswellasdetailsofthecellularmechanismsthatarenecessaryfortheorganresponses,includingproteinsynthesisandtransportandiontransports,andtheregulationoftheseresponsesbyintracellularsignalingsystems.
Examplesofpancreaticdiseasesresultingfromdysfunctionincellularmechanismsprovideemphasisoftheimportanceofthenormalphysiologicmechanisms.
TableofContents:Introduction/Anatomy/PancreaticEmbryologyandDevelopment/DigestiveEnzymes/WaterandIonSecretionfromthePancreaticDuctalSystem/RegulationofWhole-OrganPancreaticSecretion/MeasurementofExocrinePancreaticSecretioninHumans/ClinicalApplicationofKnowledgeofPancreaticPhysiology/Summary/References""1","9781615041688","9781615041695","TheOcularCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","81","2011","JeffreyKiel","UniversityofTexasHealthScienceCenteratSanAntonio"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00024ED1V01Y201012ISP012","10.
4199/C00024ED1V01Y201012ISP012","Thispresentationdescribestheuniqueanatomyandphysiologyofthevascularbedsthatservetheeye.
Theneedsforanunobstructedlightpathfromthecorneatotheretinaandarelativelyfixedcornealcurvatureanddistancebetweenrefractivestructuresposesignificantchallengesforthevasculaturetoprovidenutrientsandremovemetabolicwaste.
Tomeettheseneeds,theocularvascularbedsareconfinedtotheperipheryoftheposteriortwothirdsoftheeyeandasurrogatecirculationprovidesacontinuousflowofaqueoushumortonourishtheavascularcornea,lensandvitreouscompartment.
Theproductionofaqueoushumor(anditseaseofegressfromtheeye)alsogeneratestheintraocularpressure(IOP),whichmaintainstheshapeoftheeye.
However,theIOPalsoexertsacompressingforceontheocularbloodvesselsthatishigherthanelsewhereinthebody.
Thisisparticularlytruefortheintraocularveins,whichmusthaveapressurehigherthanIOPtoremainpatent,andsotheIOPistheeffectivevenouspressurefortheintraocularvascularbeds.
Consequently,theocularcirculationoperatesatalowerperfusionpressuregradientthanelsewhereinthebodyandismoreatriskforischemicdamagewhenfacedwithlowarterialpressure,particularlyifIOPiselevated.
Thisriskandthespecializedtissuesoftheeyegiverisetothefascinatingphysiologyoftheocularcirculations.
TableofContents:Introduction/Anatomy/Bloodflowmeasuringtechniques/Ocularperfusionpressure,IOPandtheocularStarlingresistoreffect/OcularbloodfloweffectsonIOP/Localcontrolofocularbloodflow/Neuralcontrolofocularbloodflow/Summary""1","9781615040780","9781615040797","CreatingConnectionsintheDevelopingBrain:MechanismsRegulatingCorpusCallosumDevelopment","ColloquiumSeriesontheDevelopingBrain","48","2011","LindaRichards","QueenslandBrainInstitute,UniversityofQueensland,Australia","IlanGobius","QueenslandBrainInstitute,UniversityofQueensland,Australia",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00038ED1V01Y201107DBR002","10.
4199/C00038ED1V01Y201107DBR002","Thecorpuscallosumisthelargestfibretractinthehumanbrainandsubservesmanyofthebrain'shigher-orderfunctions.
Disconnectionsyndromesresultingfromsurgicalablation,developmentalabsence(agenesisofthecorpuscallosum),disease,orinjuryofthecorpuscallosumcanhaveprofoundconsequencesoncognition.
Callosaldevelopmentinvolvesanintricateseriesofsequentialandconcurrentprocesses,includingtelencephalicinduction,midlinetissuepatterning,productionandspecificationofcallosalneurons.
Inaddition,axonextensionandlong-rangeaxonalguidancefromonehemispheretotheotherarerequiredforfunctionalcircuitformationinthecontralateralhemisphere.
Geneticortraumaticdisruptiontoanypartofthissequenceispathogenic.
Understandingthekeyprocessesinvolvedincallosaldevelopmentisthefirststepinprovidingbothbetterneuropsychologicaloutcomesandimproveddiagnosticandprognostictoolsforcongenitaldisconnectionsyndromesinthefuture.
TableofContents:Introduction/FormationoftheTelencephalicHemispheres/MidlineTissuePatterning:PreparingtheCallosalSubstrate/SpecificationofCallosalProjectionNeuronswithintheNeocortexandCingulateCortex/EstablishingtheCallosalTract/NavigatingtheMidline:GrowthoftheCorpusCallosumAcrosstheInterhemisphericMidline/ContralateralTargetingofCallosalAxons:TheRoleofNeuronalActivity/Conclusion/References""1","9781615043484","9781615043491","DevelopmentofBrainandBehaviorinBirds","ColloquiumSeriesontheDevelopingBrain","50","2011","JuliWade","MichiganStateUniversity"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00041ED1V01Y201110DBR003","10.
4199/C00041ED1V01Y201110DBR003","Sexdifferencesinbrainandbehaviorarewidespreadacrossvertebrates.
Birdsexhibitremarkableexamplesofthesetypesofparallelsbetweenstructureandfunction.
Forexample,onlymalezebrafinchessing,andthebrainareasandmusclescontrollingthelearningandproductionofthesevocalizationsaregreatlyenhancedinmalescomparedtofemales.
Thesesexdifferencesarepermanentlyestablishedindevelopment.
Somesongbirds,unlikezebrafinches,changetheirsongsseasonally.
Inanumberofthesespecies,thebrainregionsexhibitchangesinneuronlossandincorporationacrosstheseperiods.
Themechanismsinvolvedinthesetypesofsexualdifferentiationandadultplasticityaredescribed—theylikelyinvolvebothsteroidhormonesandgenetic(protein)factors.
Thestrengthoftherelationshipsbetweenmorphologyandbehavior,aswellasmanyotherfactors,hasmadebirdsoutstandingmodelsfortheinvestigationofnumerousfunctions.
Theseincludethemechanismsregulatingvocallearning,auditoryperception,neurogenesis,andcellsurvival.
Thelessonslearnedhavebroadimplicationsforhealth-relatedprocessesandbasicbiologicalprinciples.
TableofContents:Introduction/SongandSongLearning/OtherSocial/ReproductiveBehaviors/ConclusionsandIdeasforFutureDirections""1","9781615043422","9781615043439","PerinatalBrainDevelopment,Malformation,andInjury","ColloquiumSeriesontheDevelopingBrain","84","2011","AnnePenn","DivisionofNeonatalandDevelopmentalMedicine,DepartmentofPediatrics,StanfordUniversitySchoolofMedicine","JulietKnowles","LucilePackardChildren'sHospital,DepartmentofPediatrics,StanfordUniversitySchoolofMedicine",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00044ED1V01Y201109DBR006","10.
4199/C00044ED1V01Y201109DBR006","Weprovideabroadoverviewofhumanbraindevelopmentwithassociatedmalformationsandinjuriesthatoccurintheperiodbetweenearlyembryogenesisanddelivery.
Theaimofthisreviewistosummarizecurrentunderstandingofthemolecularandenvironmentalcuesthatshapethedevelopingbrain.
Foreachdevelopmentalstage,wegiveexamplesofdisordersthatarisefromgeneticand/orenvironmentalinsultstoillustratecriticalpointsofneurologicalsusceptibility.
TableofContents:Introduction/OriginoftheCentralNervousSystem:TheNeuralTube(3-4WeeksGestation)/PatterningoftheNeuralTube:ABlueprintfortheCNS/NeuralProliferationandMigration(3MonthsGestationIntoPostnatalPeriod)/OrganizationofNeuronalCircuitsandSynaptogenesis(5MonthsGestation-PostnatalYears)/GliogenesisandMyelination(5-MonthChildhood)/DevelopmentalBrainInjury:Before,During,andAfterBirth/Conclusion/References/AuthorBiographies""1","9781615043545","9781615043552","SeizuresandtheDevelopingBrain","ColloquiumSeriesontheDevelopingBrain","70","2011","AristeaGalanopoulou","AlbertEinsteinCollegeOfMedicine"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00046ED1V01Y201109DBR005","10.
4199/C00046ED1V01Y201109DBR005","Seizuresaremorecommonearlyinlifethaninadulthood.
Bidirectionalinteractionsbetweenseizuresandnormaldevelopmentalprocessesdefinetheirexpressionandoutcomes.
Severaldevelopmentallyregulatedfactorscontrolneuronalexcitability.
GABAAreceptorsholdacentralroleastheycontrolneuronalactivityinanage-specificmanner.
Earlyindevelopment,GABAAreceptorshavedepolarizingeffects,whichcontributetotheincreasedsusceptibilityofimmatureneuronstoseizuresbuttheyarealsoessentialfornormalbraindevelopment.
Duringdevelopment,thereisagradualshifttothe"adult-type"hyperpolarizingGABAAreceptorsignaling,creatingmoreefficientinhibition.
SeizuresmaydisruptGABAAreceptorsignalingbychangingtheexpressionoftheirsubunitsandbychangingthedirectionofGABAAresponses,which,incertainsituations,maybedetrimentalforbraindevelopment.
Furthermore,subcorticalnuclei,suchasthesubstantianigra,controltheexpressionandpropagationofseizuresinanage-andsex-dependentmanner.
Theseendogenouscontrolcentersandsignalingpathwaysarefurthermodifiedbyindependentgeneticepigenetic,biologic,orotherfactors,whichfurtherincreasetheheterogeneityinpresentationofseizures,theirtreatment,andtheircomorbidities.
Elucidationofthesecomplexinteractionsandidentificationofbiomarkersguidingtherapeuticinterventionswillbenecessarytoimproveourabilitytotreatearly-lifeepilepsies.
TableofContents:TableofContents:SeizuresandEpilepsy:Definitions,Classification,Models/BrainDevelopmentControlsSeizureSusceptibilityandOutcomes/Conclusions/References/AuthorBiography""1","9781615043514","9781615043521","TheImmuneSystemandtheDevelopingBrain","ColloquiumSeriesontheDevelopingBrain","128","2011","JaclynSchwarz","UniversityofDelaware","StaciD.
Bilbo","DukeUniversityandDukeInstituteforBrainSciences(DIBS)",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00045ED1V01Y201110DBR004","10.
4199/C00045ED1V01Y201110DBR004","Thedevelopingbrainisexquisitelysensitivetobothendogenousandexogenoussignalswhichdirectorsignificantlyalterthedevelopmentaltrajectoryofcells,neuralcircuits,andassociatedbehavioraloutcomesforthelifeoftheindividual.
Contrarytoinitialdogmathatthebrainisoneofthefeworganswithinthebodythatisimmune-privileged,evidenceindicatesthattheimmunesystemhasacriticalroleinbrainfunctionduringdevelopmentaswellasduringsicknessandhealthinadulthood.
Microgliaaretheprimaryimmunecellswithinthebrain,andtheyareinconstantcommunicationwiththeperipheralimmunesystemandsurroundingcelltypeswithinthebrain.
Wedescribetheimportantroleoftheimmunesystem,includingmicroglia,duringbraindevelopment,anddiscusssomeofthemanywaysinwhichimmuneactivationduringearlybraindevelopmentcanaffectthelater-lifeoutcomesofneuralfunction,immunefunction,andcognition.
Growingevidenceindicatesthatthereisastronglinkbetweenmanyneuropsychiatricdisordersandimmunedysfunction,withadistinctetiologyinneurodevelopment.
Thus,understandingtheroleoftheimmunesystemandimmuneactivationduringthecriticalperiodofbraindevelopmentisanecessarysteptowardunderstandingthepotentialoriginsofthesedevastatingdisorders.
TableofContents:Introduction/TheImmuneResponse/Brain-ImmuneCommunication/MicrogliaAreImmuneCellsoftheBrain/TheFunctionalRoleofMicrogliaandImmuneMoleculesinNeurodevelopment/Early-LifeProgrammingofBrainandBehavior:ACriticalRolefortheImmuneSystem/CommonlyUsedModelsofEarlyLifeImmuneActivationintheRodent/EarlyLifeImmuneActivationandCognitiveImpairmentinAdulthood/MechanismsUnderlyingtheEnduringChangesinNeuroimmuneFunctionCausedbyEarlyLifeInfection/Toll-LikeReceptorsandImmuneActivationDuringEarlyBrainDevelopment/EnvironmentalTriggersofTLRActivation:Long-TermProgrammingofBrainandBehavior/FutureDirectionstoUnderstandingImmuneFunctionandBrainDevelopment/References""1","9781615041565","9781615041572","IntestinalWaterandElectrolyteTransport","ColloquiumSeriesonIntegratedSystemsPhysiology","105","2012","MrinaliniRao","UniversityofIllinois","JayashreeSarathy(neeVenkatasubramanian)","UniversityofIllinoisandBenedictineUniversity","MeiAo","UniversityofIllinois",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00049ED1V01Y201112ISP031","10.
4199/C00049ED1V01Y201112ISP031","Theuniquearchitectureandphysiologyofthemammalianintestine,togetherwithatightlycoordinatedregulatorysystem,allowsforthehandlingandabsorptionofasmuchas9Loffluidadaywith98%orgreaterefficiency.
Advancesinthepast40yearshavemadeinroadsintorevealingtheintricaciesandinterplayofnumerousiontransportersandtheirmodulatorsthatareresponsibleforintestinalelectrolyteandwatertransport.
Studiesoftwodevastatingdiseases,thevirulentinfectiousdiseasecholeraandtheautosomalrecessivediseasecysticfibrosis,werelargelyresponsibleforthisinformationexplosion.
Theseadvanceshavebeencriticalinthedevelopmentofnewtherapeuticstrategiestocombatlife-threateningdiseasesofvaryingetiologiesrangingfromentericinfectionstocysticfibrosisandinflammatoryboweldiseases.
Yet,thestoryisfarfromcomplete,andprogressneedstocontinueontranslatinginformationgainedfromreductionisticcellandtissueculturemodels,invivomodels,andultimatelyhumanstudiesandonimprovingtherapeuticapproaches.
Thisbookreviewsthecurrentstatusofourknowledgeoffluidtransportacrosstheintestine,includingthecomplexitiesoftranscellularandparacellulariontransportdownthelengthoftheintestineandhowaberrationsofnormalphysiologicalprocessesleadtodisease.
TableofContents:Overview/EpithelialCellandTissueArchitecture/PrinciplesofTransepithelialElectrolyteandWaterMovement/IntestinalArchitectureandElectrolyteTransport/ElectrolyteTransporters--Pumps,Carriers,andChannels/WaterTransport/Regulation/IntestinalDisordersandAdvancesTowardBetterTreatmentofIntestinalDisorders/Conclusion/References""1","9781615043576","9781615043583","NeuralControlofGastrointestinalFunction","ColloquiumSeriesonIntegratedSystemsPhysiology","134","2012","DavidGrundy","TheUniversityofSheffield,UK","SimonBrookes","FlindersUniversity,Australia",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00048ED1V01Y201111ISP030","10.
4199/C00048ED1V01Y201111ISP030","Thegastrointestinaltractisalong,musculartuberesponsibleforthedigestionoffood,assimilationofnutrientsandeliminationofwaste.
Thisisachievedbysecretionofdigestiveenzymesandabsorptionfromtheintestinallumen,withdifferentregionsplayingspecificrolesintheprocessingofspecificnutrients.
TheseregionscomeintoplaysequentiallyasingestedmaterialismovedalongthelengthoftheGItractbycontractionsofthemusclelayers.
Insomeregionsliketheoesophagustransititrapidandmeasuredinsecondswhileinotherslikethecolontransitismeasuredinhoursandevendays,commensuratewiththerelativeslowfermentationthattakesplaceinthelargebowel.
Anhierarchyofcontrols,neuralandendocrine,servetoregulatethevariouscellulartargetsthatexistinthegutwall.
Theseincludemusclecellsforcontractionandepithelialcellsforsecretionandabsorption.
However,therearecomplexinteractionsbetweenthesedigestivemechanismsandothermechanismsthatregulatebloodflow,immunefunction,endocrinesecretionandfoodintake.
Theseensureafinebalancebetweentheostensiblyconflictingtasksofdigestionandabsorptionandprotectionfrompotentiallyharmfulingestedmaterials.
TheymatchassimilationofnutrientswithhungerandsatietyandtheyensurethatregionsoftheGItractthataremetersapartworktogetherinacoordinatedfashiontomatchthesediversefunctionstothedigestiveneedsoftheindividual.
Thisebookwillprovideanoverviewoftheneuralmechanismsthatcontrolgastrointestinalfunction.
TableofContents:NeuralControlofGastrointestinalFunction/CellsandTissues/EntericNervousSystem/FromGuttoCNS:ExtrinsicSensoryInnervation/SympatheticInnervationoftheGut/ParasympatheticInnervationoftheGut/IntegrationofFunction/References""1","9781615043644","9781615043651","PeptideBiosynthesis:ProhormoneConvertases1/3and2","ColloquiumSeriesonNeuropeptides","112","2012","AkinaHoshino","UniversityofMaryland-Baltimore","Lindberg,Iris","UniversityofMaryland-Baltimore",,,,,"2166-6628","2166-6636","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00050ED1V01Y201112NPE001","10.
4199/C00050ED1V01Y201112NPE001","Theprohormoneconvertases(PC)1/3and2arecalcium-activatedeukaryoticsubtilisinswithlowpHoptimawhichaccomplishthelimitedproteolysisofpeptidehormoneprecursorswithinneuronsandendocrinecells.
Inthislecture,wereviewthebiochemistry,regulation,androlesofPC1/3and2indisease,withanemphasisontheworkpublishedinthelast10years.
Inthe20yearssincetheirdiscovery,agreatdealhasbeenlearnedabouttheirlocalizationandcellularfunctions.
BothPCssharethesamefourdomains:thepropeptidesperformimportantrolesincontrollingactivationandtargeting;thecatalyticdomainsconferspecificity,withPC1/3possessingamorerestrictedbindingpocketthanthatofPC2;thePdomainisrequiredforexpressionandcontributestoenzymaticproperties;andtheC-terminaltailassistsinproperroutingtogranules.
PC1/3,butnotPC2,existsinfull-lengthandC-terminallytruncatedformsthatexhibitdifferentbiochemicalproperties.
Bothenzymesassociatewithbindingproteins;proSAASisthoughttomodulateprecursorcleavagebyPC1/3,whileco-expressionof7B2isobligatoryfortheformationofactivePC2.
Finally,newstudieshaverevealedanincreasinglyimportantroleforPC1/3polymorphismsandmutationsinglucosehomeostasisandobesity.
TableofContents:GeneralIntroductiontotheProhormoneConvertases/ProhormoneConvertase1/3/ProhormoneConvertase2/SummaryandFutureDirections/References/AuthorBiography""Collection","PaperbackISBN","eBookISBN","Title","所属系列","Pages","Year","Author1","A1Affiliation","Author2","A2Affiliation","Author3","A3Affiliation","Author4","A4Affiliation","ISSNprint","ISSNelec","URL","DOI","Description""2","9781615045563","9781615045570","TheMolecularBiologyofChronicHeartFailure","ColloquiumSeriesonGenomicandMolecularMedicine","90","February,2013","DhavendraKumar","InstituteofMolecularandExperimentalMedicine,CardiffUniversitySchoolofMedicine,UniversityHospitalofWales,UK"2167-7840","2167-7859","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00071ED1V01Y201212GMM003","10.
4199/C00071ED1V01Y201212GMM003","Theclinicalsyndromeofchronicheartfailure(CHF)isthehallmarkofprogressivecardiacdecompensation,oneofthemostcommonchronicmedicalconditionsthataffectaround2%oftheadultpopulationworldwideirrespectiveofethnicandgeographicorigin(Anonymous).
Apartfromischemicheartdisease,hypertension,infection,andinflammation,severalotheretiologicfactorsaccountforirreparableandirreversiblemyocardialdamageleadingtoheartfailure(HF).
Geneticandgenomicfactorsarenowincreasinglyidentifiedasoneoftheleadingunderlyingfactors(ArabandLiu2005).
Thesefactorsmayberelatedtopathogenicalterations(mutationorpolymorphism)withinspecificcardiacgenes,mutationsingenesincorporatingsingleormultiplemolecularpathways(proteinfamilies)relevanttocardiacstructureand/orfunction,geneticorgenomicpolymorphismsofuncertainsignificance(genevariants,single-nucleotidepolymorphisms(SNPs),andcopynumbervariations(CNVs)),andepigeneticorepigenomicchangesthatinfluencecardiacgenefunctionsscatteredacrossthehumangenome.
Recentgeneticandgenomicstudiesinbothsystolicanddiastolicventriculardysfunction,thehallmarkofCHF,haverevealedanumberofmutationsingenesbelongingtospecificcardiacproteinfamilies.
Forexample,around200mutationsarenowknowntoexistinaround15genescodingforseveraldifferenttypesofsarcomereproteins(LiewandDzau2004).
Thesarcomereproteinfamily,alone,accountsforthebulkofinheritedcardiomyopathiesincludinghypertrophiccardiomyopathy(HCM),dilatedcardiomyopathy(DCM),restrictivecardiomyopathy(RCM),andleftventricular(LV)non-compaction(LVNC).
Inaddition,thereareseveralotherpotentiallyrelevantfactorsinvolvingdifferentgenesandgenome-levelelements.
ThisarticlepresentsasystematicaccountontheavailablefactualinformationandinterpretationsbasedongeneticandgenomicstudiesinCHF(LiewandDzau2004).
GenomicandmolecularapproacheshaveopenedthewayforareneweddebatefortaxonomyofCHF(AshrafianandWatkins2007).
ThereviewdrawsattentiontothepotentialdiagnosticandtherapeuticimplicationsofgenomicandtranscriptionalprofilinginHFandtranslationalgenomicsresearchthatislikelytopermitgreaterpersonalizationofpreventionandtreatmentstrategiestoaddressthecomplexitiesofmanagingclinicalHF(Creemers,Wildeetal.
2011).
""2","9781615044580","9781615044597","BrainDevelopmentandSexualOrientation","ColloquiumSeriesonTheDevelopingBrain","134","August,2012","JacquesBalthazart","UniversityofLiége"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00064ED1V01Y201208DBR008","10.
4199/C00064ED1V01Y201208DBR008","Sexualorientation(homo-vs.
heterosexuality)isoneofmanysexdifferencesobservedinhumans.
Sexdifferencescanresultfromdifferentialpostnatalexperiences(interactionwithparents,environment)orfrombiologicalfactors(hormonesandgenes)actingpre-orpostnatally.
Thefirstoptionisoftenfavoredtoexplainsexualorientationalthoughitissupportedbylittleexperimentalevidence.
Incontrast,manysexuallydifferentiatedbehaviorsareorganizedduringearlylifebyanirreversibleactionofsexsteroids.
Inparticular,thepreferenceforamaleorfemalesexpartnerislargelydeterminedinrodentsbyembryonicexposuretosexsteroids.
Theearlyactionofthesesteroidsalsoseemstoaffectsexualorientationinhumans.
Indeed,clinicalconditionsassociatedwithmajorendocrinechangesduringembryoniclifeoftenresultinanincreasedincidenceofhomosexuality.
Furthermore,multiplesexuallydifferentiatedbehavioral,physiological,orevenmorphologicaltraitsthatareknowntobeorganizedbyprenatalsteroids,atleastinanimals,aresignificantlydifferentinhomo-andheterosexualpopulations.
Thus,prenatalendocrine(orgenetic)factorsseemtoinfluencesignificantlyhumansexualorientationevenifalargefractionofthevarianceremainsunexplainedtodate.
Thepossibleinteractionbetweenbiologicalfactorsactingprenatallyandpostnatalsocialinfluencesremainstobeinvestigated.
""2","9781615040872","9781615040889","EndocrineDisruptorsandTheDevelopingBrain","ColloquiumSeriesonTheDevelopingBrain","114","May,2012","AndreaC.
Gore","UniversityofTexasatAustin","SarahM.
Dickerson","UniversityofTexasatAustin",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00054ED1V01Y201204DBR007","10.
4199/C00054ED1V01Y201204DBR007","Thefieldofendocrinedisruptionhasbeenthefocusofincreasingattentionfromscientistsandthegeneralpublicinthepast30years,amidstconcernsthatexposuretoenvironmentalchemicalswiththepotentialtoalterendocrinesystemfunction,knownasendocrinedisruptingchemicals(EDCs),maybecontributingtoanoveralldeclineinwildlifepopulationsandthereproductivehealthofhumans.
TheseconcernsarebasedonobservationsofadverseeffectsofEDCsonmarineandlandanimals,anincreasedincidenceofreproductiveandendocrinediseaseinhumans,epidemiologicalevidenceforlinksbetweenbodyburdenanddisease,andendocrinedisruptioninlaboratoryanimalsfollowingexposuretoEDCs.
Owingtoitsroleinregulationofendocrinefunctionaswellasitsresponsivenesstohormones,thedevelopingbrainisanespeciallyvulnerabletargetformanyclassesofEDCs.
ThisbookwilladdresstheevidenceforEDCactiononthedevelopingbrain,organizedinto7chapters.
TopicscoveredincludebackgroundaboutEDCs,evidenceforexposures,concernsaboutEDCeffectsinthedevelopingorganism,andparticularlyonthedevelopingnervoussystem,howEDCsperturbthebrain'sneuroendocrinesystems,transgenerationalepigeneticeffectsofEDCs,EDCeffectsonnon-reproductivebehaviors,andfutureperspectives.
ThisisthefirstbookcompletelydedicatedtounderstandinglinksbetweenEDCsandthedevelopingbrain,anareaofemergingimportanceforhumanhealth.
""2","9781615045273","9781615045280","StressandtheDevelopingBrain","ColloquiumSeriesonTheDevelopingBrain","76","December,2012","LisaWright","DepartmentofPsychology&Neuroscience,DalhousieUniversity","TaraPerrot","DepartmentofPsychology&Neuroscience,DalhousieUniversity",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00069ED1V01Y201211DBR009","10.
4199/C00069ED1V01Y201211DBR009","Thehumanbraindoesnotdevelopinavacuumaccordingtoasetofpredeterminedblueprints—itisinvolvedinadynamicinterplaywiththeenvironmentthatinfluencesgeneexpressionandultimatelystructureandfunction.
Somecorticalregions,suchastheprefrontalcortex(PFC)undergostructuralchangesthroughouttheadolescentperiodandintoearlyadulthood,makingtheirstructureandfunctionsparticularlyinterestingtostudywithrespecttogene-environmentinteractions.
Repeatedexposuretostressisapredisposingfactorintheemergenceofvariousmentalillnesses,suchasanxietyanddepression,althoughthisisbynomeansanabsoluterelationship.
Whilesomepeopleappeartobevulnerabletotheeffectsofrepeatedstressors,othersareresilient,andthisindividualvariabilityispartlyduetodevelopmentalprogrammingofbrainregionsinvolvedinmodulatingstressresponding,suchasthePFC.
Inthepresentbook,wewilldiscussfeaturesofadolescentbraindevelopmentthatmayprovideabasisforneuralplasticityinstressresponding:thehighlyprotracteddevelopmentofthePFC,theprofoundchangeininterconnectednessamongcorticalandsubcorticalbrainregions,andthecharacteristic'riseandfall'patternformanyofthelate-developingaspectsofneuralarchitectureinPFCandotherstress-relatedbrainregions.
""2","9781615043781","9781615043798","ABCTransportersandHumanGeneticDisease","ColloquiumSeriesonTheGeneticBasisofDisease","84","April,2012","KarobiMoitra","NationalCancerInstituteatFrederick"2168-4006","2168-4022","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00055ED1V01Y201204GBD001","10.
4199/C00055ED1V01Y201204GBD001","TheATP-bindingcassette(ABC)transportergenesareubiquitousinthegenomesofallvertebratessofarstudied.
ThehumanABCtransportersuperfamilycontains48genes,subdividedinto7subfamiliesrangingfromAtoG(basedonsequencehomologyoftheirnucleotidebindingdomains).
TheABCproteinsencodedbythesegenesareATP-driventransmembranepumps,someofwhichpossessthecapacitytoeffluxharmfultoxicsubstancesandthereforeplayakeyroleinxenobioticdefense.
ABCproteinshavebeenevolutionarilyconservedfrombacteriatohumansandmultiplegeneduplicationanddeletioneventsintheABCgenesindicatethattheprocessofgeneevolutionisstillongoing.
Polymorphismsandvariationsinthesegenesarelinkedtovariationsinexpression,function,drugdisposition,anddrugresponse.
Singlenucleotidepolymorphisms(SNPs)inthesegenescouldbemarkersofindividualriskforadversedrugreactionsorsusceptibilitytocomplexdiseases.
Thepharmacogeneticsofthisuniquefamilyoftransportersisstillunderstudy;however,inthecontextofhumanhealth,itisawell-knownfactthatvariationsinthesetransportersaretheunderlyingcauseforseveralhumandiseasesincludingcysticfibrosis,Pseudoxanthomaelasticum(PXE),andX-linkedadenoleukodystrophy(X-ALD).
""2","9781615043866","9781615043873","ClinicalandGeneticAspectsofSuddenCardiacDeathinthePracticeofSportsMedicine","ColloquiumSeriesonGenomicandMolecularMedicine","162","June,2012","LynneMillar","St.
George'sUniversityofLondon,UK","NabeelSheikh","St.
George'sUniversityofLondon,UK","SanjaySharma","St.
George'sUniversityofLondon,UK",,,"2167-7840","2167-7859","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00062ED1V01Y201206GMM002","10.
4199/C00062ED1V01Y201206GMM002","Suddencardiacdeathistheleadingcauseofnon-traumaticmortalityinyoung(0.
5μm),initiatedbyreceptoractivationonphagocytes.
Itformsanessentialaspectofinnateimmunitythroughtheuptakeanddestructionofinfectiouspathogens,whilealsoparticipatingintheremovalofapoptoticcellsduringtissueremodelinganddevelopment.
Professionalphagocytes,suchasmacrophages,neutrophils,anddendriticcells,arewellequippedwithawiderangeofphagocyticreceptors.
Inaddition,thesespecializedleukocytescansignaltolymphocyteswithintheadaptivearmofhostimmunity.
Thisreviewemphasizestheroleoftwowell-characterizedopsonicreceptors,theFcγreceptorandthecomplementreceptor,CR3inmacrophages.
Inparticular,itfocusesonthedifferentmechanismsemployedbythesereceptorsduringparticlerecognitionandphagocyticuptake.
Bacterialspeciesoftenmanipulatephagocytesignalinginordertoevadetheirengulfmentanddegradationandconsequentlyprovidefurtherinsightintokeyregulatorsofthephagocyticprocess.
Finally,wedrawattentiontothephysiologicalrelevanceofstudyingthesimultaneousengagementofmultiplephagocyticreceptors,inordertobetterunderstandreceptorcrosstalkandtheunderlyingcoordinationofdownstreamsignalingforefficientphagocytosis.
""2","9781615045389","9781615045396","Apoptosis","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","101","April,2013","NingYang","DepartmentofBiochemistry,UniversityofAlberta","IngSwieGoping","DepartmentofBiochemistry,UniversityofAlberta",,,,,"2328-3041","2328-305X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00080ED1V01Y201303BBC003","10.
4199/C00080ED1V01Y201303BBC003","Multi-cellularorganismseliminateindividualcellsthroughaself-destructprocessknownasapoptosis.
Apoptosisiscriticalforproperdevelopmentandmaintenanceoftissuehomeostasis.
Theimportanceofthisprocessishighlightedbythefactthattoomuchortoolittleapoptosisistheunderlyingcauseofpathologiessuchascancer,autoimmunediseases(e.
g.
,lupus,arthritis),andneurodegenerativedisorders(e.
g.
,Parkinson's,Alzheimer's).
Intheearlydays,apoptoticcellswereidentifiedstrictlybycellmorphology.
Nowweknowthatbiochemicalsignaturesdefineanumberofdeathprograms,ofwhichapoptosisisthemostwidelyunderstood.
Inthisreview,wediscussgeneticinsightsgainedfromC.
elegans,theimportanceofcaspases,engulfmentofapoptoticcells,apoptoticsignals,theroleofmitochondria,theBcl-2family,andthelinkbetweendysfunctionalapoptosisanddisease.
Withineachtopic,wehighlightlandmarkstudiesthatcontributedtoourcurrentunderstandingofapoptosis.
Alltogether,thisresearchexemplifiestremendousscientificsynergybetweenthedisciplinesofgenetics,biochemistry,developmentalcellbiology,andstructuralbiology.
Continuedexplorationintomechanismsthatregulateapoptosiswillundoubtedlyleadtoinsightsintodiseaseprocesseswithpotentialtherapeuticstrategies.
""2","9781615044689","9781615044696","NeuropeptideReceptors","ColloquiumSeriesonNeuropeptides","167","May,2013","IvoneGomes","DepartmentsofPharmacologyandSystemsTherapeutics,PsychiatryandNeuroscienceandTheFriedmanBrainInstitute,MountSinaiSchoolofMedicine","JonathanWardman","DepartmentsofPharmacologyandSystemsTherapeutics,PsychiatryandNeuroscienceandTheFriedmanBrainInstitute,MountSinaiSchoolofMedicine","SteveStockton","DepartmentsofPharmacologyandSystemsTherapeutics,PsychiatryandNeuroscienceandTheFriedmanBrainInstitute,MountSinaiSchoolofMedicine",,,"2166-6628","2166-6636","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00082ED1V01Y201304NPE004","10.
4199/C00082ED1V01Y201304NPE004","Neuropeptidesmediatetheireffectsbybindingandactivatingreceptorsthatareresponsibleforconvertingtheseextracellularstimuliintointracellularresponses.
MostneuropeptidesinteractwithGprotein-coupledreceptorsthattransducethesignalbyactivatingheterotrimericGproteinsleadingtoalterationsinsecondmessengersystemstoamplifythesignalandelicittheintracellularresponse.
Inthisreview,wedescribethegeneralstructureofGprotein-coupledreceptorsincludingtheinformationobtainedfromcrystalstructuredeterminationthathasgivenaninsightintotheactivationmechanismofthesereceptors.
Inaddition,wesummarizethecomponentsofthesignaltransductionsystem(includingGproteins,effectorsandsecondmessengersgenerallyactivatedbytheneuropeptidereceptors).
Usingselectexamplesofneuropeptide-receptorsystems,wehighlighttheneuropeptidesandcorrespondingreceptorsinvolvedinmodulationofpainandanalgesia,bodyweightregulation,andhormonalregulation.
Finally,wediscusstheenzyme-linkedtyrosinekinasereceptorsactivatedbygrowthfactorsanddiscusstheemergingconceptsintargetingneuropeptidereceptorsfortheidentificationofnoveltherapeuticstargetingthesesystems.
TableofContents:Abbreviations/OverviewofNeuropeptideReceptors/GProtein-CoupledReceptors:GeneralStructure&Function/GProtein-CoupledReceptorSignaling/NeuropeptideProcessingandRegulation/NeuropeptideReceptors/Perspectives/References""2","9781615045662","9781615045679","Ascites","ColloquiumSeriesonIntegratedSystemsPhysiology","116","June,2013","JensHenriksen","UniversityofCopenhagen,Denmark","SorenMoller","UniversityofCopenhagen,Denmark",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00085ED1V01Y201305ISP039","10.
4199/C00085ED1V01Y201305ISP039","Thisvolumedealswiththehistory,aetiology,pathophysiology,symptoms,signs,prognosis,andrationaltreatmentofascites.
Duringthepastdecade,ourknowledgeofthepathophysiologyofasciteshasincreasedsubstantiallyandmorespecifictherapiesarenowbasedonaetiologyandpathophysiology.
Itistheintentionofthisbooktoreviewrecentprogressinpathophysiologyofascitesandtherapiesbasedonpathophysiology.
Althoughthedifferenttypesofasciteshaveadifferentaetiologyandverydifferentpathophysiology,thedevelopmentoffluidintheperitonealcavityisalwaysabadclinicalsign.
Ithasasevereprognosis,whichismainlydependentontheaetiologyandprogressionoftheunderlyingdisease.
However,amongpatientswithascites,theprognosismaybeverydifferent,mainlyowingtothepresenceofportalvenoushypertension,malignancyintheabdominalcavity,andend-stagecongestiveheartfailure.
Theadditionofcomplicationslikethehepatorenalsyndromeandbacterialperitonitis,whetherspontaneousorsecondary,addsheavilytothebadprognosis.
Sincehepaticascitesarebyfarthemostcomplexwithrespecttopathophysiology,complications,andtreatment,emphasisisputonthedescriptionofthisentity.
Ascitesofotheraetiologiesarementionedalongwithhepaticascites,inparticular,ifthepathophysiologydiffersfromascitesofhepaticorigin.
""2","9781615046027","9781615046034","DevelopmentalProgrammingofCardiovascularDisease","ColloquiumSeriesonIntegratedSystemsPhysiology","77","June,2013","BarbaraT.
Alexander","DepartmentofPhysiologyandBiophysics,UniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00084ED1V01Y201305ISP038","10.
4199/C00084ED1V01Y201305ISP038","Numerousepidemiologicalstudiesreportthatbirthweightisinverselyassociatedwithbloodpressure,suggestingthatslowgrowthduringfetallifeprogramshypertensionandincreasedriskforcardiovasculardiseaseinlaterlife.
Differentexperimentalmodelsareusedtoprovideproofofconceptforthetheoryofdevelopmentalprogrammingofcardiovasculardisease,andstudiesinthesedifferentanimalmodelsareprovidinginsightintotheetiologyofchronicdiseaseprogrammedbyanimbalanceinnutritionduringearlylifeorexposuretomaternalcomplicationsduringpregnancy.
Alterationsintheregulatorysystemskeytothelong-termcontrolofbloodpressureareimplicatedintheetiologyofhypertensionthatresultsfromadverseexposuresduringearlydevelopment.
Epigeneticprocessesarealsoimplicatedintheincreasedriskforprogrammedcardiovasculardiseaseandthepassageofprogrammedcardiovascularrisktothenextgeneration.
Sex,age,andearlypostnatalgrowthimpactlaterprogrammedrisk;programmedriskisalsoamplifiedinresponsetoasecondarychallengethatincludesnormalphysiologicalprocessessuchaspregnancy.
Thus,thisbookwillhighlighthoweventsduringearlylifeimpactlatercardiovascularhealthinamannerthatissex-andage-dependentandcanbetransmittedtothenextgeneration.
TableofContents:Introduction/HistoricalPerspective/EpidemiologicalStudies/ExperimentalModelsofDevelopmentalProgramming/MechanismsofDevelopmentalProgramming/BirthWeightandClinicalConsiderations/BirthWeightandCardiovascularDisease:TranslationalConsiderations/SummaryandConclusions/References/AuthorBiography""2","9781615043880","9781615043897","TheActinCytoskeletonandtheRegulationofCellMigration","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","71","June,2013","JonathanM.
Lee","UniversityofOttawa"2328-3041","2328-305X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00083ED1V01Y201305BBC005","10.
4199/C00083ED1V01Y201305BBC005","Themammaliancytoskeletonisaninternalframeworkofactin,tubulin,andintermediatefilamentproteins.
Proteinsofthesethreeclassesassemblenon-covalentlyintofilamentouspolymersthatsupportthestructuralintegrityoftherelativelyfragilelipidplasmamembrane.
Inaddition,cytoskeletalpolymersprovidethemechanicalstrengththatholdacelltogetherandanchorittoitsgrowthsubstrate.
Thecytoskeletonmustalsohavethecapacityforrapidandsubstantialremodelingandprovidethemotiveandtractorforcenecessarytodrivemotility.
Assuch,thecytoskeletonhasafunctionalduality:sufficientlyrigidtopreventplasmamembranedeformationbutpliableenoughtoallowforcytokinesis;sufficientlyadhesivetoallowfortractionbutdynamicenoughtoallowmovementfromoneplacetoanother.
Amajorresearchchallengeincytoskeletonbiologyistounderstandhowcytoskeletalproteinsassembleanddissembleinsupportofphysiologicalprocesses.
Thischapterwillfocusontheroleoftheactincytoskeletonincellmigration.
Morespecifically,wewillfocusontheactincytoskeletonofvertebratecells.
TableofContents:Introduction/TheFundamentalsofActinPolymerization/AccessoryProteinsRegulateActinPolymerizationandAssembly/CellularActinStructure/CellMigration/SummaryofCellMigration/References/AuthorBiography""2","9781615045983","9781615045990","PeripheralArterialDisease:PathophysiologyandTherapeutics","ColloquiumSeriesonIntegratedSystemsPhysiology","82","August,2013","ChristopherG.
Kevil","DepartmentofPathology,LSUHealthSciencesCenter","ShyamalC.
Bir","DepartmentofPathology,LSUHealthSciencesCenter","ChristopherB.
Pattillo","DepartmentofMolecularandCellularPhysiology,LSUHealthSciencesCenter",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00086ED1V01Y201307ISP040","10.
4199/C00086ED1V01Y201307ISP040","Peripheralarterialdisease(PAD)isacardiovasculardisorderoftheperipheralvasculatureduetoprogressiveatheroscleroticstenosisofconduitarteriesrestrictingbloodflowtotissues.
PADistypicallyadiseaseofolderindividuals,andtheincidenceofPADcontinuestoriseduetoanincreaseincardiometabolicdiseaseandanagingpopulation.
Importantly,"allcause"andcardiovascularmorbidityandmortalityaresignificantlyincreasedinPADpatients.
PADdiagnosisremainsasignificantchallenge,asalargenumberofpatientsareasymptomatic.
Moreover,PADresultsinasignificantfinancialandsocietalburdenwithunderutilizeddiagnosticsandlimitedeffectivetherapies.
HerewediscussPADsignsandsymptoms,pathophysiologicalmechanisms,currentmanagement,andfuturediseasetargetsandpossibletherapeutictreatmentsforPAD.
""2","9781615044504","9781615044511","PulmonaryGasExchange","ColloquiumSeriesonIntegratedSystemsPhysiology","86","August,2013","G.
KimPrisk","UniversityofCalifornia,SanDiego","SusanR.
Hopkins","UniversityofCalifornia,SanDiego",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00087ED1V01Y201308ISP041","10.
4199/C00087ED1V01Y201308ISP041","Thelungreceivestheentirecardiacoutputfromtherightheartandmustloadoxygenontoandunloadcarbondioxidefromperfusingbloodinthecorrectamountstomeetthemetabolicneedsofthebody.
Itdoessothroughtheprocessofpassivediffusion.
Effectivediffusionisaccomplishedbyintricateparallelstructuresofairwaysandbloodvesselsdesignedtobringventilationandperfusiontogetherinanappropriateratiointhesameplaceandatthesametime.
Gasexchangeisdeterminedbytheventilation-perfusionratioineachofthegasexchangeunitsofthelung.
Inthenormallungventilationandperfusionarewellmatched,andtheventilation-perfusionratioisremarkablyuniformamonglungunits,suchthatthepartialpressureofoxygeninthebloodleavingthepulmonarycapillariesislessthan10Torrlowerthanthatinthealveolarspace.
Indisease,thedisruptiontoventilation-perfusionmatchingandtodiffusionaltransportmayresultininefficientgasexchangeandarterialhypoxemia.
Thisvolumecoversthebasicsofpulmonarygasexchange,providingacentralunderstandingoftheprocessesinvolved,theinteractionsbetweenthecomponentsuponwhichgasexchangedepends,andbasicequationsoftheprocess.
""2","9781615045860","9781615045877","Stroke:PathophysiologyandTherapy","ColloquiumSeriesonIntegratedSystemsPhysiology","100","August,2013","JensMinnerup","UniversityofMünster,Germany","AntjeSchmidt","UniversityofMünster,Germany","ChristianeAlbert-Weissenberger","UniversityofWürzburg,Germany",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00088ED1V01Y201308ISP042","10.
4199/C00088ED1V01Y201308ISP042","Strokeisamajorglobalhealthproblembecauseofitslargecontributiontomortality,morbidity,anddisability.
Themostcommonformofstrokeisischemicstrokewhichaccountsforapproximately80%ofallstrokes.
Duringthepastdecade,ourknowledgeofthemolecularandcellularprocessesthatcontributetostrokepathophysiologyhasincreasedsubstantiallyandoffersmanytargetsforfuturetherapeuticstrategies.
Thisbookprovidesanoverviewofthecurrentknowledgeofstrokepathophysiologyandthemechanismsthatinterferewithrecoveryandregeneration.
Moreover,thisbookreviewsthelatestadvancesinthedevelopmentoffuturetherapeuticstrategies.
""2","9781615045006","9781615045013","ControlofPotassium:Distribution,Excretion,andExtracellularConcentration","ColloquiumSeriesonIntegratedSystemsPhysiology","103","August,2013","DavidB.
Young","DepartmentofPhysiologyandBiophysics,UniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00089ED1V01Y201308ISP043","10.
4199/C00089ED1V01Y201308ISP043","Severalphysiologicalmechanismsacttoregulaterenalpotassiumexcretionanddistribution.
Togethertheycompriseanintegratedcontrolsystemthatmaybeenvisionedasbeingmadeupofseveralinteractingnegativefeedbackcontrolmechanisms,allaffectingremovalofpotassiumfromtheextracellularfluidbyrenalexcretionortransferacrosscellmembranesintooroutoftheintracellularcompartment.
Theintentofthispresentationistodescribethemechanismsofpotassiumregulation,beginninginChapter1withanoverviewofthesystem,Chapter2withmechanismsthatdeterminemovementofpotassiumbetweentheextracellularandintracellularcompartments,inChapter3focusingonrenaltubulartransportsystems,andinChapter4presentingthemechanismsofcontrolofaldosteronesecretion.
Greatestemphasiswillbeondescribingtheintegratedfunctionsofthecomponents,inChapter5,astheyoperatetogetherinasystemtoregulateextracellularpotassiumconcentrationinresponsetocommonlyencounteredchallenges.
Inaddition,interactionsbetweenpotassiumregulationandcommonlyusedmedicationswillbeconsideredinChapter6,andinChapter7thecausesandtreatmentofdysregulationofpotassiumwillbediscussed.
TableofContents:Preface/Introduction/RegulatonofPotassiumDistribution/PotassiumTransportinSegmentsoftheNephron/RegulationofPotassiumExcretion/ControlofAldosteroneSecretion/SystemAnalysisofPotassiumRegulation/PharmacotherapeuticsInteractions/DisordersofPotassiumControl/References/AuthorBiography""2","9781615045846","9781615045853","CellSurvivalProgramsandIschemia/Reperfusion:Hormesis,Preconditioning,andCardioprotection","ColloquiumSeriesonIntegratedSystemsPhysiology","122","September,2013","MaikeKrenz","DepartmentofMedicalPharmacologyandPhysiology,UniversityofMissouriSchoolofMedicineandDaltonCardiovascularResearchcenter","ChristopherBaines","DepartmentofMedicalPharmacologyandPhysiology,UniversityofMissouriSchoolofMedicine,DepartmentofBiomedicalSciencesandDaltonCardiovascularResearchcenter,UniversityofMissouri","TheodoreKalogeris","DepartmentofMedicalPharmacologyandPhysiology,UniversityofMissouriSchoolofMedicine",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00090ED1V01Y201309ISP044","10.
4199/C00090ED1V01Y201309ISP044","Themajorpurposeofthisbookistoreviewtheevidencesupportingtheconceptthatintrinsiccellsurvivalprogramscanbeactivatedbyavarietyofmildlynoxiousstimuliorpharmacologicagentstoconferprotectionagainstthedeleteriouseffectsofischemia/reperfusion(I/R).
Webeginwithadiscussionoftheconceptofhormesis(atermusedmostextensivelyinthetoxicologicliteraturewhichreferstobiphasiccellularresponsesthatdependonconcentrationorintensityofastimulus),reviewtheseminalstudiesthatledtothediscoveryofthecardioprotectiveeffectsofischemicpreconditioning,andoutlineitstherapeuticpotential(Chapter1).
ThisisfollowedbyasummaryofourcurrentunderstandingofthemechanismsofI/Rinjury(Chapter2),asthisprovidesseveralpointsofinterventioninlimitingpostischemictissueinjurythatmaybetargetedbytheadaptiveprogramsinvokedbyconditioningstimuli.
Chapters3and4focusonthemechanismsunderlyingischemicpre-,post-,andremoteconditioning,whichestablishesthemechanisticrationalefordevelopmentofpharmacologicconditioningstrategiesthatmaymimictheremarkablypowerfuleffectsofischemicconditioning(andarecoveredinChapter5).
Lifestyleinterventions,includingexercise,caloricrestriction,andconsumptionofalcoholicbeveragesand/orphytochemicals,thatmayinducehormeticresponseswillalsobereviewedinthischapter.
Whilethepromiseforconditioningasatherapeuticapproachisenormous,thereareobstaclestoitspracticalapplicationinpatients,whicharecoveredinChapter6.
Thefinalchapter(Chapter7)examinestheextensionofourmechanisticunderstandingofthesignalingpathwaysinvokedbyconditioningstimuliintotherealmofgenetherapyandtothepreservationofstemcellviabilityintheharshischemicenvironmentasnaturaltranslationaloutgrowthsofpreconditioningintotherapeutics.
""2","9781615045822","9781615045839","ImmuneMechanismsofHypertension","ColloquiumSeriesonIntegratedSystemsPhysiology","86","September,2013","MichaelJ.
Ryan","UniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00092ED1V01Y201309ISP046","10.
4199/C00092ED1V01Y201309ISP046","Inthevastmajorityofpatients,hypertensionhasnoidentifiablecause.
Moreover,despitedecadesofdiscoveryandtherapeuticdevelopment,approximatelyonlyhalfofthehypertensivepatientsareachievingclinicallyrecommendedbloodpressurecontrol.
Forthesereasons,therehasbeencontinuedinterestinstudyingthefactorsthatunderliethepathogenesisofhypertension.
Oneareaofresearchthathasgarneredsignificantattentionisthepotentiallinkbetweenimmunesystemactivationandbloodpressure.
Severallinesofevidence,datingbackseveraldecades,supporttheconceptforthisassociation.
Thismonographgivesahistoryoftheearlystudieslinkingimmunesystemfunctionwithhypertensionandanoverviewofthelargenumberofstudiespublishedinthepastdecade.
Themajorfocusisonthecomponentsoftheinnateandadaptiveimmunesystemsforwhichthereisconsiderableevidenceoftheircontributionstobloodpressurecontrol.
""2","9781615046362","9781615046379","Malaria","ColloquiumSeriesonIntegratedSystemsPhysiology","187","September,2013","JulianaCarvalho-Tavares","UniversidadeFederaldeMinasGerais,BeloHorizonte,Brazil","rikaMartinsBraga","UniversidadeFederaldeMinasGerais,BeloHorizonte,Brazil",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00091ED1V01Y201309ISP045","10.
4199/C00091ED1V01Y201309ISP045","Thisebookdescribesthepathogenesisofmalariaandthemajorconsequencesoftheparasitismtothevertebratehost.
Malariaisoneoftheoldestinfectiousdiseasesofmankind,whichstillexertsahighburdenonhumanhealthandsociety.
ItiscausedbyparasitesofthegenusPlasmodium,andtransmittedbyAnophelinemosquitoes.
Despiteseveraldecadesofintensivecontrolefforts,malariaremainswidelydistributedwithanestimated3.
3billionoftheworld'spopulationatriskofinfection.
Themalarialifecycleisextremelycomplexandthebloodstageparasitesareresponsibleforallthesymptomsandpathologyofmalaria.
Becauseofthisstrictassociationbetweentheparasitesandredcells,therearenumerousconsequencestothehost'sbloodextendingfarbeyondthedirecteffectofparasitizedRBCs.
""2","9781615044283","9781615044290","ClinicalandMolecularAspectsofMotorNeuronDisease","ColloquiumSeriesonGenomicandMolecularMedicine","60","September,2013","JohnathanCooper-Knock","SheffieldInstituteforTranslationalNeuroscience(SITraN),UniversityofSheffield,UK","PamelaShaw","SheffieldInstituteforTranslationalNeuroscience(SITraN),UniversityofSheffield,UK","ThomasJenkins","SheffieldInstituteforTranslationalNeuroscience(SITraN),UniversityofSheffield,UK",,,"2167-7840","2167-7859","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00093ED1V01Y201309GMM004","10.
4199/C00093ED1V01Y201309GMM004","Inthise-book,motorneurondisease(MND)shallrefertoamyotrophiclateralsclerosis(ALS),themostcommonneurodegenerativedisorderaffectingboththeupperandlowermotorneurons.
WiththediscoveryofC9ORF72expansionsinapproximately10%ofallMNDcases,incertainpopulations,westandatthebrinkofaneweraofMNDresearchandhopefullytreatmentfacilitatedbytheabilitytoassociatearelativelylargegroupofpatientswithasimilardiseasemechanism.
ThisreviewwillsummarisebothcurrentclinicalmanagementofMNDandourpresentunderstandingofthemolecularpathogenesisofMND.
StudyofC9ORF72-MNDhasthepotentialtorapidlyadvancebothoftheseaspectsinthecomingyears.
""2","9781615046348","9781615046355","AcuteRespiratoryDistressSyndrome","ColloquiumSeriesonIntegratedSystemsPhysiology","99","October,2013","DonnaCarden","DepartmentofEmergencyMedicine,UniversityofFloridaCollegeofMedicine","MarieElie","DepartmentofEmergencyMedicine,UniversityofFloridaCollegeofMedicine",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00094ED1V01Y201309ISP047","10.
4199/C00094ED1V01Y201309ISP047","Theacuterespiratorydistresssyndrome(ARDS)isacomplexdisorderassociatedwithrapidlyprogressivelunginflammation,non-cardiogenicpulmonaryedema,hypoxemicrespiratoryfailureandoneormorewell-definedriskfactorsincludingsepsisandseveretrauma.
Sinceitsoriginaldescriptionin1967,experimentalandclinicalevidencehasprovidedconsiderableinsightintothekeyrolesderegulatedsystemicinflammationandcoagulationplayinthisdevastatingclinicalsyndrome.
DespitesubstantialadvancesinourunderstandingofthepathogenesisofARDS,untilrecently,littleprogresshadbeenmadeinuncoveringclinicalstrategiestoimprovetheoutcomeofpatientswithARDS.
However,overthepast10yearsprotectiveventilationandothersupportivemanagementstrategieshavebeenidentifiedthatmarkedlyimprovetheoutcomeinARDS.
Morerecently,researchhasidentifiedpatientsatriskforthedevelopmentofthesyndrome.
Currently,clinicaltrialsareunderway.
""2","9781615046386","9781615046393","MolecularPathologyofAlzheimer'sDisease","ColloquiumSeriesonNeurobiologyofAlzheimer'sDisease","91","October,2013","RudyCastellani","UniversityofMaryland,SchoolofMedicine","GeorgePerry","UniversityofTexas,SanAntonio",,,,,"2375-8937","2375-8945","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00095ED1V01Y201310ALZ001","10.
4199/C00095ED1V01Y201310ALZ001","Alzheimer'sDiseaseischaracterizedpathologicallybytwoprincipalhallmarklesions:thesenileplaqueandtheneurofibrillarytangle.
Sincetheidentificationofeachover100yearsago,themajorproteincomponentshavebeenelucidated.
Thishasledinturntotheelaborationofmetaboliccascadesinvolvingamyloid-βproductioninthecaseofthesenileplaque,andphosphorylated-tauproteininthecaseoftheneurofibrillarytangle.
Thepathogenesisandhistogenesisofeachhavebeenthesourceofextensiveinvestigationandsomecontroversyinrecentyears,asbothcascadeshavebeenimplicatedinthepathogenesisofAlzheimer'sDisease,relieduponinthediagnosticcriteriaforAlzheimer'sDiseaseatautopsy,andtargetedfortherapeuticintervention.
WiththeaccumulationofdataandexpansionofknowledgeofthemolecularbiologyofAlzheimer'sDisease,itappearsthattheenthusiasmforsuccessfulinterventionhasbeenpremature.
Inthisbook,wedetailthediscoveryandcharacterizationofthemajorpathologicallesions,theirassociatedmolecularbiology,theirrelationshiptoclinicaldisease,andpotentialfundamentalerrorsinunderstandingthatmaybeleadingscientificinvestigatorsinunintendeddirections.
""2","9781615044207","9781615044214","PatternFormationintheCerebellum","ColloquiumSeriesonTheDevelopingBrain","137","October,2013","CarolArmstrong","DepartmentofBiology,MountRoyalUniversity","RichardHawkes","DepartmentofCellBiologyandAnatomy,GenesandDevelopmentResearchGroupandHotchkissBrainInstitute,FacultyofMedicine,UniversityofCalgary",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00096ED1V01Y201310DBR011","10.
4199/C00096ED1V01Y201310DBR011","PatternformationhasfascinatedbiologistssincethetimeofAristotle,butonlyrecentlyhavenewtoolsbeguntorevealtheunderlyingmechanismsthatcreatethesepatternsduringdevelopment.
Inparticular,thecentralnervoussystemisdynamicallypatternedandhighlymodular,rangingfromnuclearcellclustersinthebrainstemandspinalcordtotheelaboratecytoarchitectureoftheneocortex.
Similardevelopmentalprocessesdividebrainstructuressuchasthecerebralcortex,basalganglia,superiorcolliculus,andcerebellumintothesesub-compartments.
Thewayneuralmodulesformandthemechanismsthatestablishconnectivitybetweenthesemodulesisoneofthemostcomplexproblemsinneuroscienceandalsooneofthemostimportant.
Thismonographfocusesonpatternformationinthedevelopingcerebellum.
""2","9781615046102","9781615046119","ProcessingofVEGF-Cand-DbytheProproteinConvertases:ImportanceinAngiogenesis,Lymphangiogenesis,andTumorigenesis","ColloquiumSeriesonProteinActivationandCancer","66","November,2013","GeraldineSiegfried","UniversityofBordeaux,LAMC,UMR1029,F-3400andINSERMU1029,France","MajidKhatib","UniversityofBordeaux,LAMC,UMR1029,F-3400andINSERMU1029,France",,,,,"2169-9399","2169-9410","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00097ED1V01Y201310PAC006","10.
4199/C00097ED1V01Y201310PAC006","Thevascularendothelialgrowthfactor(VEGF)familymembersthatincludeVEGF-A,-B,-C,-D,andplacentalgrowthfactor(PlGF),displaydistinctbindingaffinitiesfortheirreceptorsVEGFR-1,-2,and/or-3.
Inadditiontotheirrequirementsintheinitiation,development,andmaintenanceofbloodandlymphaticvasculature,VEGFsandVEGFRsareupregulatedduringneoplasiaandareinvolvedintheremodelingoftumoralbloodandlymphaticvasculature.
ByactivatingVEGFR-1andVEGFR-2,bothexpressedonbloodendothelialcells,VEGF-Apromotestheformationofnewtumoralbloodvesselsandtherebyacceleratestumorgrowth.
Incontrast,upregulationofVEGF-C,aligandforlymphaticendothelialVEGFR-3aswellasforVEGFR-2,inducestheformationoftumor-associatedlymphaticvesselsandthuspromotesthepassivemetastaticdisseminationoftumorcellstoregionallymphnodes.
OftheVEGFfamilymembers,onlyVEGF-Cand-DwerefoundtobeproteolyticallyprocessedbyFurin-likeenzymes.
ThisprocessingcontrolstheselectiveactivationofVEGFR-2and-3signalingduringtumorangiogenesisandlymphangiogenesis.
Here,weprovideanoverviewofangiogenesisprocessesanddiscusstheimportanceofVEGF-CandVEGF-DprecursorsprocessingbytheproproteinconvertasesduringtheactivationofVEGFR-2andVEGFR-3receptorsandthemediationoftheirfunctionsduringangiogenesis,lymphangiogenesis,andtumorigenesis.
""2","9781615046409","9781615046416","AJourneyThroughGenetics,PartI","ColloquiumSeriesonTheGeneticBasisofDisease","100","November,2013","KarobiMoitra","TrinityWashingtonUniversity"2168-4006","2168-4022","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00098ED1V01Y201310GBD005","10.
4199/C00098ED1V01Y201310GBD005","AJourneyThroughGeneticsisdesignedtotakethereaderonanincrediblejourneytoexploretheexcitingdiscoveriesingeneticsandmolecularbiology.
InPartI,thereaderwillembarkonageneticodysseystartingwiththe""FatherofGenetics,""GregorMendel,leadingontotheamazingstoryofphoto51andthediscoveryofthestructureoftheDNAdoublehelix,andculminatingwiththeinventionofoneofthemostpowerfultoolsinmolecularbiology:thepolymerasechainreaction.
Thereaderwilldiscoverthestoriesbehindthescienceofgeneticswhilegoingbehindthescenestotakeaglimpseintothelivesofpioneeringscientistsandwillultimatelycometounderstandthatpeoplearejustasimportantasthesciencetheyundertaketodo.
Inshort,scientistsarehumantoo!
Thisbookistargetedtowardundergraduatenon-majorsandalsoasa""companion""toastandardgeneticstextbookforBiologymajors.
Thebookwillalsobeusefulforanyonethatwantstounderstandthestoriesbehindthescienceofgenetics.
""2","9781615045907","9781615045914","NecrotizingEnterocolitis","ColloquiumSeriesonIntegratedSystemsPhysiology","94","December,2013","MichaelCaplan","UniversityofChicago,PritzkerSchoolofMedicine"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00099ED1V01Y201311ISP048","10.
4199/C00099ED1V01Y201311ISP048","Necrotizingenterocolitisisanacuteinflammatorynecrosisofbowelthatprimarilyafflictsprematureinfantsintheneonatalintensivecareunitsetting.
Althoughpatientswhodevelopthisdiseasehavehighmorbidityandmortalityrates,thepathogenesisispoorlyunderstood,andthereforetherearenospecificpreventiveortreatmentstrategiesthathavebeenclearlyeffective.
Recentstudieshavesuggestedthatthepathophysiologyofnecrotizingenterocolitisincludesalterationsintheinflammatoryresponseleadingtodysregulatedpro-inflammatorysignalinginprematureinfants,aswellasabnormalintestinalbacterialcolonizationpatternsthatcanactivatetheseinflammatorypathways,andthesefactorsarediscussedindepthinthefollowingchapters.
Whilehumanmilkfeedingsarecurrentlythestandardofcareforthepreventionofthischallengingcondition,newapproacheswillbedescribedbasedonsoundevidencethatmighthaveasignificantimpactforprematureinfantsthroughouttheworld.
""2","9781615044764","9781615044771","EmergingRolesforHippocampalAdultNeuralStemCellsinMemory","ColloquiumSeriesonStemCellBiology","39","December,2013","AaronFriedman","DepartmentofIntegrativeBiology,UniversityofCalifornia,Berkeley","DanielaKaufer","DepartmentofIntegrativeBiologyandHelenWillsNeuroscienceInstitute,UniversityofCalifornia,Berkeley",,,,,"2168-3972","2168-3980","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00100ED1V01Y201311SCB005","10.
4199/C00100ED1V01Y201311SCB005","Approximately50yearsago,newlygeneratedneuronswerediscoveredintheadulthippocampusoftheratbrain.
Thisdiscoverycontradictedakeyprincipleinmammaliandevelopmentalneurobiology—thatalltheneuronsofthebrainaremadeduringearlydevelopment—andledtointensivestudytofindouthownewneuronsaregeneratedandhowtheprocessofneurogenesisisregulated.
Sincethen,auniquepopulationofadultneuralstemcellshasbeenidentified,andmanyofthemolecularpathwaysthatcontroltheirself-renewal,proliferation,andcellfatehavebeenelucidated.
However,thepresenceofnewneuronsintheadultbrainalsoposesintriguingfunctionalquestionsthathave,asyet,gonelargelyunanswered.
WhyisadultneurogenesisrestrictedtoselectbrainregionsWhatfunctionalbenefitdothesenewcellsconferIndeed,thefieldofadultneurogenesisoffersauniqueopportunitytostudynaveneuronsastheymature,formconnectionswithexistingneuralnetworks,andbegintoparticipateininformationprocessing.
WereviewthebasicsofadultNSCbiologyandthematurationofnewbornneurons.
Inparticular,wefocusonnewneuronsinthehippocampus,andhowtheycontributetofunctioninthiskeymemory-formingstructureofthebrain.
""Collection","PaperbackISBN","eBookISBN","Title","所属系列","Pages","Year","Author1","A1Affiliation","Author2","A2Affiliation","Author3","A3Affiliation","Author4","A4Affiliation","ISSNprint","ISSNelec","URL","DOI","Description""3","9781615045747","9781615045754","Dengue","ColloquiumSeriesonIntegratedSystemsPhysiology","104","February,2014","RafaelEliasMarques","DepartamentodeBioquímicaeImunologia,InstitutodeCiênciasBiológicas,UniversidadeFederaldeMinasGerais,Brazil","RodrigoGuabiraba","INRACentreValdeLoire,PleSantéAnimaledeTours(PSAT),France","DanielCisalpino","DepartamentodeMicrobiologia,InstitutodeCiênciasBiológicas,UniversidadeFederaldeMinasGerais,Brazil",,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00103ED1V01Y201402ISP049","10.
4199/C00103ED1V01Y201402ISP049","Dengueisamajorpublichealthconcernthroughoutthetropicalandsub-tropicalregionsoftheworld.
Itisthemostrapidlyspreadingmosquito-borneviraldisease,witha30-foldincreaseinglobalincidenceoverthepast50years.
InfectionwithanyoftheDenguevirusserotypescanbeasymptomatic,causetheclassicdenguefever,orevolvetoseveredisease,whichleadstohypovolemicshockanddeathifuntreated.
Thereisnoapprovedspecifictreatment,prognosticmarkers,orvaccinesfordengue,inpartbecausethereisinsufficientknowledgeofdenguepathogenesis.
Inthise-book,wewillfocusonwhatwebelievetobeatruechallengeindengueresearch:tounderstandhost–pathogeninteractions.
Diseasedevelopmentresultsfromtheinteractionbetweenhostandviralfactors,inwhichthehostimmuneresponseiscritical.
Recentadvancesindengueexperimentalmodelstogetherwithclinicaldatahaveprovidedusefulinformationindicatingthatseveredenguehallmarks(excessiveproductionofpro-inflammatorycytokines,endothelialactivation,andplasmaleakage)areimmune-mediatedevents.
WehopetopresentreaderswithacomprehensivedescriptionoftheimmuneresponsetotheDenguevirus,detailinghowDENVunbalanceshosthomeostasis.
""3","9781615046485","9781615046492","IntroductiontoNeuroglia","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","74","February,2014","AlexeiVerkhratsky","FacultyofLifeSciences,TheUniversityofManchester,Manchester,U.
K.
AchucarroCenterforNeuroscience,IKERBASQUE,BasqueFoundationforScience,Spain",,"VladimirParpura","DepartmentofNeurobiology,CenterforGlialBiologyinMedicine,AtomicForceMicroscopyandNanotechnologyLaboratories,CivitanInternationalResearchCenter,EvelynF.
McKnightBrainInstitute,UniversityofAlabama,BirminghamDepartmentofBiotechnology,UniversityofRijeka,Croatia",,,,"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00102ED1V01Y201401NGL001","10.
4199/C00102ED1V01Y201401NGL001","Thisbookistheintroductiontoaseriesofe-booksdedicatedtothephysiologyandpathophysiologyofneuroglia.
Thetopicofneurogliaisgenerallyoverlookedinneurosciencecurriculaacrosstheworld,themainattentionbeingfocusedonthedescriptionofexcitabilityofneuronsandneuronalnetworks.
Theneuroglia,beingelectricallynon-excitable,areuniversallyregardedassupportivecellswhichdonotcontributetoinformationprocessing.
Thisoversimplifiedview,however,ignoresthetremendousimportanceofbrainhomeostasis,whichisimperativefortheongoingactivityofneuronalnetworks.
Italsoignoresthetruththatspecializationofneuronsandtheirabilityforrapidpropagationandmulti-levelintegrationofsignalsbecomepossibleonlybecauseofdelegationofhomeostaticabilitiestoneuroglia.
Furthermore,glialcellscontributetoinformationprocessingastheycanmodulateneuronalsynaptictransmission.
Finally,neurogliaprovidetheonlysystemofbraindefenseandassuchthesecellsareintimatelyinvolvedinalltypesofneuropathologies,andcontributetobothneuroprotectionandregenerationofthenervoussystem.
Thee-booksinthisseriesprovideaplatformforin-depthlearningofallaspectsofneuroglialcellsfunctioninhealthanddisease.
TableofContents:Acknowledgments/Introduction/Definition,Classification,andEvolutionofNeuroglia/FunctionsofNeuroglia/ConcludingRemarks/References""3","9781615046447","9781615046454","TheMolecularBiologyofNeurofibromatosisType1","ColloquiumSeriesonGenomicandMolecularMedicine","79","February,2014","MeenaUpadhyaya","InstituteofMedicalGenetics,CardiffUniversitySchoolofMedicine,UK"2167-7840","2167-7859","http://dx.
doi.
org/10.
4199/C00101ED1V01Y201312GMM005","10.
4199/C00101ED1V01Y201312GMM005","Neurofibromatosistype1(NF1)isacommonautosomaldominantlyinherited,tumourpredispositionsyndromeaffecting1/3,000-4,000individualsworldwide.
ThisinheriteddisorderresultsfromthemutationalinactivationoftheNF1geneonhumanchromosome17.
TheNF1genecontains61exonsthatgiveriseto12kbmRNAencodingneurofibromin.
The327kDa(2,818aminoacid)neurofibrominproteinisexpressedinmosttissuesandhasanumberofalternativeisoforms.
Neurofibrominisatumoursuppressorproteinanddown-regulatescellularRas.
IncreasedactiveRas-GTPlevelsalsostimulatetheimportantPI3K/AKT/mTORsignallingpathwaythatprotectscellsfromapoptosis.
ThemajorclinicalfeatuesofNF1includemultiplecafé-au-laitmacules,skinfoldfreckles,irisLischnodules,andneurofibromas.
Thediagnosticcriteriaforclinicaldiagnosishavebeenwellestablished.
However,thereareasmallnumberofcasesinwhichthediagnosisisnotcertain.
ThegermlinemutationratefortheNF1geneis10-foldhigherthanthatobservedformostotherinheriteddiseases.
Usingacombinationofdifferenttechniques,almost95%ofgermlinemutationscanbedetected.
Todate,onlytwofirmgenotypephenotypecorrelationshavebeenreported.
NF1phenotypeexhibitslargevariationswithinafamily,evidenceformodifyinglociregulatingtheexpressionofanNF1geneisbeginningtoemerge.
Wealsoaregainingknowledgeonthemolecularmechanismsassociatedwiththedevelopmentofdifferenttypesoftumours.
Itisencouragingthattheresultsofrecentlaboratoryandclinicalresearcharefinallybeingtranslatedintoclinicaltrials.
Withtheavailabilityofhigh-throughputtechnologies,sophisticatedanimalmodels,andmulti-centreclinicaltrials,thefutureforNF1sufferersislookingoptimistic.
ThisbookaimstoprovideanoverviewofthegeneticandclinicalaspectsofNF1anditsroleinbothNF1-associatedandsporadictumourdevelopment.
Itemphasizestherecentdevelopmentsinthisfieldandsomeofthepromisingon-goingclinicaltrials.
TableofContents:Abbreviations/IntroductiontoNF1/NF1-AssociatedTumours/AnimalModels,PreclinicanandClinicalTrials/SummaryandConclusion/References/TitlesofRelatedInterest/SeriesofRelatedInterest""3","9781615046508","9781615046515","ShortBowelSyndromeinChildhood","ColloquiumSeriesonIntegratedSystemsPhysiology","101","March,2014","MichaelE.
Hllwarth","DepartmentofPediatricandAdolescentSurgery,MedicalUniversityofGraz,Austria"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00104ED1V01Y201402ISP050","10.
4199/C00104ED1V01Y201402ISP050","Extensivelossofsmallbowelinallagegroupshasdramaticconsequencesonthelifestyleofthepatientandthewholefamilyandisaccompaniedbysignificantmorbidityandmortality.
Allpatientsneednutritionalandmedicalsupportandsomeofthemremaindependentonlong-termparenteraltherapy.
Recurrentsurgicalinterventionsorevenintestinaltransplantationmaybenecessary.
However,theintestinaltractexhibitsanastonishingabilitytocompensateforanextensivelossofsmallbowel.
Adaptationtothenewsituationtakesplacewithtimebystructuralandfunctionalchangesresultinginanincreasedsurfaceareawithimproveddigestiveandabsorptivecapacity.
Thisprocess,however,differsmarkedlyamongindividualpatientsdependingontheremaininglengthandfunctionalqualityofsmallbowel.
Mechanismssupporting,andcomplicationsdelaying,theadaptationprocesshavebeenstudiedextensivelyoverthepastdecades.
Thisreviewpresentsasurveyofincidence,etiology,andconsequencesofextensivelossofsmallbowel.
Ashortdescriptionofthenormaldigestiveandabsorptivefunctionofthegastrointestinaltractandthepathophysiologicalconsequencesinshortbowelcasesisfollowedbydiscussingthecurrentfieldofbasicresearch,presentingtoday'smedicalandsurgicaltreatmentmodalitiesandtherelatedresultsinpatientswithSBS.
MostofthedataarederivedfromanimalstudiesorresearchperformedonnewbornsandinfantssufferingfromSBS,butthemajoritiesareequallyrelevanttotheadolescentandadultagegroup.
TableofContents:Introduction/IncidenceandEtiology/DigestionandAbsorptionunderNormalConditions/PathophysiologyofExtensiveSmallBowelLoss/TheProcessofIntestinalAdaptation/FactorsInvolvedinIntestinalAdaptation/EstimatingFunctioningBowel-Citrulline/ConservativeTherapyofSBSinHumans/HomeParenteralNutrition/MonitoringofImportantParameters/SurgicalTherapy/Complications/Long-TermResults/References/AuthorBiography""3","9781615046522","9781615046539","ErectileDysfunction","ColloquiumSeriesonIntegratedSystemsPhysiology","71","March,2014","RanyShamloul","OttawaHospitalResearchInstitute,Ottawa,Canada;DepartmentofAndrology,CairoUniversity,Egypt","AnthonyJBella","GretaandJohnHansenChairinMen'sHealthResearch,AssistantProfessorofUrology,DepartmentofSurgery,AssociateScientist,Neuroscience,UniversityofOttawa",,,,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00105ED1V01Y201403ISP051","10.
4199/C00105ED1V01Y201403ISP051","Theunderstandingofthepathophysiologyoferectiledysfunction(ED)hasadvancedsignificantlyoverthepasttwodecades.
Inthisebook,weprovideanin-depthanalysisofthecurrentknowledgeofthepathophysiologyofEDinordertoprovidethereaderwithanup-to-dateandcomprehensiveunderstandingofthepathophysiologyofED,whichiscomplexbutfascinating.
IntensiveandintricatemechanismsgovernthedevelopmentofED.
Thesemechanismsinvolvecomplexinteractionbetweenvascular,hormonalandneuralregulation.
CurrentresearchonthecentralregulationofEDiskeyfortheadvancementofourunderstandingofthiscomplexdisease.
RecentadvancesinourknowledgeofthevascularmechanismsregulatingpenileerectionledtoappreciationofEDasanearlysymptomofcardiovasculardisease.
Majorhealthconcernssuchasatherosclerosis,hyperlipidemia,hypertensionanddiabeteshavebecomewellintegratedintotheinvestigationofED.
Extensiveresearchonthemechanismsinvolvedintheregulationofpenileerectionhaveledtounparalleledadvancesintheunderstandingofgeneralvascularregulation.
However,manyunknownsremain,whichprovidesvastopportunitiesforfuturebasicandclinicalinvestigations.
TableofContents:AnatomyofthePenis/GeneralPathophysiology/DiabetesandED/EDandCardiovascularDisease/DrugsCausingED/References/AuthorBiographies""3","9781615046300","9781615046317","ProteinTranslation","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","93","June,2014","EricJan","DepartmentofBiochemistryandMolecularBiology,UniversityofBritishColumbia"2328-3041","2328-305X","http://dx.
doi.
org/10.
4199/C00106ED1V01Y201406BBC006","10.
4199/C00106ED1V01Y201406BBC006","Proteinsynthesisisafundamentalaspectofgeneexpressionacrosskingdoms.
Theregulationoftranslationisimportantformanybiologicalprocessesincludingcellfatedetermination,development,andgrowthandisespeciallycrucialtomaintaincellularhomeostasisduringcellularstressandvirusinfection.
Misregulationofproteintranslationcancontributetodiseasessuchasdiabetes,cancer,andneurodegenerativediseases.
Inthischapter,wehighlightthebasicunderstandingofeukaryotictranslationandthemajorregulationsthatcontrolbiologicalevents.
WefocusonsignalingpathwaysthatregulateoverallproteinsynthesisandalsomechanismsthatcontroltranslationofspecificmRNAssuchascis-actingelementswithinthe5'and3untranslatedregions(UTR).
Understandingthesemechanismsprovideinsightsintothefundamentalgeneregulationsthatmayprovidenewtargetsforcombatingdiseaseandvirusinfections.
TableofContents:Introduction/TranslationalInitiation/RegulationofCap-dependentTranslation/SelectiveTranslationofmRNAs/ConcludingRemarks/Acknowledgements/References/Authorbiography""3","9781615045402","9781615045419","IntermediateFilaments","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","112","June,2014","NormandMarceau","Centrederecherchesurlecancer,UniversitéLaval,andCentrederechercheduCHUdeQuébec,QuebecCity,Qc,Canada,G1R2J6","AnneLoranger","Centrederecherchesurlecancer,UniversitéLaval,andCentrederechercheduCHUdeQuébec,QuebecCity,Qc,Canada,G1R2J6","StéphaneGilbert","Centrederecherchesurlecancer,UniversitéLaval,andCentrederechercheduCHUdeQuébec,QuebecCity,Qc,Canada,G1R2J6",,,"2328-3041","2328-305X","http://dx.
doi.
org/10.
4199/C00107ED1V01Y201406BBC007","10.
4199/C00107ED1V01Y201406BBC007","Intermediatefilaments(IFs),inconcertwithmicrofilaments(MFs)andmicrotubules(MTs),formthecytoskeleton,andeachofthesefibrillarnetworksexhibitsratheruniquestructuralandfunctionalcharacteristics.
Intermediatefilamentswerediscoveredineukaryoticcellsinthelate1960s,andtheirnamecomesfromthefactthattheirdiameterisintermediatebetweenMFsandMTs.
Incontrasttothelatter,IFsconstituteanetworkthatextendsfromthenuclearenvelopethroughoutthecytoplasm,andinmanycases,interactwithcellsurfacedomainsinvolvedincell-cellandcell-matrixinteractions.
Severalkeyfeaturesoftheirexpression,assembly,structureanddynamicsarehighlightedinthiseBook.
Forinstance,IFproteinsareencodedbyseveralgenes,whichareclassifiedintosixtypesreflectingthetissues(cells)oforigin.
Moreover,IFproteinscontainaconservedcentralα-helical(rod)domainflankedbyN-terminal(head)andC-terminal(tail)globulardomainsthatenablesassemblyoffibrousIFsexhibitingatripartitestructure.
Althoughtheroddomainisresponsiblefortheformationofthecoiled-coilframeworkandyieldsthemaindrivingforceduringtheIFproteinassembly,theheadandtaildomainscontributetomostofthestructuralheterogeneityofIForganizationandundergoseveraltypesofpost-translationalmodifications.
Furthermore,thedevelopmentofgenetargetingmethodstogeneticallyknockouttheexpressionoftheIFgenesinmicehasuncoveredthemechanicalversusnon-mechanicalfeaturesoftheIFnetworks,namely,theirinvolvementincellresponsetodiverseformsofstress,growthstimulation,migration,ordeathinsults.
Finally,thereisaccumulatingevidencerevealingthatthetissueandcell-typeexpressionofIFgenesreflectsitselfinthepresenceofcausalorpredispositionmutationsresponsiblefornumeroushumantissue-specificdiseases,knownasIF-pathies.
TableofContents:ListofAbbreviations/Introduction/IFsasaMultigeneFamilyofFilamentousProteins/NuclearLamina/IFFunctionalInterplaywithCellSurfaceDomainsandOrganelles/IFsandCellSpecialization/IFRelevancetoHumanDiseases/Conclusion/References/AuthorBiographies""3","9781615043668","9781615043675","CoronaryCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","189","July,2014","JohnathanD.
Tune","DepartmentofCellularandIntegrativePhysiology,IndianaUniversitySchoolofMedicine,Indianapolis,IN"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00111ED1V01Y201406ISP054","10.
4199/C00111ED1V01Y201406ISP054","Thecoronarycirculationisuniqueinthatitisresponsibleformaintainingadequateoxygenandsubstratedeliverytotheorganthatgeneratesthepressureneededtodrivebloodthroughouttheentirecirculatorysystem.
Inthesimplestterms,coronarybloodflowisdirectlyproportionaltothearterialpressuregradientacrossthecoronaryvasculatureandinverselyproportionaltocoronaryvascularresistance.
However,myocardialperfusioniscollectivelyregulatedbyacomplexvarietyofmechanismswhichinclude:(1)extravascularcompressiveforces;(2)diastolictimefraction;(3)coronaryperfusionpressure;(4)myocardialmetabolism(localmetabolicfactors);(5)endothelial-derivedsubstances;(6)neuro-humoralinfluences;and(7)arterialoxygentensionandcontent.
Thisbookconsiderseachofthesedeterminantswithparticularemphasisonthefunctionalinteractionbetweenthephysicalandbiologicaldeterminantsofmyocardialperfusion.
Pathophysiologicaspectsofcoronaryatherosclerosisandcardiovasculardiseasestatesarealsoconsidered.
TableofContents:Abbreviations/Acknowledgments/Introduction/BasicCoronaryAnatomy/Myocardial-CoronaryInteraction/ArterialPressureandAutoregulation/LocalMetabolicControl/Endothelial-DependentControl/NeuralActivationandCirculatingHormones/CoronaryStenosis,MyocardialIschemia,andEffectsofDisease/Summary/ReferenceList/AuthorBiography""3","9781615046607","9781615046614","EntericGlia","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","70","July,2014","BrianD.
Gulbransen","DepartmentofPhysiology,MichiganStateUniversity"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00113ED1V01Y201407NGL002","10.
4199/C00113ED1V01Y201407NGL002","Theentericnervoussystem(ENS)isacomplexneuralnetworkembeddedinthegutwallthatorchestratesthereflexbehaviorsoftheintestine.
TheENSisoftenreferredtoasthe"littlebrain"inthegutbecausetheENSismoresimilarinsize,complexityandautonomytothecentralnervoussystem(CNS)thanothercomponentsoftheautonomicnervoussystem.
Likethebrain,theENSiscomposedofneuronsthataresurroundedbyglialcells.
EntericgliaareauniquetypeofperipheralgliathataresimilartoastrocytesoftheCNS.
Yetentericglialcellsalsodifferfromastrocytesinmanyimportantways.
Therolesofentericglialcellpopulationsinthegutarebeginningtocometolightandrecentevidenceimplicatesentericgliainalmosteveryaspectofgastrointestinalphysiologyandpathophysiology.
However,elucidatingtheexactmechanismsbywhichentericgliainfluencegastrointestinalphysiologyandidentifyinghowthoserolesarealteredduringgastrointestinalpathophysiologyremainareasofintenseresearch.
Thepurposeofthise-bookistoprovideanintroductiontoentericglialcellsandtoactasaresourceforongoingstudiesonthisfascinatingpopulationofglia.
TableofContents:Introduction/AHistoricalPerspectiveonEntericGlia/EntericGlia:TheAstrogliaoftheGut/MolecularCompositionofEntericGlia/DevelopmentofEntericGlia/FunctionalRolesofEntericGlia/EntericGliaandDiseaseProcessesintheGut/ConcludingRemarks/References/AuthorBiography""3","9781615043729","9781615043736","ControlofBreathingDuringExercise","ColloquiumSeriesonIntegratedSystemsPhysiology","93","July,2014","SusanA.
Ward","EmeritusProfessor,FacultyofBiologicalScience,UniversityofLeedsandHumanBio-EnergeticsResearchCentre,Crickhowell,Powys,UnitedKingdom"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00108ED1V01Y201406ISP052","10.
4199/C00108ED1V01Y201406ISP052","Thecontrolofbreathingduringexerciseremainsthesourceofconsiderabledebate.
Classicalschemesoftheexercisehyperpneahaveincorporatedelementsofproportionalfeed-backfromchemoreceptorsites(carotidbodyandbrainstem)andfeed-forwardneurogenic(centralcommandandmusclereflex)control.
However,theprecisedetailsofthecontrolprocessarestillnotfullyresolved,reflectinginparttechnicalandinterpretationallimitationsinherentinisolatingputativecontrolmechanismsintheintactexercisinghumanandalsothechallengespresentedbytheventilatoryandgas-exchangecomplexitiesencounteredatworkrateswhichengenderametabolic(lactic)acidosis.
Althoughsomecombinationofneurogenic,chemoreflex,andcirculatory-coupledprocessesarelikelytocontributetothecontrol,intriguingly,theoverallsystemappearstoevidenceconsiderableredundancy.
This,coupledwiththelackofappreciablesteady-stateerrorsignalsinthemeanlevelsofarterialPCO2,PO2,andpHoverawiderangeofworkrates,hasmotivatedtheformulationofinnovativecontrolmodelsthatreflectnotonlyspatialinteractionsbutalsotemporalinteractions(i.
e.
,short-termandlonger-term'memory').
Thechallengeremainstodiscriminatebetweenrobustcontrolschemesthat(a)integratesuchprocesseswithinplausiblephysiologicalequivalents,and(b)accountforboththedynamicandsteady-statesystemresponseovertheentirerangeofexerciseintensities.
TableofContents:Introduction/VentilatoryRequirements/VentilatoryResponses/VentilatoryControl/Conclusions/References""3","9781615046560","9781615046577","PathogenesisofAtherosclerosis:FromCellBiologytoTherapeutics","ColloquiumSeriesonIntegratedSystemsPhysiology","125","July,2014","A.
WayneOrr","DepartmentsofPathologyandCellBiologyandAnatomyLSUHealthSciencesCenter–Shreveport","ArifYurdagulJr.
","DepartmentsofPathologyandCellBiologyandAnatomyLSUHealthSciencesCenter–Shreveport","BrijeshM.
Patel","DepartmentofMedicineDivisionofCardiologyLSUHealthSciencesCenter–Shreveport",,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00110ED1V01Y201406ISP053","10.
4199/C00110ED1V01Y201406ISP053","Thecirculatorysystemprovidesthetissuesofthebodywithoxygenandnutrientsforsurvival,allowsforthedisseminationofinflammatorycells,andclearsmetabolicwastefrombuildingupanddamagingtissue.
Atheroscleroticdisease,thebuild-upoffat,inflammatorycells,andfibrotictissueinthevesselwall,hindersthisfunction,resultingininadequateperfusionofthetargettissue.
Hypoxia,orlackofoxygen,rapidlyresultsincellulardysfunctionthatprofoundlyaffectsthefunctionalityoftheoveralltissue.
Atherosclerosis-associatedtissueischemiaandhypoxiabecauseoflossofbloodflowunderliesseveralsignificantdiseasepathologiesincludingischemicheartdisease,stroke,andperipheralarterydisease.
InthiseBook,weexaminetheprocessofatheroscleroticplaqueformationbothatthecellularlevelandthelevelofclinicalpresentation.
Throughthisbook,wehopetoimparttothereaderabetterunderstandingofhowvesselstructure,environmentalriskfactors,andgeneticpredispositioncontributetoatheroscleroticdiseaseandhowcurrentandfuturetherapiesseektocircumventthecellularprocessescontributingtoplaqueformationtoreduceatheroscleroticplaqueburdenandclinicalcomplications.
TableofContents:ListofVideos/IntroductiontoAtherosclerosis/Epidemiology/EndothelialCellActivationandArterialHemodynamics/CholesterolandCardiovascularDisease/InflammationinAtherosclerosis/SmoothMuscleCellsandPlaqueVulnerability/DiagnosingAtheroscleroticDisease/TreatmentandPrevention/SummaryandFuturePerspectives/References/AuthorBiographies""3","9781615045884","9781615045891","MultipleSclerosis:AnOverviewofClinicalFeatures,Pathophysiology,Neuroimaging,andTreatmentOptions","ColloquiumSeriesonIntegratedSystemsPhysiology","117","Sept.
2014","AlirezaMinagar","DepartmentofNeurology,LouisianaStateUniversityHealthSciencesCenter"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00116ED1V01Y201408ISP055","10.
4199/C00116ED1V01Y201408ISP055","Multiplesclerosis[MS]isoneofthemostcommonauto-immune-mediateddiseasesofthehumancentralnervoussystem[CNS]whichaffectsyoungadultsandusuallycausessignificantneurologicaldisability.
Currently,thecausesofMSarestillunclear,acureforMSremainselusiveandtheeffectivenessoftreatmentvariessignificantlyamongindividuals.
ClinicalfeaturesandneurologicaldeficitsstemmingfromthisprogressiveneurologicaldiseasearediversesinceMSpotentiallyaffectshumanCNSatalllevelsfrombraintotheendofspinalcord.
ThetriggeringeventfordevelopmentofMSremainsunknown.
ImmunopathogenesisofMSinvolvesanumberofstepswhichincludeactivationofperipheralleukocytesagainstputativeCNSantigen(s),interactionsoftheactivatedleukocyteswithinflamedcerebralendothelialcells,transendothelialmigrationofactivatedlymphocytesandmacrophagestotheCNSmilieu,andfurtherpropagationofthemassiveimmuneresponsewithintheCNS.
Suchmassiveimmuneactivationleadstolossofmyelin-oligodendrocytecomplex.
Severalimmunecelltypesandmediatorsoftheimmune-inflammatoryresponseactivelycontributetopathogenesisofMS.
GeneticfactorsarealsobelievedtoplayacentralroleinthedevelopmentofmostformsofMS.
Anotherimportantbutmuchunrecognizedandunder-researchedfeatureofMSimmunopathologyis"neurodegeneration.
"NeuronallossandaxonaldegenerationarethecorecomponentsofirreversibleandpermanentCNSatrophyanddisabilityinMS.
WhatwecallMSinrealityisaheterogeneousgroupofdiseasesandatleastfourdistinctimmunopathologicalsubtypesofMSwithdissimilarresponsestotherapywithimmunomodulatoryagentsexist.
MSisaclinicaldiagnosis,however,itsdiagnosticprocessismuchfacilitatedbyutilizationoflaboratoryandneuroimagingstudies.
PresenttherapiesofMSareeitherimmunomodulatoryagentsorimmunosuppressiveandmainlytargettheperipheralimmunesystemwiththeintentiontoamelioratetheseverityofacuterelapses,decreaseannualrelapserate,andimproveMRIlesions.
Currently,muchresearchactivityisbeingconductedtobetterunderstandthefundamentaldiseasemechanismsofMSandfindmoreeffectiveandsafertreatmentsforthisincurabledisease.
ThisbookpresentsanoverviewofMSasadiseasewithneuroinflammatoryandneurodegenerativefeaturesandtheauthorsdiscussthemostrecentfindingsaboutMSanditstreatment.
TableofContents:Introduction/ClinicalFeaturesofMultipleSclerosis/PathophysiologyofMultipleSclerosis/NeuroimagingofMultipleSclerosis/DiagnosisofMultipleSclerosis/TreatmentofMultipleSclerosis/PrognosisofMultipleSclerosis/ConcludingRemarks.
References""3","9781615046584","9781615046591","VesicularTransportintheSecretoryandEndocyticPathways","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","125","Sept.
2014","AnneMüsch","DepartmentofDevelopmental&MolecularBiologyAlbertEinsteinCollegeofMedicine"2328-3041","2328-305X","http://dx.
doi.
org/10.
4199/C0011ED1V01Y201407BBC008","10.
4199/C0011ED1V01Y201407BBC008","Theconceptofvesiculartrafficasameansofproteintransportinandoutofcellsandbetweenmembranecompartmentshasbeenestablishedsincethe1960s.
Itsbasicprinciplesarebeautifullysimple,yetthedetailsofproteintransportarecomplexenoughtofindnovelclassesoftransportvesicles,andtraffickingitinerariesstillbeingdescribedtodate.
Inthistreatise,thereaderwillbeintroducedtomechanismsofvesiclesculpting,cargoselection,vesicletargeting,andvesicleconsumptionthathaveemergedascommoncharacteristicsofmultipletransportstepsintheexocyticandendocyticpathways.
Thesefundamentalsalsorevealthebasisforthespecificityandselectivityofindividualtransportsteps.
Wewillfurtherdiscusshowproteintransportmightleadtotheestablishmentandmaintenanceoftheendomembranesystemofeukaryoticcells.
Theconceptsforthesemechanismsarebasedonexperimentalevidencecombinedwithmathematicalmodelingthatcandisclosetheminimalrequirementsforthegenerationofthedistinctmembranecompartments.
TableofContents:CompartmentalizationIsaHallmarkofEukaryoticCells/OrganellesCanBeClassifiedBasedonTheirOrigin/ThereAreMultipleEntryPointsIntotheEndomembraneSystemandaNetworkofConnectingTraffickingRoutes/ThereAreExceptionsandExtensionstotheClassicTraffickingItineraries/AMathematicalModelCanExplainHowOrganelleSizeIsEstablishedandMaintained/CoatsandSNAREsConstitutetheCoreMachineryforVesicleBuddingandFusion/AMathematicalModelExplainsHowCoatsandSNAREsAreSufficienttoGenerateOrganelleIdentity/HowVesicleFormationIsLinkedtoCargoIncorporation/RabGTPasesAretheMasterRegulatorsofVesicularTraffic/TheMechanismsandPhysiologicalRolesofEndocytosis/ModelsforProteinTransportintheGolgiApparatus/Summary/Acknowledgments/References/AuthorBiography""3","9781615046645","9781615046652","Ca2+-dependentSignalTransduction","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","68","Sept.
2014","JamesD.
Johnson","DepartmentofCellularandPhysiologicalSciences,UniversityofBritishColumbia","MichaelJ.
Bround","DepartmentofCellularandPhysiologicalSciences,UniversityofBritishColumbia","TobiasAlbrecht","DepartmentofCellularandPhysiologicalSciences,UniversityofBritishColumbia",,,"2328-3041","2328-305X","http://dx.
doi.
org/10.
4199/C00115ED1V01Y201407BBC009","10.
4199/C00115ED1V01Y201407BBC009","Inbiology,signaltransductionisthetransmissionofinformationintoandwithinthecell.
Signaltransductioneventswithinacellareofteninitiatedfromanextracellularcue.
Currentknowledgesuggeststhattherearefarfewerintracellularsecondmessengersthanextracellularcues.
Thismeansthataconservedcoresetofsecondmessengers,includingions,smallnucleotides,andlipidsmustbecoordinatedtopasstheinformationfromtheirpointoforigintotheiraudiencereceptorseffectively.
Inmanycases,signaltransductioninvolvessignificantamplification.
Oneofthebest-understoodandubiquitoussecondmessengersisioniccalcium(Ca2+).
TheknowledgesurroundingthecodingofinformationviaCa2+signalshasservedasatemplateforstudyingothersecondmessengers.
Ca2+signalingandintracellularCa2+homeostasisarehighlycomplexandstillincompletelyunderstood.
Inthischapter,willwereviewthecurrentknowledgeofCa2+signaling.
WewillfirstprovideareviewofthegeneralprinciplesofCa2+signaltransductionandexamplesofsomeofthemajorCa2+-dependentcellularprocesses.
Next,wewillreviewthemainsourcesofCa2+andthemoleculareffectorsofCa2+signals.
Then,wewillprovidesomeexamplesfromtheliteraturethatillustratehowCa2+signalingworks:howitcanmediatesignalamplification,howitencodesdifferenttypesofsignals,howitperformsagonist-specificsignalsaswellasfunction-specificsignals,signalintegrationandco-incidencedetection,andhowitcancross-talkwithothersecondmessengersignalingevents.
Throughoutthischapter,wewilluseCa2+asanexampleofaprototypicalcodedsecondmessenger,sinceitisclearthatmuchofthecomplexityofCa2+signalinglikelyappliestomanyoftheotherknownsecondmessengers.
TableofContents:GeneralIntroduction/SourcesofCa2+Signals/Ca2+-DependentProcesses:FromHighlySpecializedtoUbiquitousCellularRoles/MajorCa2+-SignalingEffectors/Ca2+SignalCoding/Acknowledgments/Bibliography/TitlesofRelatedInterest""3","9781615046546","9781615046553","CountingMoleculesWithinCells","ColloquiumSeriesonQuantitativeCellBiology","74","Sept.
2014","ValerieCoffman","DepartmentofMolecularGenetics,TheOhioStateUniversity,Columbus,Ohio","I-JuLee","DepartmentofMolecularGenetics,TheOhioStateUniversity,Columbus,OhioGraduateProgramofMolecular,Cellular,andDevelopmentBiology,TheOhioStateUniversity,Columbus,Ohio","Jian-QiuWu","DepartmentofMolecularGenetics,TheOhioStateUniversity,Columbus,OhioDepartmentofMolecularandCellularBiochemistry,TheOhioStateUniversity,Columbus,Ohio",,,"2375-7744","2375-7752","http://dx.
doi.
org/10.
4199/C00109ED1V01Y201406QCB001","10.
4199/C00109ED1V01Y201406QCB001","3","9781615046621","9781615046638","AJourneyThroughGenetics,Part2","ColloquiumSeriesonTheGeneticBasisofHumanDisease","71","Sept.
2014","KarobiMoitra","ClareBootheLuceProfessorofMolecularBiologyAssistantProfessor,TrinityWashingtonUniversity"2168-4006","2168-4022","http://dx.
doi.
org/10.
4199/C00114ED1V02Y201407GBD006","10.
4199/C00114ED1V02Y201407GBD006",""AJourneyThroughGeneticsPartII"isdesignedtocontinueontheincrediblejourneyinitiatedinPartItoexploretheexcitingdiscoveriesingeneticsandmolecularbiology.
InPartI,thereaderembarkedonageneticodysseythatstartedwiththe"FatherofGenetics,"GregorMendel,andculminatedintheinventionofoneofthemostpowerfultoolsinmolecularbiology—thepolymerasechainreaction.
Thesecondpartofthebookwilltakethereaderonajourneytoexplorethefrontiersofgeneticdiversity,genecloning,thehumanjourney,andthehumangenomeproject!
Thebookistargetedtowardundergraduatenon-majorsandalsoasa"companion"toastandardgeneticstextbookforbiologymajors.
Thebookwillalsoprovetobeusefulforanyonethatwantstounderstandthestoriesbehindthescienceofgenetics.
""3","9781615041473","9781615041480","GastrointestinalMucosalDefenseSystem","ColloquiumSeriesonIntegratedSystemsPhysiology","172","October,2014","PeterR.
Kvietys","CollegeofMedicine,AlfaisalUniversity,Riyadh,KSA","AhmedYaqinuddin","CollegeofMedicine,AlfaisalUniversity,Riyadh,KSA","WaelAlKattan","CollegeofMedicine,AlfaisalUniversity,Riyadh,KSA",,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00119ED1V01Y201409ISP058","10.
4199/C00119ED1V01Y201409ISP058","Thegastrointestinalmucosaldefensesystemservestominimizemucosalinjurybyeitheringestedorendogenouslyproducednoxioussubstances.
Themucosaldefensesystemisstratifiedintopre-epithelial(alkalinemucus),epithelial(dynamicepitheliallining),andpost-epithelial(microcirculation)components.
Themucusliningtheepithelialsurfacepresentsadiffusionalbarriertoingestedmaterial(e.
g.
,lipids)andalsoservesasanunstirredlayerinwhichapHgradientcanbeestablishedtopreventacid-inducedinjury.
Theepithelialliningpreventsentranceofanytoxicmaterialtotheinterstitiumand,shoulditbedamaged,itisrapidlyresealedbymigrationofadjacentviableepithelialcellstocoverthedefect.
Anyacidorothermaterialthathasenteredtheinterstitiumiswashedoutbyanintenseneurogenichyperemia.
Ingeneral,themucosaldefensesystemisquiteeffectiveandanyadversegastrointestinaleffectsassociatedwiththenormalcourseofnutrientassimilationareminimal.
However,therearetwosituationsinwhichthemucosaldefensesystemisknowntobeineffectiveandresultingastricmucosalinjury:inadvertentingestionofH.
pylori.
orintentionalingestionofNSAIDs.
H.
pyloricanpenetratethemucuslayersandcauseepithelialinjuryandinflammation,whileatthesametimepreventingitsclearancebythehostimmunesystem.
NSAIDsweakenthemucuslayerandcauseepithelialcellinjury.
TableofContents:Acknowledgments/Introduction/TheMucusLayer/EpithelialLining/GastrointestinalCirculation/IntegrationofMucosalDefense/MucosalDefenseSystem:Physiologic/MucosalDefenseSystem:H.
pylori/MucosalDefenseSystem:NonsteroidalAnti-InflammatoryDrugs(NSAIDS)/OverallSummaryandConclusions/References/AuthorBiographies""3","9781615045785","9781615045792","SexandGenderDifferencesinCardiovascular-RenalDiseasesandHypertension","ColloquiumSeriesonIntegratedSystemsPhysiology","97","November,2014","JaneReckelhoff","UniversityofMississippiMedicalCenter,Jackson,Mississippi"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00118ED1V01Y201409ISP057","10.
4199/C00118ED1V01Y201409ISP057","Manyofthemechanismsresponsibleforcardiovasculardiseaseandhypertensionarewellknown,andgenderisanindependentriskfactorinmanycohorts.
Howgendercontributestocardiovasculardiseasehasnotbeencompletelyelucidated.
Eveninnormotensivepopulations,bloodpressureishigherinmenthanwomen,althoughwhythisoccursisunclear.
Whilebothmenandwomensufferfromhighincidencesofcardiovasculardisease,womenaretypicallyprotectedagainstcardiovasculardiseaseuntilaftermenopause,sothatonaveragetheyareabout10yearsolderthanmenwhenthesediseasesdevelop,makingagingaconfoundingproblemcontributingtoincreasedmorbidity.
Becausehypertensionisoneoftheleadingcausesofcardiovasculardiseaseinbothmenandwomen,thisreviewwillfocusonhypertension,andthemechanismsthathavebeenfoundtoplayaroleinmediatingbloodpressurecontrolandhowtheydifferinmenandwomen.
TableofContents:OverviewandEpidemiology/GeneticandNon-GeneticModelsofHypertension/HypertensionandSympatheticNervousSystemActivation/ReninAngiotensinSystem/OxidativeStress/Endothelin/AgingandHypertension/DevelopmentalProgrammingofCardiovascularDisease/TCellsandHypertension/Genetics/SexSteroidsandReceptors/Summary/References/AuthorBiography""3","9781615046706","9781615046713","RetinalGlia","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","644","March,2015","AndreasReichenbach","PaulFlechsigInstituteforBrainResearch,UniversityofLeipzig","AndreasBringmann","DepartmentofOphthalmologyandEyeHospital,UniversityofLeipzig",,,,,"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00122ED1V01Y201412NGL003","10.
4199/C00122ED1V01Y201412NGL003","In1851,HeinrichMüllerdiscoveredwhathecalled"radialfibers"andwhatwenowcallMüllercells,astheprincipalglialcellsofthevertebrateretina.
Lateron,otherglialcelltypeswerefoundintheretina,includingastrocytes,microglia,andevenoligodendrocytes.
Itturnedoutthatretinalglialcellsareessentialconstituentsofthetissue.
Forinstance,Müllercellsappeartoconstitutethe"core"ofcolumnarunitsofclonallyandfunctionallyrelatedgroupsofneurons.
Theirprimaryfunctionistosupportneuronalfunctioningbyguidingthelighttowardsthephotoreceptorcells,removingexcessneurotransmittermoleculesfromextracellularspace,andperformingefficientclearanceofexcessextracellularpotassiumions.
Thelattertwofunctionsarealsocrucialforneuronalsurvivalandarecoupledtowaterclearancewhichisalsoessential.
Müllercellsarecapableof"sensing"neuronalactivityandmodifyingitbythereleaseofsignalsubstances(gliotransmitters).
IncasesofretinalinjuriestheMüllercellsbecomereactive,andallabove-mentionedfunctionsareimpaired.
However,suchde-differentiatedMüllercellsmayproliferate,andmayevenserveasstemcellsfortheregenerationofadamagedretina.
AswellastheMüllercells,retinalastrocytesandmicroglialcellsareimportantplayersinretinaldevelopmentandfunction.
Thisbookgivesacomprehensivesurveyofthepresentknowledgeonretinalglia.
TableofContents:RetinalStructure/RetinalAstrocytesandBloodVessels/RetinalMicroglia/RetinalOligodendroglia/MüllerCells/References/AuthorBiographies""3","9781615046768","9781615046775","NeurogliainInfectiousBrainDiseases","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","87","March,2015","GwennSkar","UniversityofNebraskaMedicalCenter,Omaha,Nebraska","JessicaSnowden","UniversityofNebraskaMedicalCenter,Omaha,Nebraska",,,,,"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00125ED1V01Y201503NGL005","10.
4199/C00125ED1V01Y201503NGL005","Inthisbook,wepresentadiscussionoftheimmunefunctionsofneurogliaandtheirinteractionswithcommoninfectiousdiseasesinthebrain.
Whilemostisknownaboutmicrogliaandastrocytes,asareextensivelyreviewedhere,ourunderstandingofotherglia,includingoligodendrocytesandependymalcells,continuestogrowintermsoftheirresponsetoinfection.
Ourdiscussionfocusesonthemostclinicallyrelevantandwell-studiedinfectiousdiseases,includingStreptococcuspneumoniae,Neisseriameningitidis,andhumanimmunodeficiencyvirus(HIV),amongothers,intheirinteractionswithmicrogliaandastrocytes.
Theseimmuneresponseswithinthecentralnervoussystemarecrucialforprotectingusfrompathogensandyetmustbecarefullybalancedwiththeneedtoprotectbrainstructuresthataresensitivetoinflammatorydamage.
Thecomplexinteractionsbetweenpathogensandglia,aswellasgliawithothercellsinthecentralnervoussystem,areanareaoffascinatingresearchthatcontinuestogrowasweattempttotranslateourunderstandingoftheseprocessestonewtreatmentandpreventionstrategies.
""3","9781615046744","9781615046751","TheRenin-AngiotensinSystemandtheKidney:NewInsightsandPerspectives","ColloquiumSeriesonIntegratedSystemsPhysiology","61","March,2015","XiaoC.
Li","LaboratoryofReceptorandSignalTransduction,DepartmentofPharmacologyandToxicology,DivisionofNephrology,DepartmentofMedicine,UniversityofMississippiMedicalCenter,Jackson,MS","JiaL.
Zhuo","LaboratoryofReceptorandSignalTransduction,DepartmentofPharmacologyandToxicology,DivisionofNephrology,DepartmentofMedicine,UniversityofMississippiMedicalCenter,Jackson,MS",,,,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00124ED1V01Y201501ISP059","10.
4199/C00124ED1V01Y201501ISP059","Therenin-angiotensinsystem(RAS)isoneofthemostimportantendocrine(tissue-to-tissue),paracrine(cell-to-cell)andintracrine(intracellular/nuclear)humoralsystemsintheregulationofbloodpressure,cardiovascular,andkidneyfunctioninhealthanddisease.
TheRAShasremarkablyevolvedfromtheinitialdiscoveryoftherate-limitingenzymerenintoacomplexbiochemicalandphysiologicalcascadeinvolvingmorethanadozenmembers.
Currently,thereareuptofiveaxesorpathwaysidentifiedintheRAS;eachhasitssubstrate,enzyme,effectorpeptide,receptor,anddownstreamsignalingpathways.
Theseincludetherenin/ACE/ANGII/AT1receptor,theAPA/ANGIII/AT2receptor,theACE2/ANG(1-7)/Masreceptor,theprorenin/proreninreceptor(PRR),andtheANGIV/AT4receptor(IRAP)pathways.
Accordingly,therolesoftheRAShaveexpandedwellbeyondtheclassicendocrineparadigmasapowerfulvasoconstrictor,apotentaldosteronestimulator,orasodium-retaininghormonalsystem.
Thegoalsofthisarticlearetoreviewanddiscussthecurrentinsightsintoandnewperspectivesontheexpression,localization,andnovelactionsoftheRASwithafocusinthekidney.
SpecialemphasiswillbeplacedonrecentlydiscoverednewmembersoftheRASderivedfromstudiesusinginnovativemutantratsormicethateitheroverexpress(knockin)oraredeficient(knockout)ofaparticularsubstrate,enzyme,ANGpeptide,orreceptor.
Thisnewknowledgewillhelpimproveourunderstandinghoweachofthesepathwaysactdirectlyorindirectlytoregulatebloodpressure,cardiovascularandkidneyfunctioninphysiology,andcanbetargetedtotreathypertension,cardiovascularandrenaldiseases.
TableofContents:Introduction/LocalizationandRolesoftheRenin/ACE/ANGII/AT1ReceptorAxisintheKidney/LocalizationandFunctionalPropertiesoftheACE2/ANG(1–7)/MasReceptorAxisintheKidney/LocalizationandRolesoftheProrenin/PRR/MAPKinasesERK1/2AxisintheKidney/TheLocalizationandPotentialRolesofotherANGPeptidesorReceptorsintheKidney/FuturePerspectives/Acknowledgements/References/AuthorBiography""3","9781615046720","9781615046737","PhysiologyofAstroglia:Channels,Receptors,Transporters,IonSignalingandGliotransmission","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","172","March,2015","AlexeiVerkhratsky","FacultyofLifeSciences,TheUniversityofManchester,Manchester,U.
K.
AchucarroCenterforNeuroscience,IKERBASQUE,BasqueFoundationforScience,Bilbao,SpainUniversityofNizhnyNovgorod,NizhnyNovgorod603022,Russia","VladimirParpura","DepartmentofNeurobiology,CenterforGlialBiologyinMedicine,AtomicForceMicroscopy0x26NanotechnologyLaboratories,CivitanInternationalResearchCenter,EvelynF.
McKnightBrainInstitute,UniversityofAlabamaatBirmingham,Birmingham,AL,U.
S.
A.
DepartmentofBiotechnology,UniversityofRijeka,Rijeka,Croatia",,,,,"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00123ED1V01Y201501NGL004","10.
4199/C00123ED1V01Y201501NGL004","Astrocytescanbedefinedasthegliainhabitingthenervoussystemwiththemainfunctioninthemaintenanceofnervoustissuehomeostasis.
Classifiedintoseveraltypesaccordingtotheirmorphologicalappearance,manyofastrocytesformareticularstructureknownasastroglialsyncytium,owingtotheircouplingviaintercellularchannelsorganizedintogapjunctions.
Notonlydoastrocytesestablishsuchhomocellularcontacts,buttheyalsoengageinintimateheterocellularinteractionswithneurons,mostnotablyatsynapticsites.
Assynapticstructureshousetheverycoreofinformationtransferandprocessinginthenervoussystem,astroglialperisynapticpositioningassuresthattheseglialcellscannourishneuronsandestablishbidirectionalcommunicationwiththem,functionsoutlinedintheconceptsoftheastrocyticcradleandmulti-partitesynapse,respectively.
Astrocytespossessarichassortmentofligandreceptors,ionandwaterchannels,andionandligandtransporters,whichcollectivelycontributetoastrocyticcontrolofhomeostasisandexcitability.
Astrogliacontrolglutamateandadenosinehomeostasistoexertmodulatoryactionsaffectingthereal-timeoperationofsynapses.
Fluctuationsofintracellularcalciumcanleadtothereleaseofvariouschemicaltransmittersfromastrocytesthroughaprocesstermedgliotransmission.
Sodiumfluctuationsarecloselyassociatedtothoseofcalciumwithbothdynamiceventsinterfacingsignalingandmetabolism.
Astrocytesappearfullyintegratedintothebraincellularcircuitry,beinganindispensablepartofneuralnetworks.
TableofContents:Acknowledgments/ListofAbbreviations/Astrocytes:GeneralPerspective/IonDistributionandMembranePotential/IonChannels/NeurotransmitterReceptors/MembraneTransporters/IonicSignalinginAstroglia/Gliotransmission:AstrocytesasSecretoryCellsoftheNervousSystem/ConcludingRemarks/References/AuthorBiographies""3","9781615046829","9781615046836","PathophysiologyofHeatStroke","ColloquiumSeriesonIntegratedSystemsPhysiology","101","April,2015","LisaR.
Leon","ThermalandMountainMedicineDivision,USArmyResearchInstituteofEnvironmentalMedicine"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00128ED1V01Y201503ISP060","10.
4199/C00128ED1V01Y201503ISP060","3","9781615046805","9781615046812","DevelopmentalGeneticsofthePharyngealArchSystem","ColloquiumSeriesonDevelopmentalBiology","108","May,2015","JeffryM.
Cesario","DepartmentofBasicScienceandCraniofacialBiology,NewYorkUniversityCollegeofDentistry,NewYork,NY","AndréLandinMalt","DepartmentofCellBiology,UniversityofVirginiaSchoolofMedicine,Charlottesville,VA","JuheeJeong","DepartmentofBasicScienceandCraniofacialBiology,NewYorkUniversityCollegeofDentistry,NewYork,NY",,,"2155-3521","2155-353X","http://dx.
doi.
org/10.
4199/C00127ED1V01Y201503DEB006","10.
4199/C00127ED1V01Y201503DEB006","Thepharyngealarchesareembryonicstructuresthatdevelopintotheface,neck,apartoftheheart,andseveralendocrineglandsinanimals.
Theyarethoughttohaveplayedakeyroleinvertebrateevolutionastheirderivativesimpactthemodeoffeedingandbreathing.
Moreover,perturbationinpharyngealarchdevelopmentisassociatedwithseveralmajorgroupsofbirthdefectsinhumans.
Duringearlyembryonicdevelopment,cellsfromallthreegermlayerscometogethertoassemblethepharyngealarches.
Subsequently,thepharyngealarchesundergogrowth,morphogenesis,andcelltypedifferentiationtogiverisetomusculoskeletal,cardiovascular,neural,andglandularcomponents.
Theseprocessesareguidedbyinteractionsamongstdifferenttissues,viasignalingmolecules.
Alargenumberofgenes,withacomplexnetworkofregulatoryrelationships,governeachaspectofpharyngealarchdevelopment.
Withtheadvanceofmoleculargeneticstoolsinmodelorganismssuchasmice,wearebeginningtounderstandthemolecularandcellularmechanismsunderlyingdevelopmentofthepharyngealarchesandrelatedbirthdefects.
ThiseBookwillprovideanintroductionintodevelopmentofthepharyngealarchsystem,withadetaileddiscussiononthegeneticregulationofthisprocess.
""3","9781615046669","9781615046676","NitricOxideintheKidney","ColloquiumSeriesonIntegratedSystemsPhysiology","47","May,2015","JenniferM.
Sasser","DepartmentofPharmacologyandToxicologyUniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00117ED1V01Y201408ISP056","10.
4199/C00117ED1V01Y201408ISP056","Nitricoxide(NO)isakeyregulatorofvariouscellularsignalingpathwaysthroughoutthebodyandplaysanimportantroleinrenalfunctionundernormalphysiologicalandpathophysiologicalconditions.
NOplaysamajorroleintheregulationofrenalhemodynamics,tubuloglomerularfeedback,sodiumtransportinthenephron,pressurenatriuresis,andrenalfibrosisandinjury;moreover,adeficiencyinNOischaracteristicofchronickidneydiseaseinbothhumanpatientsandinexperimentalanimalmodels.
ThegoalofthisbookistohighlighttheactionsofNOwithinthekidneyanditseffectsontheregulationofrenalbloodflowandtubulartransport.
""3","9781615046782","9781615046799","TheNeurovascularUnitandtheRoleofAstrocytesintheRegulationofVascularTone","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","60","June,2015","JessicaA.
Filosa","GeorgiaRegentsUniversity"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00126ED1V01Y201503NGL006","10.
4199/C00126ED1V01Y201503NGL006","Optimalcerebralbloodflowiscoordinatedbyfunctionalhyperemiaandcerebralautoregulation.
Theseprocessesensurethatthemetabolicdemandsofthebrainaremetatalltimes.
Bothinvivoandinvitrostudiessupportaroleforastrocytesintheregulationofcerebralbloodflow.
Inthiswereviewthecellularmechanismscontributingtoastrocyte-mediatedvasodilationandvasoconstrictionofparenchymalarterioles.
Primarily,wediscusshowactivity-dependentchangesinastrocyticCa2+contributetothereleaseofvasoactivesignalsinvolvedinneurovascularcoupling.
FollowingtheriseinastrocyticCa2+andphospholipaseA2activation,arachidonicacidisreleasedandmetabolizedintomultiplevasoactivesignals(e.
g.
,prostaglandins,epoxyeicosatrienoicacids,and20-HETE).
Thelevelofarterioletonealongwiththemetabolicconditionsofthetissuecanaltertheactionofthesesignalsleadingtoeithervasodilationorvasoconstriction.
Moreover,increasedCa2+alsoactivateslargeconductanceCa2+-activatedK+channelsexpressedinastrocyticendfeetprocesses.
DependingontheK+effluxconcentrationreleased,thispathwaycanalsoelicitvasodilationorvasoconstrictionofparenchymalarterioles.
Finally,weconcludebydiscussingrecentdivergentinvivofindingswhichquestionaroleforastrocyteinfunctionalhyperemia.
""3","9781615047123","9781615047130","AstrogliaandBrainMetabolism:FocusonEnergyandNeurotransmitterAminoAcidHomeostasis","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","64","July,2015","ArneSchousboe","DepartmentofDrugDesignandPharmacology,FacultyofHealthandMedicalSciences,UniversityofCopenhagen,Copenhagen,Denmark","AnneB.
Walls","DepartmentofDrugDesignandPharmacology,FacultyofHealthandMedicalSciences,UniversityofCopenhagen,Copenhagen,Denmark","LasseK.
Bak","DepartmentofDrugDesignandPharmacology,FacultyofHealthandMedicalSciences,UniversityofCopenhagen,Copenhagen,Denmark","HelleS.
Waagepetersen","DepartmentofDrugDesignandPharmacology,FacultyofHealthandMedicalSciences,UniversityofCopenhagen,Copenhagen,Denmark","2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00130ED1V01Y201506NGL007","10.
4199/C00130ED1V01Y201506NGL007","Thepresentoutlineofastrocyticmetabolicpathwaysinvolvedinglucoseandaminoacidmetabolismprovidesdetailedinformationabouttheenzymaticpathwaysinvolved,aswellasadescriptionofthebasicpropertiesoftheenzymesincludingregulatorymechanisms.
Hence,theglycolyticpathwayandglycogenmetabolismareoutlined,followedbyadetailedaccountofpyruvateoxidationanditsroleasasubstrateforthetricarboxylicacid(TCA)cycle.
Moreover,adetaileddescriptionofthemainenzymesinvolvedinglutamatemetabolismisprovidedandtheroleoftheglutamate-glutaminecycleisexplained.
Sincethistextisprimarilycoveringastrocyticmetabolism,anemphasishasbeenplacedonadiscussionofthesignificanceoftheastrocytespecificenzymespyruvatecarboxylaseandglutaminesynthetase,whichenablethesecellstoperformanetsynthesisofglutamine,theprecursorforsynthesisofglutamateandγ-aminobutyrate(GABA),themainneurotransmittersofthebrain.
Withthis,wehaveunderlinedthefundamentalimportanceofastrocyticmetabolismforneuronalfunctionwithaparticularemphasisonthefactthat,withoutcontinuoussupportfromtheastrocyticpartnersinsynapticfunction,glutamatergicandGABAergicneurotransmissionwouldnotbepossible.
Itisthoughtprovokingthattheseneurotransmissionprocesses,whichaccountforthevastmajorityofsynapticactivityinthebrain,havebeenmadetotallydependentonastrocyticmetabolicsupport,particularlywithregardtoreplenishmentoftherespectiveneurotransmitters.
""3","9781615047147","9781615047154","CrucialRoleforAstrocytesinEpilepsy","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","89","August,2015","PeterBedner","InstituteofCellularNeurosciences,UniversityofBonn,Bonn,Germany","ChristianSteinhuser","InstituteofCellularNeurosciences,UniversityofBonn,Bonn,Germany",,,,,"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00135ED1V01Y201507NGL008","10.
4199/C00135ED1V01Y201507NGL008","Thisbooksummarizescurrentevidenceofastrocytedysfunctioninepilepsyanddiscussespresumedunderlyingmechanisms.
Epilepsyischaracterizedbytheperiodicoccurrenceofseizures.
Currentlyavailableanticonvulsantdrugsandtherapiesareinsufficienttocontrollingseizuresinaboutonethirdofpatients.
Thus,thereisanurgentneedfornewtherapiesthatpreventgenerationofthedisorderandimproveseizurecontrolinindividualsalreadyafflicted.
Thevastmajorityofepilepticcasesareofidiopathicoriginwiththeirunderlyingmechanismsbeingunclear.
Neurosurgicalspecimensfrompatientspresentingwithmesialtemporallobeepilepsy(MTLE)demonstratemarkedreactivegliosis.
SincerecentstudieshaveimplicatedastrocytesinimportantphysiologicalrolesintheCNS,suchassynchronizationofneuronalfiring,itisplausiblethattheymayalsohavearoleinseizuregenerationand/orseizurespread.
Insupportofthisview,variousmembranechannels,receptors,andtransportersinastrocyticmembranesarealteredintheepilepticbrain.
Excitingly,recentevidencesuggeststhatinthecourseofthepathogenesisofMTLE,theseglialchangesalterhomeostaticnetworkfunctionsandtemporallyprecedethealterationsinneurons.
ThesefindingsmighteventuallyclassifyMTLEasaglialratherthananeuronaldisorder,andidentifyastrocytesaspromisingnewtargetsforthedevelopmentofmorespecificantiepileptogenictherapeuticstrategies.
Althoughresearchonastrocytesinepilepsyisstillinitsinfancy,thisbookclearlydemonstratesacriticalroleofastrocytesinthedisturbanceofK+andtransmitterhomeostasisanditsimpactonseizuregeneration.
""3","9781615046942","9781615046959","GeneticsofHypertension","ColloquiumSeriesonIntegratedSystemsPhysiology","56","August,2015","XiCheng","UniversityofToledo","BinaJoe","UniversityofToledo",,,,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00131ED1V01Y201506ISP062","10.
4199/C00131ED1V01Y201506ISP062","Hypertension,orelevatedbloodpressure,isamajorriskfactorforvariouscardiovascular,renaldiseases,andstroke.
TheformofhypertensionwithnoidentifiablecauseisreferredtoasEssentialHypertension.
FamilialstudiesindicatethatEssentialHypertensionisheritableand,thereby,classicalgeneticapproacheshavebeenappliedonbothhumanandothermammalianmodelsofhypertensiontomapthelocationsoftheallelicvariantswithinquantitativetraitlociforbloodpressure.
Thepostgenomeerahasfurtherelevatedthisareaofresearchintolarge-scalegenome-wideassociationstudiesofhypertensioninhumans.
Collectively,thesestudieshaveresultedintheprioritizationandcatalogingofseveralgenomicregionscontainingallelicvariantsascandidateslinkedorassociatedwithessentialhypertension.
Further,theyareprovidingevidencetosuggestthattheinheritanceofhypertensionisrathercomplex,encompassingmultiplevariantsbothwithinprotein-codingandnon-codingannotations,eachofwhichmayactindependentlyorinteractivelywithothergenesand/orenvironmentalfactorstodifferentiallyregulatebloodpressure.
Thisbookprovidesanoverviewofthevariousmethodsemployedtostudythegeneticsofhypertensionanddiscusstheprogressandprospectsofthisareaofresearchthatmaycontributetowardsindividualizedclinicalmanagementofhypertensioninthefuture.
""3","9781615042289","9781615042296","RenalMedullaryCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","104","August,2015","LouiseEvans","MedicalCollegeofWisconsin","AllenCowley","MedicalCollegeofWisconsin",,,,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00136ED1V01Y201507ISP064","10.
4199/C00136ED1V01Y201507ISP064","Thetwokidneysofmammalianorganismsreceivearound25%ofthecardiacoutputatrest,ofwhichonly~7%isdistributedtotherenalmedulla.
Despitethelowbloodflowtotherenalmedulla,smallchangesinperfusiontotheregioncanhaveprofoundeffectsonurine-concentratingabilityandtheexcretionofsodium,whichinturnaffectsthechronicregulationofbodyfluidvolumesandarterialbloodpressure.
Importantly,weknowthatifbloodflowtotherenalmedullaisnottightlyregulated,sodiumandwaterhomeostasisisimpairedandmedullaryhypoxiadevelops.
Theresultantinjuryinevitablyreducesurineconcentratingabilityandleadstohypertension.
Thisbookwilldiscussthevarietyofmechanismsthatmammalianorganismshavedevelopedtoensurethatrenalmedullarybloodflowandoxygenlevelsarepreciselyregulated.
Thisbookwillfocusontheuniqueanatomicalarrangementofthemedullarycirculation,thefunctionalrolesofmedullarybloodflow,aswellastheexperimentaltechniquesusedtoassessmedullarybloodflowandtheinsightthatthesestudieshaveprovided.
Thehormonalandnon-hormonalcontrolofmedullarybloodflowwillbeconsideredandfinallytheimpactofreducedmedullarybloodflowonbloodpressureisdiscussed.
""3","9781615046980","9781615046997","MeasuringCellMechanics","ColloquiumSeriesonQuantitativeCellBiology","75","September,2015","MargaretGardel","UniversityofChicago","PatrickOakes","UniversityofChicago",,,,,"2375-7744","2375-7752","http://dx.
doi.
org/10.
4199/C00137ED1V01Y201508QCB003","10.
4199/C00137ED1V01Y201508QCB003","Cellsareinherentlyphysicalentitiesthatbothexperiencemechanicalforcesfromtheirexternalenvironmentandgeneratetheirowninternalforcestodrivecellmotion.
Ourparticularaimhereistopresentthereaderwithanintroductiontotheprimarytoolsusedtomeasurethesemechanicalinteractionsandthematerialpropertiesofcellsthatresultfromthem.
Theseapproachescanbeappliedtoadiversearrayofphysiologicalprocessesandsystems,providingimportantinsightintotheregulatoryrolesofmechanicalinteractionsincells.
Wecovertechniquesatboththemolecularandcellularscales,includingthosethatactivelyandpassivelyprobethesystem.
Alongthewaywecoverthefundamentalprinciplesofeachapproach,whileemphasizingtherelevantlengthandtimescales,alongwiththetypicalmagnitudesofthemeasurementsthatcanbemade.
Eachsectionendsbyhighlightingusesofthevarioustechniquesinrecentrelevantpublications,illustratingtheexcitingfutureofcellmechanicsinquantitativecellbiologyresearch.
","TableofContents:Introduction/MolecularMeasurements/MechanicalPropertiesofCells/PerturbingCellularMechanics/ConcludingRemarks/References/AuthorBiographies""3","9781615044481","9781615044498","LungEndothelium","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","66","September,2015","MaryI.
Townsley","UniversityofSouthAlabama","TroyStevens","UniversityofSouthAlabama",,,,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00132ED1V01Y201506ISP063","10.
4199/C00132ED1V01Y201506ISP063","Pulmonaryendotheliumformstheinnerliningofbloodvessels,whereitinterpretsthecomplexmechanicalandchemicalenvironmentwithinthecirculationandadjustsitsbehaviortofacilitatevascularhomeostasis.
Althoughendotheliumfulfillsmanyessentialfunctions,includingregulationofvascularpressure,circulatingcelltransmigration,coagulation,andhormonemetabolismand/ordelivery,aprincipalroleistoformasemi-permeablebarrierthatlimitsfluid,soluteandmacromolecularaccesstotheinterstitialspace.
PhysiologicalpropertiesthatgovernsuchpermeabilitycharacteristicsaredefinedbytheStarlingequation,whichassumesthatendothelialcellsthroughoutthecirculationareallalike.
However,inrecentyearsithasbecomeevidentthatendothelialcellsinpulmonaryarteries,capillaryandveinsareheterogeneousinstructureandfunction.
Here,wereviewevidenceforendothelialheterogeneityamongthesepulmonaryvascularsegments,andconsidertheimplicationsforsuchheterogeneityinlungfluidbalance,especiallyasitrelatestotheStarlingequation.
","TableofContents:DefiningtheEndothelium/ThePulmonaryCirculationasContext/GeneralPropertiesofEndothelium/TransendothelialFluidExchangeandtheStarlingEquation/TheStarlingEquation,LungPermeability,andEndothelialHeterogeneity/RevisedStarlingPrinciplesHeterogeneityandOtherIssues/Summary/References/AuthorBiographies""3","9781615044962","9781615044979","BiologicallyActivePeptidesinInvertebrates","ColloquiumSeriesonNeuropeptides","182","September,2015","QingYu","SchoolofPharmacyandDepartmentofChemistry,UniversityofWisconsin–Madison","ZhidanLiang","SchoolofPharmacyandDepartmentofChemistry,UniversityofWisconsin–Madison",,,,,"2166-6628","2166-6636","http://dx.
doi.
org/10.
4199/C00120ED1V01Y201409NPE005","10.
4199/C00120ED1V01Y201409NPE005","Animalbehaviorsandemotionsarefine-tunedviasignaltransmissionandcommunicationbetweencells.
Thenervoussystemgivesinstructionsandtransmitssignalstodifferentpartsofanorganismtoproducecoordinatedactivities.
Neuronsarecorecomponentsofthenervoussystemandtheyusevariouschemicalmessengerstocommunicatewithoneanother.
Neuropeptides(NPs),whicharesmallchainsofaminoacids,representthelargestclassofsignalingmolecules.
SinceNPsaredirectlyinvolvedinmodulatingmanyphysiologicalprocesses,suchasmetabolism,reproduction,learning,memory,andsocialbehaviors–thereisagrowinginterestinstudyingtheirstructures,functions,anddistributions.
ThisbookaimstosummarizeadvancesininvertebrateNPstudiesconcerningmoleculardiversities,distributions,andbiologicalfunctions.
Inaddition,theemergingmassspectrometrictechniqueshavebeendiscussedextensivelyasapowerfultoolenablingacceleratedinvertebrateNPstudies.
","TableofContents:Acknowledgments/OverviewofNeuropeptides/Mass-Spectrometry(MS)-BasedTechniquesEnablingNeuropeptideDiscovery/MajorClassesofInvertebrateNeuropeptides/ConcludingRemarks/References/AuthorBiographies""3","9781615047161","9781615047178","ScienceandEthicsinDialogue:EthicalResearchConductandGeneticInformationApplication","ColloquiumSeriesonTheGeneticBasisofHumanDisease","163","October,2015","AnnBoyd","HoodCollege"2168-4006","2168-4022","http://dx.
doi.
org/10.
4199/C00138ED1V01Y201509GBD007","10.
4199/C00138ED1V01Y201509GBD007","ThisbookrepresentsmyexperienceteachinggraduatestudentsinBiomedicalScienceatHoodCollege.
Beingsciencemajors,thestudentshavealimitedbackgroundinphilosophyandethics.
MostofthegraduatestudentsareemployedatarearesearchlaboratorieswhilealsopursuingaMasterofSciencedegree.
Theirpracticalday-to-dayexperienceinscientificresearchishelpfulindiscussionsofresponsibleconductofresearchcases.
BeingawareofincreasedcasesofmisconducttheUnitedStatesestablishedtheOfficeofResearchIntegrity(ORI).
Theirpublication,IntroductiontotheResponsibleConductofResearch,definesmisconductasfabrication,falsification,andplagiarism.
Concernforthebreachofpublictrustwithrepercussionsinscientificfundinghasledtomandatesforcoursesinethicsforstudentspursuingascientificcareer.
Inaddition,theHumanGenomeProjectmegaprojectfundedEthical,Legal,andSocialImplicationsResearch(www.
genome.
gov/ELSI/)recognizingthatthegeneticinformationproducedbytheprojectwouldcomewithappliedethicaldilemmas.
Teachingcanbeunderstoodasconveyingknowledgefromgenerationtogeneration.
Likewisesystemsofmoralityarecollectiveacquisitionsbuiltupovermillenniawithsocialnormsandvaluesthataimtomaintainsocialorder.
Researchdoesnotsupportthepremisethatknowingtherulesofconductwillpreventmisconduct.
Indeed,compliancewithrulescangiveafalsesenseofsecurity,especiallyiftheethicalreasoninggroundingtherulesisnotunderstood.
Therefore,Itrytosketchapaththroughthepotentialphasesandavenuesofascientificcareer,imaginingthatapersonmaydobasicresearch,serveonethicscommittees,andengagethepublicinethicaluseofnewadvancesingenetics.
Asaresultthecontentofthistextisdividedintothreeparts.
Thefirstpartdealswithfoundationalmaterialonscienceandethicsandcasesthathighlightproperscientificprofessionalconduct.
Thesecondpartdealswithclinicalresearchthroughwhicharesearchdiscoveryismovedtothebedsideofpatientsandtheethicalparametersofthetransition.
Thethirdpartsketchestheethicaldilemmasevolvingfromprogressingeneticinformationtoclinicalapplications.
Helpingstudentsfindamoralcompass,agroundingofwhyoneoughttobehaveinethicalwaysintheirprofessionandmoregenerallyinlifeischallenging.
Doingsoincreasestheirawarenessandmineofpotentialdilemmasandhowtodealwiththemethically.
","TableofContents:Acknowledgments/Introduction/PartI:ResponsibleConductinResearch/ProfessionalScientificConduct/Ethics/PreventingMisconduct/PartII:ResearchwithHumanSubjects:ClinicalResearchEthics/EvolutionofRegulations/BelmontPrinciples/BalancingPrinciples/MisconductinClinicalTrials/RecognizingPatientAutonomy/PartIII:GeneticMedicine/NewParadigms/ModelAnimalsLeadtoHumanDiscoveries/GeneticTestingvs.
Screening/EthicalIssuesinGeneticMedicine/IstheProspectofEugenicsaThreattoGeneticMedicine/WhereDoWeGofromHere/Bibliography/AuthorBiography""3","9781615047185","9781615047192","MolecularBasisofDevelopmentalAnomaliesoftheHumanGastrointestinalTract","ColloquiumSeriesonGenomicandMolecularMedicine","125","December,2015","CharlesShaw-Smith","RoyalDevonandExeterHospital(Heavitreesite)2167-7840","2167-7859","http://dx.
doi.
org/10.
4199/C00139ED1V01Y201509GMM006","10.
4199/C00139ED1V01Y201509GMM006","Currentknowledgeoftheetiologyofcongenitalmalformationsofthehumangastrointestinaltractiscoveredinthisbook,prefacedbysomeintroductorynotesonembryologicaldevelopment.
Malformationsinvolvingtheesophagus,stomach,smallandlargeintestine,anusandrectum,pancreas,andhepato-billiarysystemarecovered.
Thereisafocusoncoveringthosemalformationsforwhichamoleculargeneticetiologyisunderstood,butothercausations,includingenvironmentalexposures,twinning,andunknownetiologyarealsoincluded.
Forcompleteness,somedisordersareincludedwhicharenot,strictly,malformations,orwhichdonot,strictly,involvethegastrointestinaltract.
SuchdisordersincludeHirschsprungdisease,congenitaldiaphragmatichernia,omphalocele,andgastroschisis.
Suggestedapproachestoclinicalevaluationofindividualswithgastrointestinalmalformationsareincluded.
""ColloquiumCollection","PaperbackISBN","eBookISBN","Title","所属系列","Pages","Year","ISSNprint","ISSNelec","URL","DOI","Description""4","9781615046423","9781615046430","AdolescentBrainDevelopment","ColloquiumSeriesonTheDevelopingBrain","104","04-02-20","2159-5194","2159-5208","https://doi.
org/10.
4199/C00133ED1V01Y201602DBR012","10.
4199/C00133ED1V01Y201602DBR012","Adolescentbraindevelopmentisafascinating,newlydevelopingfieldthathassomuchtoofferalmostanyoneinterestedinlearningmore.
Adolescencehasonlycometobeestablishedasauniquedevelopmentalphaseinthelastfewdecadesorso.
Wenowknowthatthehumanbrainundergoesdramaticdevelopmentalchangesinthepostnatalperiod,notonlyearlyafterbirthbutalsoextendingallthewayintoadulthood.
Thesechangesarenotuniform,inthatthebrainregionsundergoingthemostchangeduringadolescencearenotthesameastheregionsthatchangedmostintheearlylifeperiod,andtheprocessesofchangealsodifferasweage.
Someofthemostimportantchangesthatweseeduringtheadolescentperiodare:1)pruning(orremoval)ofexcessiveneuralconnections,2)increasesinwhitematter,theportionofbrainmatterthatallowsdifferentregionstocommunicatewithoneanother,and3)thinningofthecortex,whichiscomprisedoftheouterlayersofbrainmatter.
Comparedwithotherareasofthebrain,thefrontalandtemporalcorticesundergothemostprotractedchangesintheirstructure,implyingthatdevelopmentsintheseareasplayalargeroleinprovidingthefoundationforadolescentbehaviouralchanges.
Inthisbook,wecompareadolescentbehaviouralchangeswithongoingchangesinthebrainanddiscusspotentialimplicationsforhealthandeducationalpolicy-making.
""4","9781615047222","9781615047239","TheCerebralCirculation,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","80","07-29-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00141ED2V01Y201607ISP066","10.
4199/C00141ED2V01Y201607ISP066","Thise-bookwillreviewspecialfeaturesofthecerebralcirculationandhowtheycontributetothephysiologyofthebrain.
Itdescribesstructuralandfunctionalpropertiesofthecerebralcirculationthatareuniquetothebrain,anorganwithhighmetabolicdemandsandtheneedfortightwaterandionhomeostasis.
Autoregulationispronouncedinthebrain,withmyogenic,metabolicandneurogenicmechanismscontributingtomaintainrelativelyconstantbloodflowduringbothincreasesanddecreasesinpressure.
Inaddition,unlikeperipheralorganswherethemajorityofvascularresistanceresidesinsmallarteriesandarterioles,largeextracranialandintracranialarteriescontributesignificantlytovascularresistanceinthebrain.
Theprominentroleoflargearteriesincerebrovascularresistancehelpsmaintainbloodflowandprotectdownstreamvesselsduringchangesinperfusionpressure.
Thecerebralendotheliumisalsouniqueinthatitsbarrierpropertiesareinsomewaymorelikeepitheliumthanendotheliumintheperiphery.
Thecerebralendothelium,knownastheblood-brainbarrier,hasspecializedtightjunctionsthatdonotallowionstopassfreelyandhasverylowhydraulicconductivityandtranscellulartransport.
ThisspecialconfigurationmodifiesStarling'sforcesinthebrainmicrocirculationsuchthationsretainedinthevascularlumenopposewatermovementduetohydrostaticpressure.
Tightwaterregulationisnecessaryinthebrainbecauseithaslimitedcapacityforexpansionwithintheskull.
Increasedintracranialpressureduetovasogenicedemacancausesevereneurologiccomplicationsanddeath.
""4","9781615047246","9781615047253","MolecularGeneticsofThalassemiaSyndromes","ColloquiumSeriesonGenomicandMolecularMedicine","57","08-15-20","2167-7840","2167-7859","https://doi.
org/10.
4199/C00142ED1V01Y201607GMM007","10.
4199/C00142ED1V01Y201607GMM007","Thisbookreviewsthemoleculargeneticsofthethalassemiasyndromes,inheritedhemoglobindisordersthatcomprisethecommonestmonogenicdisordersglobally.
Thalassemiasarefoundinhighfrequenciesintropicalregionscorrespondingtothemalariabelt.
BetathalassemiatraitsshowhighHbA2byHPLC,andβ-globinmutations(commonlypointmutations)aredetectedbyusingARMS-PCR,reversedot-blotanalysisandβ-globingenesequencing.
Globally>300βglobingenemutationsexist,howeverregionalmutationsarelimitedto5-6commonones.
Alphaglobingenedefectscanonlybeidentifiedbymoleculartests,theexceptionbeingHbHdiseasethatshows""golfball""appearanceinHbHpreparation,pre-integrationpeaksonHPLCandafast-movingbandonhemoglobinelectrophoresis.
MultiplexGap-PCRidentifiescommonα-globingenedeletions.
SpecificPCRacrossthejunctioncausedbytheunequalcrossingovercandetectα-genetriplication.
However,heterozygosityorhomozygoustriplicationcannotberesolvedbythistechnique.
Non-deletionalα-thalassemiacanbecharacterizedbyspecificα-globingenesequencing.
IdentificationofunusualdeletionsrequiresMultiplexLigation-dependentProbeAmplification.
Inconclusion,themolecularcharacterizationofhumanglobingenedisordersisrequiredtoresolvethephenotypicallyheterogeneousthalassemiasyndromes.
Molecularanalysisisalsoanimportanttooltopreventthesedisordersbyofferingprenatalscreeninginregionswithahighdiseaseburden.
""4","9781615047208","9781615047215","RegulationofTissueOxygenation,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","99","08-19-20","2167-7840","2167-7859","https://doi.
org/10.
4199/C00140ED2V01Y201606ISP065","10.
4199/C00140ED2V01Y201606ISP065","Thispresentationdescribesvariousaspectsoftheregulationoftissueoxygenation,includingtherolesofthecirculatorysystem,respiratorysystem,andblood,thecarrierofoxygenwithinthesecomponentsofthecardiorespiratorysystem.
Therespiratorysystemtakesoxygenfromtheatmosphereandtransportsitbydiffusionfromtheairinthealveolitothebloodflowingthroughthepulmonarycapillaries.
Thecardiovascularsystemthenmovestheoxygenatedbloodfromthehearttothemicrocirculationofthevariousorgansbyconvection,whereoxygenisreleasedfromhemoglobinintheredbloodcellsandmovestotheparenchymalcellsofeachtissuebydiffusion.
Oxygenthathasdiffusedintocellsisthenutilizedinthemitochondriatoproduceadenosinetriphosphate(ATP),theenergycurrencyofallcells.
ThemitochondriaareabletoproduceATPuntiltheoxygentensionorPO2onthecellsurfacefallstoacriticallevelofabout4–5mmHg.
Thus,inordertomeettheenergeticneedsofcells,itisimportanttomaintainacontinuoussupplyofoxygentothemitochondriaatorabovethecriticalPO2.
Inordertoaccomplishthisdesiredoutcome,thecardiorespiratorysystem,includingtheblood,mustbecapableofregulationtoensuresurvivalofalltissuesunderawiderangeofcircumstances.
Thepurposeofthispresentationistoprovidebasicinformationabouttheoperationandregulationofthecardiovascularandrespiratorysystems,aswellasthepropertiesofthebloodandparenchymalcells,sothatafundamentalunderstandingoftheregulationoftissueoxygenationisachieved.
""4","9781615046904","9781615046911","X&YChromosomalVariations:Hormones,BrainDevelopment,andNeurodevelopmentalPerformance","ColloquiumSeriesonTheDevelopingBrain","122","10-14-20","2159-5194","2159-5208","https://doi.
org/10.
4199/C00134ED1V01Y201506DBR013","10.
4199/C00134ED1V01Y201506DBR013","ThisisthefirstbookonXandYchromosomaldisorderstoaddressthesecommonbutrarelydiagnosedconditions.
Thisbookseekstopresentthelatestinresearchandclinicalcareaddressingneuroimaging,theinteractionbetweenhormones,braindevelopment,andneurodevelopmentalprogression.
Thisbookwillprimarilyfocuson47,XXY(Klinefeltersyndrome,orKS),47,XYY(Jacobs'syndrome),and47,XXX(TripleX).
Morevariantdisorderssuchas48,XXXX,48,XXXYand49,XXXXYwillbediscussed.
Topicsofinterestincludeneurologicalfunctioning,neuroimaging,sociallanguage,andtheevolvingperspectivesoftheseXYchromosomaldisorders.
Theeffectsoftestosteronesupplementationinmaleswith47,XXYwillalsobeexamined.
""4","9781615046843","9781615046850","VascularSmoothMuscleFunctioninHypertension","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","96","10-21-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00129ED1V01Y201503ISP061","10.
4199/C00129ED1V01Y201503ISP061","Hypertensionisdefinedbyanincreaseinsystemicbloodpressureabovelimitsconsiderednormal,currentlysetat140mmHgforsystolicand90mmHgfordiastolicpressure.
Assumingcentralvenouspressuretobenearzero,meanarterialpressureisdeterminedbytheproductoftotalperipheralresistanceandcardiacoutput.
Inmostcasesofessentialhypertension,aswellasinanimalmodelsofhypertension,cardiacoutputanditsmaindeterminants,strokevolumeandheartrate,arenormal,whereastotalperipheralresistanceisincreased.
TotalperipheralresistanceisinfluencedbyanumberoffactorsdescribedbythePoiseuille'slaw,themostsignificantofwhichbyfaristhediameterofbloodvesselsofthearterialtree.
Sincebloodvesseldiameterisareflectionofbothvascularstructureandactiveregulationofvasculartonethroughmechanismsofvasoconstrictionandvasodilatation,itisgenerallyconsideredthatalterationsintotalperipheralresistancearedirectlydeterminedbyalterationsinvascularsmoothmusclestructureand/orfunction.
Thus,complexbloodpressureregulationsystems,includingrenal,nervous,endocrine,immune,andothers,intheirturninfluencedbygeneticorenvironmentalfactors,convergeuponthesamemolecularmechanismsthatcontrolthestructureandfunctionofvascularsmoothmuscle.
Inthiswork,ratherthanprovidingtheexhaustivelistofmodificationsinthebloodpressureregulatingsystemsthatultimatelyaffectthevasculatureinhypertension,wewillfocusonthestructuralandfunctionalalterationsofvascularsmoothmuscleperseduringhypertension.
""4","9781615047307","9781615047314","NG2-Glia(Polydendrocytes)","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","43","11-01-20","2375-9933","2375-9917","https://doi.
org/10.
4199/C00143ED1V01Y201610NGL009","10.
4199/C00143ED1V01Y201610NGL009","Classically,thecentralnervoussystem(CNS)wasconsideredtocontainneuronsandthreemaintypesofglialcells—astrocytes,oligodendrocytes,andmicroglia.
Now,ithasbeenclearlyestablishedthatNG2-gliaareafourthglialcelltypethatareidentifiedanddefinedbytheirexpressionoftheNG2chondroitinsulfateproteoglycan(Cspg4).
NG2-gliadifferentiateintooligodendrocytes,themyelin-formingcellsoftheCNS,underthecontrolofmultipleextacellularandintrinsicfactors.
Duetothis,NG2-gliaareoftenreferredtointheliteratureasoligodendrocyteprogenitorcells(OPCs).
ThenamepolydendrocyteshasbeensuggestedforNG2-glia(OPCs),toemphasizetheirnatureasafourthdistinctglialcelltype.
NG2-gliarespondrapidlytoneurotransmissionviatheirsynapticconnectionswithneuronsandtheirrepertoireofneurotransmitterreceptorsandionchannels.
BidirectionalinteractionsbetweenNG2-gliaandneuronsarealsoimportantforsynapticfunctionandneuronalintegrity.
NG2-gliarespondtomostneuropathologiesbyincreasedproliferationanddifferentiationintooligodendrocytes,whichiscriticalforreplacingdamagedmyelinafterinjuryandindemyelinatingdiseases,suchasmultiplesclerosis.
ThereisalsoevidenceNG2-gliaarecapableofgeneratingastrocytesandneuronsundersomecircumstances.
ThefullcapacityofNG2-gliaisnotyetclear,buttheirkeyfunctionisthelifelonggenerationofoligodendrocytes,whichisabsolutelycriticalforCNSfunctionandintegrity.
""4","9781615047321","9781615047338","MolecularMechanismsofBodyWaterHomeostasis","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","100","11-09-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00144ED1V01Y201610ISP067","10.
4199/C00144ED1V01Y201610ISP067","Thisbookdiscussesourintimaterelationshipwithanddependenceonwater,howthebodyregulatesitswaterlevels,andvariouspathophysiologicalstatesassociatedwithimpairmentsinbodywaterhomeostasis.
Thehumanbodyconsistsof70–80%water.
Therefore,concisecontrolofwaterhomeostasisisessentialtosurvivalandinvolvescoordinationofseveralsystems,butprimarilythebrainandkidneysystems.
Waterrequirementsoftheaveragehealthyhumanrangebetween2–4L/d,andamajorportionofthiscancomefromfoodsources.
Themajorhormonalregulatorofwaterbalanceistheanti-diuretichormone,vasopressin.
Vasopressin,a9–aminoacidpeptide,isproducedinthehypothalamus,storedintheposteriorpituitary,andsecretedwhenplasmaosmolalityrises.
Vasopressinactsonthekidneytoconservewater.
Thekidneysfilter180Lofbloodperday,consistingofabout50–65%water,andreabsorbaround99%ofthisintheproximaltubule,distaltubule,andcollectingduct,producingonly1–2Lofurine.
Thevasopressin-sensitivedistaltubuleandcollectingductareresponsibleforfine-tuningwaterreabsorption.
Conditionsexist,however,whereurinecannotbeconcentratedeffectively.
Thisisknownasdiabetesinsipidusandcanleadtodehydrationandfailuretothrive.
Attheotherextreme,hyponatremia(lowserumsodium)istheinabilitytoadequatelydiluteurineorgetridoffreebodywaterinexcessofbodyneeds,aseriousandsometimesfatalcondition.
""4","9781615047345","9781615047352","RegulationofGastrointestinalMucosalGrowth,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","132","11-23-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00145ED2V01Y201610ISP068","10.
4199/C00145ED2V01Y201610ISP068","Themammaliangastrointestinalmucosaisarapidlyself-renewingtissueinthebody,anditshomeostasisispreservedthroughthestrictregulationofepithelialcellproliferation,growtharrest,andapoptosis.
Thecontrolofthegrowthofgastrointestinalmucosaisuniqueand,comparedwithmostothertissueinthebody,complex.
Mucosalgrowthisregulatedbythesamehormonesthataltermetabolisminothertissues,butthegastrointestinalmucosaalsorespondstohosteventstriggeredbytheingestionandpresenceoffoodwithinthedigestivetract.
Theseguthormonesandpeptidesregulatethegrowthoftheexocrinepancreas,gallbladderepithelium,andthemucosaoftheoxynticglandregionofthestomachandthesmallandlargeintestines.
Luminalfactors,includingnutrientsorotherdietaryfactors,secretions,andmicrobesthatoccurwithinthelumenanddistributeoveraproximal-to-distalgradient,arealsocrucialformaintenanceofnormalgutmucosalregenerationandcouldexplainthevillous-height-crypt-depthgradientandvarietyofadaptation,sincethesefactorsarediluted,absorbed,anddestroyedastheypassdownthedigestivetract.
Recently,intestinalstemcells,cellularpolyamines,andnoncodingRNAsareshowntoplayanimportantroleintheregulationofgastrointestinalmucosalgrowthunderphysiologicalandvariouspathologicalconditions.
Inthisbook,wehighlightkeyissuesandfactorsthatcontrolgastrointestinalmucosalgrowthandhomeostasis,withspecialemphasisonthemechanismsthroughwhichepithelialrenewalandapoptosisareregulatedatthecellularandmolecularlevels.
""4","9781615047260","9781615047277","CardiovascularResponsestoExercise,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","122","12-02-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00146ED2V01Y201610ISP069","10.
4199/C00146ED2V01Y201610ISP069","Exerciseistheactofincreasingmetabolicrateforthepurposeofenhancingphysicalfitness.
Exercisecanbeoneofthemoststressfulphysiologicalresponsesthatthebodyundertakes.
Withexercise,thereareincreasesinmetabolicrate,heartrate,bloodflow(hyperemia),respiration,andheatproduction.
Theincreasedmetabolicrequirementduringexerciseiswellmetbyanincreasedbloodflow(functionalhyperemia)andoxygensupplytotheexercisingtissue,whichisregulatedbymultiplelocalandsystemicmechanisms.
Thelocalmechanisms(factors)areresponsibleformediatingthemusclehomeostasisandvascularconductancetomatchtheincreasedmetabolicrequirement,whereasthesystemicmechanismsareresponsibleforthemaintenanceofbloodpressureandglobalcardiovascularhomeostasis,includingtheincreaseinandredistributionofcardiacoutput,whichismainlymediatedbysympatheticactivation.
Forinstance,thesubstantialdecreasesinvascularresistanceandresultantlargeincreaseinbloodflowduringexerciserequirehigherbloodpressureandmorecardiacoutput,suchthatthemetabolicallyactivemusclecanbeperfusedwithadequatebloodflow.
Thisbookwillprovideanoverviewofthecardiovascularresponsestoexerciseunderphysiologicalconditionsaswellassomepathologicalcircumstances.
""4","9781615047376","9781615047383","TheBiliarySystem,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","178","12-16-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00147ED2V01Y201611ISP071","10.
4199/C00147ED2V01Y201611ISP071","Theliverisavitalorganinvolvedinnumerousmetabolicprocessessuchascholesterolandbileacidmetabolism,biliarylipidsecretion,andbileformation.
CholesterolbalanceacrosstheliverhasacrucialeffectoninfluencingplasmatotalandLDLcholesterollevelsandbiliarycholesterolconcentrations.
Cholesterolandbileacidbiosynthesesareprimarilymodulatedbynegativefeedbackregulatorymechanismsthroughthesterolregulatoryelement-bindingproteinisoform2(SREBP-2)andthefarnesoidXreceptor(FXR)pathways,respectively.
Theconversionofcholesteroltobileacidsinthelivercanbalancethefecalexcretionofbileacids,whichisanimportantroutefortheremovalofcholesterolfromthebody.
Bileformationbeginsinthebilecanaliculi,andmaintenanceoftheenterohepaticcirculationofbileacidsresultsinacontinuoussecretionofbile.
HepaticsecretionofbiliarylipidsisdeterminedmainlybyagroupofATP-bindingcassette(ABC)transportersthatarelocatedonthecanalicularmembraneofhepatocytes,whichareregulatedbyvariousnuclearreceptors.
Bileacidspromotebileflowbytheirosmoticeffects.
Also,theyareessentialfortheintestinalabsorptionofcholesterol,fattyacids,andfat-solublevitaminsandplayanimportantroleinaidingthedigestionofdietaryfat.
Bileacidsfunctionassignalingmoleculesandanti-inflammatoryagentstoregulatelipid,glucose,andenergymetabolismbyrapidlyactivatingnuclearreceptorsandcellsignalingpathways.
ThiseBooksummarizestheprogressinthemolecularandcellularmechanismsofcholesterolandbileacidmetabolismandthephysical-chemistryofbiliarylipids,withemphasisonbiliarylipidmetabolismthatisregulatedbynuclearreceptorsinthehepatobiliarysystem.
""4","9781615047390","9781615047406","TheBlood-BrainBarrierinHealthandDisease","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","67","12-16-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00148ED1V01Y201612ISP072","10.
4199/C00148ED1V01Y201612ISP072","Theblood-brainbarrier(BBB)isacomplexanddynamicstructurethatprotectsthebrainfromcellswithinthevasculature,fromtheimmunesystemandfrompathogens.
Thisbarrierispresentinarterioles,capillariesandvenulesandisformedatthelevelofadjacentendothelialcells,whicharecoupledtoastrocytes,microglia,neuronsandpericytes.
Thestructureofthisendothelialbarrierisuniqueamongendotheliaofotherorgansystemsandiscomposedofcomplexesmadeupoftight,gapandadherensjunctions.
Inaddition,itistheresponsibilityofthesurroundingcellularelementstomaintaintheintegrityofthejunctionalcomplexesandrestricttheentryofsubstancesfromthebloodintothebrain.
ChangesinpermeabilityoftheBBBduringphysiologicandpathophysiologicconditionsinvolvealterationsinspecifictransportersattheleveloftheendothelium,activationofspecificcellularsecondmessengerpathwaysand/orthedissolutionofthejunctionalcomplexescomposingtheBBB.
ThisbookfocusesonvariousaspectsthataccountfortheformationandmaintenanceoftheBBB,andondiseasestatesthatcompromisethisbarrier.
""4","9781615047468","9781615047475","PolycysticKidneyDisease","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","47","01-25-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00150ED1V01Y201612ISP073","10.
4199/C00150ED1V01Y201612ISP073","Thisbookreviewsimportantaspectsofpolycystickidneydiseases,thelatestscientificunderstandingofthediseasesandsyndromes,alongwiththetherapiesbeingdeveloped.
Cystickidneydiseasescompriseaspectrumofgeneticsyndromesdefinedbyrenalcystformationandexpansionwithvariableextrarenalmanifestations.
Themostprevalentdisorderistheautosomaldominantpolycystickidneydisease(ADPKD).
Itisthemostcommonmonogeneticdisorderinhumansandaccountsfor4.
4%ofend-stagerenaldisease(ESRD)casesintheU.
S.
PatientsinevitablyprogresstoESRDandrequirerenalreplacementtherapyintheformofdialysisortransplantation.
Throughadvancementsingenomicsandproteomicsapproaches,novelgenesresponsibleforcysticdiseaseshavebeenidentified,furtherexpandingourunderstandingofbasicmechanismsofdiseasepathogenesis.
Thehallmarkamongallcysticgeneticsyndromesistheformationandgrowthoffluid-filledcysts,whichoriginatefromtubularepitheliaofnephronsegments.
Cystsarethedisease,andtreatmentstrategiesarebeingdevelopedtotargetpreventionordelayofcystformationandexpansionatanearlystage,howevernosuchtherapyiscurrentlyapproved.
""4","9781615047444","9781615047451","ClinicalandMolecularHeterogeneityofOsteogenesisImperfecta","ColloquiumSeriesonGenomicandMolecularMedicine","63","01-30-21","2167-7840","2167-7859","https://doi.
org/10.
4199/C00149ED1V01Y201612GMM008","10.
4199/C00149ED1V01Y201612GMM008","Osteogenesisimperfecta(OI)isadiseaseencompassingagroupofdisordersmainlycharacterizedbybonefragilityandisthecommonestformofheritablebonefragility.
Inthisbook,theclinicalpresentationswithparticularemphasisonrarephenotypesassociatedwithOIarediscussedtogetherwithmolecularadvancesindiagnosisandtreatmentofOI.
ThereisabroadspectrumofclinicalseverityinOI,rangingfrommultiplefracturesinuteroandperinataldeath,tonear-normaladultstatureandlowfractureincidence.
Facialdysmorphismhasbeennoted,butisnotwelldescribed,norisitaninvariablefeature.
Sillenceetal.
,in1979,providedtheclinicalclassification,whichhasbeenfurtherexpanded.
Geneticdefectsintype1collagencanbeidentifiedin85%ofpatientswithaclinicaldiagnosisofOI,thatis,mutationsinCOL1A1/COL1A2,whichfollowsanautosomaldominantpatternofinheritance.
SeveralgeneshavenowbeenimplicatedinautosomalrecessiveformsofOIandX-linkedosteoporosis.
GiventhepossibleantenatalpresentationandprognosisassociatedwithOI,itisimportanttomakethisdiagnosisearlyandbeabletodistinguishthisfromotherlethalskeletaldysplasias.
Itisalsoimportanttodistinguishnonaccidentalinjuryfromapathologicalcauseoffractures,suchasOI,anddiagnosethispromptlyinthesesituations.
However,thisisnotalwayspossibleduetovariabilityinpresentationandinabilitytopinpointtheprecisegeneticetiologydespiteextensivegenetictesting.
OIisonesuchraregeneticconditionwheretreatmentisavailableintheformofbisphosphonates,whichhasahugeimpactonqualityoflife.
Despiteadvancesinmedicaltherapy,multidisciplinarymanagementincludingphysiotherapyremainsthemainstayoftreatmentandimprovedoutcomesinOI.
""4","9781615047482","9781615047499","TheEndocannabinoidSysteminLocalandSystemicInflammation","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","192","03-28-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00151ED1V01Y201702ISP074","10.
4199/C00151ED1V01Y201702ISP074","Thisbookfocusesontheroleoftheendocannabinoidsysteminlocalandsystemicinflammation,withindividualchapterswrittenbyexpertsinthefieldofcannabinoidresearchandmedicine.
Thetopicsexploretheactionsoftheendocannabinoidsystemontheimmunesystem,includingneuroinflammationinautoimmunedisorderssuchasmultiplesclerosis,andinneurodegenerativedisorderssuchasHuntington'sandAlzheimer's,aswellaslocalandsystemicinflammatoryconditionsaffectingorgansincludingtheeye(uveitisandcornealinflammation),thebladder(interstitialcystitis),pancreas(diabetes),cardiovascularsystem(stroke),joints(arthritis),andsepsis.
Theobjectiveofthisbookistoprovideknowledgetransferontheuseofcannabinoidsininflammatorydiseasebycriticallyexaminingpreclinicalandclinicalresearchontheimmunomodulatoryactionsoftheendocannabinoidsystem,withspecificemphasisontheactionsofcannabinoidsindiseaseswhereinflammationisaprominentcomponent.
Bydrawingtheseresultstogether,weseektoprovidefurtherunderstandingofthecomplexitiesofendocannabinoidsystemmodulationofimmunefunctionandidentifypotentialusesandlimitationsforcannabinoid-basedtherapeutics.
""4","9781615047505","9781615047512","VascularBiologyofthePlacenta,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","113","06-24-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00153ED1V01Y201704ISP075","10.
4199/C00153ED1V01Y201704ISP075","Theplacentaisanorganthatconnectsthedevelopingfetustotheuterinewall,therebyallowingnutrientuptake,wasteelimination,andgasexchangeviathemother'sbloodsupply.
Propervasculardevelopmentintheplacentaisfundamentaltoensuringahealthyfetusandsuccessfulpregnancy.
Thisbookprovidesanup-to-datesummaryandsynthesisofknowledgeregardingplacentalvascularbiologyanddiscussestherelevanceofthisvascularbedtothefunctionsofthehumanplacenta.
""4","9781615046683","9781615046690","IntroductiontoQuantitativeCellBiology","ColloquiumSeriesonQuantitativeCellBiology","50","07-21-21","2375-7744","2375-7752","https://doi.
org/10.
4199/C00121ED1V01Y201409QCB002","10.
4199/C00121ED1V01Y201409QCB002","Forthepastdecadeormore,muchofcellbiologyresearchhasbeenfocusedondeterminingthekeymoleculesinvolvedindifferentcellularprocesses,ananalyticalproblemthathasbeenamenabletobiochemicalandgeneticapproaches.
Now,wefaceanintegrativeproblemofunderstandinghowallofthesemoleculesworktogethertoproducelivingcells,achallengethatrequiresusingquantitativeapproachestomodelthecomplexinteractionswithinacell,andtestingthosemodelswithcarefulquantitativemeasurements.
Thisbookisanintroductoryoverviewofthevariousapproaches,methods,techniques,andmodelsemployedinquantitativecellbiology,whicharereviewedingreaterdetailintheothervolumesinthise-bookseries.
Particularemphasisisplacedonthegoalsandpurposeofquantitativeanalysisandmodeling,andthespecialchallengesthatcellbiologyholdsforunderstandinglifeatthephysicallevel.
""4","9781615047284","9781615047291","SexandtheDevelopingBrain,SecondEdition","ColloquiumSeriesonTheDevelopingBrain","141","09-01-21","2159-5194","2159-5208","https://doi.
org/10.
4199/C00152ED1V01Y201703DBR014","10.
4199/C00152ED1V01Y201703DBR014","Thebrainsofmalesandfemales,menandwomen,aredifferent,thatisafact.
Whatisdebatedishowdifferentandhowimportantarethosedifferences.
Sexdifferencesinthebrainaredeterminedbygenetics,hormones,andexperience,whichinhumansincludesculture,society,andparentalandpeerexpectations.
Theimportanceofnonbiologicalvariablestosexdifferencesinhumansisparamount,makingitdifficultifnotimpossibletoparseoutthosecontributionsthataretrulybiological.
Thestudyofanimalsprovidesustheopportunitytounderstandthemagnitudeandscopeofbiologicallybasedsexdifferencesinthebrain,andunderstandingthecellularmechanismsprovidesusinsightintonovelsourcesofbrainplasticity.
Manysexdifferencesareestablishedduringadevelopmentalsensitivewindowbydifferencesinthehormonalmilieuofmalesversusfemales.
Theneonataltestisproduceslargeamountsoftestosteronewhichgainsaccesstothebrainandisfurthermetabolizedintoactiveandrogensandestrogenswhichmodifybraindevelopment.
Majorparametersthatareinfluencedbyhormonesincludeneurogenesis,celldeath,neurochemicalphenotype,axonalanddendriticgrowth,andsynaptogenesis.
Varianceintheseparametersresultsinsexdifferencesinthesizeofparticularbrainregions,theprojectionsbetweenbrainregions,andthenumberandtypeofsynapseswithinparticularbrainregions.
Thecellularmechanismsarebothregionandendpointspecificandinvokemanysurprisingsystemssuchasprostaglandins,endocannabinoids,andcelldeathproteins.
Epigeneticmodificationstothegenomebothestablishandmaintainsexdifferencesinthebrainandbehavior.
Byunderstandingwhen,why,andhowsexdifferencesinthebrainareestablished,wemayalsolearnthesourceofstronggenderbiasesintherelativeriskandseverityofnumerousneurologicaldiseasesanddisordersofmentalhealth.
Boysaremuchmorelikelytobediagnosedwithautismspectrumorattentionandhyperactivitydisorders,aswellasspeechandlanguagedeficits,comparedtogirls.
Bycontrast,womenaremorelikelytosufferfromaffectivedisorders,suchasdepression,anxiety,compulsion,andeatingdisordersandmorelikelytoexperienceautoimmuneandneurodegenerativedisorders.
Schizophreniawithanearlyonsetismorecommoninmalesbutalate-onsetversionismarkedlymorefrequentinfemales.
Malebiaseddisordershaveoriginsindevelopmentwhilefemalebiaseddisordersarealmostexclusivelypost-puberty.
Thisremarkableshiftindiseaseriskdemandsourattention.
Novelinsightsintothebiologicaloriginsofdiseasearealsogainedbycomparingandcontrastingthesameprocessesindifferentsexes.
""4","9781615047567","9781615047574","Sepsis:StagingandPotentialFutureTherapies","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","91","09-12-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00157ED1V01Y201708ISP077","10.
4199/C00157ED1V01Y201708ISP077","Sepsisisalife-threateningorgandysfunctioncausedbyadysregulatedhostresponsetoinfection.
Variabilityinpathogenesisandcomplexpathophysiologyoftendelaydiagnosisandcreatesignificantchallengesforclinicalstudiesinthisgroupofcriticallyillpatients.
Mainlyforthosereasons,thereisnotherapyapprovedsofartoovercometheunderlyingimmunedysregulation.
Thisbookprovidesanoverviewaboutthestateoftheartofsepsisdiagnosticsandpotentialfuturetherapies.
Chapter1focusesontheimmunologicstagingofsepsis—thekeyforsuccessfultreatmentofthedysregulatedhotresponse.
Chapter2revealssimilaritiesintheimmuneresponseinsepsisandcancer—openingnewavenuesfornoveltherapies.
Chapter3introducesanimportantmodulatoroftheimmuneresponse—theendogenouscannabinoidsystemandelucidatesitsroleinorgandysfunctioninsepsis.
Facingtheincreasingbacterialresistancetoclassicalantibiotics,Chapter4discussestwouniquemechanismstotreatinfectionandinflammationinsepsis:ironchelation,andthesphingosinepathway.
Theauthors,allexpertsinexperimentalandclinicalsepsisresearch,seektoprovidefurtherunderstandingofthecomplexitiesoftheimmuneresponseasthephysiologicalbasisforthedevelopmentofnewtherapeuticsinsepsis.
""4","9781615047529","9781615047536","FromGenetoTherapy:UnderstandingHumanDiseasethroughGenetics","ColloquiumSeriesonTheGeneticBasisofHumanDisease","89","09-13-21","2168-4006","2168-4022","https://doi.
org/10.
4199/C00154ED1V01Y201707GBD008","10.
4199/C00154ED1V01Y201707GBD008","ThisColloquiumLectureprovidesanoverviewoftheprogressmadeinmolecularmedicineapplyinggeneticsandgenomicstotheunderstanding,diagnosis,andtreatmentofhumandiseases.
Specifically,themethodsforidentifyinggenesinvolvedinhumandiseasesaredescribed.
Examplesfrom10genesanddiseaseswillbeprovided,drawingontheauthor'sresearch.
TopicsincludeexamplesfromsimpleMendeliandiseases,suchascysticfibrosis,inheritedcancers,oncogenesactivatedbychromosomaltranslocations,hostgenesinvolvedininfectiousdisease,genesidentifiedviagenomewideassociationstudies,pathogenscausingcancer,andgenefamiliescontributingtomultiplediseases.
Foreachexample,historicaldetailswillbeprovidedasbackgroundforreaderstounderstandthecontextandprocessofthediscoveries,technologiesexplained,andcurrentunderstandingandtreatmentimplicationsdetailed.
""4","9781615047543","9781615047550","EndothelialLuminalMembrane-Glycocalyx:FunctionalitiesinHealthandDisease","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","159","11-03-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00155ED1V01Y201708ISP076","10.
4199/C00155ED1V01Y201708ISP076","Thisbookfocusesonthestructural,biochemical,anddiversefunctionalpropertiesoftheendothelialluminalmembraneglycocalyx(ELMG),anorganellewhichconstitutestheendothelialcell"membrane.
"Itisintendedtoprovidethenewcomerwithabroad,basic,andbriefperspectiveoftheluminalendothelialvascularmembrane,andforthemoreestablishedinvestigator,abasicoverviewandintegratedperspectiveofthe"universe"weexplore.
Theendotheliumisanassortmentofheterogeneousregulatorycellswhosecytoplasmandcellmembranesarejoined,formingfunctionalunits.
Thereisatremendousamountofliteratureontheendothelialcell,constitutingseeminglyisolatedanddistinctfieldsofencapsulatedresearch.
However,themultifunctionalpropertiesofsomemoleculesgiverisetoanoverlapoffindings,frequentlyignoredbetweenthedifferentfields.
Thebookisdividedintothreeparts.
ThefirstpartconcentratesonthestructureoftheELMG,withemphasisonmorphologicalandbiochemicalcomposition.
TheimportanceofthechemicalcompositiontothephysiologicalfunctionsoftheELMG,suchassievingproperties,pharmacology,andflowsensing,isthefocusofthesecondpartofthebook.
Finally,someofthepathologiesassociatedwithELMGdysfunctionareexploredinthelastsection.
Theaimistoprovidebasicandwell-establishedknowledgeinthevariousindividualfields,identifythecurrentconceptsineacharea,anddiscusstheirrespectivestrengthsandweaknesses(includinghiddenproblems).
Finally,theoverallgoalistointegrateareaswhereoverlapisclearlyindicated,bringingthemalltogethertoprovidethefirsteverbasic,integrative,panoramicbird's-eyeviewofthefield.
""4","9781615047581","9781615047598","AlexanderDisease:AGuideforPatientsandFamilies","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","96","11-15-21","2375-9933","2375-9917","https://doi.
org/10.
4199/C00156ED1V01Y201708NGL010","10.
4199/C00156ED1V01Y201708NGL010","ThisbookoffersacomprehensiveoverviewofAlexanderdisease,arareanddevastatingneurologicaldisorderthatoftenaffectsthewhitematterofthebrainandspinalcord.
ItsdistinctiveneuropathologyconsistsofabundantRosenthalfiberswithinastrocytes(oneofthefourmajorcelltypesofthecentralnervoussystem).
NearlyallcasesarecausedbyvariantsinthegeneencodingtheintermediatefilamentproteinGFAP,buthowthesechangesinGFAPleadtothewidespreadmanifestationsofdiseaseispoorlyunderstood.
Astrocytes,whilediscoveredoveracenturyago,arethemselvesstillmuchofamystery.
Theyexhibitconsiderablediversity,defyprecisedefinition,andyetactivelyregulatemanyaspectsofnervoussystemfunctioning.
WealsohaveincompleteunderstandingofRosenthalfibers,oddstructuresthatcontainGFAPasjustoneofmanycomponents.
Whethertheyaretoxicorprotectiveisunknown.
Moreover,RosenthalfibersarenotabsolutelyuniquetoAlexanderdisease,andareseensporadicallyinawidevarietyofotherconditions,includingbraintumorsandmultiplesclerosis.
GFAPisthethirdunknown.
Itisanancientprotein,arisingearlyintheevolutionofvertebrates,butitsroleinnormalbiologyisstillamatterofdebate.
YetAlexanderdiseaseshows,withoutadoubt,thatchangingjustasingleofits432aminoacidscanleadtocatastrophe,notjustintheastrocyteswhereGFAPisproducedbutalsointheothercellswithwhichastrocytesinteract.
Despitealloftheunknowns,muchhasbeenlearnedinthepast20years,anditistimetosharethisknowledge.
Thisbookisintendedforrecentlydiagnosedpatientsandfamilies,aswellasnon-specialistresearchersinterestedinthisneurologicaldisease.
Itcovershistoricalorigins,thestateofcurrentknowledge,andprospectsforwhatliesahead,withcitationstotheprimaryliteraturegiventhroughout.
""4","9781615047604","9781615047611","PathophysiologyofPulmonaryHypertension","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","104","11-23-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00158ED1V01Y201710ISP078","10.
4199/C00158ED1V01Y201710ISP078","Pulmonaryhypertensionisalife-threateningdiseasewithnoknowncure.
Hereweprovideaconciseyetcomprehensivereviewofthecurrentknowledgeaboutthepathophysiologyofpulmonaryhypertension(PH).
Theunderlyingsignalingmechanismsinvolvedinpulmonaryvascularremodelingandtheexaggeratedvascularcontractility,twocharacteristicfeaturesofpulmonaryhypertension,arediscussedindepth.
Therolesofinflammation,immunity,andrightventricularfunctioninthepathobiologyofpulmonaryhypertensionarediscussed.
Theepidemiologyofthefivegroupsofpulmonaryhypertension(WorldHealthOrganizationclassification;Nice,2013)isalsobrieflydescribed.
AclearunderstandingofourcurrentknowledgeaboutthepathogenesisofPHisessentialforfurtherexplorationoftheunderlyingmechanismsinvolvedinthisdiseaseandforthedevelopmentofnewtherapeuticmodalities.
Thisbookshouldbeofinteresttoresearchersandgraduatestudents,bothinbasicresearchandinclinicalsettings,inthefieldsofpulmonaryvascularbiologyandpulmonaryhypertension.
",".
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持续更新"
morganclaypool.
com/doi/abs/10.
2200/S00050ED1V01Y200609ANT002""Collection1","1598291823","ElectronicallyScannedArrays","电子扫描阵列","2007","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00081ED1V01Y200612ANT006""Collection1","1598290541","ImplantedAntennasinMedicalWirelessCommunications","医学无线通信中的嵌入式天线","2006","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00024ED1V01Y200605ANT001""Collection1","1598291769","IntroductiontoSmartAntennas","智能天线介绍","2007","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00079ED1V01Y200612ANT005""Collection1","1598290266","ReconfigurableAntennas","可重构天线","2007","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00067ED1V01Y200707ANT004""Collection1","1598295268","AConciseIntroductiontoMultiagentSystemsandDistributedArtificialIntelligence","多智能体系统和分布式人工智能简介","2007","SynthesisLecturesonArtificialIntelligenceandMachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00091ED1V01Y200705AIM002""Collection1","1598291262","IntelligentAutonomousRobotics:ARobotSoccerCaseStudy","智能型自治机器人技术:足球机器人案例学习","2007","SynthesisLecturesonArtificialIntelligenceandMachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00090ED1V01Y200705AIM001""Collection1","1598291505","AdvancedProbabilityTheoryforBiomedicalEngineers","面向生物医学工程师的高等概率论","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00063ED1V01Y200610BME011""Collection1","1598290487","ArtificialOrgans","人造器官","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00023ED1V01Y200604BME004""Collection1","1598290606","BasicProbabilityTheoryforBiomedicalEngineers","面向生物医学工程师的基础概率论","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00037ED1V01Y200606BME005""Collection1","1598291327","Bioinstrumentation","生物仪器","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00043ED1V01Y200608BME006""Collection1","1598291386","Bionanotechnology","生物纳米技术","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00051ED1V01Y200610BME007""Collection1","1598290347","Brain-MachineInterfaceEngineering","自动计算机接口工程","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00053ED1V01Y200710BME017""Collection1","1598292927","CapstoneDesignCourses:ProducingIndustry-ReadyBiomedicalEngineers","顶点设计教程:培养成熟的生物医学工程师","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00097ED1V01Y200709BME015""Collection1","1598295322","EstimationofCorticalConnectivityinHumans:AdvancedSignalProcessingTechniques","关于人类皮层链接的估计:高级信号处理技术","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00094ED1V01Y200708BME013""Collection1","1598290967","FundamentalsofRespiratorySoundsandAnalysis","呼吸音分析基础","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00054ED1V01Y200609BME008""Collection1","1598290363","ImageandSignalProcessingforNetworkedeHealthApplications","网络的电子健康应用程序的图像和信号处理","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00015ED1V01Y200602BME002""Collection1","1598291408","IntermediateProbabilityTheoryforBiomedicalEngineers","面向生物医学工程师的中级概率论","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00062ED1V01Y200610BME010""Collection1","1598291963","IntroductiontoStatisticsforBiomedicalEngineers","面向生物医学工程师的统计学介绍","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00095ED1V01Y200708BME014""Collection1","1598295500","MultimodalImaginginNeurology","神经学多峰成像","2007","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00099ED1V01Y200710BME016""Collection1","1598290622","SensoryOrganReplacementandRepair","感知器官的代替和修复","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00022ED1V01Y200604BME003""Collection1","159829038X","SignalProcessingofRandomPhysiologicalSignals","随机生理学信号处理","2006","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00012ED1V01Y200602BME001""Collection1","1598291106","NetworkSimulation","网络模拟仿真","2006","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00046ED1V01Y200609CNT001""Collection1","1598290401","CodeDivisionMultipleAccess(CDMA)","码分多址联接方式","2006","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00017ED1V01Y200508COM002""Collection1","1598292641","FundamentalsofSpreadSpectrumModulation","扩频调制基础","2007","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00096ED1V01Y200708COM003""Collection1","1598290169","GameTheoryforWirelessEngineers","无限工程师的博弈论","2006","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00014ED1V01Y200508COM001""Collection1","1598290789","AdaptiveMeshRefinementinTime-DomainNumericalElectromagnetics","时域数字电磁体中的自适应网格加密","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00052ED1V01Y200609CEM011""Collection1","1598290568","ComputationalElectronics","计算机电子学","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00026ED1V01Y200605CEM006""Collection1","1598295357","ElectromagneticScatteringusingtheIterativeMulti-RegionTechnique","基于重复多子域技术的电磁散射","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00055ED1V01Y200710CEM019""Collection1","1598295381","ElectromagneticsandAntennaOptimizationusingTaguchi'sMethod","基于Taguchi方法的电磁场和天线优化","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00083ED1V01Y200710CEM018""Collection1","1598290746","ExploitationofaShip'sMagneticFieldSignatures","舰艇磁特征的开发利用","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00034ED1V01Y200605CEM009""Collection1","1598290800","FrequencyDomainHybridFiniteElementMethodsinElectromagnetics","电磁学频域有限要素分析法","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00038ED1V01Y200606CEM010""Collection1","159829170X","FundamentalsofElectromagnetics1:InternalBehaviorofLumpedElements","电磁学基础1:集总元件的内部行为","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00077ED1V01Y200612CEM014""Collection1","1598291726","FundamentalsofElectromagnetics2:QuasistaticsandWaves","电磁学基础2:量子统计和波","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00078ED1V01Y200612CEM015""Collection1","1598290282","Higher-OrderFDTDSchemesforWaveguidesandAntennaStructures","波导和天线结构的高阶时域有限差分设计","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00018ED1V01Y200604CEM003""Collection1","1598290460","IntroductiontotheFiniteElementMethodinElectromagnetics","电磁学有限要素分析法介绍","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00019ED1V01Y200604CEM004""Collection1","1598290126","MappedVectorBasisFunctionsforElectromagneticIntegralEquations","电磁积分方程的映射向量基础工程","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00008ED1V01Y200508CEM001""Collection1","159829184X","MellinTransformMethodforIntegralEvaluation","梅林变换积分求值","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00076ED1V01Y200612CEM013""Collection1","1598292501","ModelingaShip'sFerromagneticSignatures","船舶磁性特征建模","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00092ED1V01Y200706CEM016""Collection1","1598290142","MRTD(MultiResolutionTimeDomain)MethodinElectromagnetics","电磁学中的时域多分辨分析","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00009ED1V01Y200508CEM002""Collection1","1598290827","PerfectlyMatchedLayer(PML)forComputationalElectromagnetics","计算机电磁学的完全匹配层","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00030ED1V01Y200605CEM008""Collection1","159829024X","SupportVectorMachinesforAntennaArrayProcessingandElectromagnetics","天线阵列处理和电磁学的支持向量机","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00020ED1V01Y200604CEM005""Collection1","1598290509","TheTransmission-LineModeling(TLM)MethodinElectromagnetics","电磁学传输线矩阵法","2006","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00027ED1V01Y200605CEM007""Collection1","1598292447","Three-DimensionalIntegrationandModeling:ARevolutioninRFandWirelessPackaging","三维集成和建模:RF和无线封装的变革","2007","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00080ED1V01Y200710CEM017""Collection1","159829122X","ChipMultiprocessorArchitecture:TechniquestoImproveThroughputandLatency","芯片多处理器结构","2007","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00093ED1V01Y200707CAC003""Collection1","1598291181","QuantumComputingforComputerArchitects","计算机结构的量子计算","2006","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00066ED1V01Y200610CAC001""Collection1","1598291246","TransactionalMemory","事务型存储器","2007","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00070ED1V01Y200611CAC002""Collection1","1598291165","ABlossomingDevelopmentofSplines","样条线的迅速发展","2006","SynthesisLecturesonComputerGraphicsandAnimation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00041ED1V01200607CGR001""Collection1","1598291149","HighFidelityHapticRendering","高保真触觉渲染","2006","SynthesisLecturesonComputerGraphicsandAnimation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00045ED1V01Y200609CGR002""Collection1","159829010X","TheTheoryofTimedI/OAutomata","时间输入/输出自动机理论","2006","SynthesisLecturesonComputerScience","系列:计算机科学","1932-1228","1932-1686","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00006ED1V01Y200508CSL001""Collection1","1598291947","TheReactionWheelPendulum","反作用轮摆","2007","SynthesisLecturesonControlandMechatronics","系列:机电与控制","1939-0564","1939-0572","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00085ED1V01Y200702CRM001""Collection1","1598295411","AtmelAVRMicrocontrollerPrimer:ProgrammingandInterfacing","AtmelAVR单片机入门:编程和接口","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00100ED1V01Y200712DCS015""Collection1","1598295292","FiniteStateMachine-DatapathDesign,Optimization,andImplementation","有限状态机—数据通道设计,优化和植入","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00087ED1V01Y200702DCS014""Collection1","1598291343","High-SpeedDigitalSystemDesign","高速数字系统设计","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00044ED1V01Y200609DCS005""Collection1","1598291068","IntroductiontoLogicSynthesisusingVerilogHDL","使用VerilogHDL的逻辑合成介绍","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00060ED1V01Y200610DCS006""Collection1","1598290584","MicrocontrollersFundamentalsforEngineersandScientists","面向工程师和科学家的微控制器基础","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00025ED1V01Y200605DCS001""Collection1","1598291904","Multiple-ValuedLogic:ConceptsandRepresentations","多值逻辑:概念和表示","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00065ED1V01Y200709DCS012""Collection1","1598290681","PragmaticCircuits:D-CandTimeDomain","实用电路:D-C和时域","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00031ED1V01Y200605DCS002""Collection1","1598290703","PragmaticCircuits:FrequencyDomain","实用电路:频域","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00032ED1V01Y200605DCS003""Collection1","159829072X","PragmaticCircuits:SignalsandFilters","实用电路:信号和滤波器","2006","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00033ED1V01Y200605DCS004""Collection1","1598291920","PragmaticLogic","实用逻辑","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00084ED1V01Y200702DCS013""Collection1","1598291602","PSpiceforAnalogCommunicationsEngineering","模拟通信工程的PSpice设计","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00071ED1V01Y200612DCS009""Collection1","1598291564","PSpiceforCircuitTheoryandElectronicDevices","电路理论和电子设备的Pspice设计","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00068ED1V01Y200611DCS007""Collection1","1598291629","PSpiceforDigitalCommunicationsEngineering","数字通信工程的PSpice设计","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00072ED1V01Y200612DCS010""Collection1","1598291645","PSpiceforDigitalSignalProcessing","数字信号处理的PSpice设计","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00073ED1V01Y200612DCS011""Collection1","1598291580","PSpiceforFiltersandTransmissionLines","滤波器和传输线的PSpice设计","2007","SynthesisLecturesonDigitalCircuitsandSystems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00069ED1V01Y200611DCS008""Collection1","1598291424","LearningProgrammingUsingMatlab","学用Matlab编程","2006","SynthesisLecturesonElectricalEngineering","系列:电机工程","1559-811X","1559-8128","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00051ED1V01Y200609EEL003""Collection1","1598290029","UnderstandingCircuits","了解电路","2005","SynthesisLecturesonElectricalEngineering","系列:电机工程","1559-811X","1559-8128","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00003ED1V01Y200508EEL001""Collection1","1598293400","GlobalWarmingandtheFutureoftheEarth","全球变暖与地球的未来","2007","SynthesisLecturesonEnergyandtheEnvironment:Technology,Science,andSociety","系列:能源与环境","1940-851X","1942-4361","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00098ED1V01Y200709EGY001""Collection1","1598291866","EssentialsofAppliedMathematicsforScientistsandEngineers","面向科学家和工程师的应用数学要素","2007","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00082ED1V01Y200612ENG003""Collection1","1598291742","ProjectManagementforEngineeringDesign","工程设计项目管理","2007","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00075ED1V01Y200612ENG002""Collection1","1598291300","RelativisticFlightMechanicsandSpaceTravel","相对飞行力学和宇宙航行","2006","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00042ED1V01Y200611ENG001""Collection1","1598293486","TensorPropertiesofSolids,PartOne","固体张力特质,第一部分","2007","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00057ED1V01Y200712ENG04""Collection1","1598293486","TensorPropertiesofSolids,PartTwo","固体张力特质,第二部分","2007","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00058ED1V01Y200712ENG05""Collection1","1598290908","EngineeringEthics:Peace,Justice,andtheEarth","工程学伦理:和平,正义和地球","2006","SynthesisLecturesonEngineers,Technology,andSociety","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00039ED1V01Y200606ETS001""Collection1","1598292188","Engineering,Poverty,andtheEarth","工程学,贫困和地球","2007","SynthesisLecturesonEngineers,Technology,andSociety","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00088ED1V01Y200704ETS004""Collection1","159829136X","EngineerswithinaLocalandGlobalSociety","地方和全球社会中的工程师","2006","SynthesisLecturesonEngineers,Technology,andSociety","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00059ED1V01Y200609ETS002""Collection1","1598291521","Globalization,Engineering,andCreativity","全球化,工程和创造","2007","SynthesisLecturesonEngineers,Technology,andSociety","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00064ED1V01Y200610ETS003""Collection1","1598290185","BiomedicalImageAnalysis:Tracking","生物医学影像分析:追踪","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00002ED1V01Y200508IVM002""Collection1","1598290444","JointSource-ChannelVideoTransmission","联合信源信道视频传输","2007","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00061ED1V01Y200707IVM010""Collection1","1598290762","LightFieldSampling","光场采样","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00035ED1V01Y200606IVM006""Collection1","1598290223","ModernImageQualityAssessment","现代影像质量评估","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00010ED1V01Y200508IVM003""Collection1","1598290428","MPEG-4BeyondConventionalVideoCoding","MPEG4——超乎寻常的视频编码","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00011ED1V01Y200508IVM004""Collection1","1598290525","Real-TimeImageandVideoProcessing","实时影像和视频处理","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00021ED1V01Y200604IVM005""Collection1","1598290061","RecognitionofHumansandTheirActivitiesUsingVideo","人和行为的视频识别","2005","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00002ED1V01Y200508IVM001""Collection1","1598290843","SuperResolutionofImagesandVideo","影像和视频的超级解决方案","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00036ED1V01Y200606IVM007""Collection1","1598291009","TensorVoting","TensorVoting技术","2006","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00049ED1V01Y200609IVM008""Collection1","1598291289","ControllingEnergyDemandinMobileComputingSystems","移动计算系统中的控制能量需求","2007","SynthesisLecturesonMobileandPervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00089ED1V01Y200704MPC002""Collection1","1598291084","RFIDExplained","RFID解释","2006","SynthesisLecturesonMobileandPervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00040ED1V01Y200602MPC001""Collection1","1598291122","DigitalControlinPowerElectronics","电源设备中的数字控制","2006","SynthesisLecturesonPowerElectronics","系列:电力电子","1931-9525","1931-9533","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00047ED1V01Y200609PEL002""Collection1","1598290320","PowerElectronicsforModernWindTurbines","现代风能发电的电源电子","2006","SynthesisLecturesonPowerElectronics","系列:电力电子","1931-9525","1931-9533","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00014ED1V01Y200602PEL001""Collection1","1598290304","NonlinearSourceSeparation","非线性信源的分离","2006","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00016ED1V01Y200602SPR002""Collection1","1598290002","SpectralAnalysisofSignals","信号光谱分析","2005","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00001ED1V01Y200508SPR001""Collection1","1598295756","TheTheoryofLinearPrediction","线性预测理论","2007","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00086ED1V01Y200712SPR003""Collection1","1598290045","Hf-BasedHigh-kDielectrics","基于HF的高K值电解质","2005","SynthesisLecturesonSolidStateMaterialsandDevices","系列:固态材料与设备","1932-1260","1932-1724","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00005ED1V01Y200508SSM001""Collection1","1598290665","OpticalInterconnects","光学互联","2007","SynthesisLecturesonSolidStateMaterialsandDevices","系列:固态材料与设备","1932-1260","1932-1724","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00029ED1V01Y200605SSM002""Collection1","1598290088","ArticulationandIntelligibility","音和清晰度","2005","SynthesisLecturesonSpeechandAudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00004ED1V01Y200508SAP001""Collection1","1598290649","DynamicSpeechModels","动态演讲模型","2006","SynthesisLecturesonSpeechandAudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00028ED1V01Y200605SAP002""Collection1","1598291041","LatentSemanticMapping:PrinciplesandApplications","潜在语义描绘:原理和应用","2007","SynthesisLecturesonSpeechandAudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00048ED1V01Y200609SAP003""Collection1","1598291688","UnderstandingtheFinancialScore","财务分数理解","2007","SynthesisLecturesonTechnology,Management,andEntrepreneurship","系列:技术、管理与企业精神","1933-978X","1933-9798","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00074ED1V01Y200612TME001""文集","ISBN","文献名(英文)","文献名(中文)","出版年份","所属系列(英文)","所属系列(中文)","ISSNPRINT","ISSNELEC","URL""Collection2","9781598296723","AdvancesinWaveform-AgileSensingforTracking","基于追踪的灵敏波形感应高级技巧","2008","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00168ED1V01Y200812ASE002""Collection2","9781598296211","DespeckleFilteringAlgorithmsandSoftwareforUltrasoundImaging","超声影像滤波算法和软件","2008","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00116ED1V01Y200805ASE001""Collection2","9781598298147","GeneralizedTransmissionLineMethodtoStudytheFar-zoneRadiationofAntennasunderaMultilayerStructure","研究多层结构下天线远区场辐射的普遍化传输线方法","2009","SynthesisLecturesonAntennas","系列:天线","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00156ED1V01Y200810ANT009""Collection2","1-59829-088-6","MultiantennaSystemsforMIMOCommunications","MIMO通信的多天线系统","2008","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00104ED1V01Y200803ANT007""Collection2","9781598296518","NarrowbandDirectionofArrivalEstimationforAntennaArrays","天线阵列窄带波达方向估计","2008","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00118ED1V01Y200805ANT008""Collection2","1-59829-593-4","EssentialsofGameTheory","博弈论类要","2008","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00108ED1V01Y200802AIM003""Collection2","9781598296600","RepresentationDiscoveryusingHarmonicAnalysis","使用谐波分析的表示法发现","2008","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00130ED1V01Y200806AIM004""Collection2","9781598295450","ActionProgrammingLanguages","Action编程语言","2008","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00143ED1V01Y200807AIM005""Collection2","9781598295481","IntroductiontoSemi-SupervisedLearning","半监督学习介绍","2009","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00196ED1V01Y200906AIM006""Collection2","9781598296938","MarkovLogic:AnInterfaceLayerforArtificialIntelligence","马尔科夫逻辑:人工智能接口层","2009","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00206ED1V01Y200907AIM007""Collection2","9781598296181","IntroductiontoContinuumBiomechanics","连续介质生物力学介绍","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00121ED1V01Y200805BME019""Collection2","1-59829-294-3","ABiosystemsApproachtoIndustrialPatientMonitoringandDiagnosticDevices","病人监测与诊断仪器的生物系统研究","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00101ED1V01Y200702BME012""Collection2","9781598298284","AnOutlineofInformationalGenetics","信息遗传学概述","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00151ED1V01Y200809BME023""Collection2","9781598299519","BasicFeedbackControlsinBiomedicine","生物医学基本反馈控制","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00157ED1V01Y200812BME027""Collection2","9781598298451","IntroductiontoBiomedicalEngineering:BiomechanicsandBioelectricity,PartI","生物医学工程介绍:生物医学和生物电第1部分","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00182ED1V01Y200903BME028""Collection2","9781598296129","IntroductoryMedicalImaging","医疗成像介绍","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00165ED1V01Y200811BME026""Collection2","9781598292855","LandmarkingandSegmentationof3DCTImages","3DCT影像标志和分割","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1932-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00185ED1V01Y200903BME030""Collection2","9781598297119","LungSounds:AnAdvancedSignalProcessingPerspective","肺音:高级信号处理展望","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00127ED1V01Y200811BME009""Collection2","9781598296815","NeuralInterfacing:ForgingtheHuman-MachineConnection","神经接口:打造人机接口","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00148ED1V01Y200809BME022""Collection2","9781598296754","QuantitativeNeurophysiology","定量神经生理学","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00125ED1V01Y200808BME021""Collection2","1-59829-578-0","TheEffectsofHypergravityandMicrogravityonBiomedicalExperiments","超微重力生物医学影响实验","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00105ED1V01Y200801BME018""Collection2","9781598292978","UnderstandingAtrialFibrillation,PartI","理解心房纤颤,第1部分","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00152ED1V01Y200809BME024""Collection2","9781598298376","UnderstandingAtrialFibrillation,PartII","理解心房纤颤,第2部分","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00153ED1V01Y200809BME025""Collection2","9781598298468","IntroductiontoBiomedicalEngineering:BiomechanicsandBioelectricity,PartII","生物医学工程介绍:生物医学和生物电第2部分","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00183ED1V01Y200903BME029""Collection2","9781598299762","PhonocardiographySignalProcessing","心音图描记法信号处理","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00187ED1V01Y200904BME031""Collection2","9781608451258","StrategicHealthTechnologyIncorporation","战略卫生技术团体","2009","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00216ED1V01Y200908BME032""Collection2","9781598296396","Tremor:FromPathogenesistoTreatment","颤动:从发病机理到治疗手段","2008","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00129ED1V01Y200807BME020""Collection2","9781608451494","JointSourceChannelCodingusingArithmeticCodes","基于算术码的联合信源信道编码","2009","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00222ED1V01Y200911COM004""Collection2","9781608453009","AnIntroductiontoLocallyCorrectedNystromMethod","高阶局部修正的Nystrom方法介绍","2009","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00217ED1V01Y200910CEM025""Collection2","1-59829-318-0","ModernEMCAnalysisTechniquesVolumeI:Time-DomainComputationalSchemes","现代EMC分析技术卷1:时域计算方案","2008","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00113ED1V01Y200804CEM021""Collection2","1-59829-3203","ModernEMCAnalysisTechniquesVolumeII:ModelsandApplications","现代EMC分析技术卷2:模型和应用","2008","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00114ED1V01Y200804CEM022""Collection2","9781598292480","ReductionofaShip'sMagneticFieldSignatures","船体磁特征的减少","2008","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00150ED1V01Y200809CEM023""Collection2","9781598291490","IntegralEquationMethodsforElectromagneticandElasticWaves","电磁波与弹性波的积分方程方法","2008","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00102ED1V01Y200807CEM012""Collection2","1-59829-614-3","ParticleSwarmOptimization:APhysics-BasedApproach","颗粒群优化:基于物理的方法","2008","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00110ED1V01Y200804CEM020""Collection2","9781598298260","TransientSignalsonTransmissionLines","传输线上的瞬变信号","2009","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00155ED1V01Y200812CEM024""Collection2","9781598292084","ComputerArchitectureTechniquesforPower-Efficiency","基于节能的计算机结构技术","2008","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00119ED1V01Y200805CAC004""Collection2","9781598299540","FaultTolerantComputerArchitecture","可容错计算机结构","2009","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00192ED1V01Y200904CAC005""Collection2","9781598295856","On-ChipNetworks","芯片网络","2009","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00209ED1V01Y200907CAC008""Collection2","9781598295573","TheDatacenterasaComputer:AnIntroductiontotheDesignofWarehouse-ScaleMachines","计算机数据中心:库房机器设计介绍","2009","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00193ED1V01Y200905CAC006""Collection2","9781598295887","TheMemorySystem","存储器系统","2009","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00201ED1V01Y200907CAC007""Collection2","9781598292152","HighDynamicRangeVideo","高动态范围视频","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00109ED1V01Y200806CGR005""Collection2","9781598292114","InteractiveShapeDesign","交互式形状设计","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00122ED1V01Y200806CGR006""Collection2","9781608450183","IntroductoryTilingTheoryforComputerGraphics","计算机图形Tiling理论介绍","2009","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00207ED1V01Y200907CGR011""Collection2","9781598296457","PracticalGlobalIlluminationwithIrradianceCaching","使用辐照缓存的全局照明实践","2009","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00180ED1V01Y200903CGR010""Collection2","9781598297935","Real-TimeMassiveModelRendering","实时大规模模型利用","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00131ED1V01Y200807CGR007""Collection2","1-59829-559-4","GPU-BasedTechniquesforGlobalIlluminationEffects","基于GPU的全局光照效果技术","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00107ED1V01Y200801CGR004""Collection2","1-59829-562-4","HighDynamicRangeImageReconstruction","高动态范围图像重构","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00103ED1V01Y200711CGR003""Collection2","9781598299304","InformationTheoryToolsforComputerGraphics","计算机图形信息论工具","2009","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00208ED1V01Y200909CGR012""Collection2","9781598296419","VirtualCrowds:Methods,Simulation,andControl","虚拟人群:方法,仿真和控制","2008","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00123ED1V01Y200808CGR008""Collection2","9781598299663","WangTilesinComputerGraphics","计算机图形中基于WangTiles的纹理合成","2009","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S000179ED1V01Y200903CGR009""Collection2","9781608452453","Image-BasedModelingofPlantsandTrees","植物和树的影像建模","2009","SynthesisLecturesonComputerVision","系列:计算机视觉","2153-1056","2153-1064","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00205ED1V01Y200911COV001""Collection2","9781598299090","ModelingandDataMininginBlogosphere","博客世界中的建模和数据挖掘","2009","SynthesisLecturesonDataMiningandKnowledgeDiscovery","系列:数据挖掘和知识发现","2151-0067","2151-0075","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00213ED1V01Y200907DMK001""Collection2","9781598293517","AnIntroductiontoLogicCircuitTesting","逻辑电路测试介绍","2008","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00149ED1V01Y200808DCS017""Collection2","9781598299823","DesigningAsynchronousCircuitsusingNULLConventionLogic(NCL)","基于非传统逻辑的异步电路设计","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00202ED1V01Y200907DCS023""Collection2","9781608451289","EmbeddedSystemsDesignwiththeAtmelAVRMicrocontrollerPartI","AtmelAVR微控制器嵌入式系统设计第1部分","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00138ED1V01Y200910DCS024""Collection2","9781608453320","EmbeddedSystemsDesignwiththeAtmelAVRMicrocontrollerPartII","AtmelAVR微控制器嵌入式系统设计第2部分","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00225ED1V01Y200910DCS025""Collection2","9781598299427","MismatchandNoiseinModernICProcesses","现代IC处理中的失陪和噪音","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00171ED1V01Y200901DCS019""Collection2","9781598296907","AsynchronousSequentialMachineDesignandAnalysis","异步时序机的设计和分析","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00160ED1V01Y200811DCS018""Collection2","9781598299793","DevelopingEmbeddedSoftwareusingDaVinciandOMAPTechnology","DaVinci和OMAP技术嵌入式软件开发","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00189ED1V01Y200904DCS021""Collection2","9781608450091","EmbeddedSystemsInterfacingforEngineersusingtheFreescaleHCS08MicrocontrollerII:DigitalandAnalogHardwareInterfacing","基于FreescaleHCS08微控制器的工程嵌入式系统接口技术:数字和模拟硬件接口","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00199ED1V01Y200906DCS022""Collection2","9781608450060","EmbeddedSystemsInterfacingforEngineersusingtheFreescaleHCS08MicrocontrollerPartI:AssemblyLanguageProgramming","基于FreescaleHCS08微控制器的工程嵌入式系统接口技术:汇编语言编程","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00188ED1V01Y200906DCS020""Collection2","9781598297980","PragmaticPower","实用电源","2008","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00145ED1V01Y200808DCS016""Collection2","9781598293357","HittingtheWall:AVisionofaSecureEnergyFuture","撞墙效应:安全能源未来视界","2008","SynthesisLecturesonEnergyandtheEnvironment","系列:能源与环境","1940-851X","1942-4361","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00124ED1V01Y200805EGY003""Collection2","9781598293302","NonimagingOpticsinSolarEnergy","太阳能非成像光学","2008","SynthesisLecturesonEnergyandtheEnvironment","系列:能源与环境","1940-851X","1940-851X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00120ED1V01Y200807EGY002""Collection2","9781598297669","CAD/CAMofSculpturedSurfacesonMulti-AxisNCMachine","复杂曲面多轴数控机床的CAD/CAM设计","2008","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00141ED1V01Y200806ENG008""Collection2","9781598297607","IntroductiontoEngineering:AStarter'sGuidewithHands-OnAnalogMultimediaExplorations","工程技术介绍:实用模拟媒体探索新手指南","2008","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00139ED1V01Y200806ENG006""Collection2","9781598297638","IntroductiontoEngineering:AStarter'sGuidewithHands-OnDigitalMultimediaandRoboticsExplorations","工程技术介绍:实用数字媒体和机器人技术探索新手指南","2008","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00140ED1V01Y200806ENG007""Collection2","9781598292992","StyleandEthicsofCommunicationinScienceandEngineering","科学工程通信的道德风气","2009","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00128ED1V01Y200809ENG009""Collection2","9781608452637","GeometricProgrammingforDesignandCostOptimization","基于设计和成本优化的几何设计","2009","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00221ED1V01Y200909ENG010""Collection2","9781598296693","Engineering:WomenandLeadership","工程技术:女性与领导力","2008","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00111ED1V01Y200804ETS005""Collection2","1-59829-623-5","BridgingtheGapBetweenEngineeringandtheGlobalWorld","架连工程技术与世界","2008","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00112ED1V01Y200804ETS006""Collection2","1-59829-626-4","EngineeringandSocialJustice","工程技术与社会正义","2008","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00117ED1V01Y200805ETS007""Collection2","9781598296631","EngineeringandSociety:WorkingTowardsSocialJusticePartI","工程技术与社会:为了社会正义工作第1部分","2009","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00136ED1V01Y200905ETS008""Collection2","9781598296655","EngineeringandSociety:WorkingTowardsSocialJusticePartII","工程技术与社会:为了社会正义工作第2部分","2009","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00137ED1V01Y200905ETS009""Collection2","9781598296662","EngineeringandSociety:WorkingTowardsSocialJusticePartIII","工程技术与社会:为了社会正义工作第3部分","2009","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00195ED1V01Y200905ETS010""Collection2","9781598295979","DependencyParsing","依存分析","2009","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00169ED1V01Y200901HLT002""Collection2","9781598296006","SpokenDialogueSystems","口头对话系统","2009","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00204ED1V01Y200910HLT005""Collection2","9781598299335","IntroductiontoChineseNaturalLanguageProcessing","中文处理介绍","2009","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00211ED1V01Y200909HLT004""Collection2","9781598297393","IntroductiontoLinguisticAnnotationandTextAnalytics","语言注释和文字分析介绍","2009","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00194ED1V01Y200905HLT003""Collection2","9781598295917","StatisticalLanguageModelsforInformationRetrieval","信息检索的统计语言模型","2009","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00158ED1V01Y200811HLT001""Collection2","9781598299458","SemioticEngineeringMethodsforScientificResearchinHCI","HCI中科学研究的符号工程学方法","2009","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00173ED1V01Y200901HCI002""Collection2","9781598298581","CommonGroundinElectronicallyMediatedConversation","电子调解对话的共性","2009","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00154ED1V01Y200810HCI001""Collection2","9781598299915","Context-AwareMobileComputing","上下为文感知型移动计算技术","2009","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00135ED1V01Y200905HCI004""Collection2","9781608450244","DesigningforUserEngagement:AestheticandAttractiveUserInterfaces","用户参与设计:美观有吸引力的人机界面","2009","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00210ED1V01Y200910HCI005""Collection2","9781598299885","StudiesofWorkandtheWorkplaceinHCI:ConceptsandTechniques","HCI中工作和工作点的研究:概念和技术","2009","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00177ED1V01Y200903HCI003""Collection2","9781598290219","BiomedicalImageAnalysis:Segmentation","生物医学影像分析:分割","2009","SynthesisLecturesonImage,Video,&MultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00133ED1V01Y200807IVM009""Collection2","9781598292336","TheStructureandPropertiesofColorSpacesandtheRepresentationofColorImages","色彩空间和色彩影像表现的结构和特质","2009","SynthesisLecturesonImage,Video,&MultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00224ED1V01Y200910IVM011""Collection2","9781598297720","AutomatedMetadatainMultimediaInformationSystems","多媒体信息系统的自动化元数据","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00167ED1V01Y200812ICR002""Collection2","9781598297843","ExploratorySearch:BeyondtheQuery-ResponseParadigm","探索:超越应答系统模板","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00174ED1V01Y200901ICR003""Collection2","9781598297454","NewConceptsinDigitalReference","数字引用的新概念","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00166ED1V01Y200812ICR001""Collection2","9781598299069","ReadingandWritingtheElectronicBook","读写电子书","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00215ED1V01Y200907ICR009""Collection2","9781608450008","FacetedSearch","面搜索","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00190ED1V01Y200904ICR005""Collection2","9781608450923","HypermediaGenes:AnEvolutionaryPerspectiveofConcepts,ModelsandArchitecture","超媒体基因:概念,模型和结构的革命","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00223ED1V01Y200910ICR011""Collection2","9781598299601","InformationArchitecture:TheDesignandIntegrationofInformationSpaces","信息结构:信息空间的设计与整合","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00214ED1V01Y200910ICR008""Collection2","9781598299946","IntroductiontoWebometrics","网络计量学介绍","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00176ED1V01Y200903ICR004""Collection2","9781598298529","UnderstandingUser-WebInteractionsviaWebAnalytics","基于网站分析上人机界面交互的理解","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00191ED1V01Y200904ICR006""Collection2","9781598297874","XMLRetrieval","XML检索","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00203ED1V01Y200907ICR007""Collection2","9781598292121","OperatingSystemSecurity","操作系统安全","2008","SynthesisLecturesonInformationSecurity,Privacy,andTrust","系列:信息安全、隐秘与信任","1945-9742","1945-9750","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00126ED1V01Y200808SPT001""Collection2","9781598298857","FundamentalsofPlasticsThermoforming","塑料热压成型基础","2009","SynthesisLecturesonMaterialsEngineering","系列:材料工程","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00184ED1V01Y200904MRE001""Collection2","9781598298239","AGyrovectorSpaceApproachtoHyperbolicGeometry","双曲几何GyrovectorSpace研究","2008","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00175ED1V01Y200901MAS004""Collection2","9781598298024","AnIntroductiontoMultivariableMathematics","多元数学介绍","2008","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00147ED1V01Y200808MAS003""Collection2","9781598298055","JordanCanonicalForm:ApplicationtoDifferentialEquations","Jordan表准形:微分方程上的应用","2008","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00146ED1V01Y200808MAS002""Collection2","9781608452514","JordanCanonicalForm:TheoryandPractice","Jordan表准形:理论与实践","2009","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00218ED1V01Y200908MAS006""Collection2","9781598297782","StatisticsisEasy!
","统计学很简单!
","2008","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00142ED1V01Y200807MAS001""Collection2","9781598298208","TheGeometryofWalkerManifolds","WalkerManifolds几何学","2009","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1930-1743","1930-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00197ED1V01Y200906MAS005""Collection2","1-59829-202-2","ReplicatedDataManagementforMobileComputing","基于移动计算的重复数据管理","2008","SynthesisLecturesonMobile&PervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00132ED1V01Y200807MPC005""Collection2","9781608452545","APracticalGuidetoTestingWirelessSmartphoneApplications","智能机应用程序测试实验指南","2009","SynthesisLecturesonMobile&PervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00219ED1V01Y200909MPC006""Collection2","1-59829-120-3","ApplicationDesignforWearableComputing","便携计算机应用程序设计","2008","SynthesisLecturesonMobile&PervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00106ED1V01Y200801MPC003""Collection2","1-59829-581-8","LocationSystems:AnIntroductiontotheTechnologyBehindLocationAwareness","定位系统:位置侦测以后的技术介绍","2008","SynthesisLecturesonMobile&PervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00115ED1V01Y200804MPC004""Collection2","9781598299854","India'sNuclearFuelCycle:UnravelingtheImpactoftheUS-IndiaNuclearAccord","印度核燃料循环:揭示美印核能合作的影响","2009","SynthesisLecturesonNuclearTechnology&Society","系列:核技术与社会","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S000181ED1V01Y200908NTS001""Collection2","9781598297331","QuantumComputerScience","量子计算机科学","2009","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00159ED1V01Y200810QMC002""Collection2","9781598296563","QuantumWalksforComputerScientists","计算机科学家们的量子步伐","2008","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00144ED1V01Y200808QMC001""Collection2","9781598298611","DesignandDevelopmentofRFIDandRFID-EnabledSensorsonFlexibleLowCostSubstrates","RFID和灵活低成本电路板上RFID感应器的设计开发","2009","SynthesisLecturesonRF/Microwaves","系列:射频/微波","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00172ED1V01Y200905MRF001""Collection2","9781598298420","AdvancedRadarDetectionSchemesunderMismatchedSignalModels","不匹配信号模型的高级雷达检测技术","2009","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00170ED1V01Y200902SPR008""Collection2","9781598298918","DSPforMATLABandLabVIEWI:FundamentalsofDiscreteSignalProcessing","基于Matlab和Labview的DSP设计:离散信号处理基础","2008","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S000161ED1V01Y200811SPR004""Collection2","9781598298949","DSPforMATLABandLabVIEWII:DiscreteFrequencyTransforms","基于Matlab和Labview的DSP设计:离散频率变换","2008","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S000162ED1V01Y200811SPR005""Collection2","9781598298970","DSPforMATLABandLabVIEWIII:DigitalFilterDesign","基于Matlab和Labview的DSP设计:数字滤波器设计","2008","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S000163ED1V01Y200811SPR006""Collection2","9781598299007","DSPforMATLABandLabVIEWIV:LMSAdaptiveFiltering","基于Matlab和Labview的DSP设计:LMS自适应滤波器","2009","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00164ED1V01Y200811SPR007""Collection2","9781598292596","Fixed-PointSignalProcessors","定点信号处理器","2009","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00220ED1V01Y200909SPR009""Collection2","9781598293098","DiscriminativeLearningforSpeechRecognition","语音识别的判别学习","2008","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00134ED1V01Y200807SAP004""Collection2","9781598298390","Multi-PitchEstimation","多音高估计","2009","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00178ED1V01Y200903SAP005""Collection2","9781598299489","GenomeRefactoring","基因组重组","2009","SynthesisLecturesonSyntheticBiology","系列:合成生物学","2151-0008","2151-0016","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00200ED1V01Y200906SBI001""Collection2","9781598298765","ArticularCartilageTissueEngineering","关节软骨组织工程","2009","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00212ED1V01Y200910TIS003""Collection2","9781598298734","EngineeringtheKneeMeniscus","膝盖半月板工程","2009","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00186ED1V01Y200903TIS001""Collection2","9781598299977","TissueEngineeringofTemporomandibularJointCartilage","人工颞下颌软骨的组织工程.
","2009","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00198ED1V01Y200906TIS002""文集","ISBN","文献名(英文)","文献名(中文)","出版年份","所属系列(英文)","所属系列(中文)","ISSNPRINT","ISSNELEC","URL""Collection3","9781608455775","AdaptiveHigh-ResolutionSensorWaveformDesignforTracking","用于追踪的自适应高分辨率传感波形设计","2010","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00311ED1V01Y201011ASE004""Collection3","9781608453887","AlgorithmsandSoftwareforPredictiveandPerceptualModelingofSpeech","语音预测和感知建模的算法和软件","2011","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00333ED1V01Y201102ASE007""Collection3","9781608453856","MATLABSoftwarefortheCodeExcitedLinearPredictionAlgorithm:TheFederalStandard-1016","基于码激励线性预测算法的Matlab软件:联邦标准-1016","2010","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00252ED1V01Y201001ASE003""Collection3","9781598297027","OFDMSystemsforWirelessCommunications","基于无线通信的OFDM系统","2010","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00255ED1V01Y201002ASE005""Collection3","9781608451074","AdvancesinModernBlindSignalSeparationAlgorithms:TheoryandApplications","现代盲信号分离:理论和应用","2010","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00258ED1V01Y201003ASE006""Collection3","9781608455812","Meta-SmithChartsandTheirPotentialApplications","Meta-Smith图表和潜在应用","2010","SynthesisLecturesonAntennas","系列:天线","1932-6076","1932-6084","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00276ED1V01Y201009ANT010""Collection3","9781608456178","LearningwithSupportVectorMachines","使用支持向量机的学习","2011","SynthesisLecturesonArtificalIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00324ED1V01Y201102AIM010""Collection3","9781608454938","AlgorithmsforReinforcementLearning","强化学习算法","2010","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00268ED1V01Y201005AIM009""Collection3","9781598297423","DataIntegration:TheRelationalLogicApproach","数据整合:相关逻辑实现","2010","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00226ED1V01Y200911AIM008""Collection3","9781598299694","VisualObjectRecognition","视觉目标认知","2011","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00332ED1V01Y201103AIM011""Collection3","9781608450305","AnalysisofOrientedTexturewithApplicationtotheDetectionofArchitecturalDistortioninMammorgrams","有取向性组织分析—乳房结构扭曲检测应用","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00301ED1V01Y201010BME038""Collection3","9781608456321","DigitalImageProcessingforOphthalmology:DetectionoftheOpticNerveHead","眼科学数字影像处理:视神经头检测","2011","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00335ED1V01Y201102BME040""Collection3","9781598298673","FundamentalsofBiomedicalTransportProcesses","生物医学传递过程基础","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00288ED1V01Y201007BME037""Collection3","9781608454501","TheGraphTheoreticalApproachinBrainFunctionalNetworks","脑功能网络中的图形理论探索","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00279ED1V01Y201004BME036""Collection3","9781608452330","ModelsofHorizontalEyeMovements,PartI:EarlyModelsofSaccadesandSmoothPursuit","水平眼动模型第1部分:早期扫视和平稳跟踪","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00263ED1V01Y201003BME034""Collection3","9781608454471","ModelsofHorizontalEyeMovements,PartII:A3rdOrderLinearSaccadeModel","水平眼动模型第2部分:3阶线性扫视模型","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00264ED1V01Y201003BME035""Collection3","9781608450336","ModelingandAnalysisofShapewithApplicationsinComputer-AidedDiagnosisofBreastCancer","基于计算机辅助诊断乳腺癌应用程序的建模和分析","2011","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00325ED1V01Y201012BME039""Collection3","9781608451616","BiomedicalTechnologyAssessment:The3QMethod","生物医学技术评价:3Q方法","2010","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00256ED1V01Y201002BME033""Collection3","9781608450954","CommunicationNetworks:AConciseIntroduction","通信网络:简述","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00254ED1V01Y201002CNT004""Collection3","9781608454099","NetworkGames:Theory,Models,andDynamics","网络游戏:理论、方法和动态","2011","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00330ED1V01Y201101CNT009""Collection3","9781598299243","PathProblemsinNetworks","网络路径问题","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00245ED1V01Y201001CNT003""Collection3","9781598299182","PerformanceModelingofCommunicationNetworkswithMarkovChains","马尔科夫链通信网络的性能建模","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00269ED1V01Y201004CNT005""Collection3","9781608450770","PerformanceModeling,LossNetworks,andStatisticalMultiplexing","性能建模,损耗网络和统计复用","2009","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00241ED1V01Y200911CNT002""Collection3","9781608454624","SchedulingandCongestionControlforWirelessandProcessingNetworks","无线和处理网络的计划和阻塞控制","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00270ED1V01Y201008CNT006""Collection3","9781608454563","StochasticNetworkOptimizationwithApplicationtoCommunicationandQueueingSystems","应用通信和排队系统的随机网络优化","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00271ED1V01Y201006CNT007""Collection3","9781608450800","AnIntroductiontoModelsofOnlinePeer-to-PeerSocialNetworking","P2P社交网络模型介绍","2010","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00313ED1V01Y201011CNT008""Collection3","9781608452606","BasicSimulationModelsofPhaseTrackingDevicesusingMATLAB","基于Matlab的相位跟踪设备的基础仿真模型","2010","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00245ED1V01Y201009COM005""Collection3","9781598299038","AnalysisandDesignofSubstrateIntegratedWaveguideUsingEfficient2DHybridMethod","基于高效2D混合方法的基片集成波导的分析和设计","2010","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00259ED1V01Y201003CEM026""Collection3","9781608455232","IntroductiontotheFinite-DifferenceTime-Domain(FDTD)MethodforElectromagnetics","电磁学有限差分时域法介绍","2011","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00316ED1V01Y201012CEM027""Collection3","9781608454686","ComputerArchitecturePerformanceEvaluationStandards","计算机结构性能评估标准","2010","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00273ED1V01Y201006CAC010""Collection3","9781608454594","DynamicBinaryModification:Tools,Techniques,andApplications","动态二元修正:工具、技术和应用","2011","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1932-3235","1932-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00345ED1V01Y201104CAC015""Collection3","9781608454037","HighPerformanceDatacenterNetworks:Architectures,Algorithms,andOpportunities","高性能数据中心网络:结构、算法和机会","2011","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00341ED1V01Y201103CAC014""Collection3","9781608453375","IntroductiontoReconfigurableSupercomputing","超级计算重构介绍","2009","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00238ED1V01Y200911CAC009""Collection3","9781608455652","APrimeronMemoryConsistencyandCacheCoherence","存储一致性和Cache一致性初探","2011","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00346ED1V01Y201104CAC016""Collection3","9781608456208","QuantumComputingforComputerArchitects,SecondEdition","计算机结构的量子计算,第二版","2011","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00331ED1V01Y201101CAC013""Collection3","9781608452361","TransactionalMemory,2ndEdition","事务存储器,第二版","2010","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00272ED1V01Y201006CAC011""Collection3","9781608454532","ProcessorMicroarchitecture:AnImplementationPerspective","处理器微体系结构:执行视角","2010","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00309ED1V01Y201011CAC012""Collection3","9781608454211","RethinkingQuaternions","四元数的再思考","2010","SynthesisLecturesonComputerGraphics&Animation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00292ED1V01Y201008CGR013""Collection3","9781608454419","AnalyticalPerformanceModelingforComputerSystems","计算机系统分析性能模型","2010","SynthesisLecturesonComputerScience","系列:计算机科学","1932-1228","1932-1686","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00282ED1V01Y201005CSL002""Collection3","9781608456963","StoringClockedProgramsInsideDNA:ASimplifyingFrameworkforNanocomputing","储藏于DNA中的定时程序:纳米计算的单一框架","2011","SynthesisLecturesonComputerScience","系列:计算机科学","1932-1228","1932-1686","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00343ED1V01Y201103CSL004""Collection3","9781608456567","ScienceFictionPrototyping:DesigningtheFuturewithScienceFiction","科幻小说原型:用科幻小说设计未来","2011","SynthesisLecturesonComputerScience","系列:计算机科学","1932-1228","1932-1686","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00336ED1V01Y201102CSL003""Collection3","9781608451340","Boosting-BasedFaceDetectionandAdaptation","基于Boosting算法的脸部检测和视觉调整","2010","SynthesisLecturesonComputerVision","系列:计算机视觉","2153-1056","2153-1064","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00300ED1V01Y201009COV002""Collection3","9781608455843","DeformableSurface3DReconstructionfromMonocularImages","基于单目图像的可变形表面3D重建","2010","SynthesisLecturesonComputerVision","系列:计算机视觉","2153-1056","2153-1064","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00319ED1V01Y201012COV003""Collection3","9781608453764","AccessControlinDataManagementSystems","数据管理系统的入口控制","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00281ED1V01Y201005DTM004""Collection3","9781608451937","AdvancedMetasearchEngineTechnology","高级搜索引擎技术","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00307ED1V01Y201011DTM011""Collection3","9781608452736","DataStreamManagement","数据流管理","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00284ED1V01Y201006DTM005""Collection3","9781608453825","DatabaseReplication","数据库复制","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00296ED1V01Y201008DTM007""Collection3","9781608452217","AnIntroductiontoDuplicateDetection","重复检测介绍","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00262ED1V01Y201003DTM003""Collection3","9781608451968","KeywordSearchinDatabases","数据库中的关键词检索","2009","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00231ED1V01Y200912DTM001""Collection3","9781608455386","MultidimensionalDatabasesandDataWarehousing","多维数据库和数据仓储","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00299ED1V01Y201009DTM009""Collection3","9781608457205","Peer-to-PeerDataManagement","P2P数据管理","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00338ED1V01Y201104DTM015""Collection3","9781608455683","ProbabilisticRankingTechniquesinRelationalDatabases","关系数据库中的概率排序技术","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00344ED1V01Y201103DTM014""Collection3","9781608454129","RelationalandXMLDataExchange","XML和关系数据交换","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00297ED1V01Y201008DTM008""Collection3","9781608452828","User-CenteredDataManagement","以用户为中心的数据管理","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00285ED1V01Y201006DTM006""Collection3","9781608452484","WebPageRecommendationModels:TheoryandAlgorithms","网络页面推荐模型:理论和算法","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00305ED1V01Y201010DTM010""Collection3","9781608454778","FundamentalsofObjectDatabases:Object-OrientedandObject-RelationalDesign","目标数据库基础:目标导向和目标相关设计","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00315ED1V01Y201012DTM012""Collection3","9781608454341","UncertainSchemaMatching","不确定模式匹配","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00337ED1V01Y201102DTM013""Collection3","9781608452170","Privacy-PreservingDataPublishing:AnOverview","隐私保护数据的出版:概况","2010","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00237ED1V01Y201003DTM002""Collection3","9781608453559","CommunityDetectionandMininginSocialMedia","社会媒体中社团的寻找和挖掘","2010","SynthesisLecturesonDataMiningandKnowledgeDiscovery","系列:数据挖掘和知识发现","2151-0067","2151-0075","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00298ED1V01Y201009DMK003""Collection3","9781608452859","EnsembleMethodsinDataMining:ImprovingAccuracyThroughCombiningPredictions","数据挖掘中的集合方法","2010","SynthesisLecturesonDataMiningandKnowledgeDiscovery","系列:数据挖掘和知识发现","2151-0067","2151-0075","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00240ED1V01Y200912DMK002""Collection3","9781608454389","ArduinoMicrocontrollerProcessingforEveryone,PartI","Arduino微控制器处理第1部分","2010","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00280ED1V01Y201005DCS028""Collection3","9781608454884","ArduinoMicrocontrollerProcessingforEveryone,PartII","Arduino微控制器处理第2部分","2010","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00283ED1V01Y201005DCS029""Collection3","9781608451791","DigitalSystemVerification:ACombinedFormalMethodsandSimulationFramework","数字系统验证:一种组合形式方法和仿真框架","2010","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00257ED1V01Y201002DCS027""Collection3","9781608454990","IntroductiontoEmbeddedSystems:UsingANSICandtheArduinoDevelopmentEnvironment","嵌入式系统介绍:使用ANSIC和Arduino开发环境","2010","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00291ED1V01Y201007DCS030""Collection3","9781608457144","MicrocontrollerProgrammingandInterfacing:TexasInstrumentsMSP430PARTI","微处理器编程和界面连接:德州仪器MSP430第一部分","2011","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00317ED1V01Y201105DCS032""Collection3","9781608457526","MicrocontrollerProgrammingandInterfacing:TexasInstrumentsMSP430PARTII","微处理器编程和界面连接:德州仪器MSP430第二部分","2011","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00340ED1V01Y201105DCS033""Collection3","9781608456697","PragmaticElectricalEngineering:Fundamentals","语用电机工程:基本原理","2011","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00242ED1V01Y201105DCS031""Collection3","9781608451821","ProgressinApplicationsofBooleanFunctions","应用程序和布尔功能的进步","2009","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00243ED1V01Y200912DCS026""Collection3","9781608452941","CommunicationandAgreementAbstractionsforFault-TolerantAsynchronousDistributedSystems","可容错异步分布式系统的通信和协议抽象系统","2010","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00236ED1V01Y201004DCT002""Collection3","9781608451371","TheMobileAgentRendezvousProblemintheRing","Ring中移动主体汇聚问题","2010","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00278ED1V01Y201004DCT001""Collection3","9781608455904","NewModelsforPopulationProtocols","PopulationProtocols的新模式","2011","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00328ED1V01Y201101DCT006""Collection3","9781608450121","PrinciplesofTransactionalMemory","事务存储原理","2010","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00253ED1V01Y201009DCT004""Collection3","9781608450039","TheTheoryofTimedI/OAutomata,SecondEdition","时间输入/输出自动机理论,第二版","2010","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00310ED1V01Y201011DCT005""Collection3","9781608455263","Fault-TolerantAgreementinSynchronousMessage-PassingSystems","同步消息传递系统的容错协议","2010","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00294ED1V01Y201009DCT003""Collection3","9781608456086","FinShapeThermalOptimizationUsingBejan'sConstructalTheory","使用Bejan构造理论的鳍状热优化","2011","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00318ED1V01Y201102ENG013""Collection3","9781608456116","GeometricProgrammingforDesignandCostOptimization,SecondEdition","基于设计和预算优化的几何图形编程,第二版","2010","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00314ED1V01Y201011ENG012""Collection3","9781608455140","SurviveandThrive:AGuideforUntenuredFaculty","生存与发展:非长期员工导引","2010","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00234ED1V01Y201009ENG011""Collection3","9781608457021","SystemsEngineering:BuildingSuccessfulSystems","系统工程:构建成功的系统","2011","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00349ED1V01Y201104ENG014""Collection3","9781608455997","APhilosophyofTechnology:FromTechnicalArtefactstoSociotechnicalSystems","技术哲学:从技术人工物到社会技术系统","2011","SynthesisLecturesonEngineers,TechnologyandSociety","系列:工程师、技术与社会","1933-3633","1933-3641","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00321ED1V01Y201012ETS014""Collection3","9781608450718","EngineeringandSustainableCommunityDevelopment","工程技术和可持续社区的发展","2010","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00247ED1V01Y201001ETS011""Collection3","9781608451524","HumanitarianEngineering","人道主义工程技术","2010","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3641","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00248ED1V01Y201006ETS012""Collection3","9781608451647","NeedsandFeasibility:AGuideforEngineersDoingCommunityProjects","需要和可行性:给做社区项目工程师的导航","2010","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1947-3633","1947-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00249ED1V01Y201001ETS013""Collection3","9781608456291","TragedyintheGulfofMexico:TheNeedforaNewEngineeringEthic","墨西哥湾的悲剧:对新工程道德的需求","2010","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1947-3633","1947-3461","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00322ED1V01Y201012ETS015""Collection3","9781608457380","AHybridImagination:ScienceandTechnologyinCulturalPerspective","一种混合想象:文化透视中的科学与技术","2011","SynthesisLecturesonEngineers,Technology,&Society","系列:工程师、技术与社会","1933-3633","1933-3641","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00339ED1V01Y201104ETS016""Collection3","9781608455799","WhatisGlobalEngineeringEducationForTheMakingofInternationalEducators,Part1","全球工程教育为了什么创造国际教育者,第一部分","2010","SynthesisLecturesonGlobalEngineering","系列:全局工程","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00302ED1V01Y201010GES001""Collection3","9781608455447","WhatisGlobalEngineeringEducationForTheMakingofInternationalEducators,Part2","全球工程教育为了什么创造国际教育者,第二部分","2010","SynthesisLecturesonGlobalEngineering","系列:全局工程","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00303ED1V01Y201010GES002""Collection3","9781608454716","AutomatedGrammaticalErrorDetectionforLanguageLearners","为语言学习者的自动语法错误检测","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00275ED1V01Y201006HLT009""Collection3","9781608453405","ComputationalModelingofHumanLanguageAcquisition","人类语言获取的计算机建模","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00304ED1V01Y201010HLT011""Collection3","9781598298642","Cross-LanguageInformationRetrieval","跨语言信息检索","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00266ED1V01Y201005HLT008""Collection3","9781608453436","Data-IntensiveTextProcessingwithMapReduce","基于MapReduce的数据密集型文章处理","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00274ED1V01Y201006HLT007""Collection3","9781598297966","IntroductiontoArabicNaturalLanguageProcessing","阿拉伯语处理介绍","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00277ED1V01Y201008HLT010""Collection3","9781598298321","SemanticRoleLabeling","语义角色标注","2010","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00239ED1V01Y200912HLT006""Collection3","9781608457083","LearningtoRankforInformationRetrievalandNaturalLanguageProcessing","信息获取和自然语言处理","2011","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00348ED1V01Y201104HLT012""Collection3","9781608450541","DesigningandEvaluatingUsableTechnologyinIndustrialResearch:ThreeCaseStudies","工业研究中可用技术的设计和评估:三个案例研究","2010","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00228ED1V01Y200911HCR007""Collection3","9781608450459","Experience-CenteredDesign:Designers,Users,andCommunitiesinDialogue","经验设计:对话中的设计者、用户和社区","2010","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00229ED1V01Y201003HCI009""Collection3","9781608450480","ExperienceDesign:TechnologyforAlltheRightReasons","经验设计:为了所有正确原因的技术","2010","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00261ED1V01Y201003HCI008""Collection3","9781608455966","GeographicalDesign:SpatialCognitionandGeographicalInformationScience","地理学设计:空间认知和地理信息科学","2011","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00342ED1V01Y201103HCI011""Collection3","9781608450275","InteractingwithInformation","信息交互","2010","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00227ED1V01Y200911HCI006""Collection3","9781608453733","User-CenteredAgileMethods","以用户为中心的便捷方法","2010","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00286ED1V01Y201002HCI010""Collection3","9781608453580","EstimatingtheQueryDifficultyforInformationRetrieval","信息检索中查询难易度的估计","2010","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00235ED1V01Y201004ICR015""Collection3","9781598299632","InformationConcepts:FromBookstoCyberspaceIdentities","信息概念:从书到赛博空间","2010","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00306ED1V01Y201010ICR016""Collection3","9781608453344","iRODSPrimer:IntegratedRule-OrientedDataSystem","iRODS入门:完整规则导向数据系统","2010","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00233ED1V01Y200912ICR012""Collection3","9781598299571","KnowledgeManagement(KM)inOrganizations:TheoreticalFoundationsandPractice","组织中的知识管理:理论基础和实践","2011","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00323ED1V01Y201012ICR018""Collection3","9781608450985","MultimediaInformationRetrieval","多媒体信息搜索","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00244ED1V01Y200912ICR010""Collection3","9781608451432","OnlineMultiplayerGames","在线多人游戏","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00232ED1V01Y200912ICR013""Collection3","9781608451227","CollaborativeSearch:Who,What,Where,When,andWhy","协同搜索:谁,什么,哪里,何时,为什么","2009","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00230ED1V01Y200912ICR014""Collection3","9781608455089","Search-BasedApplications:AttheConfluenceofSearchandDatabaseTechnologies","基于检索的应用:检索汇合及数据库技术","2010","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00320ED1V01Y201012ICR017""Collection3","9781598296303","AnalysisTechniquesforInformationSecurity","信息安全分析技术","2010","SynthesisLecturesonInformationSecurity,Privacy,andTrust","系列:信息安全、隐秘与信任","1945-9742","1945-9750","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00260ED1V01Y201003SPT002""Collection3","9781608456147","TheIntegral:ACruxforAnalysis","积分:分析症结","2011","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00327ED1V01Y201101MAS009""Collection3","9781608454969","LecturesonFinancialMathematics:DiscreteAssetPricing","金融数学讲座:离散资产定价","2010","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00293ED1V01Y201008MAS007""Collection3","9781608455713","StatisticsisEasy!
SecondEdition","统计学很简单!
第二版","2010","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00295ED1V01Y201009MAS008""Collection3","9781598299274","TheLandscapeofPervasiveComputingStandards","普适计算标准远景","2010","SynthesisLecturesonMobile&PervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00267ED1V01Y201004MPC007""Collection3","9781608450602","BroadbandQuantumCryptography","宽带量子密码学","2010","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00265ED1V01Y201004QMC003""Collection3","9781608454907","TheComplexityofNoise:APhilosophicalOutlookonQuantumErrorCorrection","噪声复杂度:量子错误更正的学术观点","2010","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00290ED1V01Y201007QMC004""Collection3","9781608456994","APerspectiveonSingle-ChannelFrequency-DomainSpeechEnhancement","单通道频率域语音增强透视","2011","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00344ED1V01Y201104SAP008""Collection3","9781598293074","SparseAdaptiveFiltersforEchoCancellation","用于回声消除的自适应滤波器研+C53究","2010","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00289ED1V01Y201006SAP006""Collection3","9781608456055","SpeechEnhancementintheKarhunen-LoeveExpansionDomain","Karhunen-Loeve展开域内的语音加强","2011","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00326ED1V01Y201101SAP007""Collection3","9781598299120","BacterialSensors:SyntheticDesignandApplicationPrinciples","细菌感应器:合成设计和应用原理","2010","SynthesisLecturesonSyntheticBiology","系列:合成生物学","2151-0008","2151-0016","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00312ED1V01Y201011SBI002""Collection3","9781608451760","OutoftheComfortZone:NewWaystoTeach,Learn,andAssessEssentialProfessionalSkills","非适宜温度:教,学和获取专业技能的新方法","2010","SynthesisLecturesonTechnology,Management,andEntrepreneurship","系列:技术、管理与企业精神","1933-978X","1933-9798","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00251ED1V01Y201001TME002""Collection3","9781608454310","LinkedData:EvolvingtheWebintoaGlobalDataSpace","关联数据:Web进化为全局数据空间","2011","SynthesisLecturesontheSemanticWeb","系列:语义网","暂无","暂无","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00334ED1V01Y201102WBE001""Collection3","9781608451739","BiologicFoundationsforSkeletalTissueEngineering","骨骼组织工程中的生物学原理","2011","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00329ED1V01Y201101TIS007""Collection3","9781608451708","FundamentalBiomechanicsinBoneTissueEngineering","骨骼组织工程中的基础生物力学","2010","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00246ED1V01Y200912TIS004""Collection3","9781608452149","RegenerativeDentistry","再生牙科医学技术","2010","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00287ED1V01Y201006TIS006""Collection3","9781608454655","CellsandBiomaterialsforIntervertebralDiscRegeneration","脊椎盘再生细胞和生物材料","2010","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00250ED1V01Y201006TIS005""Collection3","9781608455935","AGuidetoVisualMulti-LevelInterfaceDesignfromSynthesisofEmpiricalStudyEvidence","综合实例研究证明中视觉多层界面导引","2010","SynthesisLecturesonVisualization","系列:可视化","2159-516X","2159-5178","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00308ED1V01Y201011VIS001""文集","ISBN","文献名(英文)","出版年份","所属系列(英文)","所属系列(中文)","ISSNPRINT","ISSNELEC","URL""Collection4","9781608458028","AnalysisoftheMPEG-1LayerIII(MP3)AlgorithmUsingMATLAB","2012","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00382ED1V01Y201110ASE009""Collection4","9781608457540","TheoryandApplicationsofGaussianQuadratureMethods","2011","SynthesisLecturesonAlgorithmsandSoftwareinEngineering","系列:工程算法与软件","1938-1727","1938-1735","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00366ED1V01Y201105ASE008""Collection4","pending","ActiveLearning","2012","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00429ED1V01Y201207AIM018""Collection4","9781608456536","ComputationalAspectsofCooperativeGameTheory","2011","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00355ED1V01Y201107AIM016""Collection4","9781608455171","HumanComputation","2011","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00371ED1V01Y201107AIM013""Collection4","pending","PlanningwithMarkovDecisionProcesses:AnAIPerspective","2012","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00426ED1V01Y201206AIM017""Collection4","9781608455874","AShortIntroductiontoPreferences:BetweenAIandSocialChoice","2011","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00372ED1V01Y201107AIM014""Collection4","9781598296068","TradingAgents","2011","SynthesisLecturesonArtificialIntelligence&MachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00370ED1V01Y201107AIM012""Collection4","9781608457298","RepresentationsandTechniquesfor3DObjectRecognitionandSceneInterpretation","2011","SynthesisLecturesonArtificialIntelligenceandMachineLearning","系列:人工智能与机器学习","1939-4608","1939-4616","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00370ED1V01Y201107AIM015""Collection4","9781608457410","DesignandtheDigitalDivide:Insightsfrom40YearsinComputerSupportforOlderandDisabledPeople","2011","SynthesisLecturesonAssistive,Rehabilitative,andHealth-PreservingTechnologies","系列:辅助、复健及保健技术","2162-7258","2162-7266","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00369ED1V01Y201106ARH001""Collection4","9781608455201","Zero-EffortTechnologies:Considerations,Challenges,andUseinHealth,Wellness,andRehabilitation","2011","SynthesisLecturesonAssistive,Rehabilitative,andHealth-PreservingTechnologies","系列:辅助、复健及保健技术","2162-7258","2162-7266","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00380ED1V01Y201108ARH002""Collection4","9781608451463","ComputationalGenomicSignatures","2011","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00360ED1V01Y201105BME041""Collection4","9781608453702","EthicsforBioengineers","2012","SynthesisLecturesonBiomedicalEngineering","系列:生物医学工程","1930-0328","1930-0336","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00393ED1V01Y201111BME042""Collection4","9781608456932","NSSimulatorforBeginners","2012","SynthesisLecturesonCommunicationNetworks","系列:通信网络","1935-4185","1935-4193","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00397ED1V01Y201112CNT010""Collection4","pending","BlockTransceivers:OFDMandBeyond","2012","SynthesisLecturesonCommunications","系列:通信","1932-1244","1932-1708","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00424ED1V01Y201206COM007""Collection4","pending","ScatteringAnalysisofPeriodicStructuresUsingFinite-DifferenceTime-DomainMethod","2012","SynthesisLecturesonComputationalElectromagnetics","系列:计算电磁学","1932-1252","1932-1716","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00415ED1V01Y201204CEM028""Collection4","9781608458424","AutomaticParallelization:AnOverviewofFundamentalCompilerTechniques","2012","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00340ED1V01Y201201CAC019""Collection4","9781598297546","Multi-CoreCacheHierarchies","2011","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00365ED1V01Y201105CAC017""Collection4","9781608456666","PhaseChangeMemory:FromDevicestoSystems","2012","SynthesisLecturesonComputerArchitecture","系列:计算机体系结构","1935-3235","1935-3243","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00381ED1V01Y201109CAC018""Collection4","9781608456505","GazingatGames:AnIntroductiontoEyeTrackingControl","2012","SynthesisLecturesonComputerGraphicsandAnimation","系列:CG动画","1933-8996","1933-9003","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00395ED1V01Y201111CGR014""Collection4","9781608456758","CameraNetworks:TheAcquisitionandAnalysisofVideosoverWideAreas","2012","SynthesisLecturesonComputerVision","系列:计算机视觉","2153-1056","2153-1064","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00400ED1V01Y201201COV004""Collection4","9781608456628","ControlSystemsSynthesis:AFactorizationApproach,PartI","2011","SynthesisLecturesonControl&Mechatronics","系列:机电与控制","1939-0564","1939-0572","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00351ED1V01Y201105CRM002""Collection4","9781608456635","ControlSystemsSynthesis:AFactorizationApproach,PartII","2011","SynthesisLecturesonControl&Mechatronics","系列:机电与控制","1939-0564","1939-0572","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00358ED1V01Y201105CRM003""Collection4","pending","MobileRoboticsforMultidisciplinaryStudy","2012","SynthesisLecturesonControl&Mechatronics","系列:机电与控制","1939-0564","1939-0572","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00407ED1V01Y201203CRM004""Collection4","pending","BusinessProcesses:ADatabasePerspective","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00430ED1V01Y201206DTM027""Collection4","9781608457632","DatabaseRepairsandConsistentQueryAnswering","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00379ED1V01Y201108DTM020""Collection4","pending","DataProtectionfromInsiderThreats","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00431ED1V01Y201207DTM028""Collection4","9781608456024","DeclarativeNetworking","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00403ED1V01Y201202DTM023""Collection4","pending","DeepWebQueryInterfaceUnderstandingandIntegration","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00419ED1V01Y201205DTM026""Collection4","9781608457960","Full-Text(Substring)IndexesinExternalMemory","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00396ED1V01Y201111DTM022""Collection4","9781608452798","FundamentalsofPhysicalDesignandQueryCompilation","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00363ED1V01Y201105DTM018""Collection4","9781608453528","ManagingEventInformation:Modeling,Retrieval,andApplications","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00374ED1V01Y201107DTM019""Collection4","9781608453917","MethodsforMiningandSummarizingTextConversations","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00363ED1V01Y201105DTM017""Collection4","pending","P2PTechniquesforDecentralizedApplications","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00414ED1V01Y201204DTM025""Collection4","9781608456819","ProbabilisticDatabases","2011","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00362ED1V01Y201105DTM016""Collection4","9781608457663","QueryAnswerAuthentication","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00405ED1V01Y201202DTM024""Collection4","9781608458332","SpatialDataManagement","2012","SynthesisLecturesonDataManagement","系列:数据管理","2153-5418","2153-5426","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00394ED1V01Y201111DTM021""Collection4","pending","MiningHeterogeneousInformationNetworks:PrinciplesandMethodologies","2012","SynthesisLecturesonDataMiningandKnowledgeDiscovery","系列:数据挖掘和知识发现","2151-0067","2151-0075","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00433ED1V01Y201207DMK005""Collection4","pending","PrivacyinSocialNetworks","2012","SynthesisLecturesonDataMiningandKnowledgeDiscovery","系列:数据挖掘和知识发现","2151-0067","2151-0075","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00408ED1V01Y201203DMK004""Collection4","9781608458059","AdvancedCircuitSimulationUsingMultisimWorkbench","2012","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00399ED1V01Y201112DCS036""Collection4","pending","ArduinoMicrocontroller:ProcessingforEveryone!
SecondEdition","2012","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00421ED1V01Y201205DCS038""Collection4","pending","AtmelAVRMicrocontrollerPrimer:ProgrammingandInterfacing,SecondEdition","2012","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00427ED1V01Y201206DCS039""Collection4","9781608457571","CircuitAnalysiswithMultisim","2011","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00386ED1V01Y201109DCS035""Collection4","9781608456727","PragmaticElectricalEngineering:Signals&Systems","2011","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00353ED1V01Y201105DCS034""Collection4","pending","RepresentationofMultiple-ValuedLogicFunctions","2012","SynthesisLecturesonDigitalCircuits&Systems","系列:数字电路与系统","1932-3166","1932-3174","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00420ED1V01Y201205DCS037""Collection4","9781608456840","QuorumSystems:WithApplicationstoStorageandConsensus","2012","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00402ED1V01Y201202DCT009""Collection4","9781608452880","CooperativeTask-OrientedComputing:AlgorithmsandComplexity","2011","SynthesisLecturesonDistributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00376ED1V01Y201108DCT007""Collection4","9781608450428","LinkReversalAlgorithms","2011","SynthesisLecturesonDstributedComputingTheory","系列:分布式计算理论","2155-1626","2155-1634","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00389ED1V01Y201111DCT008""Collection4","pending","CraftingYourResearchFuture:AGuidetoSuccessfulMaster'sandPh.
D.
DegreesinScience&Engineering","2012","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00412ED1V01Y201203ENG018""Collection4","9781608453641","EngineeringThermodynamicsand21stCenturyEnergyProblems","2011","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00387ED1V01Y201110ENG016""Collection4","pending","FundamentalsofEngineeringEconomicsandDecisionAnalysis","2012","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00410ED1V01Y201203ENG018""Collection4","9781608458681","ALittleBookonTeaching:ABeginner'sGuideforEducatorsofEngineeringandAppliedScience","2012","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00406ED1V01Y201203ENG017""Collection4","9781608457113","MATLABforEngineeringandtheLifeSciences","2011","SynthesisLecturesonEngineering","系列:工程","1939-5221","1939-523X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00375ED1V01Y201107ENG015""Collection4","9781608457908","Engineers,Society,andSustainability","2011","SynthesisLecturesonEngineers,Technology,andSociety","系列:工程师、技术与社会","1933-3633","1933-3633","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00378ED1V01Y201108ETS017""Collection4","pending","ActivityTheoryinHCI:FundamentalsandReflections","2012","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00413ED1V01Y201203HCI013""Collection4","9781608457502","ConceptualModels:CoretoGoodDesign","2012","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00391ED1V01Y201111HCI012""Collection4","pending","HCITheory:Classical,Modern,andContemporary","2012","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00418ED1V01Y201205HCI014""Collection4","pending","MakingClaims:KnowledgeDesign,Capture,andSharinginHCI","2012","SynthesisLecturesonHuman-CenteredInformatics","系列:人本信息","1946-7680","1946-7699","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00423ED1V01Y201205HCI015""Collection4","9781608455119","BitextAlignment","2011","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00367ED1V01Y201106HLT014""Collection4","9781608457359","DiscourseProcessing","2012","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00354ED1V01Y201111HLT015""Collection4","9781608454068","LinguisticStructurePrediction","2011","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00361ED1V01Y201105HLT013""Collection4","pending","SentimentAnalysisandOpinionMining","2012","SynthesisLecturesonHumanLanguageTechnologies","系列:人类语言技术","1947-4040","1947-4059","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00416ED1V01Y201204HLT016""Collection4","9781608458202","RemoteSensingImageProcessing","2012","SynthesisLecturesonImage,Video,andMultimediaProcessing","系列:图像、视频与多媒体处理","1559-8136","1559-8144","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00392ED1V01Y201107IVM012""Collection4","9781598299724","InformationRetrievalEvaluation","2011","SynthesisLecturesonInformationConcepts,Retrieval&Services","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00368ED1V01Y201105ICR019""Collection4","pending","TheFutureofPersonalInformationManagement","2012","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00411ED1V01Y201203ICR021""Collection4","9781608456901","SearchUserInterfaceDesign","2011","SynthesisLecturesonInformationConcepts,Retrieval,andServices","系列:信息概念、获取与服务","1947-945X","1947-9468","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00371ED1V01Y201111ICR020""Collection4","pending","EnhancingInformationSecurityandPrivacybyCombiningBiometricswithCryptography","2012","SynthesisLecturesonInformationSecurity,Privacy,andTrust","系列:信息安全、隐秘与信任","1945-9742","1945-9750","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00417ED1V01Y201205SPT003""Collection4","9781608456598","MatricesinEngineeringProblems","2011","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00352ED1V01Y201105MAS010""Collection4","9781598299151","ChaoticMaps:Dynamics,Fractals,andRapidFluctuations","2011","SynthesisLecturesonMathematics&Statistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00373ED1V01Y201107MAS011""Collection4","9781608457816","EssentialsofAppliedMathematicsforEngineersandScientists,SecondEdition","2012","SynthesisLecturesonMathematicsandStatistics","系列:数学与统计","1938-1743","1938-1751","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00377ED1V01Y201202MAS012""Collection4","9781608458677","MobilePlatformsandDevelopmentEnvironments","2012","SynthesisLecturesonMobileandPervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00404ED1V01Y201202MPC009""Collection4","9781608457328","QualityofServiceinWirelessNetworksOverUnlicensedSpectrum","2012","SynthesisLecturesonMobileandPervasiveComputing","系列:移动计算与普适计算","1933-9011","1933-902X","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00383ED1V01Y201109MPC008""Collection4","9781608458172","TheSmartGrid:AdaptingthePowerSystemtoNewChallenges","2011","SynthesisLecturesonPowerElectronics","系列:电力电子","1931-9525","1931-9533","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00385ED1V01Y201109PEL003""Collection4","pending","High-levelStructuresforQuantumComputing","2012","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00422ED1V01Y201205QMC006""Collection4","9781608458271","QuantumRadar","2011","SynthesisLecturesonQuantumComputing","系列:量子计算","1945-9726","1945-9734","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00384ED1V01Y201110QMC005""Collection4","9781608457939","ProcessingofSeismicReflectionDatausingMATLAB","2011","SynthesisLecturesonSignalProcessing","系列:信号处理","1932-1236","1932-1694","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00384ED1V01Y201109SPR010""Collection4","pending","ArticulatorySpeechSynthesisfromtheFluidDynamicsoftheVocalApparatus","2012","SynthesisLecturesonSpeech&AudioProcessing","系列:语音与音频处理","1932-121X","1932-1678","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00398ED1V01Y201112SAP009""Collection4","9781608457472","SustainableInnovation","2011","SynthesisLecturesonTechnology,Management,&Entrepreneurship","系列:技术、管理与企业精神","1933-978X","1933-9798","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00359ED1V01Y201105TME003""Collection4","9781608457878","CentralNervousSystemTissueEngineering:CurrentConsiderationsandStrategies","2012","SynthesisLecturesonTissueEngineering","系列:组织工程","1944-0316","1944-0308","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00390ED1V01Y201111TIS008""Collection4","9781608456260","DataRepresentations,Transformations,andStatisticsforVisualReasoning","2011","SynthesisLecturesonVisualization","系列:可视化","pending","pending","http://www.
morganclaypool.
com/doi/abs/10.
2200/S00357ED1V01Y201105VIS002",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"Collection","PaperbackISBN","eBookISBN","Title","所属系列","Pages","Year","Author1","A1Affiliation","Author2","A2Affiliation","Author3","A3Affiliation","Author4","A4Affiliation","ISSNprint","ISSNelec","URL","DOI","Description""1","9781615041145","9781615041152","ProcessMonitoringandQualitybyDesignforBiotechnologyProducts","ColloquiumSeriesonBiotechnology","38","2010","NeslihanDelacruz"2159-2969","2159-2950","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00019ED1V01Y201011BTY001","10.
4199/C00019ED1V01Y201011BTY001","TraditionalpharmaceuticaldevelopmentisanunwieldyprocessrequiringextensiveexperimentationandlongleadtimesbeforeprocessscientistscanfullyunderstandtheeffectthatprocessparameterssuchaspH,temperature,cellviability,orprocessyieldmayhaveontheproductacceptability.
Implementationofqualitybydesignisascience-basedapproachthatallowstheoperatingrangesandtheacceptancecriteriatobeestablishedbasedontheimpactonproductqualityattributes.
Duringmanufacturing,processmonitoringbecomespartofacontinuousverificationeffortandstatisticalcontrollimitscanbeusedtosignalpotentialtrendsordriftsintheprocess.
Singlemanufacturingbatchesthatareaberrantarereadilyidentified.
Themeldingofscientificunderstanding,informationsystemsarchitecture,instrumentation,software,andpersonneltrainingprovidesalargereturnoninvestmentbyensuringthatthemanufacturingprocessproducesaconsistentpharmaceuticalproductthatmeetsacceptablereleasestandardsforhumanuse.
TableofContents:Abbreviations/Introduction/FromtheTraditionalDevelopmentPathtoQualitybyDesign/ContinuousProcessVerificationandProcessMonitoring/ProcessMonitoringandStatisticalControlLimits/MultivariateAnalysis:AMatureStateofStatisticalProcessMonitoring/Conclusion/Bibliography""1","9781615040636","9781615040643","FGFSignallinginVertebrateDevelopment","ColloquiumSeriesonDevelopmentalBiology","75","2010","MaryElizabethPownall","UniversityofYork","HarryIsaacs","UniversityofYork",,,,,"2155-3521","2155-353X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00011ED1V01Y201004DEB002","10.
4199/C00011ED1V01Y201004DEB002","Thefibroblastgrowthfactors(FGFs)representoneoftherelativelyfewfamiliesofextracellularsignallingpeptidesthathavebeenshowninrecentdecadestobekeyregulatorsofmetazoandevelopment.
FGFsarerequiredformultipleprocessesinbothprotostomeanddeuterostomegroups.
GiventhewiderangeofregulatoryrolesattributedtotheFGFs,itisperhapsnotsurprisingthatmisregulationofthissignallingpathwayhasbeenimplicatedinanumberofhumandiseaseconditions.
ThefocusofthepresentreviewistolookatthefundamentalcomponentsoftheFGFpathwayandillustratehowthishighlyconservedregulatorycassettehasbeendeployedtoregulatemultiple,diverseprocessesduringvertebratedevelopment.
ThisreviewwillexploreexamplesfromseveralvertebratemodelorganismsandincludediscussionsoftheroleofFGFsignallinginregulatingtheestablishmentofthemesoderm,neuralpatterning,morphogenesis,myogenesis,limbdevelopment,andtheestablishmentofright–leftasymmetry.
TableofContents:Introduction/FGFLigands/FGFReceptors/HeparanSulphateProteoglycans/FGFSignalTransduction/Regulators/IntegrationwithOtherSignallingPathways/MesodermInduction/NeuralInduction/FGFSignallingandPosteriorNeuralPatterning/FGFSignallingattheIsthmicOrganizer/FGFSignallingattheAnteriorNeuralRidge/Morphogenesis/Somitogenesis/FGFandMyogenesis/LimbDevelopment/FGFandLeft-RightAsymmetry/Perspectives/References/AbouttheAuthors""1","9781615041022","9781615041039","InductionandSegregationoftheVertebrateCranialPlacodes","ColloquiumSeriesonDevelopmentalBiology","83","2010","Byung-YongPark","ChonbukNationalUniversity,CollegeofVeterinaryMedicine","Jean-PierreSaint-Jeannet","UniversityofPennsylvania,SchoolofVeterinaryMedicine",,,,,"2155-3521","2155-353X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00014ED1V01Y201007DEB003","10.
4199/C00014ED1V01Y201007DEB003","Duringevolutionthevertebrateheadhasacquiredanumberofuniquefeaturesincludingspecializedpairedsenseorgansandcranialsensoryganglia.
Theseevolutionarynoveltiesarisefromdiscretethickeningsoftheheadectodermknownascranialplacodes.
Theyincludetheadenohypophyseal,olfactory,lens,trigeminal,profundal,otic,epibranchialandlaterallineplacodes.
Whiledistinctinthederivativesandcelltypestheywillform,allcranialplacodesoriginatefromacommonpreplacodaldomainsurroundingtheanteriorneuralplate.
Recentevidencesuggeststhattheinductionofthispre-placodaldomainanditssubsequentsubdivisionintoindividualplacodeswithspecificidentitiesisamulti-stepprocess.
Herewedescribethedevelopmentoftheseplacodesandtheirderivativesandsummarizerecentadvancesinthecharacterizationoftherepertoireoftranscriptionfactorsunderlyingtheirdevelopment.
Wealsoreviewrecentstudiesthathavestartedtoaddresstheroleofseveralclassesofsignalingmoleculesinplacodeinductionandsegregation,includingBoneMorphogeneticProteins,FibroblastGrowthFactorsandWntmolecules.
TableofContents:Introduction/CranialPlacodesandTheirDerivatives/MolecularIdentityofCranialPlacodes/InductionandSegregationoftheCranialPlacodes/Conclusion/Acknowledgments/References/AuthorBiographies""1","9781615040513","9781615040520","MaternalControlofDevelopmentinVertebrates","ColloquiumSeriesonDevelopmentalBiology","196","2010","FlorenceMarlow","AlbertEinsteinCollegeofMedicine"2155-3521","2155-353X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00023ED1V01Y201012DEB005","10.
4199/C00023ED1V01Y201012DEB005","EggsofallanimalscontainmRNAsandproteinsthataresuppliedtoordepositedintheeggasitdevelopsduringoogenesis.
Thesematernalgeneproductsregulateallaspectsofoocytedevelopment,andanembryofullyreliesonthesematernalgeneproductsforallaspectsofitsearlydevelopment,includingfertilization,transitionsbetweenmeioticandmitoticcellcycles,andactivationofitsowngenome.
Giventhediverseprocessesrequiredtoproduceadevelopmentallycompetenteggandembryo,itisnotsurprisingthatmaternalgeneproductsarenotonlyessentialfornormalembryonicdevelopmentbutalsoforfertility.
Thisreviewprovidesanoverviewoffundamentalaspectsofoocyteandearlyembryonicdevelopmentandtheinterferenceandgeneticapproachesthathaveprovidedaccesstomaternallyregulatedaspectsofvertebratedevelopment.
Someofthepathwaysandmoleculeshighlightedinthisreview,inparticular,Bmps,Wnts,smallGTPases,cytoskeletalcomponents,andcellcycleregulators,arewellknownandareessentialregulatorsofmultipleaspectsofanimaldevelopment,includingoogenesis,earlyembryogenesis,organogenesis,andreproductivefitnessoftheadultanimal.
Specificexamplesofdevelopmentalprocessesundermaternalcontrolandtheessentialproteinswillbeexploredineachchapter,andwhereknownconservedaspectsordivergentrolesforthesematernalregulatorsofearlyvertebratedevelopmentwillbediscussedthroughoutthisreview.
TableofContents:Introduction/Oogenesis:FromGermlineStemCellstoGermlineCysts/OocytePolarityandtheEmbryonicAxes:TheBalbianiBody,anAncientOocyteAsymmetry/PreparingDevelopmentallyCompetentEggs/EggActivation/BlockingPolyspermy/Cleavage/Mitosis:GoingMulticellular/Maternal–ZygoticTransition/Reprogramming:EpigeneticModificationsandZygoticGenomeActivation/Dorsal–VentralAxisFormationbeforeZygoticGenomeActivationinZebrafishandFrogs/MaternalTGF-βandtheDorsal–VentralEmbryonicAxis/MaternalControlAfterZygoticGenomeActivation/CompensationbyStableMaternalProteins/MaternalContributionstoGermlineEstablishmentorMaintenance/Perspective/Acknowledgments/References""1","9781615040483","9781615040490","TranscriptionalControlofNeuralCrestDevelopment","ColloquiumSeriesonDevelopmentalBiology","227","2010","BrianNelms","VanderbiltUniversity","PatriciaLabosky","VanderbiltUniversity",,,,,"2155-3521","2155-353X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00010ED1V01Y201003DEB001","10.
4199/C00010ED1V01Y201003DEB001","Theneuralcrestisaremarkableembryonicpopulationofcellsfoundonlyinvertebratesandhasthepotentialtogiverisetomanydifferentcelltypescontributingthroughoutthebody.
Thesederivativesrangefromthemesenchymalboneandcartilagecomprisingthefacialskeleton,toneuronalderivativesoftheperipheralsensoryandautonomicnervoussystems,tomelanocytesthroughoutthebody,andtosmoothmuscleofthegreatarteriesoftheheart.
Forthesecellstocorrectlyprogressfromanunspecified,nonmigratorypopulationtoawidearrayofdynamic,differentiatedcelltypes—someofwhichretainstemcellcharacteristicspresumablytoreplenishthesederivatives—requiresacomplexnetworkofmolecularswitchestocontrolthegeneprogramsgivingthesecellstheirdefiningstructural,enzymatic,migratory,andsignalingcapacities.
Thisreviewwillbringtogethercurrentknowledgeofneuralcrest-specifictranscriptionfactorsgoverningtheseprogressionsthroughoutthecourseofdevelopment.
Amorethoroughunderstandingofthemechanismsoftranscriptionalcontrolindifferentiationwillaidinstrategiesdesignedtopushundifferentiatedcellstowardaparticularlineage,andunravelingtheseprocesseswillhelptowardreprogrammingcellsfromadifferentiatedtoamorenaivestate.
TableofContents:Introduction/APGenes/bHLHGenes/ETSGenes/FoxGenes/HomeoboxGenes/HoxGenes/LimGenes/PaxGenes/POUDomainGenes/RAR/RXRGenes/SmadGenes/SoxGenes/ZincFingerGenes/OtherMiscellaneousGenes/References/AuthorBiographies""1","9781615040544","9781615040551","Wnt/β-cateninSignalinginVertebratePosteriorNeuralDevelopment","ColloquiumSeriesonDevelopmentalBiology","79","2010","YanivM.
Elkouby","DepartmentofBiochemistry,TheRappaportFamilyInstituteforResearchintheMedicalSciences,FacultyofMedicine,Technion-IsraelInstituteofTechnology","DaleFrank","DepartmentofBiochemistry,TheRappaportFamilyInstituteforResearchintheMedicalSciences,FacultyofMedicine,Technion-IsraelInstituteofTechnology",,,,,"2155-3521","2155-353X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00015ED1V01Y201007DEB004","10.
4199/C00015ED1V01Y201007DEB004","TheWnt/β-cateninsignalingpathwayisakeyregulatorofcellfatespecification,differentiation,andgrowthinmultiplesystemsthroughouttheanimalkingdom.
Invertebrateposteriorneuraldevelopment,Wnt/β-cateninsignalingcontrolsthiscomplexmultistepprocess.
Itinitiallyinducestheposteriorregionsofthenervoussystem,includingthemid-hindbrainborder,hindbrain,spinalcordandneuralcrest,andthensubsequentlyfine-tunesthepatternofeachregionanddeterminesthedifferentcellfateswithinthem.
Inthisreview,weexplorethefunctionoftheWnt/β-cateninpathwayduringtheformationofthesespecificposteriorneuralregions.
WehaveexaminedtheimportanttranscriptionaltargetsoftheWnt/β-cateninpathwayactingdownstreamtomediateitsmorphogeneticactivity.
Differentregulatorynetworksareactivatedindifferentposteriorneuralregions,andthesenetworksinducespecificneuralcelltypesineachregion.
EludidatinghoweachofthesenetworksspecifydifferentcellfatesiscrucialforunderstandingthebasictenetsofhowWntmorphogeneticactivityinducestheposteriornervoussystemduringtheearlieststagesofvertebratedevelopment.
TableofContents:Introduction/MakingtheNeuralRear/WntMorphogeneticActivityinNeuralPosteriorInduction/InductionoftheMidbrain–HindbrainBorder/InductionoftheHindbrain/InductionoftheSpinalCord/DownstreamofWnt:HindbrainorSpinalCord/NeuralCrestInduction/Anti-WntAnteriorDeterminants/TheRoleofMesodermandSpecificWntLigandsinNeuralPatterning/ConcludingRemarks/References""1","9781615043309","9781615043316","Angiogenesis","ColloquiumSeriesonIntegratedSystemsPhysiology","84","2010","ThomasAdair","UniversityofMississippiMedicalCenter","Jean-PierreMontani","UniversityofMississippiMedicalCenter",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00017ED1V01Y201009ISP010","10.
4199/C00017ED1V01Y201009ISP010","Angiogenesisisthegrowthofbloodvesselsfromtheexistingvasculature.
Thefieldofangiogenesishasgrownenormouslyinthepast30years,withonly40paperspublishedin1980andnearly6000in2010.
WhyhastherebeenthisexplosivegrowthinangiogenesisresearchAngiogenictherapiesprovideapotentialtoconquercancer,heartdiseases,andmorethan70oflife'smostthreateningmedicalconditions.
Thelivesofatleast1billionpeopleworldwidecouldbeimprovedwithangiogenictherapy,accordingtotheAngiogenesisFoundation.
Inthislittlebook,weprovideasimpleapproachtounderstandtheessentialelementsoftheangiogenicprocess,wecritiquethemostpowerfulangiogenesisassaysthatareusedtodiscoverproangiogenicandantiangiogenicsubstances,andweprovideanin-depthphysiologicalperspectiveonhowangiogenesisisregulatedinnormal,healthytissuesofthehumanbody.
Alltissuesofthebodyrequireacontinuoussupplyofoxygentoburnmetabolicsubstratesthatareneededforenergy.
Oxygenisconductedtothesetissuesbybloodcapillaries:morecapillariescanimprovetissueoxygenationandthusenhanceenergyproduction;fewercapillariescanleadtohypoxiaandevenanoxiainthetissues.
Thismeansthatangiogenictherapiesdesignedtocontrolthegrowthandregressionofbloodcapillariescanbeusedtoimprovethesurvivalofpoorlyperfusedtissuesthatareessentialtothebody(heart,brain,skeletalmuscle,etc.
)andtoridthebodyofunwantedtissues(tumors).
TableofContents:OverviewofAngiogenesis/AngiogenesisAssays/Regulation:MetabolicFactors/Regulation:MechanicalFactors/Glossary/References/AuthorBiographies""1","9781615040667","9781615040674","CapillaryFluidExchange:Regulation,Functions,andPathology","ColloquiumSeriesonIntegratedSystemsPhysiology","94","2010","JoshuaScallan","UniversityofMissouri-Columbia","VirginiaHuxley","UniversityofMissouri-Columbia","RonaldKorthuis","UniversityofMissouri-Columbia",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00006ED1V01Y201002ISP003","10.
4199/C00006ED1V01Y201002ISP003","Thepartitionoffluidbetweenthevascularandinterstitialcompartmentsisregulatedbyforces(hydrostaticandoncotic)operatingacrossthemicrovascularwallsandthesurfaceareasofpermeablestructurescomprisingtheendothelialbarriertofluidandsoluteexchange,aswellaswithintheextracellularmatrixandlymphatics.
Inadditiontoitsroleintheregulationofvascularvolume,transcapillaryfluidfiltrationalsoallowsforcontinuousturnoverofwaterbathingtissuecells,providingthemediumfordiffusionalfluxofoxygenandnutrientsrequiredforcellularmetabolismandremovalofmetabolicbyproducts.
Transendothelialvolumeflowhasalsobeenshowntoinfluencevascularsmoothmuscletoneinarterioles,hydraulicconductivityincapillaries,andneutrophiltransmigrationacrosspostcapillaryvenules,whiletheflowofthisfiltratethroughtheinterstitialspacesfunctionstomodifytheactivitiesofparenchymal,residenttissue,andmetastasizingtumorcells.
Likewise,theflowoflymph,whichisdrivenbycapillaryfiltration,isimportantforthetransportofimmuneandtumorcells,antigendeliverytolymphnodes,andforreturnoffilteredfluidandextravasatedproteinstotheblood.
Giventhisbackground,theaimsofthistreatisearetosummarizeourcurrentunderstandingofthefactorsinvolvedintheregulationoftranscapillaryfluidmovement,howfluidmovementsacrosstheendothelialbarrierandthroughtheinterstitiumandlymphaticvesselsinfluencecellfunctionandbehavior,andthepathophysiologyofedemaformation.
TableofContents:FluidMovementAcrosstheEndothelialBarrier/TheInterstitium/TheLymphaticVasculature/PathophysiologyofEdemaFormation""1","9781615041503","9781615041510","ColonicMotility","ColloquiumSeriesonIntegratedSystemsPhysiology","157","2010","SushilSarna","UniversityofTexasMedicalBranch"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00020ED1V01Y201011ISP011","10.
4199/C00020ED1V01Y201011ISP011","Threedistincttypesofcontractionsperformcolonicmotilityfunctions.
Rhythmicphasiccontractions(RPCs)causeslownetdistalpropulsionwithextensivemixing/turningover.
Infrequentlyoccurringgiantmigratingcontractions(GMCs)producemassmovements.
ToniccontractionsaidRPCsintheirmotorfunction.
Thespatiotemporalpatternsofthesecontractionsdiffermarkedly.
TheamplitudeanddistanceofpropagationofaGMCareseveral-foldlargerthanthoseofanRPC.
Theentericneuronsandsmoothmusclecellsarethecoreregulatorsofallthreetypesofcontractions.
Theregulationofcontractionsbythesemechanismsismodifiablebyextrinsicfactors:CNS,autonomicneurons,hormones,inflammatorymediators,andstressmediators.
OnlytheGMCsproducedescendinginhibition,whichaccommodatesthelargebolusbeingpropelledwithoutincreasingmuscletone.
Thestrongcompressionofthecolonwallgeneratesafferentsignalsthatarebelownociceptivethresholdinhealthysubjects.
However,thesesignalsbecomenociceptive;iftheamplitudesofGMCsincrease,afferentnervesbecomehypersensitive,ordescendinginhibitionisimpaired.
TheGMCsalsoprovidetheforceforrapidpropulsionoffecesanddescendinginhibitiontorelaxtheinternalanalsphincterduringdefecation.
ThedysregulationofGMCsisamajorfactorincolonicmotilitydisorders:irritablebowelsyndrome(IBS),inflammatoryboweldisease(IBD),anddiverticulardisease(DD).
FrequentmassmovementsbyGMCscausediarrheaindiarrheapredominantIBS,IBD,andDD,whileadecreaseinthefrequencyofGMCscausesconstipation.
TheGMCsgeneratetheafferentsignalsforintermittentshort-livedepisodesofabdominalcrampinginthesedisorders.
EpigeneticdysregulationduetoadverseeventsinearlylifeisoneofthemajorfactorsingeneratingthesymptomsofIBSinadulthood.
TableofContents:Introduction/RegulatoryMechanisms/ColonicMotilityinHealth/ColonicMotilityDysfunction/References""1","9781615040216","9781615040223","ControlofCardiacOutput","ColloquiumSeriesonIntegratedSystemsPhysiology","97","2010","DavidYoung","UniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00008ED1V01Y201002ISP006","10.
4199/C00008ED1V01Y201002ISP006","Althoughcardiacoutputismeasuredastheflowofbloodfromtheleftventricleintotheaorta,thesystemthatcontrolscardiacoutputincludesmanyothercomponentsbesidestheheartitself.
Theheart'srateofoutputcannotexceedtherateofvenousreturntoit,andtherefore,thefactorsgoverningvenousreturnareprimarilyresponsibleforcontrolofoutputfromtheheart.
Venousreturnisaffectedbyitspressuregradientandresistancetoflowthroughoutthevascularsystem.
Thepressuregradientforvenousreturnisafunctionofseveralfactorsincludingthebloodvolumeflowingthroughthesystem,theunstressedvascularvolumeofthecirculatorysystem,itscapacitance,meansystemicpressure,andrightatrialpressure.
Resistancetovenousreturnisthesumoftotalvascularresistancefromtheaorticvalvetotherightatrium.
Thesympatheticnervoussystemandvasoactivecirculatinghormonesaffectshort-termresistance,whereaslocaltissuebloodflowautoregulatorymechanismsarethedominantdeterminantsoflong-termresistancetovenousreturn.
Thestrengthofcontractionoftheheartrespondstochangesinatrialpressuredrivenbychangesinvenousreturn,withsmallchangesinatrialpressureelicitinglargechangesinstrengthofcontraction,asdescribedbytheFrank–Starlingmechanism.
Inaddition,theautonomicnervoussysteminputtotheheartaltersmyocardialpumpingabilityinresponsetocardiovascularchallenges.
Thefunctionofthecardiovascularsystemisstronglyaffectedbytheoperationoftherenalsodiumexcretion–bodyfluidvolume–arterialpressurenegativefeedbacksystemthatmaintainsarterialbloodpressureatacontrolledvalueoverlongperiods.
Theintentofthisvolumeistointegratethebasicknowledgeofthesecardiovascularsystemcomponentsintoanunderstandingofcardiacoutputregulation.
TableofContents:Introduction/VenousReturn/CardiacFunction/IntegratedAnalysisofCardiacOutputControl/AnalysisofCardiacOutputRegulationbyComputerSimulation/AnalysisofCardiacOutputControlinResponsetoChallenges/Conclusion/References/AuthorBiography""1","9781615040094","9781615040100","HepaticCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","174","2010","W.
WayneLautt","UniversityofManitoba"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00004ED1V01Y200910ISP001","10.
4199/C00004ED1V01Y200910ISP001","TheHepaticcirculationisuniqueamongvascularbeds.
Themostobviousuniquefeaturesincludethedualvascularsupply;themechanismofintrinsicregulationofthehepaticartery(thehepaticarterialbufferresponse);thefactthatportalbloodflow,supplyingtwothirdsofliverbloodflow,isnotcontrolleddirectlybytheliver;thefactthat20%ofthecardiacoutputrushesthroughthemostvascularizedorganinthebody,drivenbyapressuregradientofonlyafewmillimetersofmercury;theextremelydistensiblecapacitanceandvenousresistancesites;theunidirectionalacinarbloodflowthatregulatesparenchymalcellmetabolicspecialization;andthehighconcentrationofmacrophagic(Kupffer)cellsfilteringtheblood.
Theliveristheonlyorganreportedtohaveregionalbloodflowmonitoredbytheautonomicnervoussystem.
Thismechanism,whendysfunctional,accountsforthehepatorenalsyndromeandoffersamechanistictherapeutictargettotreatthissyndrome.
Thetriggerforliverregenerationisdependentonhepatichemodynamicssothatchronicliverbloodflowregulateslivercellmass.
Insevereliverdisease,thewholebodycirculationisreorganized,byformingportacavalshunts,toaccommodatetheincreasedintrahepaticvenousresistance.
Theseshuntsprotectthevenousdrainageofthesplanchnicorgansbutleadtolossofmajorregulatoryrolesoftheliver.
Thedevelopmentofknowledgeofthehepaticvasculatureispresentedfromahistoricalperspectivewithmodernconceptssummarizedbasedontheperspectiveoftheauthor'sfourdecadesofdevotiontothismostmarvelousoforgans.
TableofContents:Acknowledgements/HistoricalPerspectives/Overview/FluidExchange/Capacitance/ResistanceintheHepaticArtery/ResistanceintheVenousSystem/FetalandNeonatalHepaticCirculation/InVivoPharmacodynamicApproaches/NitricOxide/Adenosine/HepaticNerves/HepaticCirculationandToxicology/HepatorenalSyndrome/IntegrativeHepaticResponsetoHemorrhage/BloodFlowRegulationofHepatocyteProliferation/MultipleMechanismsMaintainingaConstantHepaticBloodFlowtoLiverMassRatio/PathopharmacologyandRepurposingDrugsasaResearchStrategy/References""1","9781615041657","9781615041664","InflammationandtheMicrocirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","87","2010","D.
NeilGranger","LouisianaStateUniversity","ElenaSenchenkova","LouisianaStateUniversity",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00013ED1V01Y201006ISP008","10.
4199/C00013ED1V01Y201006ISP008","Themicrocirculationishighlyresponsiveto,andavitalparticipantin,theinflammatoryresponse.
Allsegmentsofthemicrovasculature(arterioles,capillaries,andvenules)exhibitcharacteristicphenotypicchangesduringinflammationthatappeartobedirectedtowardenhancingthedeliveryofinflammatorycellstotheinjured/infectedtissue,isolatingtheregionfromhealthytissueandthesystemiccirculation,andsettingthestagefortissuerepairandregeneration.
Thebestcharacterizedresponsesofthemicrocirculationtoinflammationincludeimpairedvasomotorfunction,reducedcapillaryperfusion,adhesionofleukocytesandplatelets,activationofthecoagulationcascade,andenhancedthrombosis,increasedvascularpermeability,andanincreaseintherateofproliferationofbloodandlymphaticvessels.
Avarietyofcellsthatnormallycirculateinblood(leukocytes,platelets)orresidewithinthevesselwall(endothelialcells,pericytes)orintheperivascularspace(mastcells,macrophages)areactivatedinresponsetoinflammation.
Theactivationproductsandchemicalmediatorsreleasedfromthesecellsactthroughdifferentwell-characterizedsignalingpathwaystoinducethephenotypicchangesinmicrovesselfunctionthataccompanyinflammation.
Drugsthattargetaspecificmicrovascularresponsetoinflammation,suchasleukocyte-endothelialcelladhesionorangiogenesis,haveshownpromiseinboththepreclinicalandclinicalstudiesofinflammatorydisease.
Futureresearcheffortsinthisareawilllikelyidentifynewavenuesfortherapeuticinterventionininflammation.
TableofContents:Introduction/HistoricalPerspectives/AnatomicalConsiderations/ImpairedVasomotorResponses/CapillaryPerfusion/Angiogenesis/Leukocyte–EndothelialCellAdhesion/Platelet–VesselWallInteractions/CoagulationandThrombosis/EndothelialBarrierDysfunction/Epilogue/References""1","9781615040391","9781615040407","Platelet-VesselWallInteractionsinHemostasisandThrombosis","ColloquiumSeriesonIntegratedSystemsPhysiology","75","2010","RolandoRumbaut","MichaelE.
DeBakeyVAMedicalCenterandBaylorCollegeofMedicine","PerumalThiagarajan","MichaelE.
DeBakeyVAMedicalCenterandBaylorCollegeofMedicine",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00007ED1V01Y201002ISP004","10.
4199/C00007ED1V01Y201002ISP004","Plateletsareessentialmediatorsofthephysiologicprocessofhemostasisandpathologicthrombosis.
Whileplateletsdonotinteractwithvascularwallsundernormalconditions,vascularinjuryorinflammationresultinacoordinatedseriesofeventsincludingplateletadhesion,aggregation,andpromotionofcoagulation.
Inthisreview,wedescribetheprimarymechanismsinvolvedintheseresponsesinvariousvascularbedsofbothmacro-andmicrovessels,andoutlinekeyunresolvedaspectsoftheseimportantinteractions.
TableofContents:Introduction/GeneralCharacteristicsofPlatelets/PlateletAdhesiontoVascularWalls/PlateletAggregation/PlateletRecruitmentandBloodCoagulation/Arterial,Venous,andMicrovascularHemostasis/Thrombosis/Summary""1","9781615041800","9781615041817","RegulationofVascularSmoothMuscleFunction","ColloquiumSeriesonIntegratedSystemsPhysiology","62","2010","RaoufKhalil","BrighamandWomen'sHospitalandHarvardMedicalSchoolBoston,Massachusetts"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00012ED1V01Y201005ISP007","10.
4199/C00012ED1V01Y201005ISP007","Vascularsmoothmuscle(VSM)constitutesmostofthetunicamediainbloodvesselsandplaysanimportantroleinthecontrolofvasculartone.
Ca2+isamajorregulatorofVSMcontractionandisstrictlyregulatedbyanintricatesystemofCa2+mobilizationandCa2+homeostaticmechanisms.
Theinteractionofaphysiologicalagonistwithitsplasmamembranereceptorstimulatesthehydrolysisofmembranephospholipidsandincreasesthegenerationofinositol1,4,5-trisphosphate(IP3)anddiacylglycerol(DAG).
IP3stimulatesCa2+releasefromtheintracellularstoresinthesarcoplasmicreticulum.
AgonistsalsostimulateCa2+influxfromtheextracellularspaceviavoltage-gated,receptor-operated,andstore-operatedchannels.
Ca2+homeostaticmechanismstendtodecreasetheintracellularfreeCa2+concentration([Ca2+]i)byactivatingCa2+extrusionviatheplasmalemmalCa2+pumpandtheNa+/Ca2+exchangerandtheuptakeofexcessCa2+bythesarcoplasmicreticulumandpossiblythemitochondria.
Athresholdincreasein[Ca2+]iactivatesCa2+-dependentmyosinlightchain(MLC)phosphorylation,stimulatesactin–myosininteraction,andinitiatesVSMcontraction.
Theagonist-inducedmaintainedincreaseinDAGalsoactivatesspecificproteinkinaseC(PKC)isoforms,whichinturncausephosphorylationofcytoplasmicsubstratesthatincreasethecontractilemyofilamentsforcesensitivitytoCa2+andtherebyenhanceVSMcontraction.
AgonistscouldalsoactivateRhokinase(ROCK),leadingtoinhibitionofMLCphosphataseandfurtherenhancementofthemyofilamentsforcesensitivitytoCa2+.
Thecombinedincreasesin[Ca2+]i,PKCandROCKactivitycausesignificantvasoconstrictionandcouldalsostimulateVSMhypertrophyandhyperplasia.
Theprotractedandprogressiveactivationoftheseprocessescouldleadtopathologicalvascularremodelingandvasculardisease.
TableofContents:Acknowledgments/Introduction/Ca2+ReleasefromtheIntracellularStores/Ca2+EntryfromtheExtracellularSpace/MechanismsofCa2+Homeostasis/Ca2+-DependentMyosinLightChainPhosphorylation/ProteinKinaseC/RhoKinaseinVascularSmoothMuscle/VascularSmoothMuscleDysfunctionandVascularDisease/Summary/References/AuthorBiography""1","9781615040124","9781615040131","TheCerebralCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","59","2010","MarilynCipolla","UniversityofVermontCollegeofMedicine"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00005ED1V01Y200912ISP002","10.
4199/C00005ED1V01Y200912ISP002","Thispresentationdescribesstructuralandfunctionalpropertiesofthecerebralcirculationthatareuniquetothebrain,anorganwithhighmetabolicdemands,andtheneedfortightwaterandionhomeostasis.
Autoregulationispronouncedinthebrain,withmyogenic,metabolic,andneurogenicmechanismscontributingtomaintainrelativelyconstantbloodflowduringbothincreasesanddecreasesinpressure.
Inaddition,unlikeperipheralorganswherethemajorityofvascularresistanceresidesinsmallarteriesandarterioles,largeextracranialandintracranialarteriescontributesignificantlytovascularresistanceinthebrain.
Theprominentroleoflargearteriesincerebrovascularresistancehelpsmaintainbloodflowandprotectdownstreamvesselsduringchangesinperfusionpressure.
Thecerebralendotheliumisalsouniqueinthatitsbarrierpropertiesareinsomewaymorelikeepitheliumthanendotheliumintheperiphery.
Thecerebralendothelium,knownastheblood-brainbarrier,hasspecializedtightjunctionsthatdonotallowionstopassfreelyandhasverylowhydraulicconductivityandtranscellulartransport.
ThisspecialconfigurationmodifiesStarling'sforcesinthebrainsuchthationsretainedinthevascularlumenopposewatermovementduetohydrostaticpressure.
Tightwaterregulationisnecessaryinthebrainbecauseithaslimitedcapacityforexpansionwithintheskull.
Increasedintracranialpressureduetovasogenicedemacancausesevereneurologiccomplicationsanddeath.
Thischapterwillreviewthesespecialfeaturesofthecerebralcirculationandhowtheycontributetothephysiologyofthebrain.
TableofContents:Introduction/AnatomyandUltrastructure/PerivascularInnervation/RegulationofCerebrovascularTone/ControlofCerebralBloodFlow/BarriersoftheCNS/Summary/References""1","9781615041176","9781615041183","TheGastrointestinalCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","127","2010","PeterKvietys","LondonHealthSciencesCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00009ED1V01Y201002ISP005","10.
4199/C00009ED1V01Y201002ISP005","Themicrocirculationofthegastrointestinaltractisunderthecontrolofbothmyogenicandmetabolicregulatorysystems.
Themyogenicmechanismcontributestobasalvasculartoneandtheregulationoftransmuralpressure,whilethemetabolicmechanismisresponsibleformaintaininganappropriatebalancebetweenO2demandandO2delivery.
Inthepostprandialstate,hydrolyticproductsoffooddigestionelicitahyperemia,whichservestomeettheincreasedO2demandofnutrientassimilation.
Metabolicallylinkedfactors(e.
g.
,tissuepO2,adenosine)areprimarilyresponsibleforthisfunctionalhyperemia.
Thefenestratedcapillariesofthegastrointestinalmucosaarerelativelypermeabletosmallhydrolyticproductsoffooddigestion(e.
g.
,glucose),yetrestrictthetranscapillarymovementoflargermolecules(e.
g.
,albumin).
Thisallowsfortheabsorptionofhydrolyticproductsoffooddigestionwithoutcompromisingtheoncoticpressuregradientgoverningtranscapillaryfluidmovementandedemaformation.
Thegastrointestinalmicrocirculationisalsoanimportantcomponentofthemucosaldefensesystemwhosefunctionistoprevent(andrapidlyrepair)inadvertentepithelialinjurybypotentiallynoxiousconstituentsofchyme.
Twopathologicalconditionsinwhichthegastrointestinalcirculationplaysanimportantroleareischemia/reperfusionandchronicportalhypertension.
Ischemia/reperfusionresultsinmucosaledemaanddisruptionoftheepitheliumdue,inpart,toaninflammatoryresponse(e.
g.
,increaseincapillarypermeabilitytomacromoleculesandneutrophilinfiltration).
Chronicportalhypertensionresultsinanincreaseingastrointestinalbloodflowduetoanimbalanceinvasodilatorandvasoconstrictorinfluencesonthemicrocirculation.
TableofContents:Introduction/Anatomy/RegulationofVascularToneandOxygenation/ExtrinsicVasoregulation:NeuralandHumoral/PostprandialHyperemia/TranscapillarySoluteExchange/TranscapillaryFluidExchange/InteractionofCapillaryandInterstitialForces/GastrointestinalCirculationandMucosalDefense/GastrointestinalCirculationandMucosalPathologyI:Ischemia/Reperfusion/GastrointestinalCirculationandMucosalPathologyII:ChronicPortalHypertension/SummaryandConclusions/References/AuthorBiography""1","9781615040452","9781615040469","VascularBiologyofthePlacenta","ColloquiumSeriesonIntegratedSystemsPhysiology","98","2010","YupingWang","LouisianaStateUniversity"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00016ED1V01Y201008ISP009","10.
4199/C00016ED1V01Y201008ISP009","Theplacentaisanorganthatconnectsthedevelopingfetustotheuterinewall,therebyallowingnutrientuptake,wasteelimination,andgasexchangeviathemother'sbloodsupply.
Propervasculardevelopmentintheplacentaisfundamentaltoensuringahealthyfetusandsuccessfulpregnancy.
Thisbookprovidesanup-to-datesummaryandsynthesisofknowledgeregardingplacentalvascularbiologyanddiscussestherelevanceofthisvascularbedtothefunctionsofthehumanplacenta.
TableofContents:Introduction/PlacentalBloodCirculation/StructureofthePlacenta/CellTypesofthePlacenta/OxygenTensionandPlacentalVascularDevelopment/VasculogenesisandAngiogenesisofHumanPlacenta/AngiogenicFactors/VasoactivatorsandPlacentalVasoactivity/LymphaticPhenotypicCharacteristicsoftheHumanPlacenta/PlacentalTissueandCordBloodStemCells/Summary/Acknowledgment/References""1","9781615042678","9781615042685","CellOrigin,Structure,andFunction:HowCellsMakeaLiving","ColloquiumSeriesontheCellBiologyofMedicine","48","2010","JoelPardee","CEO,NeuralEssenceLLC"2153-0513","2153-0521","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00022ED1V01Y201012CBM005","10.
4199/C00022ED1V01Y201012CBM005","Inthislecture,wewillbrieflyreviewtheprinciplesofphysics,centralmetabolism,andcellbiologythatmakehealthpossible.
Thisexerciseisappropriateforthoseofuswhohavesetbeforeourselvestheproblemofunderstandingandpreservinglifeprocesses,becauseitisthroughthemediumofacellthatenergycreateslife.
Weareawarethatlifeprocessesrequireacomplexsetofbiochemicalreactions.
Butthatisnotenough.
Notonlyarecomplexreactionsnecessary,butsuperimposedonthisessentialrequirementisthenecessitytobuildandmaintainadynamiccellularstructure.
Chemicalenergybuildscells.
Inthislecture,wewillseehowcellsextractenergyfromtheentropicdissolutionoftheuniverse,howtheextractedenergyisusedtobuildcellstructure,andhowcellstructuredeterminescellfunction.
TableofContents:OriginandEnergyofLife/HowCellsMakeaLiving/OrderFromChaos:EntropyandTheRiverofTime/CapturingEntropy/CellArchitecture/WhyCellsareCompartmentalized.
TheFunctionofOrganelles/CellFunction/TheSecretoryPathway/TheGolgiApparatus/Mitochondria/TheCytoskeleton:HowOrganellesareOrganized/VesicleTransport/Mitosis/EnergyandMetabolism/References""1","9781615040001","9781615040018","HowtheHeartDevelops","ColloquiumSeriesontheCellBiologyofMedicine","68","2010","DonaldFischman","WeillCornellMedicalCollege"2153-0513","2153-0521","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00001ED1V01Y200904CBM001","10.
4199/C00001ED1V01Y200904CBM001","Withpossibleexceptionoftheatomicclock,theheartmaybethemostperfectmachineeverdevised.
Howitdevelopsfromasimpleembryonictubeisafascinatingstoryofbiologyandlendsagreatdealofinsightintothesourceofheartdefectsthataffectchildrenandadultsalike.
Centraltothisentirelectureisthefactthatthefetusresidesinanaquaticenvironment.
Oxygenatedbloodarrivesfromtheplacentaanddeoxygenatedreturnstotheplacenta.
Thelungsplaynoroleindeliveringoxygenorremovingcarbondioxidetoorfromthecirculation.
Thus,thefetusmainly(butnotexclusively)requiresathree-chamberedheartratherthanthefourchamberedheartthatweareallfamiliarwith.
Thisresemblesfishcirculationinwhichbloodleavestheheartintoanaorticsacfromwhichemanatetheaorticarchesthatdeliverbloodtothegills,whereitisoxygenatedandCO2isremoved.
Bloodthengoestothedorsalaortaefornourishingthebodytissues.
Inafishthereisnoneedforafour-chamberedheart,sincefishdonotuselungstoaeratethebloodorremoveCO2.
Althoughthefetuslacksgillsandstilldevelopsafour-chamberedheart,muchoffetalcirculatoryphysiologydependsona""quasi-three-chamberedcirculation""thatbypassesthepulmonarycirculation.
Uponbirth,this""aquatic""circulationmustchangewithinminutestopermitlungfunction.
Thetopicstofollowtracehowthiscirculationdevelopsandhowitchangesuponbirth.
TableofContents:FetalandEmbryonicHematopoiesis/FormationofthePrecardiacMesodermandFateMappingDuringGastrulation/TubularHeart/CardiacLooping/PericardialCavity/EndocardialCushions/AtrialSeptation/VentricularSeptation/PartitioningoftheBulbusCordisandTruncusArteriosus/ConductingSystem/CellLineagesDuringHeartDevelopment/CirculationatTermandChangesuponBirth/RecommendedReadings""1","9781615040032","9781615040049","SkeletalMuscle&MuscularDystrophy:AVisualApproach","ColloquiumSeriesontheCellBiologyofMedicine","56","2010","DonaldFischman","WeillCornellMedicalCollege"2153-0513","2153-0521","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00002ED1V01Y200904CBM002","10.
4199/C00002ED1V01Y200904CBM002","Histologically,muscleisconvenientlydividedintotwogroups,striatedandnonstriated,basedonwhetherthecellsexhibitcross-striationsinthelightmicroscope(Figure3).
Smoothmuscleisinvoluntary:itscontractioniscontrolledbytheautonomicnervoussystem.
Striatedmuscleincludesbothcardiac(involuntary)andskeletal(voluntary).
Theformerisinnervatedbyvisceralefferentfibersoftheautonomicnervoussystem,whereasthelatterisinnervatedbysomaticefferentfibers,mostofwhichhavetheircellbodiesintheventral,motorhornofthespinalcord.
Smoothmuscleisdesignedtohaveslow,relativelysustainedcontractions,whilestriatedmusclecontractsrapidlyandusuallyphasically.
Bothcardiacandsmoothmusclecellsaremononucleated,whereasskeletalmusclecells(fibers)aremultinucleated.
[Inagingheartsorhypertrophiedhearts,cardiacmusclecellsareoftenbinucleated.
]Multinucleationofskeletalmusclearisesduringdevelopmentbythecytoplasmicfusionofmuscleprecursorcells,myoblasts.
Adultskeletalmusclecellsdonotdivide;thatisalsotrueofmostcardiacmyocytes.
However,skeletalmuscleexhibitsaconsiderableamountofregenerationafterinjury.
Thisisbecauseadultskeletalmusclecontainsastemcell,thesatellitecell,whichliesbeneaththebasementmembranesurroundingthemusclefibers.
[Themultinucleationofcardiacmusclearisesfromkaryokinesiswithoutcytokinesis.
]AdiagrammaticseriesofenlargementsofskeletalmuscleareshowninFigure4.
Abundleofmusclefibers(fasciculus)iscutfromthedeltoidmuscle.
Eachmusclecellistermedamyofiberormusclefiber.
Eachmusclefibercontainscontractileorganellestermedmyofibrils,whichcontainthecontractileunitsofmuscletermedsarcomeres.
Thesarcomeresarecomposedofmyofilaments,whichinturnarecomposedofcontractileproteins.
Muscleconnectivetissuelayersareorganizedinconcentriclayersthatareimportantintheentryandexitofvesselsandnervestoandfromthetissue.
TheseareshowninFigure5.
Theoutermostlayeristheepimysiumormusclesheath.
Connectivetissueseptae(perimysium)runradiallyintothemuscletissue,dividingitintomusclefascicles.
Thedeepestlayer,surroundingeachofthemusclefibersistheendomysium.
Theendomysiumisindirectcontactwithabasallaminathatensheatheseachmusclefiber.
Itsurroundstheplasmamembraneofthemusclefibertermedthesarcolemma.
TableofContents:TheMuscleCell(Myofiber)/TheSarcomere/TheMyosinMolecule/RegulationofMuscleContraction/TheSarcoplasmicReticulum/MuscleFiberTypes/TheMyotendonJunction/TheSatelliteCell/MuscularDystrophy/RecommendedReadings""1","9781615040063","9781615040070","TheActinCytoskeletoninCellMotility,Cancer,andInfection","ColloquiumSeriesontheCellBiologyofMedicine","57","2010","JoelPardee","President,NeuralEssence,formerlyfacultyandDeanforGraduateResearch,WeillCornellSchoolofMedicine"2153-0513","2153-0521","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00003ED1V01Y200907CBM003","10.
4199/C00003ED1V01Y200907CBM003","Bynowitisabundantlyclearthatthecellsofourbodieshavetheabilitytomovebecauseoftheiractincytoskeleton.
Fromtheearliestcellmigrationsintheembryothatservetoformtheprimordialtissuelayerstotheoutgrowthofneurons,thecontractionsofourheartandskeletalmuscles,andthemetastasisofcancercells,itistheregulatedactionoftheactincytoskeletonthatpropelsourvariousmotions.
Inthischapterwewillexaminethebiochemicalandcellbiologicalmechanismsthatcontrolactin-basedcellmotility.
Wewillseethatcellmigrationalongasubstratumoccursinthreefundamentalphasesthatareexquisitelyorchestratedinsequence.
Cellmigrationoccursbyaninitialextensionofthefrontedgeofthecell,followedcloselybycontractionofthecell'srearendtopushcytoplasmintothenewlyformedextension.
Asthecell'snewleadingedgeextends,attachmentsitesareassembledonthecellfloor,andextendthroughtheplasmamembranetocouplethemigratingcelltotheunderlyingsurface.
Howthecellknowswheretogo,whentodetachandreattachduringthemigration,andhowtokeepeachprocessunderstrictcontrolisastorywellworthhearing,becauseitismotilityandadhesionthatmakeamulticellularlifesuchasourspossible.
TableofContents:TheCytoskeleton/HowCellsMove/RegulationoftheActinCytoskeleton/TheRoleofMyosininCellMotility/TheRoleofCellAdhesioninCellMotility/RecommendedReadings""1","9781615040759","9781615040766","UnderstandingBreastCancer:CellBiologyandTherapy","ColloquiumSeriesontheCellBiologyofMedicine","52","2010","JoelPardee","CEO,NeuralEssenceLLCandformerlyAssociateDean,WeillCornellMedicalCollege"2153-0513","2153-0521","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00021ED1V01Y201012CBM004","10.
4199/C00021ED1V01Y201012CBM004","Themysteriousdiseaseofcancer,includingbreastcancer,hasplaguedmankindsincethedawnofrecordedhistory.
Regardingtheelusivecauseofthedisease,the""FatherofMedicine,""HippocratesofAthens(460–377BC),wrotethat,""Forinstabilityischaracteristicofthehumoursandsotheymaybeeasilyalteredbynatureandbychance.
""Theenigmahaspersisteduntiltoday.
In1971,thenPresidentRichardNixonsignedtheNationalCancerActanddeclareda""WaronCancer.
""Hebelievedthecounselofscientistsandphysiciansthatifsufficientresourceswerecommittedtothefight,cancercouldbevirtuallyeliminatedwithin5years.
Theprophesyfailed.
Althoughmortalityfromafewcancers,mostnotablyleukemias,hasbeensignificantlyreduced,carcinomas,cancersoftheepithelium,whichaccountfor80%ofcancerdeaths,remainunchanged.
Whiletremendousadvanceshavetakenplaceinourunderstandingofthemolecularandcellularmechanismsoperantincancer,ithasprovenexceedinglydifficulttopreventtheoccurrenceortohalttheprogressofthedisease.
Theverybesttherapyremainsearlydetectionwhiletheprimarytumorissmallandlocalizedtoasinglesite,followedbyremovaloftheoffendinggrowthbysurgeryand/orradiation.
Thegreatchallengeoffindingacureconfrontsusyet,anditiseffectiveinterventionatthemolecularlevelthatoffersourbesthope.
Westillmustfindthe""magicbullet.
""TableofContents:TheProblemofCancer/HowCarcinomasBecomeLethal/BreastCancer/BreastCancerandEstrogen/TreatingBreastCancer/Conclusion/References""1","9781615040605","9781615040612","SexandtheDevelopingBrain","ColloquiumSeriesontheDevelopingBrain","110","2010","MargaretMcCarthy","UniversityofMaryland"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00018ED1V01Y201010DBR001","10.
4199/C00018ED1V01Y201010DBR001","Thebrainsofmalesandfemales,menandwomen,aredifferent—thatisafact.
Whatisdebatedishowdifferentandhowimportantthosedifferencesare.
Sexdifferencesinthebrainaredeterminedbygenetics,hormones,andexperience,whichinhumansincludesculture,society,andparentalandpeerexpectations.
Theimportanceofnonbiologicalvariablestosexdifferencesinhumansisparamount,makingitdifficultifnotimpossibletoparseoutthosecontributionsthataretrulybiological.
Thestudyofanimalsprovidesustheopportunitytounderstandthemagnitudeandscopeofbiologicallybasedsexdifferencesinthebrainandunderstandingthecellularmechanismsprovidesusinsightintonovelsourcesofbrainplasticity.
Manysexdifferencesareestablishedduringadevelopmentalsensitivewindowbydifferencesinthehormonalmilieuofmalesversusfemales.
Theneonataltestisproduceslargeamountsoftestosterone,whichgainsaccesstothebrainandisfurthermetabolizedintoactiveandrogensandestrogens,whichmodifybraindevelopment.
Majorparametersthatareinfluencedbyhormonesincludeneurogenesis,celldeath,neurochemicalphenotype,axonalanddendriticgrowth,andsynaptogenesis.
Varianceintheseparametersresultsinsexdifferencesinthesizeofparticularbrainregions,theprojectionsbetweenbrainregions,andthenumberandtypeofsynapseswithinparticularbrainregions.
Thecellularmechanismsarebothregionandendpointspecificandinvokemanysurprisingsystemssuchasprostaglandins,endocannabinoids,andcelldeathproteins.
Byunderstandingwhen,why,andhowsexdifferencesinthebrainareestablished,wemayalsolearnthesourceofstronggenderbiasesintherelativeriskandseverityofnumerousneurologicaldiseasesanddisordersofmentalhealth,includingbutnotlimitedtoautism,dyslexia,attentiondeficitdisorder,schizophrenia,Alzheimer's,multiplesclerosis,Parkinson's,andmajordepressivedisorder.
TableofContents:Introduction/SexDeterminationversusSexDifferentiation/Masculinization,Feminization,andDefeminization/SteroidHormonesArePotentModulatorsofBrainDevelopment/SexDifferencesintheBrainAreEstablishedDuringaDevelopmentalSensitiveWindow/SexDifferencesinPhysiologyandBehaviorAreCoordinated/KnockoutsoftheRule:MicewithNullMutationsofSteroidReceptors,SteroidogenicEnzymes,andBindingProteins/SteroidsInfluenceMultipleEndpointstoOrganizetheBrain/CellularMechanismsofSteroid-MediatedOrganizationoftheBrain/WingedMessengers:LessonsfromBirdsandFlies/SexualDifferentiationofthePrimateBrain/SexualDifferentiationoftheHumanBrain/OvercomingtheHegemonyofHormones:GenesMatterToo/TheValueofUnderstandingtheEffectofSexontheDevelopingBrain/References""1","9781615043453","9781615043460","CardiovascularResponsestoExercise","ColloquiumSeriesonIntegratedSystemsPhysiology","124","2011","LushaXiang","UniversityofMississippiMedicalCenter","RobertHester","UniversityofMississippiMedicalCenter",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00040ED1V01Y201109ISP027","10.
4199/C00040ED1V01Y201109ISP027","Exerciseistheactofincreasingmetabolicrateforthepurposeofenhancingphysicalfitness.
Exercisecanbeoneofthemoststressfulphysiologicalresponsesthatthebodyundertakes.
Withexercise,thereareincreasesinmetabolicrate,heartrate,bloodflow(hyperemia),respiration,andheatproduction.
Theincreasedmetabolicrequirementduringexerciseiswellmetbyanincreasedbloodflow(functionalhyperemia)andoxygensupplytotheexercisingtissue,whichisregulatedbymultiplelocalandsystemicmechanisms.
Thelocalmechanisms(factors)areresponsibleformediatingthemusclehomeostasisandvascularconductancetomatchtheincreasedmetabolicrequirement,whereasthesystemicmechanismsareresponsibleforthemaintenanceofbloodpressureandglobalcardiovascularhomeostasis,includingtheincreaseinandredistributionofcardiacoutput,whichismainlymediatedbysympatheticactivation.
Forinstance,thesubstantialdecreasesinvascularresistanceandresultantlargeincreaseinbloodflowduringexerciserequirehigherbloodpressureandmorecardiacoutput,suchthatthemetabolicallyactivemusclecanbeperfusedwithadequatebloodflow.
Thisbookwillprovideanoverviewofthecardiovascularresponsestoexerciseunderphysiologicalconditionsaswellassomepathologicalcircumstances.
TableofContents:CapillaryPerfusioninSkeletalMuscleDuringExercise/LocalControlofArteriolarDiameterandBloodFlowDuringExercise/SystemicControlofCardiovascularResponsetoExercise/CardiovascularResponsetoExerciseunderPathologicalConditions/References/AuthorBiography""1","9781615042104","9781615042111","EndothelinintheKidney","ColloquiumSeriesonIntegratedSystemsPhysiology","88","2011","DavidPollock","GeorgiaHealthSciencesUniversity","ErikaBoesen","GeorgiaHealthSciencesUniversity",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00042ED1V01Y201110ISP028","10.
4199/C00042ED1V01Y201110ISP028","Thediscoveryofapotentvasoconstrictor,endothelin(ET)-1,derivedfromvascularendothelialcellswasamongavarietyofkeylinesofinvestigationthathelpedtofuelamajorexplosionofstudiesrelatedtoendothelialcellbiology.
Thiswasparticularlyevidentwithinthepharmaceuticalindustrywherereceptorantagonistswerequicklydevelopedandarenowonthemarketfortreatmentofpulmonaryhypertensionandindevelopmentforotherdiseasessuchasdiabeticnephropathyandcancer.
Importantly,weknowthatthekidneycontainsthehighestlevelofET-1productionandreceptorexpressioninthebodywhereithasbeendemonstratedtofunctionasapro-natriureticautocrineandparacrinefactorthatisactivatedinconditionsofhighsaltintake.
ThiseBookprovidesareviewofthevariousmechanismswherebyET-1hasbeenshowntofunctionwithinthekidneythroughawiderangeofactionsthatincludedirecteffectsontubulartransport,intrarenalhemodynamics,aswellasneuralandendocrinefunctions.
Muchhasyettobediscerned,butitisclearthattheETsystemisamajorphysiologicalregulatoroffluid-electrolytebalanceandbloodpressurethroughtheserenalactions.
TableofContents:DiscoveryofEndothelin/BasicBiologyoftheEndothelinSystem/RenalLocalization/RenalHemodynamics/RenalTubularActionsofEndothelin/EndothelininNeuralModulationofRenalFunction/PhysiologicalRoleofEndothelin/EndothelininRenalPathology/References/AuthorBiographies""1","9781615043392","9781615043408","EntericNervousSystem:TheBrain-in-the-Gut","ColloquiumSeriesonIntegratedSystemsPhysiology","172","2011","JackieD.
Wood","OhioStateUniversity"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00039ED1V01Y201107ISP026","10.
4199/C00039ED1V01Y201107ISP026","Minute-to-minutebehaviorofthealimentarytractreflectstheintegratedfunctioningofthegut'smusculature,secretoryglandsandblood–lymphaticvasculature.
Activityofthethreeeffectorsystemstogeneratefunctionallyeffectivepatternsofbehavior,whichareadaptivefordifferingdigestivestates,isorganizedandcoordinatedbytheentericnervoussystem(i.
e.
,thebrain-in-the-gut).
Theheuristicmodelfortheentericnervoussystem(ENS)isthesameasforallintegrativenervoussystems,whetherinvertebrateorinvertebrateanimals.
Likeotherintegrativenervoussystems,suchasthespinalcordandbrainstem,theENSfunctionswithsensoryneurons,interneuronsandmotorneurons.
ThatthegutdoesnotworkwithouttheENScanbemadeasanabsolutestatement.
ThisisapparentinitsabsenceinterminalregionsofthelargeintestineinHirschsprung'sdiseaseinhumansandanimalswhereitisreflectedbydysfunctionalmotility,failureofdefecationandproximalfecalcompactionwithinaproximalmegacolon.
AutoimmuneablationoftheENSintheloweresophagealsphincterunderliesthepathophysiologyofachalasia.
Furthermore,neuropathicdegenerationofENSneuronsinirritablebowelsyndrome,otherfunctionalgastrointestinaldisorders,intestinalpseudoobstruction,Chagasdisease,paraneoplasticsyndromeandentericganglionitis,underliesthemorbidityassociatedwiththesedisorders.
TheimpactoftheseclinicaldisordersonqualityoflifeandcostofhealthcareisareminderoftheimportanceoftheENSforanormallyfunctioninggut.
Moreover,ourincompleteunderstandingofthepathobiologyofthesedisordershighlightsaneedforresearchdirectedtoexpansionofcurrentknowledgeoftheneurobiologyoftheENSatalllevelsoforganizationfromthecellularbiologyofindividualneuronstothebiophysicsofintegratednetworkstowholeorganbehavior.
InvestigationofthenormalanddisorderedENSanditsinteractionswiththecentralnervoussystemisabranchofneurogastroenterology.
Neurogastroenterologyisascientificandclinicalsubspecialtyofgastroenterologythatdealswiththeneuralmechanismsthatinfluencefunctionofthedigestivetractandthatunderlieprojectionofconscioussensationstothegut.
TableofContents:Introduction/HistoricalPerspective/HeuisticModel/Microanatomy/SensoryNeurophysiology/Interneurons/EntericMotorNeurons/DisinhibitoryMotorDisorders/NeuronalElectricalBehavior/SynapticTransmission/OrganLevelIntegration/GastricMotorIntegration/IntegratedControloftheSmallandLargeIntestines/PlasticityintheENS/SmallIntestineMotility/Defecation/References""1","9781615042135","9781615042142","HemeOxygenaseandtheKidney","ColloquiumSeriesonIntegratedSystemsPhysiology","80","2011","DavidStec","UniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00036ED1V01Y201107ISP024","10.
4199/C00036ED1V01Y201107ISP024","Hemeoxygenases(HOs)aretheenzymesresponsibleforthebreakdownofhemeandthegenerationofbiliverdin/bilirubinandcarbonmonoxide(CO).
Thekidneyisacomplexorganconsistingofmanydifferentcelltypesallworkingtogetherforthesinglepurposeoffilteringthebloodtoeliminatewasteproductsandconservingions,minerals,andwaternecessaryforlife.
HOenzymesandtheirproductsplayacriticalroleinthenormalfunctionofthekidneyaswellasprotectingthekidneyfromvariousinsultsincludingischemiaandexposuretonephrotoxins.
Forexample,theHOmetabolite,bilirubin,isapotentantioxidantwhichcanlimitdamagetorenaltubularepithelialcellsfollowingexposuretonephrotoxinsassociatedwithchemotherapyortraumaticinjury.
AnotherHOmetabolite,CO,isanimportantvasodilatorofrenalbloodvesselsandhelpsprotectagainstseveredecreasesinrenalbloodflowinconditionsasdiverseasexposuretoradiocontrastagentsandinhypertension-inducedkidneydisease.
HOanditsmetabolitesalsoplayanimportantroleinthesurvivalofkidneycellsafteracuteandchronicinjuriesbyregulatingimportantcellgrowthandprogrammedcelldeathpathways.
TheintentofthisvolumeistohighlighttheimportantrolethatHOenzymesandtheirrelatedmetabolites,bilirubinandCO,playintheregulationofrenalfunctionandintheresponseofthekidneytobothacuteandchronicpathologies.
TableofContents:IntroductiontotheHOSystem/HOandRenalVascularFunction/HOandRenalTubuleFunction/HOandAcuteKidneyInjury/HOandChronicKidneyInjury/FutureofRenalHOResearch/References""1","9781615041626","9781615041633","HemorheologyandHemodynamics","ColloquiumSeriesonIntegratedSystemsPhysiology","140","2011","GilesCokelet","MontanaStateUniversity"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00033ED1V01Y201106ISP021","10.
4199/C00033ED1V01Y201106ISP021","Fromtheperspectiveofbloodflow,bloodhassomeunusualproperties:itisasuspensionofbloodcellsofwhichtheredbloodcellsaremostnumerousandarebothdeformable(atmoderateandhighflowrates)andwillaggregateunderconditionsofslowflow.
Also,thecellularvolumeconcentrationishigh(about40-45%).
Thesefeaturescausebloodtohavevariableviscosity,dependentonflowconditions,andcausebothredbloodcellsedimentationandsyneresiseffectsunderslowflowconditions(whichcanleadtorheologicalartifacts).
Theseeffectsalsocauseunusualflowphenomenawhenbloodflowsinsystemsofsmalldiametervessels(especiallyfordiametersofabout500μmorless).
Thesephenomenaareseeninnon-uniformcelldistributionsinvesselcrosssections,acell-poorlayerofmostlybloodplasmaatvesselswalls,non-proportionatecellulardistributionduringbloodflowthroughvascularbifurcations,whichleadstoaverywidedistributionofvesselcellularconcentrations(fromzerotosystemicvalues)inthesmallervesselsofthemicrocirculation,etc.
Allthesephenomenaarediscussedinthisbook,aswellasthedifficultiespresentedbyinvivomicrovesselshavingnon-idealgeometries.
TableofContents:Introduction/TheCompositionofBlood/Viscometers/ConstitutiveEquations/AtLast,ExperimentalData!
/SomeInVitroBloodFlows/TheFahraeusEffect/TheFahreus-LindqvistEffect/InVitroArterial-TypeBifurcationExperimentalData/InVivoExperimentalBifurcationData/FlowinMicrovascularNetworks/Optimization/ConcludingStatement/References""1","9781615041442","9781615041459","IntestinalImmuneSystem","ColloquiumSeriesonIntegratedSystemsPhysiology","122","2011","SoichiroMiura","NationalDefenseMedicalCollege","RyotaHokari","NationalDefenseMedicalCollege","ShunsukeKomoto","NationalDefenseMedicalCollege",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00037ED1V01Y201107ISP025","10.
4199/C00037ED1V01Y201107ISP025","Intheintestine,auniqueimmunologicalsystemthatisdifferentfromthesystemicimmunesystemexiststoprovideadaptiveimmunityinresponsetoluminalbacteriaanddietaryantigens.
Therearemanylymphoidcellaggregatescalledgut-associatedlymphoidtissue(GALT)includingPeyer'spatches(PPs),whichfunctionasimportantinductionsitesforthemucosalimmuneresponse.
M-cellsarepresentintheepitheliumofPPs,havingaspecializedstructureforuptakeofmacromoleculessuchasbacteria.
InadditiontoGALT,thereareabundantlymphoidcellsintheintestinallaminapropria,wheretheymainlyplayaroleasimmuneeffectorcells.
Astronginnateimmunesystemthatmainlyconsistsofdendriticcells,macrophages,andγδTlymphocytesalsoexistsintheintestinalmucosatoassistthebarrierfunctionofintestinalepithelialcells.
Theintestinalmucosathusshowsauniquemorphologicalstructurewithmanyimmunecellsbeingpresentunderphysiologicalconditions.
Thisconditionisknownas""controlledinflammation.
""Theseabundantimmunecellsalsohavecharacteristicfunctions:theyare""negativelyregulated""andhavebeeneducatednottooverreactunnecessarilytotheintestinalluminalmilieu.
MainplayersthatcontrolinflammationoftheintestinalmucosaincluderegulatorycytokinesandregulatoryTcellswhichinduceoraltolerancetointestinalbacteriaandfoodantigens,andthesecretoryIgAsystem.
Themaintenanceofuniqueimmunologicalactivityintheintestineisalsorelatedtoanorganized,orchestratedlymphocytemigratorymechanismcalledthe""commonmucosalimmunesystem.
""Thesenegativeregulatorymechanismsoftheintestinalimmunesystemaredisturbedincertaindiseaseconditions,causingtheimmunocompetentcellstorespondtofoodcomponentsandcommensalbacteriabybecomingactivatedandtooverproduceinflammatorycytokinesandchemokines.
Thesediseaseconditionsincludefoodallergies,suchasceliacdisease,andtheinflammatoryboweldiseases,suchasulcerativecolitisandCrohn'sdisease,althoughtheirexactetiologicalmechanismsremaintoberevealed.
TableofContents:Introduction/GALT:ItsStructureandFormation/IntestinalEpithelialCellsandTheirImmuneFunction/InnateImmunityintheIntestinalMucosa/IntraepithelialLymphocytes(IELs)/LymphoidCellTraffickinginIntestinalImmunology/SiteofInductionofMucosalImmunityandAntigenPresentationbyDendriticCells/ProductionofSecretoryIgA(SIgA)/EffectorSiteofAcquiredImmunityandTHelperCellSubpopulation/ImmuneRegulatorySystemandOralTolerance/FoodAllergyandCeliacDisease/InflammatoryBowelDiseases/EntericInfectionwithPathogenicMicrobesandMucosalImmunity/References""1","9781615043330","9781615043347","MotorFunctionofthePharynx,Esophagus,anditsSphincters","ColloquiumSeriesonIntegratedSystemsPhysiology","84","2011","RaviMittal","UniversityofCalifornia,SanDiego"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00030ED1V01Y201104ISP018","10.
4199/C00030ED1V01Y201104ISP018","Deglutitionoraswallowbeginsasavoluntaryactintheoralcavitybutproceedsautonomouslyinthepharynxandesophagus.
Bilateralsequencedactivationandinhibitionofmorethan25pairsofmusclesofmouth,pharynx,larynx,andesophagusisrequiredduringaswallow.
Asingleswallowelicitsperistalsisinthepharynxandesophagusalongwithrelaxationofupperandloweresophagealsphincters.
Multipleswallows,atcloselyspacedtimeintervals,demonstratedeglutitiveinhibition;sphinctersremainrelaxedduringtheentireperiod,butonlythelastswallowelicitsperistalsis.
Laryngealinletclosureorairwayprotectionisveryimportantduringswallow.
Upperpartoftheesophagusthatincludesupperesophagealsphincteriscomposedofskeletalmuscles,middleesophagusiscomposedofamixtureofskeletalandsmoothmuscles,andloweresophagus,includingloweresophagealsphincter,iscomposedofsmoothmuscles.
Peristalsisprogressesinseamlessfashion,despiteseparatecontrolmechanism,fromtheskeletaltosmoothmuscleesophagus.
Theesophagus'scircularandlongitudinalmusclelayerscontractsynchronouslyduringperistalsis.
Sphinctersmaintaincontinuoustone;neuromuscularmechanismsfortonicclosureintheupperandloweresophagealsphinctersaredifferent.
Loweresophagealsphinctertransientrelaxation,belchingmechanism,regurgitation,vomiting,andrefluxaremediatedviathebrainstem.
TableofContents:Introduction/CentralProgramGeneratorandBrainStem/Pharynx-Anatomy,NeuralInnervation,andMotorPattern/UpperEsophagealSphincter/NeuromuscularAnatomyofEsophagusandLowerEsophagealSphincter/ExtrinsicInnervation:ParasympatheticandSympathetic/InterstitialCellsofCajal/RecordingTechniques/MotorPatternsoftheEsophagus-AboralandOralTransport/DeglutitiveInhibitionandMuscleRefractoriness/PeristalsisintheCircularandLongitudinalMusclesoftheEsophagus/NeuralandMyogenicMechanismofPeristalsis/CentralMechanismofPeristalsis-CorticalandBrainStemControl/PeripheralMechanismsofPeristalsis/CentralVersusPeripheralMechanismofDeglutitiveInhibition/NeuralControlofLongitudinalMuscleContraction/ModulationofPrimaryandSecondaryPeristalsis/NeuralControlofLowerEsophagealSphincterandCruralDiaphragm/LowerEsophagealSphincter/Swallow-InducedLESRelaxation/CruralDiaphragmContributiontoEGJandNeuralControl/TransientLESRelaxationandPharmacologicalInhibition/ComplianceoftheEGJ/References""1","9781615042319","9781615042326","NeuralControlofRenalFunction","ColloquiumSeriesonIntegratedSystemsPhysiology","96","2011","UllaKopp","UniversityofIowaCarverCollegeofMedicineandDepartmentofVeteransAffairsMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00034ED1V01Y201106ISP022","10.
4199/C00034ED1V01Y201106ISP022","Thekidneyisinnervatedwithefferentsympatheticnervefibersreachingtherenalvasculature,thetubules,thejuxtaglomerulargranularcells,andtherenalpelvicwall.
Therenalsensorynervesaremainlyfoundintherenalpelvicwall.
Increasesinefferentrenalsympatheticnerveactivityreducerenalbloodflowandurinarysodiumexcretionbyactivationofα1-adrenoceptorsandincreasereninsecretionratebyactivationofβ1-adrenoceptors.
Inresponsetonormalphysiologicalstimulation,changesinefferentrenalsympatheticnerveactivitycontributeimportantlytohomeostaticregulationofsodiumandwaterbalance.
Therenalmechanosensorynervesareactivatedbystretchoftherenalpelvictissueproducedbyincreasesinrenalpelvicpressureofamagnitudethatmayoccurduringincreasedurineflowrate.
Activationofthesensorynerveselicitsaninhibitoryrenorenalreflexresponseconsistingofdecreasesinefferentrenalsympatheticnerveactivityleadingtonatriuresis.
Increasingefferentsympatheticnerveactivityincreasesafferentrenalnerveactivitywhich,inturn,decreasesefferentrenalsympatheticnerveactivitybyactivationoftherenorenalreflexes.
Thus,activationoftheafferentrenalnervesbufferschangesinefferentrenalsympatheticnerveactivityintheoverallgoalofmaintainingsodiumbalance.
Inpathologicalconditionsofsodiumretention,impairmentoftheinhibitoryrenorenalreflexescontributestoaninappropriatelyincreasedefferentrenalsympatheticnerveactivityinthepresenceofsodiumretention.
Instatesofrenaldiseaseorinjury,thereisashiftfrominhibitorytoexcitatoryreflexesoriginatinginthekidney.
Studiesinessentialhypertensivepatientshaveshownthatrenaldenervationresultsinlong-termreductioninarterialpressure,suggestinganimportantrolefortheefferentandafferentrenalnervesinhypertension.
TableofContents:PartI:EfferentRenalSympatheticNerves/Introduction/Neuroanatomy/NeuralControlofRenalHemodynamics/NeuralControlofRenalTubularFunction/NeuralControlofReninSecretionRate/PartII:AfferentRenalSensoryNerves/Introduction/Neuroanatomy/RenorenalReflexes/MechanismsInvolvedintheActivationofAfferentRenalSensoryNerves/PartIII:PathophysiologicalStates/EfferentRenalSympatheticNerves/AfferentRenalSensoryNerves/Conclusions/References""1","9781615043620","9781615043637","ReactiveOxygenSpeciesandtheCardiovascularSystem","ColloquiumSeriesonIntegratedSystemsPhysiology","102","2011","AugustoMontezano","UniversityofOttawaandUniversityofGlasgow","Touyz,Rhian","UniversityofOttawaandUniversityofGlasgow",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00043ED1V01Y201112ISP032","10.
4199/C00043ED1V01Y201112ISP032","Reactiveoxygenspecies(ROS)influencevariousphysiologicalprocessesincludinghostdefense,hormonebiosynthesis,andcellularsignaling.
IncreasedROSproduction(oxidativestress)isimplicatedinmanydiseasesofthecardiovascularsystem,includinghypertension,atherosclerosis,cardiacfailure,stroke,diabetes,andkidneydisease.
ROSareproducedthroughoutthecardiovascularsystem,inthekidneyandcentralandperipheralnervoussystem.
Amajorsourceforcardiovascular,renal,andneuralROSisafamilyofnon-phagocyticNAD(P)Hoxidases,includingtheprototypicNox2homologue-basedNAD(P)Hoxidase,aswellasotherNAD(P)Hoxidases,suchasNox1andNox4.
Otherpossiblesourcesincludemitochondrialelectrontransportenzymes,xanthineoxidase,cyclooxygenase,lipoxygenase,anduncouplednitricoxidesynthase(NOS).
NAD(P)Hoxidase-derivedROSisimportantinregulatingendothelialfunctionandvasculartoneandoxidativestressisimplicatedinendothelialdysfunction,inflammation,hypertrophy,apoptosis,migration,fibrosis,angiogenesisandrarefaction,importantprocessesinvolvedinvascularremodelingincardiovasculardisease.
Thesefindingshaveevokedconsiderableinterestbecauseofthepossibilitiesthattherapiestargetedagainstnon-phagocyticNAD(P)HoxidasetodecreaseROSgenerationand/orstrategiestoincreasenitricoxide(NO)availabilityandantioxidantsmaybeusefulinminimizingvascularinjuryandtherebypreventorregresstargetorgandamageassociatedwithhypertensionandothercardiovasculardiseases.
""1","9781615041749","9781615041756","RegulationofCardiacContractility","ColloquiumSeriesonIntegratedSystemsPhysiology","50","2011","R.
JohnSolaro","UniversityofIllinoisatChicago"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00030ED1V01Y201104ISP018","10.
4199/C00030ED1V01Y201104ISP018","Contractilitydescribestherelativeabilityofthehearttoejectastrokevolume(SV)atagivenprevailingafterload(arterialpressure)andpreload(end-diastolicvolume;EDV).
VariousmeasuresofcontractilityarerelatedtothefractionastheSV/EDVortheejectionfraction,andthedynamicsofejectionasdeterminedfrommaximumpressureriseintheventriclesorarteriesorfromaorticflowvelocitiesdeterminedbyechocardiography.
Atthecellularlevel,theultimatedeterminantofcontractilityistherelativetensiongenerationandshorteningcapabilityofthemolecularmotors(myosincross-bridges)ofthesarcomeresasdeterminedbytheratesandextentofCaactivation,theturnoverkineticsofthecross-bridges,andtherelativeCaresponsivenessofthesarcomeres.
Engagementoftheregulatorysignalingcascadescontrollingcontractilityoccurswithoccupancyandsignaltransductionbyreceptorsforneurohumorsoftheautonomicnervoussystemaswellasgrowthandstresssignalingpathways.
ContractilityisalsodeterminedbytheprevailingconditionsofpH,temperature,andredoxstate.
Short-termcontrolofcontractilityisfullyexpressedduringexercise.
Inlong-termresponsestostressesontheheart,contractilityismodifiedbycellularremodelingandalteredsignalingthatmaycompensateforatimebutwhichultimatelymayfail,leadingtodisorders.
TableofContents:Introduction:ContractilityandtheIntegrativeBiologyoftheMyocardium/ControlofContractilityIsattheCellularLevelofOrganization/LeftVentricularDiastolicandSystolicPressure,Ejection,andRelaxationReflectSarcomericMechanicalProperties/IntegrationofSarcomereMechanicswithCardiacFunctionClarifiestheMeaningofPreload,Afterload,andContractility/PressureVolumeLoopsProvideaQuantificationofContractility/PhosphorylationsofRegulatoryProteinsinExcitationContractionCouplingModifyContractilitybyControllingCellularCa+Fluxes,theResponseoftheMyofilamentstoCa+,andtheKineticsoftheCross-BridgeCycle/ContractilityMayBeAlteredbyaVarietyofMechanismsNotInvolvingaProminentRolefortheAutonomicNervousSystem/CardiacFunctionCurvesProvideaCompactGraphicalRepresentationofRegulationofCOandSV/HeartFailureasaFailureofContractility/References""1","9781615041206","9781615041213","RegulationofEndothelialBarrierFunction","ColloquiumSeriesonIntegratedSystemsPhysiology","146","2011","SarahYuan","UniversityofCalifornia,Davis","RobertRigor","UniversityofCalifornia,Davis",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00025ED1V01Y201101ISP013","10.
4199/C00025ED1V01Y201101ISP013","Thevascularendotheliumliningtheinnersurfaceofbloodvesselsservesasthefirstinterfaceforcirculatingbloodcomponentstointeractwithcellsofthevascularwallandsurroundingextravasculartissues.
Inadditiontoregulatingblooddeliveryandperfusion,amajorfunctionofvascularendothelia,especiallythoseinexchangemicrovessels(capillariesandpostcapillaryvenules),istoprovideasemipermeablebarrierthatcontrolsblood–tissueexchangeoffluids,nutrients,andmetabolicwasteswhilepreventingpathogensorharmfulmaterialsinthecirculationfromenteringintotissues.
Duringhostdefenseagainstinfectionortissueinjury,endothelialbarrierdysfunctionoccursasaconsequenceaswellascauseofinflammatoryresponses.
Plasmaleakagedisturbsfluidhomeostasisandimpairstissueoxygenation,apathophysiologicalprocesscontributingtomultipleorgandysfunctionassociatedwithtrauma,infection,metabolicdisorder,andotherformsofdisease.
Inthisbook,weprovideanupdatedoverviewofmicrovascularendothelialbarrierstructureandfunctioninhealthanddisease.
Thediscussionisinitiatedwiththebasicphysiologicalprinciplesoffluidandsolutetransportacrossmicrovascularendothelium,followedbydetailedinformationonendothelialcell–cellandcell–matrixinteractionsandtheexperimentaltechniquesthatareemployedtomeasureendothelialpermeability.
Furtherdiscussionfocusesonthesignalingandmolecularmechanismsofendothelialbarrierresponsestovariousstimulationsordrugs,aswellastheirrelevancetoseveralcommonclinicalconditions.
Takentogether,thisbookprovidesacomprehensiveanalysisofmicrovascularendothelialcellandmolecularpathophysiology.
Suchinformationwillassistscientistsandcliniciansinadvancedbasicandclinicalresearchforimprovedhealthcare.
TableofContents:Acknowledgments/Introduction/StructureandFunctionofExchangeMicrovessels/MethodsforMeasuringPermeability/TheEndothelialBarrier/SignalingMechanismsintheRegulationofEndothelialPermeability/EndothelialBarrierProtectors/PathophysiologyandClinicalRelevance/Conclusion/References""1","9781615041329","9781615041336","RegulationofGastrointestinalMucosalGrowth","ColloquiumSeriesonIntegratedSystemsPhysiology","114","2011","Jian-YingWang","UniversityofMarylandSchoolofMedicineandBaltimoreVeteransAffairsMedicalCenter","RaoN.
Jaladanki","UniversityofMarylandSchoolofMedicineandBaltimoreVeteransAffairsMedicalCenter",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00028ED1V01Y201103ISP015","10.
4199/C00028ED1V01Y201103ISP015","Themammaliangastrointestinalmucosaisarapidlyself-renewingtissueinthebody,anditshomeostasisispreservedthroughthestrictregulationofepithelialcellproliferation,growtharrest,andapoptosis.
Thecontrolofthegrowthofgastrointestinalmucosaisuniqueand,comparedwithmostothertissueinthebody,complex.
Mucosalgrowthisregulatedbythesamehormonesthataltermetabolisminothertissues,butthegastrointestinalmucosaalsorespondstoahostofeventstriggeredbytheingestionandpresenceoffoodwithinthedigestivetract.
Theseguthormonesandpeptidesregulatethegrowthoftheexocrinepancreas,gallbladderepithelium,andthemucosaoftheoxynticglandregionofthestomachandthesmallandlargeintestines.
Luminalfactors(nutrientsorotherdietaryfactors,secretions,andmicrobes),whichoccurwithinthelumenanddistributeoveraproximal-to-distalgradient,arealsocrucialforthemaintenanceofthenormalgutmucosalgrowthandcouldexplainthevillousheight–cryptdepthgradientandvarietyofadaptationssincethesefactorsarediluted,absorbed,anddestroyedastheypassdownthedigestivetract.
Recently,intestinalstemcellsandpolyaminesareshowntoplayanimportantroleintheregulationofgastrointestinalmucosalgrowthunderphysiologicalandvariouspathologicalconditions.
Inthischapter,wehighlightkeyissuesandfactorsthatcontrolgastrointestinalmucosalgrowth,withspecialemphasisonthemechanismsthroughwhichepithelialrenewalisregulatedbypolyaminesatthecellularandmolecularlevels.
TableofContents:Introduction/IntestinalArchitectureandDevelopment/CharacteristicsofGutMucosalGrowth/IntestinalStemCells/RoleofGIHormonesontheGutMucosalGrowth/PeptideGrowthFactorsinGIMucosalGrowth/LuminalNutrientsandMicrobesinGutMucosalGrowth/PolyaminesintheRegulationofMucosalGrowth/SummaryandConclusions/Acknowledgments/References""1","9781615041770","9781615041787","RegulationofTissueOxygenation","ColloquiumSeriesonIntegratedSystemsPhysiology","100","2011","RolandPittman","VirginiaCommonwealthUniversity"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00029ED1V01Y201103ISP017","10.
4199/C00029ED1V01Y201103ISP017","Thispresentationdescribesvariousaspectsoftheregulationoftissueoxygenation,includingtherolesofthecirculatorysystem,respiratorysystem,andblood,thecarrierofoxygenwithinthesecomponentsofthecardiorespiratorysystem.
Therespiratorysystemtakesoxygenfromtheatmosphereandtransportsitbydiffusionfromtheairinthealveolitothebloodflowingthroughthepulmonarycapillaries.
Thecardiovascularsystemthenmovestheoxygenatedbloodfromthehearttothemicrocirculationofthevariousorgansbyconvection,whereoxygenisreleasedfromhemoglobinintheredbloodcellsandmovestotheparenchymalcellsofeachtissuebydiffusion.
Oxygenthathasdiffusedintocellsisthenutilizedinthemitochondriatoproduceadenosinetriphosphate(ATP),theenergycurrencyofallcells.
ThemitochondriaareabletoproduceATPuntiltheoxygentensionorPOintheirvicinityfallstoacriticallevelofabout1mmHg.
Thus,inordertomeettheenergeticneedsofcells,itisimportanttomaintainacontinuoussupplyofoxygentothemitochondriaatorabovethecriticalPO.
Inordertoaccomplishthisdesiredoutcome,thecardiorespiratorysystem,includingtheblood,mustbecapableofregulationtoensuresurvivalofalltissuesunderawiderangeofcircumstances.
Thepurposeofthispresentationistoprovidebasicinformationabouttheoperationandregulationofthecardiovascularandrespiratorysystems,aswellasthepropertiesofthebloodandparenchymalcells,sothatafundamentalunderstandingoftheregulationoftissueoxygenationisachieved.
TableofContents:Introduction/TheCirculatorySystemandOxygenTransport/TheRespiratorySystemandOxygenTransport/OxygenTransport/ChemicalRegulationofRespiration/TissueGasTransport/OxygenTransportinNormalandPathologicalSituations:DefectsandCompensations/MatchingOxygenSupplytoOxygenDemand/ExerciseandHemorrhage/MeasurementofOxygen/Summary/References/Biography""1","9781615041831","9781615041848","SkeletalMuscleCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","144","2011","RonaldKorthuis","UniversityofMissouriSchoolofMedicine"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00035ED1V01Y201106ISP023","10.
4199/C00035ED1V01Y201106ISP023","Theaimofthistreatiseistosummarizethecurrentunderstandingofthemechanismsforbloodflowcontroltoskeletalmuscleunderrestingconditions,howperfusioniselevated(exercisehyperemia)tomeettheincreaseddemandforoxygenandothersubstratesduringexercise,mechanismsunderlyingthebeneficialeffectsofregularphysicalactivityoncardiovascularhealth,theregulationoftranscapillaryfluidfiltrationandproteinfluxacrossthemicrovascularexchangevessels,andtheroleofchangesintheskeletalmusclecirculationinpathologicstates.
Skeletalmuscleisuniqueamongorgansinthatitsbloodflowcanchangeoveraremarkablylargerange.
Comparedtobloodflowatrest,musclebloodflowcanincreasebymorethan20-foldonaverageduringintenseexercise,whileperfusionofcertainindividualwhitemusclesorportionsofthosemusclescanincreasebyasmuchas80-fold.
Thisiscomparedtomaximalincreasesof4-to6-foldinthecoronarycirculationduringexercise.
Theseincreasesinmuscleperfusionarerequiredtomeettheenormousdemandsforoxygenandnutrientsbytheactivemuscles.
Becauseofitslargemassandthefactthatskeletalmusclesreceive25%ofthecardiacoutputatrest,sympatheticallymediatedvasoconstrictioninvesselssupplyingthistissueallowscentralhemodynamicvariables(e.
g.
,bloodpressure)tobesparedduringstressessuchashypovolemicshock.
Sympatheticvasoconstrictioninskeletalmuscleinsuchpathologicconditionsalsoeffectivelyshuntsbloodflowawayfrommusclestotissuesthataremoresensitivetoreductionsintheirbloodsupplythatmightotherwiseoccur.
Again,becauseofitslargemassandpercentageofcardiacoutputdirectedtoskeletalmuscle,alterationsinbloodvesselstructureandfunctionwithchronicdisease(e.
g.
,hypertension)contributesignificantlytothepathologyofsuchdisorders.
Alterationsinskeletalmusclevascularresistanceand/orintheexchangepropertiesofthisvascularbedalsomodifytranscapillaryfluidfiltrationandsolutemovementacrossthemicrovascularbarriertoinfluencemusclefunctionandcontributetodiseasepathology.
Finally,itisclearthatexercisetraininginducesanadaptivetransformationtoaprotectedphenotypeinthevasculaturesupplyingskeletalmuscleandothertissuestopromoteoverallcardiovascularhealth.
TableofContents:Introduction/AnatomyofSkeletalMuscleandItsVascularSupply/RegulationofVascularToneinSkeletalMuscle/ExerciseHyperemiaandRegulationofTissueOxygenationDuringMuscularActivity/MicrovascularFluidandSoluteExchangeinSkeletalMuscle/SkeletalMuscleCirculationinAgingandDiseaseStates:ProtectiveEffectsofExercise/References""1","9781615041237","9781615041244","TheEndothelium,PartI:MultipleFunctionsoftheEndothelialCells--FocusonEndothelium-DerivedVasoactiveMediators","ColloquiumSeriesonIntegratedSystemsPhysiology","306","2011","MichelFélétou","InstitutdeRecherchesServier"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00031ED1V01Y201105ISP019","10.
4199/C00031ED1V01Y201105ISP019","Theendothelium,amonolayerofendothelialcells,constitutestheinnercellularliningofthebloodvessels(arteries,veinsandcapillaries)andthelymphaticsystem,andthereforeisindirectcontactwiththeblood/lymphandthecirculatingcells.
Theendotheliumisamajorplayerinthecontrolofbloodfluidity,plateletaggregationandvasculartone,amajoractorintheregulationofimmunology,inflammationandangiogenesis,andanimportantmetabolizingandanendocrineorgan.
Endothelialcellscontrolsvasculartone,andtherebybloodflow,bysynthesizingandreleasingrelaxingandcontractingfactorssuchasnitricoxide,metabolitesofarachidonicacidviathecyclooxygenases,lipoxygenasesandcytochromeP450pathways,variouspeptides(endothelin,urotensin,CNP,adrenomedullin,etc.
),adenosine,purines,reactiveoxygenspeciesandsoon.
Additionally,endothelialectoenzymesarerequiredstepsinthegenerationofvasoactivehormonessuchasangiotensinII.
Anendothelialdysfunctionlinkedtoanimbalanceinthesynthesisand/orthereleaseofthesevariousendothelialfactorsmayexplaintheinitiationofcardiovascularpathologies(fromhypertensiontoatherosclerosis)ortheirdevelopmentandperpetuation.
TableofContents:Introduction/MultipleFunctionsoftheEndothelialCells/CalciumSignalinginVascularCellsandCell-to-CellCommunications/Endothelium-DependentRegulationofVascularTone/Conclusion/References""1","9781615043378","9781615043361","TheEndothelium,PartII:EDHF-MediatedResponses""TheClassicalPathway""","ColloquiumSeriesonIntegratedSystemsPhysiology","306","2011","MichelFélétou","InstitutdeRecherchesServier"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00032ED1V01Y201105ISP020","10.
4199/C00032ED1V01Y201105ISP020","Theendotheliumcontrolsvasculartonebyreleasingvariousvasoactivesubstances.
Additionally,anotherpathwayassociatedwiththehyperpolarizationofbothendothelialandvascularsmoothmusclecellscontributesalsotoendothelium-dependentrelaxations(EDHF-mediatedresponses).
TheseresponsesinvolveanincreaseintheintracellularCaconcentrationoftheendothelialcellsfollowedbytheopeningofCa-activatedKchannelsofsmallandintermediateconductances(SKCaandIKCa).
Thesechannelsshowadistinctsubcellulardistribution,suggestingthattheiractivationcouldbeelicitedbydistinctstimuli.
FollowingKCaactivation,theendothelialhyperpolarizationcanbeconductedtotheunderlyingsmoothmusclecellsbyelectricalcouplingthroughmyo-endothelialgapjunctions.
Inaddition,thepotassiumeffluxcanleadtotheaccumulationofpotassiumionsintheintercellularspaceandthesubsequentactivationofsmoothmuscleKir2.
1and/orNa/K-ATPase.
Thehyperpolarizationofthesmoothmusclecellsproducesvascularrelaxation,predominantlybyclosingvoltage-gatedcalciumchannels,andvasodilatation.
EDHFmediatedresponsesarealteredinvariouspathologiesor,conversely,actasacompensatingmechanismwhenotherendothelialpathwaysareimpaired.
AbettercharacterizationofEDHF-mediatedresponsesshouldallowdeterminingwhetherornotnewdrugabletargetscanbeidentifiedwithinthisendothelialpathwayforthetreatmentofcardiovasculardiseases.
TableofContents:Endothelium-DependentHyperpolarizations:TheClassical""EDHF""Pathway/Conclusion/References""1","9781615041985","9781615041992","TheEntericMicrobiota","ColloquiumSeriesonIntegratedSystemsPhysiology","88","2011","FranciscoGuarner","DigestiveSystemResearchUnit,UniversityHospitalValld'Hebron,Spain"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00047ED1V01Y201110ISP029","10.
4199/C00047ED1V01Y201110ISP029","Thehumangutisthenaturalhabitatforadiverseanddynamicmicrobialecosystemhavinganimportantimpactonhealthanddisease.
Bacteriahavelivedinandonanimalhostssincemulticellularlifeevolvedabout1billionyearsago.
Hostsprovidehabitatandnutritiontothemicrobialcommunitiesandderivemanybenefitsfromtheirgueststhatcontributewithmetabolic(recoveryofenergyandnutrients),defensive(barriereffectagainstinvaders)andtrophic(immuneregulation,neuro-endocrinedevelopment)functions.
Severaldiseasestatesordisordershavebeenassociatedwithchangesinthecompositionorfunctionoftheentericmicrobiota,includinginflammatoryboweldiseases,obesityandthemetabolicsyndrome.
Probioticsandprebioticscanbeusedtoimprovesymbiosisbetweenentericmicrobiotaandhost,orcorrectstatesofdysbiosis.
TableofContents:MicrobialCommunities/Host-MicrobeInteractionsintheGut/CompositionoftheHumanEntericMicrobiota/AcquisitionoftheEntericMicrobiota/DysfunctionoftheEntericMicrobiota/TherapeuticManipulationoftheEntericMicrobiota/References/AuthorBiography""1","9781615041381","9781615041398","TheExocrinePancreas","ColloquiumSeriesonIntegratedSystemsPhysiology","64","2011","StephenPandol","UniversityofCalifornia,DepartmentofVeteransAffairs"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00026ED1V01Y201102ISP014","10.
4199/C00026ED1V01Y201102ISP014","Thesecretionsoftheexocrinepancreasprovidefordigestionofamealintocomponentsthatarethenavailableforprocessingandabsorptionbytheintestinalepithelium.
Withouttheexocrinepancreas,malabsorptionandmalnutritionresult.
Thischapterdescribesthecellularparticipantsresponsibleforthesecretionofdigestiveenzymesandfluidthatincombinationprovideapancreaticsecretionthataccomplishesthedigestivefunctionsofthegland.
Keycellularparticipants,theacinarcellandtheductcell,areresponsiblefordigestiveenzymeandfluidsecretion,respectively,oftheexocrinepancreas.
Thischapterdescribestheneurohumoralpathwaysthatmediatethepancreaticresponsetoamealaswellasdetailsofthecellularmechanismsthatarenecessaryfortheorganresponses,includingproteinsynthesisandtransportandiontransports,andtheregulationoftheseresponsesbyintracellularsignalingsystems.
Examplesofpancreaticdiseasesresultingfromdysfunctionincellularmechanismsprovideemphasisoftheimportanceofthenormalphysiologicmechanisms.
TableofContents:Introduction/Anatomy/PancreaticEmbryologyandDevelopment/DigestiveEnzymes/WaterandIonSecretionfromthePancreaticDuctalSystem/RegulationofWhole-OrganPancreaticSecretion/MeasurementofExocrinePancreaticSecretioninHumans/ClinicalApplicationofKnowledgeofPancreaticPhysiology/Summary/References""1","9781615041688","9781615041695","TheOcularCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","81","2011","JeffreyKiel","UniversityofTexasHealthScienceCenteratSanAntonio"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00024ED1V01Y201012ISP012","10.
4199/C00024ED1V01Y201012ISP012","Thispresentationdescribestheuniqueanatomyandphysiologyofthevascularbedsthatservetheeye.
Theneedsforanunobstructedlightpathfromthecorneatotheretinaandarelativelyfixedcornealcurvatureanddistancebetweenrefractivestructuresposesignificantchallengesforthevasculaturetoprovidenutrientsandremovemetabolicwaste.
Tomeettheseneeds,theocularvascularbedsareconfinedtotheperipheryoftheposteriortwothirdsoftheeyeandasurrogatecirculationprovidesacontinuousflowofaqueoushumortonourishtheavascularcornea,lensandvitreouscompartment.
Theproductionofaqueoushumor(anditseaseofegressfromtheeye)alsogeneratestheintraocularpressure(IOP),whichmaintainstheshapeoftheeye.
However,theIOPalsoexertsacompressingforceontheocularbloodvesselsthatishigherthanelsewhereinthebody.
Thisisparticularlytruefortheintraocularveins,whichmusthaveapressurehigherthanIOPtoremainpatent,andsotheIOPistheeffectivevenouspressurefortheintraocularvascularbeds.
Consequently,theocularcirculationoperatesatalowerperfusionpressuregradientthanelsewhereinthebodyandismoreatriskforischemicdamagewhenfacedwithlowarterialpressure,particularlyifIOPiselevated.
Thisriskandthespecializedtissuesoftheeyegiverisetothefascinatingphysiologyoftheocularcirculations.
TableofContents:Introduction/Anatomy/Bloodflowmeasuringtechniques/Ocularperfusionpressure,IOPandtheocularStarlingresistoreffect/OcularbloodfloweffectsonIOP/Localcontrolofocularbloodflow/Neuralcontrolofocularbloodflow/Summary""1","9781615040780","9781615040797","CreatingConnectionsintheDevelopingBrain:MechanismsRegulatingCorpusCallosumDevelopment","ColloquiumSeriesontheDevelopingBrain","48","2011","LindaRichards","QueenslandBrainInstitute,UniversityofQueensland,Australia","IlanGobius","QueenslandBrainInstitute,UniversityofQueensland,Australia",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00038ED1V01Y201107DBR002","10.
4199/C00038ED1V01Y201107DBR002","Thecorpuscallosumisthelargestfibretractinthehumanbrainandsubservesmanyofthebrain'shigher-orderfunctions.
Disconnectionsyndromesresultingfromsurgicalablation,developmentalabsence(agenesisofthecorpuscallosum),disease,orinjuryofthecorpuscallosumcanhaveprofoundconsequencesoncognition.
Callosaldevelopmentinvolvesanintricateseriesofsequentialandconcurrentprocesses,includingtelencephalicinduction,midlinetissuepatterning,productionandspecificationofcallosalneurons.
Inaddition,axonextensionandlong-rangeaxonalguidancefromonehemispheretotheotherarerequiredforfunctionalcircuitformationinthecontralateralhemisphere.
Geneticortraumaticdisruptiontoanypartofthissequenceispathogenic.
Understandingthekeyprocessesinvolvedincallosaldevelopmentisthefirststepinprovidingbothbetterneuropsychologicaloutcomesandimproveddiagnosticandprognostictoolsforcongenitaldisconnectionsyndromesinthefuture.
TableofContents:Introduction/FormationoftheTelencephalicHemispheres/MidlineTissuePatterning:PreparingtheCallosalSubstrate/SpecificationofCallosalProjectionNeuronswithintheNeocortexandCingulateCortex/EstablishingtheCallosalTract/NavigatingtheMidline:GrowthoftheCorpusCallosumAcrosstheInterhemisphericMidline/ContralateralTargetingofCallosalAxons:TheRoleofNeuronalActivity/Conclusion/References""1","9781615043484","9781615043491","DevelopmentofBrainandBehaviorinBirds","ColloquiumSeriesontheDevelopingBrain","50","2011","JuliWade","MichiganStateUniversity"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00041ED1V01Y201110DBR003","10.
4199/C00041ED1V01Y201110DBR003","Sexdifferencesinbrainandbehaviorarewidespreadacrossvertebrates.
Birdsexhibitremarkableexamplesofthesetypesofparallelsbetweenstructureandfunction.
Forexample,onlymalezebrafinchessing,andthebrainareasandmusclescontrollingthelearningandproductionofthesevocalizationsaregreatlyenhancedinmalescomparedtofemales.
Thesesexdifferencesarepermanentlyestablishedindevelopment.
Somesongbirds,unlikezebrafinches,changetheirsongsseasonally.
Inanumberofthesespecies,thebrainregionsexhibitchangesinneuronlossandincorporationacrosstheseperiods.
Themechanismsinvolvedinthesetypesofsexualdifferentiationandadultplasticityaredescribed—theylikelyinvolvebothsteroidhormonesandgenetic(protein)factors.
Thestrengthoftherelationshipsbetweenmorphologyandbehavior,aswellasmanyotherfactors,hasmadebirdsoutstandingmodelsfortheinvestigationofnumerousfunctions.
Theseincludethemechanismsregulatingvocallearning,auditoryperception,neurogenesis,andcellsurvival.
Thelessonslearnedhavebroadimplicationsforhealth-relatedprocessesandbasicbiologicalprinciples.
TableofContents:Introduction/SongandSongLearning/OtherSocial/ReproductiveBehaviors/ConclusionsandIdeasforFutureDirections""1","9781615043422","9781615043439","PerinatalBrainDevelopment,Malformation,andInjury","ColloquiumSeriesontheDevelopingBrain","84","2011","AnnePenn","DivisionofNeonatalandDevelopmentalMedicine,DepartmentofPediatrics,StanfordUniversitySchoolofMedicine","JulietKnowles","LucilePackardChildren'sHospital,DepartmentofPediatrics,StanfordUniversitySchoolofMedicine",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00044ED1V01Y201109DBR006","10.
4199/C00044ED1V01Y201109DBR006","Weprovideabroadoverviewofhumanbraindevelopmentwithassociatedmalformationsandinjuriesthatoccurintheperiodbetweenearlyembryogenesisanddelivery.
Theaimofthisreviewistosummarizecurrentunderstandingofthemolecularandenvironmentalcuesthatshapethedevelopingbrain.
Foreachdevelopmentalstage,wegiveexamplesofdisordersthatarisefromgeneticand/orenvironmentalinsultstoillustratecriticalpointsofneurologicalsusceptibility.
TableofContents:Introduction/OriginoftheCentralNervousSystem:TheNeuralTube(3-4WeeksGestation)/PatterningoftheNeuralTube:ABlueprintfortheCNS/NeuralProliferationandMigration(3MonthsGestationIntoPostnatalPeriod)/OrganizationofNeuronalCircuitsandSynaptogenesis(5MonthsGestation-PostnatalYears)/GliogenesisandMyelination(5-MonthChildhood)/DevelopmentalBrainInjury:Before,During,andAfterBirth/Conclusion/References/AuthorBiographies""1","9781615043545","9781615043552","SeizuresandtheDevelopingBrain","ColloquiumSeriesontheDevelopingBrain","70","2011","AristeaGalanopoulou","AlbertEinsteinCollegeOfMedicine"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00046ED1V01Y201109DBR005","10.
4199/C00046ED1V01Y201109DBR005","Seizuresaremorecommonearlyinlifethaninadulthood.
Bidirectionalinteractionsbetweenseizuresandnormaldevelopmentalprocessesdefinetheirexpressionandoutcomes.
Severaldevelopmentallyregulatedfactorscontrolneuronalexcitability.
GABAAreceptorsholdacentralroleastheycontrolneuronalactivityinanage-specificmanner.
Earlyindevelopment,GABAAreceptorshavedepolarizingeffects,whichcontributetotheincreasedsusceptibilityofimmatureneuronstoseizuresbuttheyarealsoessentialfornormalbraindevelopment.
Duringdevelopment,thereisagradualshifttothe"adult-type"hyperpolarizingGABAAreceptorsignaling,creatingmoreefficientinhibition.
SeizuresmaydisruptGABAAreceptorsignalingbychangingtheexpressionoftheirsubunitsandbychangingthedirectionofGABAAresponses,which,incertainsituations,maybedetrimentalforbraindevelopment.
Furthermore,subcorticalnuclei,suchasthesubstantianigra,controltheexpressionandpropagationofseizuresinanage-andsex-dependentmanner.
Theseendogenouscontrolcentersandsignalingpathwaysarefurthermodifiedbyindependentgeneticepigenetic,biologic,orotherfactors,whichfurtherincreasetheheterogeneityinpresentationofseizures,theirtreatment,andtheircomorbidities.
Elucidationofthesecomplexinteractionsandidentificationofbiomarkersguidingtherapeuticinterventionswillbenecessarytoimproveourabilitytotreatearly-lifeepilepsies.
TableofContents:TableofContents:SeizuresandEpilepsy:Definitions,Classification,Models/BrainDevelopmentControlsSeizureSusceptibilityandOutcomes/Conclusions/References/AuthorBiography""1","9781615043514","9781615043521","TheImmuneSystemandtheDevelopingBrain","ColloquiumSeriesontheDevelopingBrain","128","2011","JaclynSchwarz","UniversityofDelaware","StaciD.
Bilbo","DukeUniversityandDukeInstituteforBrainSciences(DIBS)",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00045ED1V01Y201110DBR004","10.
4199/C00045ED1V01Y201110DBR004","Thedevelopingbrainisexquisitelysensitivetobothendogenousandexogenoussignalswhichdirectorsignificantlyalterthedevelopmentaltrajectoryofcells,neuralcircuits,andassociatedbehavioraloutcomesforthelifeoftheindividual.
Contrarytoinitialdogmathatthebrainisoneofthefeworganswithinthebodythatisimmune-privileged,evidenceindicatesthattheimmunesystemhasacriticalroleinbrainfunctionduringdevelopmentaswellasduringsicknessandhealthinadulthood.
Microgliaaretheprimaryimmunecellswithinthebrain,andtheyareinconstantcommunicationwiththeperipheralimmunesystemandsurroundingcelltypeswithinthebrain.
Wedescribetheimportantroleoftheimmunesystem,includingmicroglia,duringbraindevelopment,anddiscusssomeofthemanywaysinwhichimmuneactivationduringearlybraindevelopmentcanaffectthelater-lifeoutcomesofneuralfunction,immunefunction,andcognition.
Growingevidenceindicatesthatthereisastronglinkbetweenmanyneuropsychiatricdisordersandimmunedysfunction,withadistinctetiologyinneurodevelopment.
Thus,understandingtheroleoftheimmunesystemandimmuneactivationduringthecriticalperiodofbraindevelopmentisanecessarysteptowardunderstandingthepotentialoriginsofthesedevastatingdisorders.
TableofContents:Introduction/TheImmuneResponse/Brain-ImmuneCommunication/MicrogliaAreImmuneCellsoftheBrain/TheFunctionalRoleofMicrogliaandImmuneMoleculesinNeurodevelopment/Early-LifeProgrammingofBrainandBehavior:ACriticalRolefortheImmuneSystem/CommonlyUsedModelsofEarlyLifeImmuneActivationintheRodent/EarlyLifeImmuneActivationandCognitiveImpairmentinAdulthood/MechanismsUnderlyingtheEnduringChangesinNeuroimmuneFunctionCausedbyEarlyLifeInfection/Toll-LikeReceptorsandImmuneActivationDuringEarlyBrainDevelopment/EnvironmentalTriggersofTLRActivation:Long-TermProgrammingofBrainandBehavior/FutureDirectionstoUnderstandingImmuneFunctionandBrainDevelopment/References""1","9781615041565","9781615041572","IntestinalWaterandElectrolyteTransport","ColloquiumSeriesonIntegratedSystemsPhysiology","105","2012","MrinaliniRao","UniversityofIllinois","JayashreeSarathy(neeVenkatasubramanian)","UniversityofIllinoisandBenedictineUniversity","MeiAo","UniversityofIllinois",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00049ED1V01Y201112ISP031","10.
4199/C00049ED1V01Y201112ISP031","Theuniquearchitectureandphysiologyofthemammalianintestine,togetherwithatightlycoordinatedregulatorysystem,allowsforthehandlingandabsorptionofasmuchas9Loffluidadaywith98%orgreaterefficiency.
Advancesinthepast40yearshavemadeinroadsintorevealingtheintricaciesandinterplayofnumerousiontransportersandtheirmodulatorsthatareresponsibleforintestinalelectrolyteandwatertransport.
Studiesoftwodevastatingdiseases,thevirulentinfectiousdiseasecholeraandtheautosomalrecessivediseasecysticfibrosis,werelargelyresponsibleforthisinformationexplosion.
Theseadvanceshavebeencriticalinthedevelopmentofnewtherapeuticstrategiestocombatlife-threateningdiseasesofvaryingetiologiesrangingfromentericinfectionstocysticfibrosisandinflammatoryboweldiseases.
Yet,thestoryisfarfromcomplete,andprogressneedstocontinueontranslatinginformationgainedfromreductionisticcellandtissueculturemodels,invivomodels,andultimatelyhumanstudiesandonimprovingtherapeuticapproaches.
Thisbookreviewsthecurrentstatusofourknowledgeoffluidtransportacrosstheintestine,includingthecomplexitiesoftranscellularandparacellulariontransportdownthelengthoftheintestineandhowaberrationsofnormalphysiologicalprocessesleadtodisease.
TableofContents:Overview/EpithelialCellandTissueArchitecture/PrinciplesofTransepithelialElectrolyteandWaterMovement/IntestinalArchitectureandElectrolyteTransport/ElectrolyteTransporters--Pumps,Carriers,andChannels/WaterTransport/Regulation/IntestinalDisordersandAdvancesTowardBetterTreatmentofIntestinalDisorders/Conclusion/References""1","9781615043576","9781615043583","NeuralControlofGastrointestinalFunction","ColloquiumSeriesonIntegratedSystemsPhysiology","134","2012","DavidGrundy","TheUniversityofSheffield,UK","SimonBrookes","FlindersUniversity,Australia",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00048ED1V01Y201111ISP030","10.
4199/C00048ED1V01Y201111ISP030","Thegastrointestinaltractisalong,musculartuberesponsibleforthedigestionoffood,assimilationofnutrientsandeliminationofwaste.
Thisisachievedbysecretionofdigestiveenzymesandabsorptionfromtheintestinallumen,withdifferentregionsplayingspecificrolesintheprocessingofspecificnutrients.
TheseregionscomeintoplaysequentiallyasingestedmaterialismovedalongthelengthoftheGItractbycontractionsofthemusclelayers.
Insomeregionsliketheoesophagustransititrapidandmeasuredinsecondswhileinotherslikethecolontransitismeasuredinhoursandevendays,commensuratewiththerelativeslowfermentationthattakesplaceinthelargebowel.
Anhierarchyofcontrols,neuralandendocrine,servetoregulatethevariouscellulartargetsthatexistinthegutwall.
Theseincludemusclecellsforcontractionandepithelialcellsforsecretionandabsorption.
However,therearecomplexinteractionsbetweenthesedigestivemechanismsandothermechanismsthatregulatebloodflow,immunefunction,endocrinesecretionandfoodintake.
Theseensureafinebalancebetweentheostensiblyconflictingtasksofdigestionandabsorptionandprotectionfrompotentiallyharmfulingestedmaterials.
TheymatchassimilationofnutrientswithhungerandsatietyandtheyensurethatregionsoftheGItractthataremetersapartworktogetherinacoordinatedfashiontomatchthesediversefunctionstothedigestiveneedsoftheindividual.
Thisebookwillprovideanoverviewoftheneuralmechanismsthatcontrolgastrointestinalfunction.
TableofContents:NeuralControlofGastrointestinalFunction/CellsandTissues/EntericNervousSystem/FromGuttoCNS:ExtrinsicSensoryInnervation/SympatheticInnervationoftheGut/ParasympatheticInnervationoftheGut/IntegrationofFunction/References""1","9781615043644","9781615043651","PeptideBiosynthesis:ProhormoneConvertases1/3and2","ColloquiumSeriesonNeuropeptides","112","2012","AkinaHoshino","UniversityofMaryland-Baltimore","Lindberg,Iris","UniversityofMaryland-Baltimore",,,,,"2166-6628","2166-6636","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00050ED1V01Y201112NPE001","10.
4199/C00050ED1V01Y201112NPE001","Theprohormoneconvertases(PC)1/3and2arecalcium-activatedeukaryoticsubtilisinswithlowpHoptimawhichaccomplishthelimitedproteolysisofpeptidehormoneprecursorswithinneuronsandendocrinecells.
Inthislecture,wereviewthebiochemistry,regulation,androlesofPC1/3and2indisease,withanemphasisontheworkpublishedinthelast10years.
Inthe20yearssincetheirdiscovery,agreatdealhasbeenlearnedabouttheirlocalizationandcellularfunctions.
BothPCssharethesamefourdomains:thepropeptidesperformimportantrolesincontrollingactivationandtargeting;thecatalyticdomainsconferspecificity,withPC1/3possessingamorerestrictedbindingpocketthanthatofPC2;thePdomainisrequiredforexpressionandcontributestoenzymaticproperties;andtheC-terminaltailassistsinproperroutingtogranules.
PC1/3,butnotPC2,existsinfull-lengthandC-terminallytruncatedformsthatexhibitdifferentbiochemicalproperties.
Bothenzymesassociatewithbindingproteins;proSAASisthoughttomodulateprecursorcleavagebyPC1/3,whileco-expressionof7B2isobligatoryfortheformationofactivePC2.
Finally,newstudieshaverevealedanincreasinglyimportantroleforPC1/3polymorphismsandmutationsinglucosehomeostasisandobesity.
TableofContents:GeneralIntroductiontotheProhormoneConvertases/ProhormoneConvertase1/3/ProhormoneConvertase2/SummaryandFutureDirections/References/AuthorBiography""Collection","PaperbackISBN","eBookISBN","Title","所属系列","Pages","Year","Author1","A1Affiliation","Author2","A2Affiliation","Author3","A3Affiliation","Author4","A4Affiliation","ISSNprint","ISSNelec","URL","DOI","Description""2","9781615045563","9781615045570","TheMolecularBiologyofChronicHeartFailure","ColloquiumSeriesonGenomicandMolecularMedicine","90","February,2013","DhavendraKumar","InstituteofMolecularandExperimentalMedicine,CardiffUniversitySchoolofMedicine,UniversityHospitalofWales,UK"2167-7840","2167-7859","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00071ED1V01Y201212GMM003","10.
4199/C00071ED1V01Y201212GMM003","Theclinicalsyndromeofchronicheartfailure(CHF)isthehallmarkofprogressivecardiacdecompensation,oneofthemostcommonchronicmedicalconditionsthataffectaround2%oftheadultpopulationworldwideirrespectiveofethnicandgeographicorigin(Anonymous).
Apartfromischemicheartdisease,hypertension,infection,andinflammation,severalotheretiologicfactorsaccountforirreparableandirreversiblemyocardialdamageleadingtoheartfailure(HF).
Geneticandgenomicfactorsarenowincreasinglyidentifiedasoneoftheleadingunderlyingfactors(ArabandLiu2005).
Thesefactorsmayberelatedtopathogenicalterations(mutationorpolymorphism)withinspecificcardiacgenes,mutationsingenesincorporatingsingleormultiplemolecularpathways(proteinfamilies)relevanttocardiacstructureand/orfunction,geneticorgenomicpolymorphismsofuncertainsignificance(genevariants,single-nucleotidepolymorphisms(SNPs),andcopynumbervariations(CNVs)),andepigeneticorepigenomicchangesthatinfluencecardiacgenefunctionsscatteredacrossthehumangenome.
Recentgeneticandgenomicstudiesinbothsystolicanddiastolicventriculardysfunction,thehallmarkofCHF,haverevealedanumberofmutationsingenesbelongingtospecificcardiacproteinfamilies.
Forexample,around200mutationsarenowknowntoexistinaround15genescodingforseveraldifferenttypesofsarcomereproteins(LiewandDzau2004).
Thesarcomereproteinfamily,alone,accountsforthebulkofinheritedcardiomyopathiesincludinghypertrophiccardiomyopathy(HCM),dilatedcardiomyopathy(DCM),restrictivecardiomyopathy(RCM),andleftventricular(LV)non-compaction(LVNC).
Inaddition,thereareseveralotherpotentiallyrelevantfactorsinvolvingdifferentgenesandgenome-levelelements.
ThisarticlepresentsasystematicaccountontheavailablefactualinformationandinterpretationsbasedongeneticandgenomicstudiesinCHF(LiewandDzau2004).
GenomicandmolecularapproacheshaveopenedthewayforareneweddebatefortaxonomyofCHF(AshrafianandWatkins2007).
ThereviewdrawsattentiontothepotentialdiagnosticandtherapeuticimplicationsofgenomicandtranscriptionalprofilinginHFandtranslationalgenomicsresearchthatislikelytopermitgreaterpersonalizationofpreventionandtreatmentstrategiestoaddressthecomplexitiesofmanagingclinicalHF(Creemers,Wildeetal.
2011).
""2","9781615044580","9781615044597","BrainDevelopmentandSexualOrientation","ColloquiumSeriesonTheDevelopingBrain","134","August,2012","JacquesBalthazart","UniversityofLiége"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00064ED1V01Y201208DBR008","10.
4199/C00064ED1V01Y201208DBR008","Sexualorientation(homo-vs.
heterosexuality)isoneofmanysexdifferencesobservedinhumans.
Sexdifferencescanresultfromdifferentialpostnatalexperiences(interactionwithparents,environment)orfrombiologicalfactors(hormonesandgenes)actingpre-orpostnatally.
Thefirstoptionisoftenfavoredtoexplainsexualorientationalthoughitissupportedbylittleexperimentalevidence.
Incontrast,manysexuallydifferentiatedbehaviorsareorganizedduringearlylifebyanirreversibleactionofsexsteroids.
Inparticular,thepreferenceforamaleorfemalesexpartnerislargelydeterminedinrodentsbyembryonicexposuretosexsteroids.
Theearlyactionofthesesteroidsalsoseemstoaffectsexualorientationinhumans.
Indeed,clinicalconditionsassociatedwithmajorendocrinechangesduringembryoniclifeoftenresultinanincreasedincidenceofhomosexuality.
Furthermore,multiplesexuallydifferentiatedbehavioral,physiological,orevenmorphologicaltraitsthatareknowntobeorganizedbyprenatalsteroids,atleastinanimals,aresignificantlydifferentinhomo-andheterosexualpopulations.
Thus,prenatalendocrine(orgenetic)factorsseemtoinfluencesignificantlyhumansexualorientationevenifalargefractionofthevarianceremainsunexplainedtodate.
Thepossibleinteractionbetweenbiologicalfactorsactingprenatallyandpostnatalsocialinfluencesremainstobeinvestigated.
""2","9781615040872","9781615040889","EndocrineDisruptorsandTheDevelopingBrain","ColloquiumSeriesonTheDevelopingBrain","114","May,2012","AndreaC.
Gore","UniversityofTexasatAustin","SarahM.
Dickerson","UniversityofTexasatAustin",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00054ED1V01Y201204DBR007","10.
4199/C00054ED1V01Y201204DBR007","Thefieldofendocrinedisruptionhasbeenthefocusofincreasingattentionfromscientistsandthegeneralpublicinthepast30years,amidstconcernsthatexposuretoenvironmentalchemicalswiththepotentialtoalterendocrinesystemfunction,knownasendocrinedisruptingchemicals(EDCs),maybecontributingtoanoveralldeclineinwildlifepopulationsandthereproductivehealthofhumans.
TheseconcernsarebasedonobservationsofadverseeffectsofEDCsonmarineandlandanimals,anincreasedincidenceofreproductiveandendocrinediseaseinhumans,epidemiologicalevidenceforlinksbetweenbodyburdenanddisease,andendocrinedisruptioninlaboratoryanimalsfollowingexposuretoEDCs.
Owingtoitsroleinregulationofendocrinefunctionaswellasitsresponsivenesstohormones,thedevelopingbrainisanespeciallyvulnerabletargetformanyclassesofEDCs.
ThisbookwilladdresstheevidenceforEDCactiononthedevelopingbrain,organizedinto7chapters.
TopicscoveredincludebackgroundaboutEDCs,evidenceforexposures,concernsaboutEDCeffectsinthedevelopingorganism,andparticularlyonthedevelopingnervoussystem,howEDCsperturbthebrain'sneuroendocrinesystems,transgenerationalepigeneticeffectsofEDCs,EDCeffectsonnon-reproductivebehaviors,andfutureperspectives.
ThisisthefirstbookcompletelydedicatedtounderstandinglinksbetweenEDCsandthedevelopingbrain,anareaofemergingimportanceforhumanhealth.
""2","9781615045273","9781615045280","StressandtheDevelopingBrain","ColloquiumSeriesonTheDevelopingBrain","76","December,2012","LisaWright","DepartmentofPsychology&Neuroscience,DalhousieUniversity","TaraPerrot","DepartmentofPsychology&Neuroscience,DalhousieUniversity",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00069ED1V01Y201211DBR009","10.
4199/C00069ED1V01Y201211DBR009","Thehumanbraindoesnotdevelopinavacuumaccordingtoasetofpredeterminedblueprints—itisinvolvedinadynamicinterplaywiththeenvironmentthatinfluencesgeneexpressionandultimatelystructureandfunction.
Somecorticalregions,suchastheprefrontalcortex(PFC)undergostructuralchangesthroughouttheadolescentperiodandintoearlyadulthood,makingtheirstructureandfunctionsparticularlyinterestingtostudywithrespecttogene-environmentinteractions.
Repeatedexposuretostressisapredisposingfactorintheemergenceofvariousmentalillnesses,suchasanxietyanddepression,althoughthisisbynomeansanabsoluterelationship.
Whilesomepeopleappeartobevulnerabletotheeffectsofrepeatedstressors,othersareresilient,andthisindividualvariabilityispartlyduetodevelopmentalprogrammingofbrainregionsinvolvedinmodulatingstressresponding,suchasthePFC.
Inthepresentbook,wewilldiscussfeaturesofadolescentbraindevelopmentthatmayprovideabasisforneuralplasticityinstressresponding:thehighlyprotracteddevelopmentofthePFC,theprofoundchangeininterconnectednessamongcorticalandsubcorticalbrainregions,andthecharacteristic'riseandfall'patternformanyofthelate-developingaspectsofneuralarchitectureinPFCandotherstress-relatedbrainregions.
""2","9781615043781","9781615043798","ABCTransportersandHumanGeneticDisease","ColloquiumSeriesonTheGeneticBasisofDisease","84","April,2012","KarobiMoitra","NationalCancerInstituteatFrederick"2168-4006","2168-4022","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00055ED1V01Y201204GBD001","10.
4199/C00055ED1V01Y201204GBD001","TheATP-bindingcassette(ABC)transportergenesareubiquitousinthegenomesofallvertebratessofarstudied.
ThehumanABCtransportersuperfamilycontains48genes,subdividedinto7subfamiliesrangingfromAtoG(basedonsequencehomologyoftheirnucleotidebindingdomains).
TheABCproteinsencodedbythesegenesareATP-driventransmembranepumps,someofwhichpossessthecapacitytoeffluxharmfultoxicsubstancesandthereforeplayakeyroleinxenobioticdefense.
ABCproteinshavebeenevolutionarilyconservedfrombacteriatohumansandmultiplegeneduplicationanddeletioneventsintheABCgenesindicatethattheprocessofgeneevolutionisstillongoing.
Polymorphismsandvariationsinthesegenesarelinkedtovariationsinexpression,function,drugdisposition,anddrugresponse.
Singlenucleotidepolymorphisms(SNPs)inthesegenescouldbemarkersofindividualriskforadversedrugreactionsorsusceptibilitytocomplexdiseases.
Thepharmacogeneticsofthisuniquefamilyoftransportersisstillunderstudy;however,inthecontextofhumanhealth,itisawell-knownfactthatvariationsinthesetransportersaretheunderlyingcauseforseveralhumandiseasesincludingcysticfibrosis,Pseudoxanthomaelasticum(PXE),andX-linkedadenoleukodystrophy(X-ALD).
""2","9781615043866","9781615043873","ClinicalandGeneticAspectsofSuddenCardiacDeathinthePracticeofSportsMedicine","ColloquiumSeriesonGenomicandMolecularMedicine","162","June,2012","LynneMillar","St.
George'sUniversityofLondon,UK","NabeelSheikh","St.
George'sUniversityofLondon,UK","SanjaySharma","St.
George'sUniversityofLondon,UK",,,"2167-7840","2167-7859","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00062ED1V01Y201206GMM002","10.
4199/C00062ED1V01Y201206GMM002","Suddencardiacdeathistheleadingcauseofnon-traumaticmortalityinyoung(0.
5μm),initiatedbyreceptoractivationonphagocytes.
Itformsanessentialaspectofinnateimmunitythroughtheuptakeanddestructionofinfectiouspathogens,whilealsoparticipatingintheremovalofapoptoticcellsduringtissueremodelinganddevelopment.
Professionalphagocytes,suchasmacrophages,neutrophils,anddendriticcells,arewellequippedwithawiderangeofphagocyticreceptors.
Inaddition,thesespecializedleukocytescansignaltolymphocyteswithintheadaptivearmofhostimmunity.
Thisreviewemphasizestheroleoftwowell-characterizedopsonicreceptors,theFcγreceptorandthecomplementreceptor,CR3inmacrophages.
Inparticular,itfocusesonthedifferentmechanismsemployedbythesereceptorsduringparticlerecognitionandphagocyticuptake.
Bacterialspeciesoftenmanipulatephagocytesignalinginordertoevadetheirengulfmentanddegradationandconsequentlyprovidefurtherinsightintokeyregulatorsofthephagocyticprocess.
Finally,wedrawattentiontothephysiologicalrelevanceofstudyingthesimultaneousengagementofmultiplephagocyticreceptors,inordertobetterunderstandreceptorcrosstalkandtheunderlyingcoordinationofdownstreamsignalingforefficientphagocytosis.
""2","9781615045389","9781615045396","Apoptosis","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","101","April,2013","NingYang","DepartmentofBiochemistry,UniversityofAlberta","IngSwieGoping","DepartmentofBiochemistry,UniversityofAlberta",,,,,"2328-3041","2328-305X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00080ED1V01Y201303BBC003","10.
4199/C00080ED1V01Y201303BBC003","Multi-cellularorganismseliminateindividualcellsthroughaself-destructprocessknownasapoptosis.
Apoptosisiscriticalforproperdevelopmentandmaintenanceoftissuehomeostasis.
Theimportanceofthisprocessishighlightedbythefactthattoomuchortoolittleapoptosisistheunderlyingcauseofpathologiessuchascancer,autoimmunediseases(e.
g.
,lupus,arthritis),andneurodegenerativedisorders(e.
g.
,Parkinson's,Alzheimer's).
Intheearlydays,apoptoticcellswereidentifiedstrictlybycellmorphology.
Nowweknowthatbiochemicalsignaturesdefineanumberofdeathprograms,ofwhichapoptosisisthemostwidelyunderstood.
Inthisreview,wediscussgeneticinsightsgainedfromC.
elegans,theimportanceofcaspases,engulfmentofapoptoticcells,apoptoticsignals,theroleofmitochondria,theBcl-2family,andthelinkbetweendysfunctionalapoptosisanddisease.
Withineachtopic,wehighlightlandmarkstudiesthatcontributedtoourcurrentunderstandingofapoptosis.
Alltogether,thisresearchexemplifiestremendousscientificsynergybetweenthedisciplinesofgenetics,biochemistry,developmentalcellbiology,andstructuralbiology.
Continuedexplorationintomechanismsthatregulateapoptosiswillundoubtedlyleadtoinsightsintodiseaseprocesseswithpotentialtherapeuticstrategies.
""2","9781615044689","9781615044696","NeuropeptideReceptors","ColloquiumSeriesonNeuropeptides","167","May,2013","IvoneGomes","DepartmentsofPharmacologyandSystemsTherapeutics,PsychiatryandNeuroscienceandTheFriedmanBrainInstitute,MountSinaiSchoolofMedicine","JonathanWardman","DepartmentsofPharmacologyandSystemsTherapeutics,PsychiatryandNeuroscienceandTheFriedmanBrainInstitute,MountSinaiSchoolofMedicine","SteveStockton","DepartmentsofPharmacologyandSystemsTherapeutics,PsychiatryandNeuroscienceandTheFriedmanBrainInstitute,MountSinaiSchoolofMedicine",,,"2166-6628","2166-6636","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00082ED1V01Y201304NPE004","10.
4199/C00082ED1V01Y201304NPE004","Neuropeptidesmediatetheireffectsbybindingandactivatingreceptorsthatareresponsibleforconvertingtheseextracellularstimuliintointracellularresponses.
MostneuropeptidesinteractwithGprotein-coupledreceptorsthattransducethesignalbyactivatingheterotrimericGproteinsleadingtoalterationsinsecondmessengersystemstoamplifythesignalandelicittheintracellularresponse.
Inthisreview,wedescribethegeneralstructureofGprotein-coupledreceptorsincludingtheinformationobtainedfromcrystalstructuredeterminationthathasgivenaninsightintotheactivationmechanismofthesereceptors.
Inaddition,wesummarizethecomponentsofthesignaltransductionsystem(includingGproteins,effectorsandsecondmessengersgenerallyactivatedbytheneuropeptidereceptors).
Usingselectexamplesofneuropeptide-receptorsystems,wehighlighttheneuropeptidesandcorrespondingreceptorsinvolvedinmodulationofpainandanalgesia,bodyweightregulation,andhormonalregulation.
Finally,wediscusstheenzyme-linkedtyrosinekinasereceptorsactivatedbygrowthfactorsanddiscusstheemergingconceptsintargetingneuropeptidereceptorsfortheidentificationofnoveltherapeuticstargetingthesesystems.
TableofContents:Abbreviations/OverviewofNeuropeptideReceptors/GProtein-CoupledReceptors:GeneralStructure&Function/GProtein-CoupledReceptorSignaling/NeuropeptideProcessingandRegulation/NeuropeptideReceptors/Perspectives/References""2","9781615045662","9781615045679","Ascites","ColloquiumSeriesonIntegratedSystemsPhysiology","116","June,2013","JensHenriksen","UniversityofCopenhagen,Denmark","SorenMoller","UniversityofCopenhagen,Denmark",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00085ED1V01Y201305ISP039","10.
4199/C00085ED1V01Y201305ISP039","Thisvolumedealswiththehistory,aetiology,pathophysiology,symptoms,signs,prognosis,andrationaltreatmentofascites.
Duringthepastdecade,ourknowledgeofthepathophysiologyofasciteshasincreasedsubstantiallyandmorespecifictherapiesarenowbasedonaetiologyandpathophysiology.
Itistheintentionofthisbooktoreviewrecentprogressinpathophysiologyofascitesandtherapiesbasedonpathophysiology.
Althoughthedifferenttypesofasciteshaveadifferentaetiologyandverydifferentpathophysiology,thedevelopmentoffluidintheperitonealcavityisalwaysabadclinicalsign.
Ithasasevereprognosis,whichismainlydependentontheaetiologyandprogressionoftheunderlyingdisease.
However,amongpatientswithascites,theprognosismaybeverydifferent,mainlyowingtothepresenceofportalvenoushypertension,malignancyintheabdominalcavity,andend-stagecongestiveheartfailure.
Theadditionofcomplicationslikethehepatorenalsyndromeandbacterialperitonitis,whetherspontaneousorsecondary,addsheavilytothebadprognosis.
Sincehepaticascitesarebyfarthemostcomplexwithrespecttopathophysiology,complications,andtreatment,emphasisisputonthedescriptionofthisentity.
Ascitesofotheraetiologiesarementionedalongwithhepaticascites,inparticular,ifthepathophysiologydiffersfromascitesofhepaticorigin.
""2","9781615046027","9781615046034","DevelopmentalProgrammingofCardiovascularDisease","ColloquiumSeriesonIntegratedSystemsPhysiology","77","June,2013","BarbaraT.
Alexander","DepartmentofPhysiologyandBiophysics,UniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00084ED1V01Y201305ISP038","10.
4199/C00084ED1V01Y201305ISP038","Numerousepidemiologicalstudiesreportthatbirthweightisinverselyassociatedwithbloodpressure,suggestingthatslowgrowthduringfetallifeprogramshypertensionandincreasedriskforcardiovasculardiseaseinlaterlife.
Differentexperimentalmodelsareusedtoprovideproofofconceptforthetheoryofdevelopmentalprogrammingofcardiovasculardisease,andstudiesinthesedifferentanimalmodelsareprovidinginsightintotheetiologyofchronicdiseaseprogrammedbyanimbalanceinnutritionduringearlylifeorexposuretomaternalcomplicationsduringpregnancy.
Alterationsintheregulatorysystemskeytothelong-termcontrolofbloodpressureareimplicatedintheetiologyofhypertensionthatresultsfromadverseexposuresduringearlydevelopment.
Epigeneticprocessesarealsoimplicatedintheincreasedriskforprogrammedcardiovasculardiseaseandthepassageofprogrammedcardiovascularrisktothenextgeneration.
Sex,age,andearlypostnatalgrowthimpactlaterprogrammedrisk;programmedriskisalsoamplifiedinresponsetoasecondarychallengethatincludesnormalphysiologicalprocessessuchaspregnancy.
Thus,thisbookwillhighlighthoweventsduringearlylifeimpactlatercardiovascularhealthinamannerthatissex-andage-dependentandcanbetransmittedtothenextgeneration.
TableofContents:Introduction/HistoricalPerspective/EpidemiologicalStudies/ExperimentalModelsofDevelopmentalProgramming/MechanismsofDevelopmentalProgramming/BirthWeightandClinicalConsiderations/BirthWeightandCardiovascularDisease:TranslationalConsiderations/SummaryandConclusions/References/AuthorBiography""2","9781615043880","9781615043897","TheActinCytoskeletonandtheRegulationofCellMigration","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","71","June,2013","JonathanM.
Lee","UniversityofOttawa"2328-3041","2328-305X","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00083ED1V01Y201305BBC005","10.
4199/C00083ED1V01Y201305BBC005","Themammaliancytoskeletonisaninternalframeworkofactin,tubulin,andintermediatefilamentproteins.
Proteinsofthesethreeclassesassemblenon-covalentlyintofilamentouspolymersthatsupportthestructuralintegrityoftherelativelyfragilelipidplasmamembrane.
Inaddition,cytoskeletalpolymersprovidethemechanicalstrengththatholdacelltogetherandanchorittoitsgrowthsubstrate.
Thecytoskeletonmustalsohavethecapacityforrapidandsubstantialremodelingandprovidethemotiveandtractorforcenecessarytodrivemotility.
Assuch,thecytoskeletonhasafunctionalduality:sufficientlyrigidtopreventplasmamembranedeformationbutpliableenoughtoallowforcytokinesis;sufficientlyadhesivetoallowfortractionbutdynamicenoughtoallowmovementfromoneplacetoanother.
Amajorresearchchallengeincytoskeletonbiologyistounderstandhowcytoskeletalproteinsassembleanddissembleinsupportofphysiologicalprocesses.
Thischapterwillfocusontheroleoftheactincytoskeletonincellmigration.
Morespecifically,wewillfocusontheactincytoskeletonofvertebratecells.
TableofContents:Introduction/TheFundamentalsofActinPolymerization/AccessoryProteinsRegulateActinPolymerizationandAssembly/CellularActinStructure/CellMigration/SummaryofCellMigration/References/AuthorBiography""2","9781615045983","9781615045990","PeripheralArterialDisease:PathophysiologyandTherapeutics","ColloquiumSeriesonIntegratedSystemsPhysiology","82","August,2013","ChristopherG.
Kevil","DepartmentofPathology,LSUHealthSciencesCenter","ShyamalC.
Bir","DepartmentofPathology,LSUHealthSciencesCenter","ChristopherB.
Pattillo","DepartmentofMolecularandCellularPhysiology,LSUHealthSciencesCenter",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00086ED1V01Y201307ISP040","10.
4199/C00086ED1V01Y201307ISP040","Peripheralarterialdisease(PAD)isacardiovasculardisorderoftheperipheralvasculatureduetoprogressiveatheroscleroticstenosisofconduitarteriesrestrictingbloodflowtotissues.
PADistypicallyadiseaseofolderindividuals,andtheincidenceofPADcontinuestoriseduetoanincreaseincardiometabolicdiseaseandanagingpopulation.
Importantly,"allcause"andcardiovascularmorbidityandmortalityaresignificantlyincreasedinPADpatients.
PADdiagnosisremainsasignificantchallenge,asalargenumberofpatientsareasymptomatic.
Moreover,PADresultsinasignificantfinancialandsocietalburdenwithunderutilizeddiagnosticsandlimitedeffectivetherapies.
HerewediscussPADsignsandsymptoms,pathophysiologicalmechanisms,currentmanagement,andfuturediseasetargetsandpossibletherapeutictreatmentsforPAD.
""2","9781615044504","9781615044511","PulmonaryGasExchange","ColloquiumSeriesonIntegratedSystemsPhysiology","86","August,2013","G.
KimPrisk","UniversityofCalifornia,SanDiego","SusanR.
Hopkins","UniversityofCalifornia,SanDiego",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00087ED1V01Y201308ISP041","10.
4199/C00087ED1V01Y201308ISP041","Thelungreceivestheentirecardiacoutputfromtherightheartandmustloadoxygenontoandunloadcarbondioxidefromperfusingbloodinthecorrectamountstomeetthemetabolicneedsofthebody.
Itdoessothroughtheprocessofpassivediffusion.
Effectivediffusionisaccomplishedbyintricateparallelstructuresofairwaysandbloodvesselsdesignedtobringventilationandperfusiontogetherinanappropriateratiointhesameplaceandatthesametime.
Gasexchangeisdeterminedbytheventilation-perfusionratioineachofthegasexchangeunitsofthelung.
Inthenormallungventilationandperfusionarewellmatched,andtheventilation-perfusionratioisremarkablyuniformamonglungunits,suchthatthepartialpressureofoxygeninthebloodleavingthepulmonarycapillariesislessthan10Torrlowerthanthatinthealveolarspace.
Indisease,thedisruptiontoventilation-perfusionmatchingandtodiffusionaltransportmayresultininefficientgasexchangeandarterialhypoxemia.
Thisvolumecoversthebasicsofpulmonarygasexchange,providingacentralunderstandingoftheprocessesinvolved,theinteractionsbetweenthecomponentsuponwhichgasexchangedepends,andbasicequationsoftheprocess.
""2","9781615045860","9781615045877","Stroke:PathophysiologyandTherapy","ColloquiumSeriesonIntegratedSystemsPhysiology","100","August,2013","JensMinnerup","UniversityofMünster,Germany","AntjeSchmidt","UniversityofMünster,Germany","ChristianeAlbert-Weissenberger","UniversityofWürzburg,Germany",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00088ED1V01Y201308ISP042","10.
4199/C00088ED1V01Y201308ISP042","Strokeisamajorglobalhealthproblembecauseofitslargecontributiontomortality,morbidity,anddisability.
Themostcommonformofstrokeisischemicstrokewhichaccountsforapproximately80%ofallstrokes.
Duringthepastdecade,ourknowledgeofthemolecularandcellularprocessesthatcontributetostrokepathophysiologyhasincreasedsubstantiallyandoffersmanytargetsforfuturetherapeuticstrategies.
Thisbookprovidesanoverviewofthecurrentknowledgeofstrokepathophysiologyandthemechanismsthatinterferewithrecoveryandregeneration.
Moreover,thisbookreviewsthelatestadvancesinthedevelopmentoffuturetherapeuticstrategies.
""2","9781615045006","9781615045013","ControlofPotassium:Distribution,Excretion,andExtracellularConcentration","ColloquiumSeriesonIntegratedSystemsPhysiology","103","August,2013","DavidB.
Young","DepartmentofPhysiologyandBiophysics,UniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00089ED1V01Y201308ISP043","10.
4199/C00089ED1V01Y201308ISP043","Severalphysiologicalmechanismsacttoregulaterenalpotassiumexcretionanddistribution.
Togethertheycompriseanintegratedcontrolsystemthatmaybeenvisionedasbeingmadeupofseveralinteractingnegativefeedbackcontrolmechanisms,allaffectingremovalofpotassiumfromtheextracellularfluidbyrenalexcretionortransferacrosscellmembranesintooroutoftheintracellularcompartment.
Theintentofthispresentationistodescribethemechanismsofpotassiumregulation,beginninginChapter1withanoverviewofthesystem,Chapter2withmechanismsthatdeterminemovementofpotassiumbetweentheextracellularandintracellularcompartments,inChapter3focusingonrenaltubulartransportsystems,andinChapter4presentingthemechanismsofcontrolofaldosteronesecretion.
Greatestemphasiswillbeondescribingtheintegratedfunctionsofthecomponents,inChapter5,astheyoperatetogetherinasystemtoregulateextracellularpotassiumconcentrationinresponsetocommonlyencounteredchallenges.
Inaddition,interactionsbetweenpotassiumregulationandcommonlyusedmedicationswillbeconsideredinChapter6,andinChapter7thecausesandtreatmentofdysregulationofpotassiumwillbediscussed.
TableofContents:Preface/Introduction/RegulatonofPotassiumDistribution/PotassiumTransportinSegmentsoftheNephron/RegulationofPotassiumExcretion/ControlofAldosteroneSecretion/SystemAnalysisofPotassiumRegulation/PharmacotherapeuticsInteractions/DisordersofPotassiumControl/References/AuthorBiography""2","9781615045846","9781615045853","CellSurvivalProgramsandIschemia/Reperfusion:Hormesis,Preconditioning,andCardioprotection","ColloquiumSeriesonIntegratedSystemsPhysiology","122","September,2013","MaikeKrenz","DepartmentofMedicalPharmacologyandPhysiology,UniversityofMissouriSchoolofMedicineandDaltonCardiovascularResearchcenter","ChristopherBaines","DepartmentofMedicalPharmacologyandPhysiology,UniversityofMissouriSchoolofMedicine,DepartmentofBiomedicalSciencesandDaltonCardiovascularResearchcenter,UniversityofMissouri","TheodoreKalogeris","DepartmentofMedicalPharmacologyandPhysiology,UniversityofMissouriSchoolofMedicine",,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00090ED1V01Y201309ISP044","10.
4199/C00090ED1V01Y201309ISP044","Themajorpurposeofthisbookistoreviewtheevidencesupportingtheconceptthatintrinsiccellsurvivalprogramscanbeactivatedbyavarietyofmildlynoxiousstimuliorpharmacologicagentstoconferprotectionagainstthedeleteriouseffectsofischemia/reperfusion(I/R).
Webeginwithadiscussionoftheconceptofhormesis(atermusedmostextensivelyinthetoxicologicliteraturewhichreferstobiphasiccellularresponsesthatdependonconcentrationorintensityofastimulus),reviewtheseminalstudiesthatledtothediscoveryofthecardioprotectiveeffectsofischemicpreconditioning,andoutlineitstherapeuticpotential(Chapter1).
ThisisfollowedbyasummaryofourcurrentunderstandingofthemechanismsofI/Rinjury(Chapter2),asthisprovidesseveralpointsofinterventioninlimitingpostischemictissueinjurythatmaybetargetedbytheadaptiveprogramsinvokedbyconditioningstimuli.
Chapters3and4focusonthemechanismsunderlyingischemicpre-,post-,andremoteconditioning,whichestablishesthemechanisticrationalefordevelopmentofpharmacologicconditioningstrategiesthatmaymimictheremarkablypowerfuleffectsofischemicconditioning(andarecoveredinChapter5).
Lifestyleinterventions,includingexercise,caloricrestriction,andconsumptionofalcoholicbeveragesand/orphytochemicals,thatmayinducehormeticresponseswillalsobereviewedinthischapter.
Whilethepromiseforconditioningasatherapeuticapproachisenormous,thereareobstaclestoitspracticalapplicationinpatients,whicharecoveredinChapter6.
Thefinalchapter(Chapter7)examinestheextensionofourmechanisticunderstandingofthesignalingpathwaysinvokedbyconditioningstimuliintotherealmofgenetherapyandtothepreservationofstemcellviabilityintheharshischemicenvironmentasnaturaltranslationaloutgrowthsofpreconditioningintotherapeutics.
""2","9781615045822","9781615045839","ImmuneMechanismsofHypertension","ColloquiumSeriesonIntegratedSystemsPhysiology","86","September,2013","MichaelJ.
Ryan","UniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00092ED1V01Y201309ISP046","10.
4199/C00092ED1V01Y201309ISP046","Inthevastmajorityofpatients,hypertensionhasnoidentifiablecause.
Moreover,despitedecadesofdiscoveryandtherapeuticdevelopment,approximatelyonlyhalfofthehypertensivepatientsareachievingclinicallyrecommendedbloodpressurecontrol.
Forthesereasons,therehasbeencontinuedinterestinstudyingthefactorsthatunderliethepathogenesisofhypertension.
Oneareaofresearchthathasgarneredsignificantattentionisthepotentiallinkbetweenimmunesystemactivationandbloodpressure.
Severallinesofevidence,datingbackseveraldecades,supporttheconceptforthisassociation.
Thismonographgivesahistoryoftheearlystudieslinkingimmunesystemfunctionwithhypertensionandanoverviewofthelargenumberofstudiespublishedinthepastdecade.
Themajorfocusisonthecomponentsoftheinnateandadaptiveimmunesystemsforwhichthereisconsiderableevidenceoftheircontributionstobloodpressurecontrol.
""2","9781615046362","9781615046379","Malaria","ColloquiumSeriesonIntegratedSystemsPhysiology","187","September,2013","JulianaCarvalho-Tavares","UniversidadeFederaldeMinasGerais,BeloHorizonte,Brazil","rikaMartinsBraga","UniversidadeFederaldeMinasGerais,BeloHorizonte,Brazil",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00091ED1V01Y201309ISP045","10.
4199/C00091ED1V01Y201309ISP045","Thisebookdescribesthepathogenesisofmalariaandthemajorconsequencesoftheparasitismtothevertebratehost.
Malariaisoneoftheoldestinfectiousdiseasesofmankind,whichstillexertsahighburdenonhumanhealthandsociety.
ItiscausedbyparasitesofthegenusPlasmodium,andtransmittedbyAnophelinemosquitoes.
Despiteseveraldecadesofintensivecontrolefforts,malariaremainswidelydistributedwithanestimated3.
3billionoftheworld'spopulationatriskofinfection.
Themalarialifecycleisextremelycomplexandthebloodstageparasitesareresponsibleforallthesymptomsandpathologyofmalaria.
Becauseofthisstrictassociationbetweentheparasitesandredcells,therearenumerousconsequencestothehost'sbloodextendingfarbeyondthedirecteffectofparasitizedRBCs.
""2","9781615044283","9781615044290","ClinicalandMolecularAspectsofMotorNeuronDisease","ColloquiumSeriesonGenomicandMolecularMedicine","60","September,2013","JohnathanCooper-Knock","SheffieldInstituteforTranslationalNeuroscience(SITraN),UniversityofSheffield,UK","PamelaShaw","SheffieldInstituteforTranslationalNeuroscience(SITraN),UniversityofSheffield,UK","ThomasJenkins","SheffieldInstituteforTranslationalNeuroscience(SITraN),UniversityofSheffield,UK",,,"2167-7840","2167-7859","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00093ED1V01Y201309GMM004","10.
4199/C00093ED1V01Y201309GMM004","Inthise-book,motorneurondisease(MND)shallrefertoamyotrophiclateralsclerosis(ALS),themostcommonneurodegenerativedisorderaffectingboththeupperandlowermotorneurons.
WiththediscoveryofC9ORF72expansionsinapproximately10%ofallMNDcases,incertainpopulations,westandatthebrinkofaneweraofMNDresearchandhopefullytreatmentfacilitatedbytheabilitytoassociatearelativelylargegroupofpatientswithasimilardiseasemechanism.
ThisreviewwillsummarisebothcurrentclinicalmanagementofMNDandourpresentunderstandingofthemolecularpathogenesisofMND.
StudyofC9ORF72-MNDhasthepotentialtorapidlyadvancebothoftheseaspectsinthecomingyears.
""2","9781615046348","9781615046355","AcuteRespiratoryDistressSyndrome","ColloquiumSeriesonIntegratedSystemsPhysiology","99","October,2013","DonnaCarden","DepartmentofEmergencyMedicine,UniversityofFloridaCollegeofMedicine","MarieElie","DepartmentofEmergencyMedicine,UniversityofFloridaCollegeofMedicine",,,,,"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00094ED1V01Y201309ISP047","10.
4199/C00094ED1V01Y201309ISP047","Theacuterespiratorydistresssyndrome(ARDS)isacomplexdisorderassociatedwithrapidlyprogressivelunginflammation,non-cardiogenicpulmonaryedema,hypoxemicrespiratoryfailureandoneormorewell-definedriskfactorsincludingsepsisandseveretrauma.
Sinceitsoriginaldescriptionin1967,experimentalandclinicalevidencehasprovidedconsiderableinsightintothekeyrolesderegulatedsystemicinflammationandcoagulationplayinthisdevastatingclinicalsyndrome.
DespitesubstantialadvancesinourunderstandingofthepathogenesisofARDS,untilrecently,littleprogresshadbeenmadeinuncoveringclinicalstrategiestoimprovetheoutcomeofpatientswithARDS.
However,overthepast10yearsprotectiveventilationandothersupportivemanagementstrategieshavebeenidentifiedthatmarkedlyimprovetheoutcomeinARDS.
Morerecently,researchhasidentifiedpatientsatriskforthedevelopmentofthesyndrome.
Currently,clinicaltrialsareunderway.
""2","9781615046386","9781615046393","MolecularPathologyofAlzheimer'sDisease","ColloquiumSeriesonNeurobiologyofAlzheimer'sDisease","91","October,2013","RudyCastellani","UniversityofMaryland,SchoolofMedicine","GeorgePerry","UniversityofTexas,SanAntonio",,,,,"2375-8937","2375-8945","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00095ED1V01Y201310ALZ001","10.
4199/C00095ED1V01Y201310ALZ001","Alzheimer'sDiseaseischaracterizedpathologicallybytwoprincipalhallmarklesions:thesenileplaqueandtheneurofibrillarytangle.
Sincetheidentificationofeachover100yearsago,themajorproteincomponentshavebeenelucidated.
Thishasledinturntotheelaborationofmetaboliccascadesinvolvingamyloid-βproductioninthecaseofthesenileplaque,andphosphorylated-tauproteininthecaseoftheneurofibrillarytangle.
Thepathogenesisandhistogenesisofeachhavebeenthesourceofextensiveinvestigationandsomecontroversyinrecentyears,asbothcascadeshavebeenimplicatedinthepathogenesisofAlzheimer'sDisease,relieduponinthediagnosticcriteriaforAlzheimer'sDiseaseatautopsy,andtargetedfortherapeuticintervention.
WiththeaccumulationofdataandexpansionofknowledgeofthemolecularbiologyofAlzheimer'sDisease,itappearsthattheenthusiasmforsuccessfulinterventionhasbeenpremature.
Inthisbook,wedetailthediscoveryandcharacterizationofthemajorpathologicallesions,theirassociatedmolecularbiology,theirrelationshiptoclinicaldisease,andpotentialfundamentalerrorsinunderstandingthatmaybeleadingscientificinvestigatorsinunintendeddirections.
""2","9781615044207","9781615044214","PatternFormationintheCerebellum","ColloquiumSeriesonTheDevelopingBrain","137","October,2013","CarolArmstrong","DepartmentofBiology,MountRoyalUniversity","RichardHawkes","DepartmentofCellBiologyandAnatomy,GenesandDevelopmentResearchGroupandHotchkissBrainInstitute,FacultyofMedicine,UniversityofCalgary",,,,,"2159-5194","2159-5208","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00096ED1V01Y201310DBR011","10.
4199/C00096ED1V01Y201310DBR011","PatternformationhasfascinatedbiologistssincethetimeofAristotle,butonlyrecentlyhavenewtoolsbeguntorevealtheunderlyingmechanismsthatcreatethesepatternsduringdevelopment.
Inparticular,thecentralnervoussystemisdynamicallypatternedandhighlymodular,rangingfromnuclearcellclustersinthebrainstemandspinalcordtotheelaboratecytoarchitectureoftheneocortex.
Similardevelopmentalprocessesdividebrainstructuressuchasthecerebralcortex,basalganglia,superiorcolliculus,andcerebellumintothesesub-compartments.
Thewayneuralmodulesformandthemechanismsthatestablishconnectivitybetweenthesemodulesisoneofthemostcomplexproblemsinneuroscienceandalsooneofthemostimportant.
Thismonographfocusesonpatternformationinthedevelopingcerebellum.
""2","9781615046102","9781615046119","ProcessingofVEGF-Cand-DbytheProproteinConvertases:ImportanceinAngiogenesis,Lymphangiogenesis,andTumorigenesis","ColloquiumSeriesonProteinActivationandCancer","66","November,2013","GeraldineSiegfried","UniversityofBordeaux,LAMC,UMR1029,F-3400andINSERMU1029,France","MajidKhatib","UniversityofBordeaux,LAMC,UMR1029,F-3400andINSERMU1029,France",,,,,"2169-9399","2169-9410","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00097ED1V01Y201310PAC006","10.
4199/C00097ED1V01Y201310PAC006","Thevascularendothelialgrowthfactor(VEGF)familymembersthatincludeVEGF-A,-B,-C,-D,andplacentalgrowthfactor(PlGF),displaydistinctbindingaffinitiesfortheirreceptorsVEGFR-1,-2,and/or-3.
Inadditiontotheirrequirementsintheinitiation,development,andmaintenanceofbloodandlymphaticvasculature,VEGFsandVEGFRsareupregulatedduringneoplasiaandareinvolvedintheremodelingoftumoralbloodandlymphaticvasculature.
ByactivatingVEGFR-1andVEGFR-2,bothexpressedonbloodendothelialcells,VEGF-Apromotestheformationofnewtumoralbloodvesselsandtherebyacceleratestumorgrowth.
Incontrast,upregulationofVEGF-C,aligandforlymphaticendothelialVEGFR-3aswellasforVEGFR-2,inducestheformationoftumor-associatedlymphaticvesselsandthuspromotesthepassivemetastaticdisseminationoftumorcellstoregionallymphnodes.
OftheVEGFfamilymembers,onlyVEGF-Cand-DwerefoundtobeproteolyticallyprocessedbyFurin-likeenzymes.
ThisprocessingcontrolstheselectiveactivationofVEGFR-2and-3signalingduringtumorangiogenesisandlymphangiogenesis.
Here,weprovideanoverviewofangiogenesisprocessesanddiscusstheimportanceofVEGF-CandVEGF-DprecursorsprocessingbytheproproteinconvertasesduringtheactivationofVEGFR-2andVEGFR-3receptorsandthemediationoftheirfunctionsduringangiogenesis,lymphangiogenesis,andtumorigenesis.
""2","9781615046409","9781615046416","AJourneyThroughGenetics,PartI","ColloquiumSeriesonTheGeneticBasisofDisease","100","November,2013","KarobiMoitra","TrinityWashingtonUniversity"2168-4006","2168-4022","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00098ED1V01Y201310GBD005","10.
4199/C00098ED1V01Y201310GBD005","AJourneyThroughGeneticsisdesignedtotakethereaderonanincrediblejourneytoexploretheexcitingdiscoveriesingeneticsandmolecularbiology.
InPartI,thereaderwillembarkonageneticodysseystartingwiththe""FatherofGenetics,""GregorMendel,leadingontotheamazingstoryofphoto51andthediscoveryofthestructureoftheDNAdoublehelix,andculminatingwiththeinventionofoneofthemostpowerfultoolsinmolecularbiology:thepolymerasechainreaction.
Thereaderwilldiscoverthestoriesbehindthescienceofgeneticswhilegoingbehindthescenestotakeaglimpseintothelivesofpioneeringscientistsandwillultimatelycometounderstandthatpeoplearejustasimportantasthesciencetheyundertaketodo.
Inshort,scientistsarehumantoo!
Thisbookistargetedtowardundergraduatenon-majorsandalsoasa""companion""toastandardgeneticstextbookforBiologymajors.
Thebookwillalsobeusefulforanyonethatwantstounderstandthestoriesbehindthescienceofgenetics.
""2","9781615045907","9781615045914","NecrotizingEnterocolitis","ColloquiumSeriesonIntegratedSystemsPhysiology","94","December,2013","MichaelCaplan","UniversityofChicago,PritzkerSchoolofMedicine"2154-560X","2154-5626","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00099ED1V01Y201311ISP048","10.
4199/C00099ED1V01Y201311ISP048","Necrotizingenterocolitisisanacuteinflammatorynecrosisofbowelthatprimarilyafflictsprematureinfantsintheneonatalintensivecareunitsetting.
Althoughpatientswhodevelopthisdiseasehavehighmorbidityandmortalityrates,thepathogenesisispoorlyunderstood,andthereforetherearenospecificpreventiveortreatmentstrategiesthathavebeenclearlyeffective.
Recentstudieshavesuggestedthatthepathophysiologyofnecrotizingenterocolitisincludesalterationsintheinflammatoryresponseleadingtodysregulatedpro-inflammatorysignalinginprematureinfants,aswellasabnormalintestinalbacterialcolonizationpatternsthatcanactivatetheseinflammatorypathways,andthesefactorsarediscussedindepthinthefollowingchapters.
Whilehumanmilkfeedingsarecurrentlythestandardofcareforthepreventionofthischallengingcondition,newapproacheswillbedescribedbasedonsoundevidencethatmighthaveasignificantimpactforprematureinfantsthroughouttheworld.
""2","9781615044764","9781615044771","EmergingRolesforHippocampalAdultNeuralStemCellsinMemory","ColloquiumSeriesonStemCellBiology","39","December,2013","AaronFriedman","DepartmentofIntegrativeBiology,UniversityofCalifornia,Berkeley","DanielaKaufer","DepartmentofIntegrativeBiologyandHelenWillsNeuroscienceInstitute,UniversityofCalifornia,Berkeley",,,,,"2168-3972","2168-3980","http://www.
morganclaypool.
com/doi/abs/10.
4199/C00100ED1V01Y201311SCB005","10.
4199/C00100ED1V01Y201311SCB005","Approximately50yearsago,newlygeneratedneuronswerediscoveredintheadulthippocampusoftheratbrain.
Thisdiscoverycontradictedakeyprincipleinmammaliandevelopmentalneurobiology—thatalltheneuronsofthebrainaremadeduringearlydevelopment—andledtointensivestudytofindouthownewneuronsaregeneratedandhowtheprocessofneurogenesisisregulated.
Sincethen,auniquepopulationofadultneuralstemcellshasbeenidentified,andmanyofthemolecularpathwaysthatcontroltheirself-renewal,proliferation,andcellfatehavebeenelucidated.
However,thepresenceofnewneuronsintheadultbrainalsoposesintriguingfunctionalquestionsthathave,asyet,gonelargelyunanswered.
WhyisadultneurogenesisrestrictedtoselectbrainregionsWhatfunctionalbenefitdothesenewcellsconferIndeed,thefieldofadultneurogenesisoffersauniqueopportunitytostudynaveneuronsastheymature,formconnectionswithexistingneuralnetworks,andbegintoparticipateininformationprocessing.
WereviewthebasicsofadultNSCbiologyandthematurationofnewbornneurons.
Inparticular,wefocusonnewneuronsinthehippocampus,andhowtheycontributetofunctioninthiskeymemory-formingstructureofthebrain.
""Collection","PaperbackISBN","eBookISBN","Title","所属系列","Pages","Year","Author1","A1Affiliation","Author2","A2Affiliation","Author3","A3Affiliation","Author4","A4Affiliation","ISSNprint","ISSNelec","URL","DOI","Description""3","9781615045747","9781615045754","Dengue","ColloquiumSeriesonIntegratedSystemsPhysiology","104","February,2014","RafaelEliasMarques","DepartamentodeBioquímicaeImunologia,InstitutodeCiênciasBiológicas,UniversidadeFederaldeMinasGerais,Brazil","RodrigoGuabiraba","INRACentreValdeLoire,PleSantéAnimaledeTours(PSAT),France","DanielCisalpino","DepartamentodeMicrobiologia,InstitutodeCiênciasBiológicas,UniversidadeFederaldeMinasGerais,Brazil",,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00103ED1V01Y201402ISP049","10.
4199/C00103ED1V01Y201402ISP049","Dengueisamajorpublichealthconcernthroughoutthetropicalandsub-tropicalregionsoftheworld.
Itisthemostrapidlyspreadingmosquito-borneviraldisease,witha30-foldincreaseinglobalincidenceoverthepast50years.
InfectionwithanyoftheDenguevirusserotypescanbeasymptomatic,causetheclassicdenguefever,orevolvetoseveredisease,whichleadstohypovolemicshockanddeathifuntreated.
Thereisnoapprovedspecifictreatment,prognosticmarkers,orvaccinesfordengue,inpartbecausethereisinsufficientknowledgeofdenguepathogenesis.
Inthise-book,wewillfocusonwhatwebelievetobeatruechallengeindengueresearch:tounderstandhost–pathogeninteractions.
Diseasedevelopmentresultsfromtheinteractionbetweenhostandviralfactors,inwhichthehostimmuneresponseiscritical.
Recentadvancesindengueexperimentalmodelstogetherwithclinicaldatahaveprovidedusefulinformationindicatingthatseveredenguehallmarks(excessiveproductionofpro-inflammatorycytokines,endothelialactivation,andplasmaleakage)areimmune-mediatedevents.
WehopetopresentreaderswithacomprehensivedescriptionoftheimmuneresponsetotheDenguevirus,detailinghowDENVunbalanceshosthomeostasis.
""3","9781615046485","9781615046492","IntroductiontoNeuroglia","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","74","February,2014","AlexeiVerkhratsky","FacultyofLifeSciences,TheUniversityofManchester,Manchester,U.
K.
AchucarroCenterforNeuroscience,IKERBASQUE,BasqueFoundationforScience,Spain",,"VladimirParpura","DepartmentofNeurobiology,CenterforGlialBiologyinMedicine,AtomicForceMicroscopyandNanotechnologyLaboratories,CivitanInternationalResearchCenter,EvelynF.
McKnightBrainInstitute,UniversityofAlabama,BirminghamDepartmentofBiotechnology,UniversityofRijeka,Croatia",,,,"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00102ED1V01Y201401NGL001","10.
4199/C00102ED1V01Y201401NGL001","Thisbookistheintroductiontoaseriesofe-booksdedicatedtothephysiologyandpathophysiologyofneuroglia.
Thetopicofneurogliaisgenerallyoverlookedinneurosciencecurriculaacrosstheworld,themainattentionbeingfocusedonthedescriptionofexcitabilityofneuronsandneuronalnetworks.
Theneuroglia,beingelectricallynon-excitable,areuniversallyregardedassupportivecellswhichdonotcontributetoinformationprocessing.
Thisoversimplifiedview,however,ignoresthetremendousimportanceofbrainhomeostasis,whichisimperativefortheongoingactivityofneuronalnetworks.
Italsoignoresthetruththatspecializationofneuronsandtheirabilityforrapidpropagationandmulti-levelintegrationofsignalsbecomepossibleonlybecauseofdelegationofhomeostaticabilitiestoneuroglia.
Furthermore,glialcellscontributetoinformationprocessingastheycanmodulateneuronalsynaptictransmission.
Finally,neurogliaprovidetheonlysystemofbraindefenseandassuchthesecellsareintimatelyinvolvedinalltypesofneuropathologies,andcontributetobothneuroprotectionandregenerationofthenervoussystem.
Thee-booksinthisseriesprovideaplatformforin-depthlearningofallaspectsofneuroglialcellsfunctioninhealthanddisease.
TableofContents:Acknowledgments/Introduction/Definition,Classification,andEvolutionofNeuroglia/FunctionsofNeuroglia/ConcludingRemarks/References""3","9781615046447","9781615046454","TheMolecularBiologyofNeurofibromatosisType1","ColloquiumSeriesonGenomicandMolecularMedicine","79","February,2014","MeenaUpadhyaya","InstituteofMedicalGenetics,CardiffUniversitySchoolofMedicine,UK"2167-7840","2167-7859","http://dx.
doi.
org/10.
4199/C00101ED1V01Y201312GMM005","10.
4199/C00101ED1V01Y201312GMM005","Neurofibromatosistype1(NF1)isacommonautosomaldominantlyinherited,tumourpredispositionsyndromeaffecting1/3,000-4,000individualsworldwide.
ThisinheriteddisorderresultsfromthemutationalinactivationoftheNF1geneonhumanchromosome17.
TheNF1genecontains61exonsthatgiveriseto12kbmRNAencodingneurofibromin.
The327kDa(2,818aminoacid)neurofibrominproteinisexpressedinmosttissuesandhasanumberofalternativeisoforms.
Neurofibrominisatumoursuppressorproteinanddown-regulatescellularRas.
IncreasedactiveRas-GTPlevelsalsostimulatetheimportantPI3K/AKT/mTORsignallingpathwaythatprotectscellsfromapoptosis.
ThemajorclinicalfeatuesofNF1includemultiplecafé-au-laitmacules,skinfoldfreckles,irisLischnodules,andneurofibromas.
Thediagnosticcriteriaforclinicaldiagnosishavebeenwellestablished.
However,thereareasmallnumberofcasesinwhichthediagnosisisnotcertain.
ThegermlinemutationratefortheNF1geneis10-foldhigherthanthatobservedformostotherinheriteddiseases.
Usingacombinationofdifferenttechniques,almost95%ofgermlinemutationscanbedetected.
Todate,onlytwofirmgenotypephenotypecorrelationshavebeenreported.
NF1phenotypeexhibitslargevariationswithinafamily,evidenceformodifyinglociregulatingtheexpressionofanNF1geneisbeginningtoemerge.
Wealsoaregainingknowledgeonthemolecularmechanismsassociatedwiththedevelopmentofdifferenttypesoftumours.
Itisencouragingthattheresultsofrecentlaboratoryandclinicalresearcharefinallybeingtranslatedintoclinicaltrials.
Withtheavailabilityofhigh-throughputtechnologies,sophisticatedanimalmodels,andmulti-centreclinicaltrials,thefutureforNF1sufferersislookingoptimistic.
ThisbookaimstoprovideanoverviewofthegeneticandclinicalaspectsofNF1anditsroleinbothNF1-associatedandsporadictumourdevelopment.
Itemphasizestherecentdevelopmentsinthisfieldandsomeofthepromisingon-goingclinicaltrials.
TableofContents:Abbreviations/IntroductiontoNF1/NF1-AssociatedTumours/AnimalModels,PreclinicanandClinicalTrials/SummaryandConclusion/References/TitlesofRelatedInterest/SeriesofRelatedInterest""3","9781615046508","9781615046515","ShortBowelSyndromeinChildhood","ColloquiumSeriesonIntegratedSystemsPhysiology","101","March,2014","MichaelE.
Hllwarth","DepartmentofPediatricandAdolescentSurgery,MedicalUniversityofGraz,Austria"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00104ED1V01Y201402ISP050","10.
4199/C00104ED1V01Y201402ISP050","Extensivelossofsmallbowelinallagegroupshasdramaticconsequencesonthelifestyleofthepatientandthewholefamilyandisaccompaniedbysignificantmorbidityandmortality.
Allpatientsneednutritionalandmedicalsupportandsomeofthemremaindependentonlong-termparenteraltherapy.
Recurrentsurgicalinterventionsorevenintestinaltransplantationmaybenecessary.
However,theintestinaltractexhibitsanastonishingabilitytocompensateforanextensivelossofsmallbowel.
Adaptationtothenewsituationtakesplacewithtimebystructuralandfunctionalchangesresultinginanincreasedsurfaceareawithimproveddigestiveandabsorptivecapacity.
Thisprocess,however,differsmarkedlyamongindividualpatientsdependingontheremaininglengthandfunctionalqualityofsmallbowel.
Mechanismssupporting,andcomplicationsdelaying,theadaptationprocesshavebeenstudiedextensivelyoverthepastdecades.
Thisreviewpresentsasurveyofincidence,etiology,andconsequencesofextensivelossofsmallbowel.
Ashortdescriptionofthenormaldigestiveandabsorptivefunctionofthegastrointestinaltractandthepathophysiologicalconsequencesinshortbowelcasesisfollowedbydiscussingthecurrentfieldofbasicresearch,presentingtoday'smedicalandsurgicaltreatmentmodalitiesandtherelatedresultsinpatientswithSBS.
MostofthedataarederivedfromanimalstudiesorresearchperformedonnewbornsandinfantssufferingfromSBS,butthemajoritiesareequallyrelevanttotheadolescentandadultagegroup.
TableofContents:Introduction/IncidenceandEtiology/DigestionandAbsorptionunderNormalConditions/PathophysiologyofExtensiveSmallBowelLoss/TheProcessofIntestinalAdaptation/FactorsInvolvedinIntestinalAdaptation/EstimatingFunctioningBowel-Citrulline/ConservativeTherapyofSBSinHumans/HomeParenteralNutrition/MonitoringofImportantParameters/SurgicalTherapy/Complications/Long-TermResults/References/AuthorBiography""3","9781615046522","9781615046539","ErectileDysfunction","ColloquiumSeriesonIntegratedSystemsPhysiology","71","March,2014","RanyShamloul","OttawaHospitalResearchInstitute,Ottawa,Canada;DepartmentofAndrology,CairoUniversity,Egypt","AnthonyJBella","GretaandJohnHansenChairinMen'sHealthResearch,AssistantProfessorofUrology,DepartmentofSurgery,AssociateScientist,Neuroscience,UniversityofOttawa",,,,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00105ED1V01Y201403ISP051","10.
4199/C00105ED1V01Y201403ISP051","Theunderstandingofthepathophysiologyoferectiledysfunction(ED)hasadvancedsignificantlyoverthepasttwodecades.
Inthisebook,weprovideanin-depthanalysisofthecurrentknowledgeofthepathophysiologyofEDinordertoprovidethereaderwithanup-to-dateandcomprehensiveunderstandingofthepathophysiologyofED,whichiscomplexbutfascinating.
IntensiveandintricatemechanismsgovernthedevelopmentofED.
Thesemechanismsinvolvecomplexinteractionbetweenvascular,hormonalandneuralregulation.
CurrentresearchonthecentralregulationofEDiskeyfortheadvancementofourunderstandingofthiscomplexdisease.
RecentadvancesinourknowledgeofthevascularmechanismsregulatingpenileerectionledtoappreciationofEDasanearlysymptomofcardiovasculardisease.
Majorhealthconcernssuchasatherosclerosis,hyperlipidemia,hypertensionanddiabeteshavebecomewellintegratedintotheinvestigationofED.
Extensiveresearchonthemechanismsinvolvedintheregulationofpenileerectionhaveledtounparalleledadvancesintheunderstandingofgeneralvascularregulation.
However,manyunknownsremain,whichprovidesvastopportunitiesforfuturebasicandclinicalinvestigations.
TableofContents:AnatomyofthePenis/GeneralPathophysiology/DiabetesandED/EDandCardiovascularDisease/DrugsCausingED/References/AuthorBiographies""3","9781615046300","9781615046317","ProteinTranslation","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","93","June,2014","EricJan","DepartmentofBiochemistryandMolecularBiology,UniversityofBritishColumbia"2328-3041","2328-305X","http://dx.
doi.
org/10.
4199/C00106ED1V01Y201406BBC006","10.
4199/C00106ED1V01Y201406BBC006","Proteinsynthesisisafundamentalaspectofgeneexpressionacrosskingdoms.
Theregulationoftranslationisimportantformanybiologicalprocessesincludingcellfatedetermination,development,andgrowthandisespeciallycrucialtomaintaincellularhomeostasisduringcellularstressandvirusinfection.
Misregulationofproteintranslationcancontributetodiseasessuchasdiabetes,cancer,andneurodegenerativediseases.
Inthischapter,wehighlightthebasicunderstandingofeukaryotictranslationandthemajorregulationsthatcontrolbiologicalevents.
WefocusonsignalingpathwaysthatregulateoverallproteinsynthesisandalsomechanismsthatcontroltranslationofspecificmRNAssuchascis-actingelementswithinthe5'and3untranslatedregions(UTR).
Understandingthesemechanismsprovideinsightsintothefundamentalgeneregulationsthatmayprovidenewtargetsforcombatingdiseaseandvirusinfections.
TableofContents:Introduction/TranslationalInitiation/RegulationofCap-dependentTranslation/SelectiveTranslationofmRNAs/ConcludingRemarks/Acknowledgements/References/Authorbiography""3","9781615045402","9781615045419","IntermediateFilaments","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","112","June,2014","NormandMarceau","Centrederecherchesurlecancer,UniversitéLaval,andCentrederechercheduCHUdeQuébec,QuebecCity,Qc,Canada,G1R2J6","AnneLoranger","Centrederecherchesurlecancer,UniversitéLaval,andCentrederechercheduCHUdeQuébec,QuebecCity,Qc,Canada,G1R2J6","StéphaneGilbert","Centrederecherchesurlecancer,UniversitéLaval,andCentrederechercheduCHUdeQuébec,QuebecCity,Qc,Canada,G1R2J6",,,"2328-3041","2328-305X","http://dx.
doi.
org/10.
4199/C00107ED1V01Y201406BBC007","10.
4199/C00107ED1V01Y201406BBC007","Intermediatefilaments(IFs),inconcertwithmicrofilaments(MFs)andmicrotubules(MTs),formthecytoskeleton,andeachofthesefibrillarnetworksexhibitsratheruniquestructuralandfunctionalcharacteristics.
Intermediatefilamentswerediscoveredineukaryoticcellsinthelate1960s,andtheirnamecomesfromthefactthattheirdiameterisintermediatebetweenMFsandMTs.
Incontrasttothelatter,IFsconstituteanetworkthatextendsfromthenuclearenvelopethroughoutthecytoplasm,andinmanycases,interactwithcellsurfacedomainsinvolvedincell-cellandcell-matrixinteractions.
Severalkeyfeaturesoftheirexpression,assembly,structureanddynamicsarehighlightedinthiseBook.
Forinstance,IFproteinsareencodedbyseveralgenes,whichareclassifiedintosixtypesreflectingthetissues(cells)oforigin.
Moreover,IFproteinscontainaconservedcentralα-helical(rod)domainflankedbyN-terminal(head)andC-terminal(tail)globulardomainsthatenablesassemblyoffibrousIFsexhibitingatripartitestructure.
Althoughtheroddomainisresponsiblefortheformationofthecoiled-coilframeworkandyieldsthemaindrivingforceduringtheIFproteinassembly,theheadandtaildomainscontributetomostofthestructuralheterogeneityofIForganizationandundergoseveraltypesofpost-translationalmodifications.
Furthermore,thedevelopmentofgenetargetingmethodstogeneticallyknockouttheexpressionoftheIFgenesinmicehasuncoveredthemechanicalversusnon-mechanicalfeaturesoftheIFnetworks,namely,theirinvolvementincellresponsetodiverseformsofstress,growthstimulation,migration,ordeathinsults.
Finally,thereisaccumulatingevidencerevealingthatthetissueandcell-typeexpressionofIFgenesreflectsitselfinthepresenceofcausalorpredispositionmutationsresponsiblefornumeroushumantissue-specificdiseases,knownasIF-pathies.
TableofContents:ListofAbbreviations/Introduction/IFsasaMultigeneFamilyofFilamentousProteins/NuclearLamina/IFFunctionalInterplaywithCellSurfaceDomainsandOrganelles/IFsandCellSpecialization/IFRelevancetoHumanDiseases/Conclusion/References/AuthorBiographies""3","9781615043668","9781615043675","CoronaryCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","189","July,2014","JohnathanD.
Tune","DepartmentofCellularandIntegrativePhysiology,IndianaUniversitySchoolofMedicine,Indianapolis,IN"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00111ED1V01Y201406ISP054","10.
4199/C00111ED1V01Y201406ISP054","Thecoronarycirculationisuniqueinthatitisresponsibleformaintainingadequateoxygenandsubstratedeliverytotheorganthatgeneratesthepressureneededtodrivebloodthroughouttheentirecirculatorysystem.
Inthesimplestterms,coronarybloodflowisdirectlyproportionaltothearterialpressuregradientacrossthecoronaryvasculatureandinverselyproportionaltocoronaryvascularresistance.
However,myocardialperfusioniscollectivelyregulatedbyacomplexvarietyofmechanismswhichinclude:(1)extravascularcompressiveforces;(2)diastolictimefraction;(3)coronaryperfusionpressure;(4)myocardialmetabolism(localmetabolicfactors);(5)endothelial-derivedsubstances;(6)neuro-humoralinfluences;and(7)arterialoxygentensionandcontent.
Thisbookconsiderseachofthesedeterminantswithparticularemphasisonthefunctionalinteractionbetweenthephysicalandbiologicaldeterminantsofmyocardialperfusion.
Pathophysiologicaspectsofcoronaryatherosclerosisandcardiovasculardiseasestatesarealsoconsidered.
TableofContents:Abbreviations/Acknowledgments/Introduction/BasicCoronaryAnatomy/Myocardial-CoronaryInteraction/ArterialPressureandAutoregulation/LocalMetabolicControl/Endothelial-DependentControl/NeuralActivationandCirculatingHormones/CoronaryStenosis,MyocardialIschemia,andEffectsofDisease/Summary/ReferenceList/AuthorBiography""3","9781615046607","9781615046614","EntericGlia","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","70","July,2014","BrianD.
Gulbransen","DepartmentofPhysiology,MichiganStateUniversity"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00113ED1V01Y201407NGL002","10.
4199/C00113ED1V01Y201407NGL002","Theentericnervoussystem(ENS)isacomplexneuralnetworkembeddedinthegutwallthatorchestratesthereflexbehaviorsoftheintestine.
TheENSisoftenreferredtoasthe"littlebrain"inthegutbecausetheENSismoresimilarinsize,complexityandautonomytothecentralnervoussystem(CNS)thanothercomponentsoftheautonomicnervoussystem.
Likethebrain,theENSiscomposedofneuronsthataresurroundedbyglialcells.
EntericgliaareauniquetypeofperipheralgliathataresimilartoastrocytesoftheCNS.
Yetentericglialcellsalsodifferfromastrocytesinmanyimportantways.
Therolesofentericglialcellpopulationsinthegutarebeginningtocometolightandrecentevidenceimplicatesentericgliainalmosteveryaspectofgastrointestinalphysiologyandpathophysiology.
However,elucidatingtheexactmechanismsbywhichentericgliainfluencegastrointestinalphysiologyandidentifyinghowthoserolesarealteredduringgastrointestinalpathophysiologyremainareasofintenseresearch.
Thepurposeofthise-bookistoprovideanintroductiontoentericglialcellsandtoactasaresourceforongoingstudiesonthisfascinatingpopulationofglia.
TableofContents:Introduction/AHistoricalPerspectiveonEntericGlia/EntericGlia:TheAstrogliaoftheGut/MolecularCompositionofEntericGlia/DevelopmentofEntericGlia/FunctionalRolesofEntericGlia/EntericGliaandDiseaseProcessesintheGut/ConcludingRemarks/References/AuthorBiography""3","9781615043729","9781615043736","ControlofBreathingDuringExercise","ColloquiumSeriesonIntegratedSystemsPhysiology","93","July,2014","SusanA.
Ward","EmeritusProfessor,FacultyofBiologicalScience,UniversityofLeedsandHumanBio-EnergeticsResearchCentre,Crickhowell,Powys,UnitedKingdom"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00108ED1V01Y201406ISP052","10.
4199/C00108ED1V01Y201406ISP052","Thecontrolofbreathingduringexerciseremainsthesourceofconsiderabledebate.
Classicalschemesoftheexercisehyperpneahaveincorporatedelementsofproportionalfeed-backfromchemoreceptorsites(carotidbodyandbrainstem)andfeed-forwardneurogenic(centralcommandandmusclereflex)control.
However,theprecisedetailsofthecontrolprocessarestillnotfullyresolved,reflectinginparttechnicalandinterpretationallimitationsinherentinisolatingputativecontrolmechanismsintheintactexercisinghumanandalsothechallengespresentedbytheventilatoryandgas-exchangecomplexitiesencounteredatworkrateswhichengenderametabolic(lactic)acidosis.
Althoughsomecombinationofneurogenic,chemoreflex,andcirculatory-coupledprocessesarelikelytocontributetothecontrol,intriguingly,theoverallsystemappearstoevidenceconsiderableredundancy.
This,coupledwiththelackofappreciablesteady-stateerrorsignalsinthemeanlevelsofarterialPCO2,PO2,andpHoverawiderangeofworkrates,hasmotivatedtheformulationofinnovativecontrolmodelsthatreflectnotonlyspatialinteractionsbutalsotemporalinteractions(i.
e.
,short-termandlonger-term'memory').
Thechallengeremainstodiscriminatebetweenrobustcontrolschemesthat(a)integratesuchprocesseswithinplausiblephysiologicalequivalents,and(b)accountforboththedynamicandsteady-statesystemresponseovertheentirerangeofexerciseintensities.
TableofContents:Introduction/VentilatoryRequirements/VentilatoryResponses/VentilatoryControl/Conclusions/References""3","9781615046560","9781615046577","PathogenesisofAtherosclerosis:FromCellBiologytoTherapeutics","ColloquiumSeriesonIntegratedSystemsPhysiology","125","July,2014","A.
WayneOrr","DepartmentsofPathologyandCellBiologyandAnatomyLSUHealthSciencesCenter–Shreveport","ArifYurdagulJr.
","DepartmentsofPathologyandCellBiologyandAnatomyLSUHealthSciencesCenter–Shreveport","BrijeshM.
Patel","DepartmentofMedicineDivisionofCardiologyLSUHealthSciencesCenter–Shreveport",,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00110ED1V01Y201406ISP053","10.
4199/C00110ED1V01Y201406ISP053","Thecirculatorysystemprovidesthetissuesofthebodywithoxygenandnutrientsforsurvival,allowsforthedisseminationofinflammatorycells,andclearsmetabolicwastefrombuildingupanddamagingtissue.
Atheroscleroticdisease,thebuild-upoffat,inflammatorycells,andfibrotictissueinthevesselwall,hindersthisfunction,resultingininadequateperfusionofthetargettissue.
Hypoxia,orlackofoxygen,rapidlyresultsincellulardysfunctionthatprofoundlyaffectsthefunctionalityoftheoveralltissue.
Atherosclerosis-associatedtissueischemiaandhypoxiabecauseoflossofbloodflowunderliesseveralsignificantdiseasepathologiesincludingischemicheartdisease,stroke,andperipheralarterydisease.
InthiseBook,weexaminetheprocessofatheroscleroticplaqueformationbothatthecellularlevelandthelevelofclinicalpresentation.
Throughthisbook,wehopetoimparttothereaderabetterunderstandingofhowvesselstructure,environmentalriskfactors,andgeneticpredispositioncontributetoatheroscleroticdiseaseandhowcurrentandfuturetherapiesseektocircumventthecellularprocessescontributingtoplaqueformationtoreduceatheroscleroticplaqueburdenandclinicalcomplications.
TableofContents:ListofVideos/IntroductiontoAtherosclerosis/Epidemiology/EndothelialCellActivationandArterialHemodynamics/CholesterolandCardiovascularDisease/InflammationinAtherosclerosis/SmoothMuscleCellsandPlaqueVulnerability/DiagnosingAtheroscleroticDisease/TreatmentandPrevention/SummaryandFuturePerspectives/References/AuthorBiographies""3","9781615045884","9781615045891","MultipleSclerosis:AnOverviewofClinicalFeatures,Pathophysiology,Neuroimaging,andTreatmentOptions","ColloquiumSeriesonIntegratedSystemsPhysiology","117","Sept.
2014","AlirezaMinagar","DepartmentofNeurology,LouisianaStateUniversityHealthSciencesCenter"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00116ED1V01Y201408ISP055","10.
4199/C00116ED1V01Y201408ISP055","Multiplesclerosis[MS]isoneofthemostcommonauto-immune-mediateddiseasesofthehumancentralnervoussystem[CNS]whichaffectsyoungadultsandusuallycausessignificantneurologicaldisability.
Currently,thecausesofMSarestillunclear,acureforMSremainselusiveandtheeffectivenessoftreatmentvariessignificantlyamongindividuals.
ClinicalfeaturesandneurologicaldeficitsstemmingfromthisprogressiveneurologicaldiseasearediversesinceMSpotentiallyaffectshumanCNSatalllevelsfrombraintotheendofspinalcord.
ThetriggeringeventfordevelopmentofMSremainsunknown.
ImmunopathogenesisofMSinvolvesanumberofstepswhichincludeactivationofperipheralleukocytesagainstputativeCNSantigen(s),interactionsoftheactivatedleukocyteswithinflamedcerebralendothelialcells,transendothelialmigrationofactivatedlymphocytesandmacrophagestotheCNSmilieu,andfurtherpropagationofthemassiveimmuneresponsewithintheCNS.
Suchmassiveimmuneactivationleadstolossofmyelin-oligodendrocytecomplex.
Severalimmunecelltypesandmediatorsoftheimmune-inflammatoryresponseactivelycontributetopathogenesisofMS.
GeneticfactorsarealsobelievedtoplayacentralroleinthedevelopmentofmostformsofMS.
Anotherimportantbutmuchunrecognizedandunder-researchedfeatureofMSimmunopathologyis"neurodegeneration.
"NeuronallossandaxonaldegenerationarethecorecomponentsofirreversibleandpermanentCNSatrophyanddisabilityinMS.
WhatwecallMSinrealityisaheterogeneousgroupofdiseasesandatleastfourdistinctimmunopathologicalsubtypesofMSwithdissimilarresponsestotherapywithimmunomodulatoryagentsexist.
MSisaclinicaldiagnosis,however,itsdiagnosticprocessismuchfacilitatedbyutilizationoflaboratoryandneuroimagingstudies.
PresenttherapiesofMSareeitherimmunomodulatoryagentsorimmunosuppressiveandmainlytargettheperipheralimmunesystemwiththeintentiontoamelioratetheseverityofacuterelapses,decreaseannualrelapserate,andimproveMRIlesions.
Currently,muchresearchactivityisbeingconductedtobetterunderstandthefundamentaldiseasemechanismsofMSandfindmoreeffectiveandsafertreatmentsforthisincurabledisease.
ThisbookpresentsanoverviewofMSasadiseasewithneuroinflammatoryandneurodegenerativefeaturesandtheauthorsdiscussthemostrecentfindingsaboutMSanditstreatment.
TableofContents:Introduction/ClinicalFeaturesofMultipleSclerosis/PathophysiologyofMultipleSclerosis/NeuroimagingofMultipleSclerosis/DiagnosisofMultipleSclerosis/TreatmentofMultipleSclerosis/PrognosisofMultipleSclerosis/ConcludingRemarks.
References""3","9781615046584","9781615046591","VesicularTransportintheSecretoryandEndocyticPathways","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","125","Sept.
2014","AnneMüsch","DepartmentofDevelopmental&MolecularBiologyAlbertEinsteinCollegeofMedicine"2328-3041","2328-305X","http://dx.
doi.
org/10.
4199/C0011ED1V01Y201407BBC008","10.
4199/C0011ED1V01Y201407BBC008","Theconceptofvesiculartrafficasameansofproteintransportinandoutofcellsandbetweenmembranecompartmentshasbeenestablishedsincethe1960s.
Itsbasicprinciplesarebeautifullysimple,yetthedetailsofproteintransportarecomplexenoughtofindnovelclassesoftransportvesicles,andtraffickingitinerariesstillbeingdescribedtodate.
Inthistreatise,thereaderwillbeintroducedtomechanismsofvesiclesculpting,cargoselection,vesicletargeting,andvesicleconsumptionthathaveemergedascommoncharacteristicsofmultipletransportstepsintheexocyticandendocyticpathways.
Thesefundamentalsalsorevealthebasisforthespecificityandselectivityofindividualtransportsteps.
Wewillfurtherdiscusshowproteintransportmightleadtotheestablishmentandmaintenanceoftheendomembranesystemofeukaryoticcells.
Theconceptsforthesemechanismsarebasedonexperimentalevidencecombinedwithmathematicalmodelingthatcandisclosetheminimalrequirementsforthegenerationofthedistinctmembranecompartments.
TableofContents:CompartmentalizationIsaHallmarkofEukaryoticCells/OrganellesCanBeClassifiedBasedonTheirOrigin/ThereAreMultipleEntryPointsIntotheEndomembraneSystemandaNetworkofConnectingTraffickingRoutes/ThereAreExceptionsandExtensionstotheClassicTraffickingItineraries/AMathematicalModelCanExplainHowOrganelleSizeIsEstablishedandMaintained/CoatsandSNAREsConstitutetheCoreMachineryforVesicleBuddingandFusion/AMathematicalModelExplainsHowCoatsandSNAREsAreSufficienttoGenerateOrganelleIdentity/HowVesicleFormationIsLinkedtoCargoIncorporation/RabGTPasesAretheMasterRegulatorsofVesicularTraffic/TheMechanismsandPhysiologicalRolesofEndocytosis/ModelsforProteinTransportintheGolgiApparatus/Summary/Acknowledgments/References/AuthorBiography""3","9781615046645","9781615046652","Ca2+-dependentSignalTransduction","ColloquiumSeriesonBuildingBlocksoftheCell:CellStructureandFunction","68","Sept.
2014","JamesD.
Johnson","DepartmentofCellularandPhysiologicalSciences,UniversityofBritishColumbia","MichaelJ.
Bround","DepartmentofCellularandPhysiologicalSciences,UniversityofBritishColumbia","TobiasAlbrecht","DepartmentofCellularandPhysiologicalSciences,UniversityofBritishColumbia",,,"2328-3041","2328-305X","http://dx.
doi.
org/10.
4199/C00115ED1V01Y201407BBC009","10.
4199/C00115ED1V01Y201407BBC009","Inbiology,signaltransductionisthetransmissionofinformationintoandwithinthecell.
Signaltransductioneventswithinacellareofteninitiatedfromanextracellularcue.
Currentknowledgesuggeststhattherearefarfewerintracellularsecondmessengersthanextracellularcues.
Thismeansthataconservedcoresetofsecondmessengers,includingions,smallnucleotides,andlipidsmustbecoordinatedtopasstheinformationfromtheirpointoforigintotheiraudiencereceptorseffectively.
Inmanycases,signaltransductioninvolvessignificantamplification.
Oneofthebest-understoodandubiquitoussecondmessengersisioniccalcium(Ca2+).
TheknowledgesurroundingthecodingofinformationviaCa2+signalshasservedasatemplateforstudyingothersecondmessengers.
Ca2+signalingandintracellularCa2+homeostasisarehighlycomplexandstillincompletelyunderstood.
Inthischapter,willwereviewthecurrentknowledgeofCa2+signaling.
WewillfirstprovideareviewofthegeneralprinciplesofCa2+signaltransductionandexamplesofsomeofthemajorCa2+-dependentcellularprocesses.
Next,wewillreviewthemainsourcesofCa2+andthemoleculareffectorsofCa2+signals.
Then,wewillprovidesomeexamplesfromtheliteraturethatillustratehowCa2+signalingworks:howitcanmediatesignalamplification,howitencodesdifferenttypesofsignals,howitperformsagonist-specificsignalsaswellasfunction-specificsignals,signalintegrationandco-incidencedetection,andhowitcancross-talkwithothersecondmessengersignalingevents.
Throughoutthischapter,wewilluseCa2+asanexampleofaprototypicalcodedsecondmessenger,sinceitisclearthatmuchofthecomplexityofCa2+signalinglikelyappliestomanyoftheotherknownsecondmessengers.
TableofContents:GeneralIntroduction/SourcesofCa2+Signals/Ca2+-DependentProcesses:FromHighlySpecializedtoUbiquitousCellularRoles/MajorCa2+-SignalingEffectors/Ca2+SignalCoding/Acknowledgments/Bibliography/TitlesofRelatedInterest""3","9781615046546","9781615046553","CountingMoleculesWithinCells","ColloquiumSeriesonQuantitativeCellBiology","74","Sept.
2014","ValerieCoffman","DepartmentofMolecularGenetics,TheOhioStateUniversity,Columbus,Ohio","I-JuLee","DepartmentofMolecularGenetics,TheOhioStateUniversity,Columbus,OhioGraduateProgramofMolecular,Cellular,andDevelopmentBiology,TheOhioStateUniversity,Columbus,Ohio","Jian-QiuWu","DepartmentofMolecularGenetics,TheOhioStateUniversity,Columbus,OhioDepartmentofMolecularandCellularBiochemistry,TheOhioStateUniversity,Columbus,Ohio",,,"2375-7744","2375-7752","http://dx.
doi.
org/10.
4199/C00109ED1V01Y201406QCB001","10.
4199/C00109ED1V01Y201406QCB001","3","9781615046621","9781615046638","AJourneyThroughGenetics,Part2","ColloquiumSeriesonTheGeneticBasisofHumanDisease","71","Sept.
2014","KarobiMoitra","ClareBootheLuceProfessorofMolecularBiologyAssistantProfessor,TrinityWashingtonUniversity"2168-4006","2168-4022","http://dx.
doi.
org/10.
4199/C00114ED1V02Y201407GBD006","10.
4199/C00114ED1V02Y201407GBD006",""AJourneyThroughGeneticsPartII"isdesignedtocontinueontheincrediblejourneyinitiatedinPartItoexploretheexcitingdiscoveriesingeneticsandmolecularbiology.
InPartI,thereaderembarkedonageneticodysseythatstartedwiththe"FatherofGenetics,"GregorMendel,andculminatedintheinventionofoneofthemostpowerfultoolsinmolecularbiology—thepolymerasechainreaction.
Thesecondpartofthebookwilltakethereaderonajourneytoexplorethefrontiersofgeneticdiversity,genecloning,thehumanjourney,andthehumangenomeproject!
Thebookistargetedtowardundergraduatenon-majorsandalsoasa"companion"toastandardgeneticstextbookforbiologymajors.
Thebookwillalsoprovetobeusefulforanyonethatwantstounderstandthestoriesbehindthescienceofgenetics.
""3","9781615041473","9781615041480","GastrointestinalMucosalDefenseSystem","ColloquiumSeriesonIntegratedSystemsPhysiology","172","October,2014","PeterR.
Kvietys","CollegeofMedicine,AlfaisalUniversity,Riyadh,KSA","AhmedYaqinuddin","CollegeofMedicine,AlfaisalUniversity,Riyadh,KSA","WaelAlKattan","CollegeofMedicine,AlfaisalUniversity,Riyadh,KSA",,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00119ED1V01Y201409ISP058","10.
4199/C00119ED1V01Y201409ISP058","Thegastrointestinalmucosaldefensesystemservestominimizemucosalinjurybyeitheringestedorendogenouslyproducednoxioussubstances.
Themucosaldefensesystemisstratifiedintopre-epithelial(alkalinemucus),epithelial(dynamicepitheliallining),andpost-epithelial(microcirculation)components.
Themucusliningtheepithelialsurfacepresentsadiffusionalbarriertoingestedmaterial(e.
g.
,lipids)andalsoservesasanunstirredlayerinwhichapHgradientcanbeestablishedtopreventacid-inducedinjury.
Theepithelialliningpreventsentranceofanytoxicmaterialtotheinterstitiumand,shoulditbedamaged,itisrapidlyresealedbymigrationofadjacentviableepithelialcellstocoverthedefect.
Anyacidorothermaterialthathasenteredtheinterstitiumiswashedoutbyanintenseneurogenichyperemia.
Ingeneral,themucosaldefensesystemisquiteeffectiveandanyadversegastrointestinaleffectsassociatedwiththenormalcourseofnutrientassimilationareminimal.
However,therearetwosituationsinwhichthemucosaldefensesystemisknowntobeineffectiveandresultingastricmucosalinjury:inadvertentingestionofH.
pylori.
orintentionalingestionofNSAIDs.
H.
pyloricanpenetratethemucuslayersandcauseepithelialinjuryandinflammation,whileatthesametimepreventingitsclearancebythehostimmunesystem.
NSAIDsweakenthemucuslayerandcauseepithelialcellinjury.
TableofContents:Acknowledgments/Introduction/TheMucusLayer/EpithelialLining/GastrointestinalCirculation/IntegrationofMucosalDefense/MucosalDefenseSystem:Physiologic/MucosalDefenseSystem:H.
pylori/MucosalDefenseSystem:NonsteroidalAnti-InflammatoryDrugs(NSAIDS)/OverallSummaryandConclusions/References/AuthorBiographies""3","9781615045785","9781615045792","SexandGenderDifferencesinCardiovascular-RenalDiseasesandHypertension","ColloquiumSeriesonIntegratedSystemsPhysiology","97","November,2014","JaneReckelhoff","UniversityofMississippiMedicalCenter,Jackson,Mississippi"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00118ED1V01Y201409ISP057","10.
4199/C00118ED1V01Y201409ISP057","Manyofthemechanismsresponsibleforcardiovasculardiseaseandhypertensionarewellknown,andgenderisanindependentriskfactorinmanycohorts.
Howgendercontributestocardiovasculardiseasehasnotbeencompletelyelucidated.
Eveninnormotensivepopulations,bloodpressureishigherinmenthanwomen,althoughwhythisoccursisunclear.
Whilebothmenandwomensufferfromhighincidencesofcardiovasculardisease,womenaretypicallyprotectedagainstcardiovasculardiseaseuntilaftermenopause,sothatonaveragetheyareabout10yearsolderthanmenwhenthesediseasesdevelop,makingagingaconfoundingproblemcontributingtoincreasedmorbidity.
Becausehypertensionisoneoftheleadingcausesofcardiovasculardiseaseinbothmenandwomen,thisreviewwillfocusonhypertension,andthemechanismsthathavebeenfoundtoplayaroleinmediatingbloodpressurecontrolandhowtheydifferinmenandwomen.
TableofContents:OverviewandEpidemiology/GeneticandNon-GeneticModelsofHypertension/HypertensionandSympatheticNervousSystemActivation/ReninAngiotensinSystem/OxidativeStress/Endothelin/AgingandHypertension/DevelopmentalProgrammingofCardiovascularDisease/TCellsandHypertension/Genetics/SexSteroidsandReceptors/Summary/References/AuthorBiography""3","9781615046706","9781615046713","RetinalGlia","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","644","March,2015","AndreasReichenbach","PaulFlechsigInstituteforBrainResearch,UniversityofLeipzig","AndreasBringmann","DepartmentofOphthalmologyandEyeHospital,UniversityofLeipzig",,,,,"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00122ED1V01Y201412NGL003","10.
4199/C00122ED1V01Y201412NGL003","In1851,HeinrichMüllerdiscoveredwhathecalled"radialfibers"andwhatwenowcallMüllercells,astheprincipalglialcellsofthevertebrateretina.
Lateron,otherglialcelltypeswerefoundintheretina,includingastrocytes,microglia,andevenoligodendrocytes.
Itturnedoutthatretinalglialcellsareessentialconstituentsofthetissue.
Forinstance,Müllercellsappeartoconstitutethe"core"ofcolumnarunitsofclonallyandfunctionallyrelatedgroupsofneurons.
Theirprimaryfunctionistosupportneuronalfunctioningbyguidingthelighttowardsthephotoreceptorcells,removingexcessneurotransmittermoleculesfromextracellularspace,andperformingefficientclearanceofexcessextracellularpotassiumions.
Thelattertwofunctionsarealsocrucialforneuronalsurvivalandarecoupledtowaterclearancewhichisalsoessential.
Müllercellsarecapableof"sensing"neuronalactivityandmodifyingitbythereleaseofsignalsubstances(gliotransmitters).
IncasesofretinalinjuriestheMüllercellsbecomereactive,andallabove-mentionedfunctionsareimpaired.
However,suchde-differentiatedMüllercellsmayproliferate,andmayevenserveasstemcellsfortheregenerationofadamagedretina.
AswellastheMüllercells,retinalastrocytesandmicroglialcellsareimportantplayersinretinaldevelopmentandfunction.
Thisbookgivesacomprehensivesurveyofthepresentknowledgeonretinalglia.
TableofContents:RetinalStructure/RetinalAstrocytesandBloodVessels/RetinalMicroglia/RetinalOligodendroglia/MüllerCells/References/AuthorBiographies""3","9781615046768","9781615046775","NeurogliainInfectiousBrainDiseases","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","87","March,2015","GwennSkar","UniversityofNebraskaMedicalCenter,Omaha,Nebraska","JessicaSnowden","UniversityofNebraskaMedicalCenter,Omaha,Nebraska",,,,,"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00125ED1V01Y201503NGL005","10.
4199/C00125ED1V01Y201503NGL005","Inthisbook,wepresentadiscussionoftheimmunefunctionsofneurogliaandtheirinteractionswithcommoninfectiousdiseasesinthebrain.
Whilemostisknownaboutmicrogliaandastrocytes,asareextensivelyreviewedhere,ourunderstandingofotherglia,includingoligodendrocytesandependymalcells,continuestogrowintermsoftheirresponsetoinfection.
Ourdiscussionfocusesonthemostclinicallyrelevantandwell-studiedinfectiousdiseases,includingStreptococcuspneumoniae,Neisseriameningitidis,andhumanimmunodeficiencyvirus(HIV),amongothers,intheirinteractionswithmicrogliaandastrocytes.
Theseimmuneresponseswithinthecentralnervoussystemarecrucialforprotectingusfrompathogensandyetmustbecarefullybalancedwiththeneedtoprotectbrainstructuresthataresensitivetoinflammatorydamage.
Thecomplexinteractionsbetweenpathogensandglia,aswellasgliawithothercellsinthecentralnervoussystem,areanareaoffascinatingresearchthatcontinuestogrowasweattempttotranslateourunderstandingoftheseprocessestonewtreatmentandpreventionstrategies.
""3","9781615046744","9781615046751","TheRenin-AngiotensinSystemandtheKidney:NewInsightsandPerspectives","ColloquiumSeriesonIntegratedSystemsPhysiology","61","March,2015","XiaoC.
Li","LaboratoryofReceptorandSignalTransduction,DepartmentofPharmacologyandToxicology,DivisionofNephrology,DepartmentofMedicine,UniversityofMississippiMedicalCenter,Jackson,MS","JiaL.
Zhuo","LaboratoryofReceptorandSignalTransduction,DepartmentofPharmacologyandToxicology,DivisionofNephrology,DepartmentofMedicine,UniversityofMississippiMedicalCenter,Jackson,MS",,,,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00124ED1V01Y201501ISP059","10.
4199/C00124ED1V01Y201501ISP059","Therenin-angiotensinsystem(RAS)isoneofthemostimportantendocrine(tissue-to-tissue),paracrine(cell-to-cell)andintracrine(intracellular/nuclear)humoralsystemsintheregulationofbloodpressure,cardiovascular,andkidneyfunctioninhealthanddisease.
TheRAShasremarkablyevolvedfromtheinitialdiscoveryoftherate-limitingenzymerenintoacomplexbiochemicalandphysiologicalcascadeinvolvingmorethanadozenmembers.
Currently,thereareuptofiveaxesorpathwaysidentifiedintheRAS;eachhasitssubstrate,enzyme,effectorpeptide,receptor,anddownstreamsignalingpathways.
Theseincludetherenin/ACE/ANGII/AT1receptor,theAPA/ANGIII/AT2receptor,theACE2/ANG(1-7)/Masreceptor,theprorenin/proreninreceptor(PRR),andtheANGIV/AT4receptor(IRAP)pathways.
Accordingly,therolesoftheRAShaveexpandedwellbeyondtheclassicendocrineparadigmasapowerfulvasoconstrictor,apotentaldosteronestimulator,orasodium-retaininghormonalsystem.
Thegoalsofthisarticlearetoreviewanddiscussthecurrentinsightsintoandnewperspectivesontheexpression,localization,andnovelactionsoftheRASwithafocusinthekidney.
SpecialemphasiswillbeplacedonrecentlydiscoverednewmembersoftheRASderivedfromstudiesusinginnovativemutantratsormicethateitheroverexpress(knockin)oraredeficient(knockout)ofaparticularsubstrate,enzyme,ANGpeptide,orreceptor.
Thisnewknowledgewillhelpimproveourunderstandinghoweachofthesepathwaysactdirectlyorindirectlytoregulatebloodpressure,cardiovascularandkidneyfunctioninphysiology,andcanbetargetedtotreathypertension,cardiovascularandrenaldiseases.
TableofContents:Introduction/LocalizationandRolesoftheRenin/ACE/ANGII/AT1ReceptorAxisintheKidney/LocalizationandFunctionalPropertiesoftheACE2/ANG(1–7)/MasReceptorAxisintheKidney/LocalizationandRolesoftheProrenin/PRR/MAPKinasesERK1/2AxisintheKidney/TheLocalizationandPotentialRolesofotherANGPeptidesorReceptorsintheKidney/FuturePerspectives/Acknowledgements/References/AuthorBiography""3","9781615046720","9781615046737","PhysiologyofAstroglia:Channels,Receptors,Transporters,IonSignalingandGliotransmission","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","172","March,2015","AlexeiVerkhratsky","FacultyofLifeSciences,TheUniversityofManchester,Manchester,U.
K.
AchucarroCenterforNeuroscience,IKERBASQUE,BasqueFoundationforScience,Bilbao,SpainUniversityofNizhnyNovgorod,NizhnyNovgorod603022,Russia","VladimirParpura","DepartmentofNeurobiology,CenterforGlialBiologyinMedicine,AtomicForceMicroscopy0x26NanotechnologyLaboratories,CivitanInternationalResearchCenter,EvelynF.
McKnightBrainInstitute,UniversityofAlabamaatBirmingham,Birmingham,AL,U.
S.
A.
DepartmentofBiotechnology,UniversityofRijeka,Rijeka,Croatia",,,,,"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00123ED1V01Y201501NGL004","10.
4199/C00123ED1V01Y201501NGL004","Astrocytescanbedefinedasthegliainhabitingthenervoussystemwiththemainfunctioninthemaintenanceofnervoustissuehomeostasis.
Classifiedintoseveraltypesaccordingtotheirmorphologicalappearance,manyofastrocytesformareticularstructureknownasastroglialsyncytium,owingtotheircouplingviaintercellularchannelsorganizedintogapjunctions.
Notonlydoastrocytesestablishsuchhomocellularcontacts,buttheyalsoengageinintimateheterocellularinteractionswithneurons,mostnotablyatsynapticsites.
Assynapticstructureshousetheverycoreofinformationtransferandprocessinginthenervoussystem,astroglialperisynapticpositioningassuresthattheseglialcellscannourishneuronsandestablishbidirectionalcommunicationwiththem,functionsoutlinedintheconceptsoftheastrocyticcradleandmulti-partitesynapse,respectively.
Astrocytespossessarichassortmentofligandreceptors,ionandwaterchannels,andionandligandtransporters,whichcollectivelycontributetoastrocyticcontrolofhomeostasisandexcitability.
Astrogliacontrolglutamateandadenosinehomeostasistoexertmodulatoryactionsaffectingthereal-timeoperationofsynapses.
Fluctuationsofintracellularcalciumcanleadtothereleaseofvariouschemicaltransmittersfromastrocytesthroughaprocesstermedgliotransmission.
Sodiumfluctuationsarecloselyassociatedtothoseofcalciumwithbothdynamiceventsinterfacingsignalingandmetabolism.
Astrocytesappearfullyintegratedintothebraincellularcircuitry,beinganindispensablepartofneuralnetworks.
TableofContents:Acknowledgments/ListofAbbreviations/Astrocytes:GeneralPerspective/IonDistributionandMembranePotential/IonChannels/NeurotransmitterReceptors/MembraneTransporters/IonicSignalinginAstroglia/Gliotransmission:AstrocytesasSecretoryCellsoftheNervousSystem/ConcludingRemarks/References/AuthorBiographies""3","9781615046829","9781615046836","PathophysiologyofHeatStroke","ColloquiumSeriesonIntegratedSystemsPhysiology","101","April,2015","LisaR.
Leon","ThermalandMountainMedicineDivision,USArmyResearchInstituteofEnvironmentalMedicine"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00128ED1V01Y201503ISP060","10.
4199/C00128ED1V01Y201503ISP060","3","9781615046805","9781615046812","DevelopmentalGeneticsofthePharyngealArchSystem","ColloquiumSeriesonDevelopmentalBiology","108","May,2015","JeffryM.
Cesario","DepartmentofBasicScienceandCraniofacialBiology,NewYorkUniversityCollegeofDentistry,NewYork,NY","AndréLandinMalt","DepartmentofCellBiology,UniversityofVirginiaSchoolofMedicine,Charlottesville,VA","JuheeJeong","DepartmentofBasicScienceandCraniofacialBiology,NewYorkUniversityCollegeofDentistry,NewYork,NY",,,"2155-3521","2155-353X","http://dx.
doi.
org/10.
4199/C00127ED1V01Y201503DEB006","10.
4199/C00127ED1V01Y201503DEB006","Thepharyngealarchesareembryonicstructuresthatdevelopintotheface,neck,apartoftheheart,andseveralendocrineglandsinanimals.
Theyarethoughttohaveplayedakeyroleinvertebrateevolutionastheirderivativesimpactthemodeoffeedingandbreathing.
Moreover,perturbationinpharyngealarchdevelopmentisassociatedwithseveralmajorgroupsofbirthdefectsinhumans.
Duringearlyembryonicdevelopment,cellsfromallthreegermlayerscometogethertoassemblethepharyngealarches.
Subsequently,thepharyngealarchesundergogrowth,morphogenesis,andcelltypedifferentiationtogiverisetomusculoskeletal,cardiovascular,neural,andglandularcomponents.
Theseprocessesareguidedbyinteractionsamongstdifferenttissues,viasignalingmolecules.
Alargenumberofgenes,withacomplexnetworkofregulatoryrelationships,governeachaspectofpharyngealarchdevelopment.
Withtheadvanceofmoleculargeneticstoolsinmodelorganismssuchasmice,wearebeginningtounderstandthemolecularandcellularmechanismsunderlyingdevelopmentofthepharyngealarchesandrelatedbirthdefects.
ThiseBookwillprovideanintroductionintodevelopmentofthepharyngealarchsystem,withadetaileddiscussiononthegeneticregulationofthisprocess.
""3","9781615046669","9781615046676","NitricOxideintheKidney","ColloquiumSeriesonIntegratedSystemsPhysiology","47","May,2015","JenniferM.
Sasser","DepartmentofPharmacologyandToxicologyUniversityofMississippiMedicalCenter"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00117ED1V01Y201408ISP056","10.
4199/C00117ED1V01Y201408ISP056","Nitricoxide(NO)isakeyregulatorofvariouscellularsignalingpathwaysthroughoutthebodyandplaysanimportantroleinrenalfunctionundernormalphysiologicalandpathophysiologicalconditions.
NOplaysamajorroleintheregulationofrenalhemodynamics,tubuloglomerularfeedback,sodiumtransportinthenephron,pressurenatriuresis,andrenalfibrosisandinjury;moreover,adeficiencyinNOischaracteristicofchronickidneydiseaseinbothhumanpatientsandinexperimentalanimalmodels.
ThegoalofthisbookistohighlighttheactionsofNOwithinthekidneyanditseffectsontheregulationofrenalbloodflowandtubulartransport.
""3","9781615046782","9781615046799","TheNeurovascularUnitandtheRoleofAstrocytesintheRegulationofVascularTone","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","60","June,2015","JessicaA.
Filosa","GeorgiaRegentsUniversity"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00126ED1V01Y201503NGL006","10.
4199/C00126ED1V01Y201503NGL006","Optimalcerebralbloodflowiscoordinatedbyfunctionalhyperemiaandcerebralautoregulation.
Theseprocessesensurethatthemetabolicdemandsofthebrainaremetatalltimes.
Bothinvivoandinvitrostudiessupportaroleforastrocytesintheregulationofcerebralbloodflow.
Inthiswereviewthecellularmechanismscontributingtoastrocyte-mediatedvasodilationandvasoconstrictionofparenchymalarterioles.
Primarily,wediscusshowactivity-dependentchangesinastrocyticCa2+contributetothereleaseofvasoactivesignalsinvolvedinneurovascularcoupling.
FollowingtheriseinastrocyticCa2+andphospholipaseA2activation,arachidonicacidisreleasedandmetabolizedintomultiplevasoactivesignals(e.
g.
,prostaglandins,epoxyeicosatrienoicacids,and20-HETE).
Thelevelofarterioletonealongwiththemetabolicconditionsofthetissuecanaltertheactionofthesesignalsleadingtoeithervasodilationorvasoconstriction.
Moreover,increasedCa2+alsoactivateslargeconductanceCa2+-activatedK+channelsexpressedinastrocyticendfeetprocesses.
DependingontheK+effluxconcentrationreleased,thispathwaycanalsoelicitvasodilationorvasoconstrictionofparenchymalarterioles.
Finally,weconcludebydiscussingrecentdivergentinvivofindingswhichquestionaroleforastrocyteinfunctionalhyperemia.
""3","9781615047123","9781615047130","AstrogliaandBrainMetabolism:FocusonEnergyandNeurotransmitterAminoAcidHomeostasis","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","64","July,2015","ArneSchousboe","DepartmentofDrugDesignandPharmacology,FacultyofHealthandMedicalSciences,UniversityofCopenhagen,Copenhagen,Denmark","AnneB.
Walls","DepartmentofDrugDesignandPharmacology,FacultyofHealthandMedicalSciences,UniversityofCopenhagen,Copenhagen,Denmark","LasseK.
Bak","DepartmentofDrugDesignandPharmacology,FacultyofHealthandMedicalSciences,UniversityofCopenhagen,Copenhagen,Denmark","HelleS.
Waagepetersen","DepartmentofDrugDesignandPharmacology,FacultyofHealthandMedicalSciences,UniversityofCopenhagen,Copenhagen,Denmark","2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00130ED1V01Y201506NGL007","10.
4199/C00130ED1V01Y201506NGL007","Thepresentoutlineofastrocyticmetabolicpathwaysinvolvedinglucoseandaminoacidmetabolismprovidesdetailedinformationabouttheenzymaticpathwaysinvolved,aswellasadescriptionofthebasicpropertiesoftheenzymesincludingregulatorymechanisms.
Hence,theglycolyticpathwayandglycogenmetabolismareoutlined,followedbyadetailedaccountofpyruvateoxidationanditsroleasasubstrateforthetricarboxylicacid(TCA)cycle.
Moreover,adetaileddescriptionofthemainenzymesinvolvedinglutamatemetabolismisprovidedandtheroleoftheglutamate-glutaminecycleisexplained.
Sincethistextisprimarilycoveringastrocyticmetabolism,anemphasishasbeenplacedonadiscussionofthesignificanceoftheastrocytespecificenzymespyruvatecarboxylaseandglutaminesynthetase,whichenablethesecellstoperformanetsynthesisofglutamine,theprecursorforsynthesisofglutamateandγ-aminobutyrate(GABA),themainneurotransmittersofthebrain.
Withthis,wehaveunderlinedthefundamentalimportanceofastrocyticmetabolismforneuronalfunctionwithaparticularemphasisonthefactthat,withoutcontinuoussupportfromtheastrocyticpartnersinsynapticfunction,glutamatergicandGABAergicneurotransmissionwouldnotbepossible.
Itisthoughtprovokingthattheseneurotransmissionprocesses,whichaccountforthevastmajorityofsynapticactivityinthebrain,havebeenmadetotallydependentonastrocyticmetabolicsupport,particularlywithregardtoreplenishmentoftherespectiveneurotransmitters.
""3","9781615047147","9781615047154","CrucialRoleforAstrocytesinEpilepsy","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","89","August,2015","PeterBedner","InstituteofCellularNeurosciences,UniversityofBonn,Bonn,Germany","ChristianSteinhuser","InstituteofCellularNeurosciences,UniversityofBonn,Bonn,Germany",,,,,"2375-9933","2375-9917","http://dx.
doi.
org/10.
4199/C00135ED1V01Y201507NGL008","10.
4199/C00135ED1V01Y201507NGL008","Thisbooksummarizescurrentevidenceofastrocytedysfunctioninepilepsyanddiscussespresumedunderlyingmechanisms.
Epilepsyischaracterizedbytheperiodicoccurrenceofseizures.
Currentlyavailableanticonvulsantdrugsandtherapiesareinsufficienttocontrollingseizuresinaboutonethirdofpatients.
Thus,thereisanurgentneedfornewtherapiesthatpreventgenerationofthedisorderandimproveseizurecontrolinindividualsalreadyafflicted.
Thevastmajorityofepilepticcasesareofidiopathicoriginwiththeirunderlyingmechanismsbeingunclear.
Neurosurgicalspecimensfrompatientspresentingwithmesialtemporallobeepilepsy(MTLE)demonstratemarkedreactivegliosis.
SincerecentstudieshaveimplicatedastrocytesinimportantphysiologicalrolesintheCNS,suchassynchronizationofneuronalfiring,itisplausiblethattheymayalsohavearoleinseizuregenerationand/orseizurespread.
Insupportofthisview,variousmembranechannels,receptors,andtransportersinastrocyticmembranesarealteredintheepilepticbrain.
Excitingly,recentevidencesuggeststhatinthecourseofthepathogenesisofMTLE,theseglialchangesalterhomeostaticnetworkfunctionsandtemporallyprecedethealterationsinneurons.
ThesefindingsmighteventuallyclassifyMTLEasaglialratherthananeuronaldisorder,andidentifyastrocytesaspromisingnewtargetsforthedevelopmentofmorespecificantiepileptogenictherapeuticstrategies.
Althoughresearchonastrocytesinepilepsyisstillinitsinfancy,thisbookclearlydemonstratesacriticalroleofastrocytesinthedisturbanceofK+andtransmitterhomeostasisanditsimpactonseizuregeneration.
""3","9781615046942","9781615046959","GeneticsofHypertension","ColloquiumSeriesonIntegratedSystemsPhysiology","56","August,2015","XiCheng","UniversityofToledo","BinaJoe","UniversityofToledo",,,,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00131ED1V01Y201506ISP062","10.
4199/C00131ED1V01Y201506ISP062","Hypertension,orelevatedbloodpressure,isamajorriskfactorforvariouscardiovascular,renaldiseases,andstroke.
TheformofhypertensionwithnoidentifiablecauseisreferredtoasEssentialHypertension.
FamilialstudiesindicatethatEssentialHypertensionisheritableand,thereby,classicalgeneticapproacheshavebeenappliedonbothhumanandothermammalianmodelsofhypertensiontomapthelocationsoftheallelicvariantswithinquantitativetraitlociforbloodpressure.
Thepostgenomeerahasfurtherelevatedthisareaofresearchintolarge-scalegenome-wideassociationstudiesofhypertensioninhumans.
Collectively,thesestudieshaveresultedintheprioritizationandcatalogingofseveralgenomicregionscontainingallelicvariantsascandidateslinkedorassociatedwithessentialhypertension.
Further,theyareprovidingevidencetosuggestthattheinheritanceofhypertensionisrathercomplex,encompassingmultiplevariantsbothwithinprotein-codingandnon-codingannotations,eachofwhichmayactindependentlyorinteractivelywithothergenesand/orenvironmentalfactorstodifferentiallyregulatebloodpressure.
Thisbookprovidesanoverviewofthevariousmethodsemployedtostudythegeneticsofhypertensionanddiscusstheprogressandprospectsofthisareaofresearchthatmaycontributetowardsindividualizedclinicalmanagementofhypertensioninthefuture.
""3","9781615042289","9781615042296","RenalMedullaryCirculation","ColloquiumSeriesonIntegratedSystemsPhysiology","104","August,2015","LouiseEvans","MedicalCollegeofWisconsin","AllenCowley","MedicalCollegeofWisconsin",,,,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00136ED1V01Y201507ISP064","10.
4199/C00136ED1V01Y201507ISP064","Thetwokidneysofmammalianorganismsreceivearound25%ofthecardiacoutputatrest,ofwhichonly~7%isdistributedtotherenalmedulla.
Despitethelowbloodflowtotherenalmedulla,smallchangesinperfusiontotheregioncanhaveprofoundeffectsonurine-concentratingabilityandtheexcretionofsodium,whichinturnaffectsthechronicregulationofbodyfluidvolumesandarterialbloodpressure.
Importantly,weknowthatifbloodflowtotherenalmedullaisnottightlyregulated,sodiumandwaterhomeostasisisimpairedandmedullaryhypoxiadevelops.
Theresultantinjuryinevitablyreducesurineconcentratingabilityandleadstohypertension.
Thisbookwilldiscussthevarietyofmechanismsthatmammalianorganismshavedevelopedtoensurethatrenalmedullarybloodflowandoxygenlevelsarepreciselyregulated.
Thisbookwillfocusontheuniqueanatomicalarrangementofthemedullarycirculation,thefunctionalrolesofmedullarybloodflow,aswellastheexperimentaltechniquesusedtoassessmedullarybloodflowandtheinsightthatthesestudieshaveprovided.
Thehormonalandnon-hormonalcontrolofmedullarybloodflowwillbeconsideredandfinallytheimpactofreducedmedullarybloodflowonbloodpressureisdiscussed.
""3","9781615046980","9781615046997","MeasuringCellMechanics","ColloquiumSeriesonQuantitativeCellBiology","75","September,2015","MargaretGardel","UniversityofChicago","PatrickOakes","UniversityofChicago",,,,,"2375-7744","2375-7752","http://dx.
doi.
org/10.
4199/C00137ED1V01Y201508QCB003","10.
4199/C00137ED1V01Y201508QCB003","Cellsareinherentlyphysicalentitiesthatbothexperiencemechanicalforcesfromtheirexternalenvironmentandgeneratetheirowninternalforcestodrivecellmotion.
Ourparticularaimhereistopresentthereaderwithanintroductiontotheprimarytoolsusedtomeasurethesemechanicalinteractionsandthematerialpropertiesofcellsthatresultfromthem.
Theseapproachescanbeappliedtoadiversearrayofphysiologicalprocessesandsystems,providingimportantinsightintotheregulatoryrolesofmechanicalinteractionsincells.
Wecovertechniquesatboththemolecularandcellularscales,includingthosethatactivelyandpassivelyprobethesystem.
Alongthewaywecoverthefundamentalprinciplesofeachapproach,whileemphasizingtherelevantlengthandtimescales,alongwiththetypicalmagnitudesofthemeasurementsthatcanbemade.
Eachsectionendsbyhighlightingusesofthevarioustechniquesinrecentrelevantpublications,illustratingtheexcitingfutureofcellmechanicsinquantitativecellbiologyresearch.
","TableofContents:Introduction/MolecularMeasurements/MechanicalPropertiesofCells/PerturbingCellularMechanics/ConcludingRemarks/References/AuthorBiographies""3","9781615044481","9781615044498","LungEndothelium","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","66","September,2015","MaryI.
Townsley","UniversityofSouthAlabama","TroyStevens","UniversityofSouthAlabama",,,,,"2154-560X","2154-5626","http://dx.
doi.
org/10.
4199/C00132ED1V01Y201506ISP063","10.
4199/C00132ED1V01Y201506ISP063","Pulmonaryendotheliumformstheinnerliningofbloodvessels,whereitinterpretsthecomplexmechanicalandchemicalenvironmentwithinthecirculationandadjustsitsbehaviortofacilitatevascularhomeostasis.
Althoughendotheliumfulfillsmanyessentialfunctions,includingregulationofvascularpressure,circulatingcelltransmigration,coagulation,andhormonemetabolismand/ordelivery,aprincipalroleistoformasemi-permeablebarrierthatlimitsfluid,soluteandmacromolecularaccesstotheinterstitialspace.
PhysiologicalpropertiesthatgovernsuchpermeabilitycharacteristicsaredefinedbytheStarlingequation,whichassumesthatendothelialcellsthroughoutthecirculationareallalike.
However,inrecentyearsithasbecomeevidentthatendothelialcellsinpulmonaryarteries,capillaryandveinsareheterogeneousinstructureandfunction.
Here,wereviewevidenceforendothelialheterogeneityamongthesepulmonaryvascularsegments,andconsidertheimplicationsforsuchheterogeneityinlungfluidbalance,especiallyasitrelatestotheStarlingequation.
","TableofContents:DefiningtheEndothelium/ThePulmonaryCirculationasContext/GeneralPropertiesofEndothelium/TransendothelialFluidExchangeandtheStarlingEquation/TheStarlingEquation,LungPermeability,andEndothelialHeterogeneity/RevisedStarlingPrinciplesHeterogeneityandOtherIssues/Summary/References/AuthorBiographies""3","9781615044962","9781615044979","BiologicallyActivePeptidesinInvertebrates","ColloquiumSeriesonNeuropeptides","182","September,2015","QingYu","SchoolofPharmacyandDepartmentofChemistry,UniversityofWisconsin–Madison","ZhidanLiang","SchoolofPharmacyandDepartmentofChemistry,UniversityofWisconsin–Madison",,,,,"2166-6628","2166-6636","http://dx.
doi.
org/10.
4199/C00120ED1V01Y201409NPE005","10.
4199/C00120ED1V01Y201409NPE005","Animalbehaviorsandemotionsarefine-tunedviasignaltransmissionandcommunicationbetweencells.
Thenervoussystemgivesinstructionsandtransmitssignalstodifferentpartsofanorganismtoproducecoordinatedactivities.
Neuronsarecorecomponentsofthenervoussystemandtheyusevariouschemicalmessengerstocommunicatewithoneanother.
Neuropeptides(NPs),whicharesmallchainsofaminoacids,representthelargestclassofsignalingmolecules.
SinceNPsaredirectlyinvolvedinmodulatingmanyphysiologicalprocesses,suchasmetabolism,reproduction,learning,memory,andsocialbehaviors–thereisagrowinginterestinstudyingtheirstructures,functions,anddistributions.
ThisbookaimstosummarizeadvancesininvertebrateNPstudiesconcerningmoleculardiversities,distributions,andbiologicalfunctions.
Inaddition,theemergingmassspectrometrictechniqueshavebeendiscussedextensivelyasapowerfultoolenablingacceleratedinvertebrateNPstudies.
","TableofContents:Acknowledgments/OverviewofNeuropeptides/Mass-Spectrometry(MS)-BasedTechniquesEnablingNeuropeptideDiscovery/MajorClassesofInvertebrateNeuropeptides/ConcludingRemarks/References/AuthorBiographies""3","9781615047161","9781615047178","ScienceandEthicsinDialogue:EthicalResearchConductandGeneticInformationApplication","ColloquiumSeriesonTheGeneticBasisofHumanDisease","163","October,2015","AnnBoyd","HoodCollege"2168-4006","2168-4022","http://dx.
doi.
org/10.
4199/C00138ED1V01Y201509GBD007","10.
4199/C00138ED1V01Y201509GBD007","ThisbookrepresentsmyexperienceteachinggraduatestudentsinBiomedicalScienceatHoodCollege.
Beingsciencemajors,thestudentshavealimitedbackgroundinphilosophyandethics.
MostofthegraduatestudentsareemployedatarearesearchlaboratorieswhilealsopursuingaMasterofSciencedegree.
Theirpracticalday-to-dayexperienceinscientificresearchishelpfulindiscussionsofresponsibleconductofresearchcases.
BeingawareofincreasedcasesofmisconducttheUnitedStatesestablishedtheOfficeofResearchIntegrity(ORI).
Theirpublication,IntroductiontotheResponsibleConductofResearch,definesmisconductasfabrication,falsification,andplagiarism.
Concernforthebreachofpublictrustwithrepercussionsinscientificfundinghasledtomandatesforcoursesinethicsforstudentspursuingascientificcareer.
Inaddition,theHumanGenomeProjectmegaprojectfundedEthical,Legal,andSocialImplicationsResearch(www.
genome.
gov/ELSI/)recognizingthatthegeneticinformationproducedbytheprojectwouldcomewithappliedethicaldilemmas.
Teachingcanbeunderstoodasconveyingknowledgefromgenerationtogeneration.
Likewisesystemsofmoralityarecollectiveacquisitionsbuiltupovermillenniawithsocialnormsandvaluesthataimtomaintainsocialorder.
Researchdoesnotsupportthepremisethatknowingtherulesofconductwillpreventmisconduct.
Indeed,compliancewithrulescangiveafalsesenseofsecurity,especiallyiftheethicalreasoninggroundingtherulesisnotunderstood.
Therefore,Itrytosketchapaththroughthepotentialphasesandavenuesofascientificcareer,imaginingthatapersonmaydobasicresearch,serveonethicscommittees,andengagethepublicinethicaluseofnewadvancesingenetics.
Asaresultthecontentofthistextisdividedintothreeparts.
Thefirstpartdealswithfoundationalmaterialonscienceandethicsandcasesthathighlightproperscientificprofessionalconduct.
Thesecondpartdealswithclinicalresearchthroughwhicharesearchdiscoveryismovedtothebedsideofpatientsandtheethicalparametersofthetransition.
Thethirdpartsketchestheethicaldilemmasevolvingfromprogressingeneticinformationtoclinicalapplications.
Helpingstudentsfindamoralcompass,agroundingofwhyoneoughttobehaveinethicalwaysintheirprofessionandmoregenerallyinlifeischallenging.
Doingsoincreasestheirawarenessandmineofpotentialdilemmasandhowtodealwiththemethically.
","TableofContents:Acknowledgments/Introduction/PartI:ResponsibleConductinResearch/ProfessionalScientificConduct/Ethics/PreventingMisconduct/PartII:ResearchwithHumanSubjects:ClinicalResearchEthics/EvolutionofRegulations/BelmontPrinciples/BalancingPrinciples/MisconductinClinicalTrials/RecognizingPatientAutonomy/PartIII:GeneticMedicine/NewParadigms/ModelAnimalsLeadtoHumanDiscoveries/GeneticTestingvs.
Screening/EthicalIssuesinGeneticMedicine/IstheProspectofEugenicsaThreattoGeneticMedicine/WhereDoWeGofromHere/Bibliography/AuthorBiography""3","9781615047185","9781615047192","MolecularBasisofDevelopmentalAnomaliesoftheHumanGastrointestinalTract","ColloquiumSeriesonGenomicandMolecularMedicine","125","December,2015","CharlesShaw-Smith","RoyalDevonandExeterHospital(Heavitreesite)2167-7840","2167-7859","http://dx.
doi.
org/10.
4199/C00139ED1V01Y201509GMM006","10.
4199/C00139ED1V01Y201509GMM006","Currentknowledgeoftheetiologyofcongenitalmalformationsofthehumangastrointestinaltractiscoveredinthisbook,prefacedbysomeintroductorynotesonembryologicaldevelopment.
Malformationsinvolvingtheesophagus,stomach,smallandlargeintestine,anusandrectum,pancreas,andhepato-billiarysystemarecovered.
Thereisafocusoncoveringthosemalformationsforwhichamoleculargeneticetiologyisunderstood,butothercausations,includingenvironmentalexposures,twinning,andunknownetiologyarealsoincluded.
Forcompleteness,somedisordersareincludedwhicharenot,strictly,malformations,orwhichdonot,strictly,involvethegastrointestinaltract.
SuchdisordersincludeHirschsprungdisease,congenitaldiaphragmatichernia,omphalocele,andgastroschisis.
Suggestedapproachestoclinicalevaluationofindividualswithgastrointestinalmalformationsareincluded.
""ColloquiumCollection","PaperbackISBN","eBookISBN","Title","所属系列","Pages","Year","ISSNprint","ISSNelec","URL","DOI","Description""4","9781615046423","9781615046430","AdolescentBrainDevelopment","ColloquiumSeriesonTheDevelopingBrain","104","04-02-20","2159-5194","2159-5208","https://doi.
org/10.
4199/C00133ED1V01Y201602DBR012","10.
4199/C00133ED1V01Y201602DBR012","Adolescentbraindevelopmentisafascinating,newlydevelopingfieldthathassomuchtoofferalmostanyoneinterestedinlearningmore.
Adolescencehasonlycometobeestablishedasauniquedevelopmentalphaseinthelastfewdecadesorso.
Wenowknowthatthehumanbrainundergoesdramaticdevelopmentalchangesinthepostnatalperiod,notonlyearlyafterbirthbutalsoextendingallthewayintoadulthood.
Thesechangesarenotuniform,inthatthebrainregionsundergoingthemostchangeduringadolescencearenotthesameastheregionsthatchangedmostintheearlylifeperiod,andtheprocessesofchangealsodifferasweage.
Someofthemostimportantchangesthatweseeduringtheadolescentperiodare:1)pruning(orremoval)ofexcessiveneuralconnections,2)increasesinwhitematter,theportionofbrainmatterthatallowsdifferentregionstocommunicatewithoneanother,and3)thinningofthecortex,whichiscomprisedoftheouterlayersofbrainmatter.
Comparedwithotherareasofthebrain,thefrontalandtemporalcorticesundergothemostprotractedchangesintheirstructure,implyingthatdevelopmentsintheseareasplayalargeroleinprovidingthefoundationforadolescentbehaviouralchanges.
Inthisbook,wecompareadolescentbehaviouralchangeswithongoingchangesinthebrainanddiscusspotentialimplicationsforhealthandeducationalpolicy-making.
""4","9781615047222","9781615047239","TheCerebralCirculation,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","80","07-29-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00141ED2V01Y201607ISP066","10.
4199/C00141ED2V01Y201607ISP066","Thise-bookwillreviewspecialfeaturesofthecerebralcirculationandhowtheycontributetothephysiologyofthebrain.
Itdescribesstructuralandfunctionalpropertiesofthecerebralcirculationthatareuniquetothebrain,anorganwithhighmetabolicdemandsandtheneedfortightwaterandionhomeostasis.
Autoregulationispronouncedinthebrain,withmyogenic,metabolicandneurogenicmechanismscontributingtomaintainrelativelyconstantbloodflowduringbothincreasesanddecreasesinpressure.
Inaddition,unlikeperipheralorganswherethemajorityofvascularresistanceresidesinsmallarteriesandarterioles,largeextracranialandintracranialarteriescontributesignificantlytovascularresistanceinthebrain.
Theprominentroleoflargearteriesincerebrovascularresistancehelpsmaintainbloodflowandprotectdownstreamvesselsduringchangesinperfusionpressure.
Thecerebralendotheliumisalsouniqueinthatitsbarrierpropertiesareinsomewaymorelikeepitheliumthanendotheliumintheperiphery.
Thecerebralendothelium,knownastheblood-brainbarrier,hasspecializedtightjunctionsthatdonotallowionstopassfreelyandhasverylowhydraulicconductivityandtranscellulartransport.
ThisspecialconfigurationmodifiesStarling'sforcesinthebrainmicrocirculationsuchthationsretainedinthevascularlumenopposewatermovementduetohydrostaticpressure.
Tightwaterregulationisnecessaryinthebrainbecauseithaslimitedcapacityforexpansionwithintheskull.
Increasedintracranialpressureduetovasogenicedemacancausesevereneurologiccomplicationsanddeath.
""4","9781615047246","9781615047253","MolecularGeneticsofThalassemiaSyndromes","ColloquiumSeriesonGenomicandMolecularMedicine","57","08-15-20","2167-7840","2167-7859","https://doi.
org/10.
4199/C00142ED1V01Y201607GMM007","10.
4199/C00142ED1V01Y201607GMM007","Thisbookreviewsthemoleculargeneticsofthethalassemiasyndromes,inheritedhemoglobindisordersthatcomprisethecommonestmonogenicdisordersglobally.
Thalassemiasarefoundinhighfrequenciesintropicalregionscorrespondingtothemalariabelt.
BetathalassemiatraitsshowhighHbA2byHPLC,andβ-globinmutations(commonlypointmutations)aredetectedbyusingARMS-PCR,reversedot-blotanalysisandβ-globingenesequencing.
Globally>300βglobingenemutationsexist,howeverregionalmutationsarelimitedto5-6commonones.
Alphaglobingenedefectscanonlybeidentifiedbymoleculartests,theexceptionbeingHbHdiseasethatshows""golfball""appearanceinHbHpreparation,pre-integrationpeaksonHPLCandafast-movingbandonhemoglobinelectrophoresis.
MultiplexGap-PCRidentifiescommonα-globingenedeletions.
SpecificPCRacrossthejunctioncausedbytheunequalcrossingovercandetectα-genetriplication.
However,heterozygosityorhomozygoustriplicationcannotberesolvedbythistechnique.
Non-deletionalα-thalassemiacanbecharacterizedbyspecificα-globingenesequencing.
IdentificationofunusualdeletionsrequiresMultiplexLigation-dependentProbeAmplification.
Inconclusion,themolecularcharacterizationofhumanglobingenedisordersisrequiredtoresolvethephenotypicallyheterogeneousthalassemiasyndromes.
Molecularanalysisisalsoanimportanttooltopreventthesedisordersbyofferingprenatalscreeninginregionswithahighdiseaseburden.
""4","9781615047208","9781615047215","RegulationofTissueOxygenation,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","99","08-19-20","2167-7840","2167-7859","https://doi.
org/10.
4199/C00140ED2V01Y201606ISP065","10.
4199/C00140ED2V01Y201606ISP065","Thispresentationdescribesvariousaspectsoftheregulationoftissueoxygenation,includingtherolesofthecirculatorysystem,respiratorysystem,andblood,thecarrierofoxygenwithinthesecomponentsofthecardiorespiratorysystem.
Therespiratorysystemtakesoxygenfromtheatmosphereandtransportsitbydiffusionfromtheairinthealveolitothebloodflowingthroughthepulmonarycapillaries.
Thecardiovascularsystemthenmovestheoxygenatedbloodfromthehearttothemicrocirculationofthevariousorgansbyconvection,whereoxygenisreleasedfromhemoglobinintheredbloodcellsandmovestotheparenchymalcellsofeachtissuebydiffusion.
Oxygenthathasdiffusedintocellsisthenutilizedinthemitochondriatoproduceadenosinetriphosphate(ATP),theenergycurrencyofallcells.
ThemitochondriaareabletoproduceATPuntiltheoxygentensionorPO2onthecellsurfacefallstoacriticallevelofabout4–5mmHg.
Thus,inordertomeettheenergeticneedsofcells,itisimportanttomaintainacontinuoussupplyofoxygentothemitochondriaatorabovethecriticalPO2.
Inordertoaccomplishthisdesiredoutcome,thecardiorespiratorysystem,includingtheblood,mustbecapableofregulationtoensuresurvivalofalltissuesunderawiderangeofcircumstances.
Thepurposeofthispresentationistoprovidebasicinformationabouttheoperationandregulationofthecardiovascularandrespiratorysystems,aswellasthepropertiesofthebloodandparenchymalcells,sothatafundamentalunderstandingoftheregulationoftissueoxygenationisachieved.
""4","9781615046904","9781615046911","X&YChromosomalVariations:Hormones,BrainDevelopment,andNeurodevelopmentalPerformance","ColloquiumSeriesonTheDevelopingBrain","122","10-14-20","2159-5194","2159-5208","https://doi.
org/10.
4199/C00134ED1V01Y201506DBR013","10.
4199/C00134ED1V01Y201506DBR013","ThisisthefirstbookonXandYchromosomaldisorderstoaddressthesecommonbutrarelydiagnosedconditions.
Thisbookseekstopresentthelatestinresearchandclinicalcareaddressingneuroimaging,theinteractionbetweenhormones,braindevelopment,andneurodevelopmentalprogression.
Thisbookwillprimarilyfocuson47,XXY(Klinefeltersyndrome,orKS),47,XYY(Jacobs'syndrome),and47,XXX(TripleX).
Morevariantdisorderssuchas48,XXXX,48,XXXYand49,XXXXYwillbediscussed.
Topicsofinterestincludeneurologicalfunctioning,neuroimaging,sociallanguage,andtheevolvingperspectivesoftheseXYchromosomaldisorders.
Theeffectsoftestosteronesupplementationinmaleswith47,XXYwillalsobeexamined.
""4","9781615046843","9781615046850","VascularSmoothMuscleFunctioninHypertension","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","96","10-21-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00129ED1V01Y201503ISP061","10.
4199/C00129ED1V01Y201503ISP061","Hypertensionisdefinedbyanincreaseinsystemicbloodpressureabovelimitsconsiderednormal,currentlysetat140mmHgforsystolicand90mmHgfordiastolicpressure.
Assumingcentralvenouspressuretobenearzero,meanarterialpressureisdeterminedbytheproductoftotalperipheralresistanceandcardiacoutput.
Inmostcasesofessentialhypertension,aswellasinanimalmodelsofhypertension,cardiacoutputanditsmaindeterminants,strokevolumeandheartrate,arenormal,whereastotalperipheralresistanceisincreased.
TotalperipheralresistanceisinfluencedbyanumberoffactorsdescribedbythePoiseuille'slaw,themostsignificantofwhichbyfaristhediameterofbloodvesselsofthearterialtree.
Sincebloodvesseldiameterisareflectionofbothvascularstructureandactiveregulationofvasculartonethroughmechanismsofvasoconstrictionandvasodilatation,itisgenerallyconsideredthatalterationsintotalperipheralresistancearedirectlydeterminedbyalterationsinvascularsmoothmusclestructureand/orfunction.
Thus,complexbloodpressureregulationsystems,includingrenal,nervous,endocrine,immune,andothers,intheirturninfluencedbygeneticorenvironmentalfactors,convergeuponthesamemolecularmechanismsthatcontrolthestructureandfunctionofvascularsmoothmuscle.
Inthiswork,ratherthanprovidingtheexhaustivelistofmodificationsinthebloodpressureregulatingsystemsthatultimatelyaffectthevasculatureinhypertension,wewillfocusonthestructuralandfunctionalalterationsofvascularsmoothmuscleperseduringhypertension.
""4","9781615047307","9781615047314","NG2-Glia(Polydendrocytes)","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","43","11-01-20","2375-9933","2375-9917","https://doi.
org/10.
4199/C00143ED1V01Y201610NGL009","10.
4199/C00143ED1V01Y201610NGL009","Classically,thecentralnervoussystem(CNS)wasconsideredtocontainneuronsandthreemaintypesofglialcells—astrocytes,oligodendrocytes,andmicroglia.
Now,ithasbeenclearlyestablishedthatNG2-gliaareafourthglialcelltypethatareidentifiedanddefinedbytheirexpressionoftheNG2chondroitinsulfateproteoglycan(Cspg4).
NG2-gliadifferentiateintooligodendrocytes,themyelin-formingcellsoftheCNS,underthecontrolofmultipleextacellularandintrinsicfactors.
Duetothis,NG2-gliaareoftenreferredtointheliteratureasoligodendrocyteprogenitorcells(OPCs).
ThenamepolydendrocyteshasbeensuggestedforNG2-glia(OPCs),toemphasizetheirnatureasafourthdistinctglialcelltype.
NG2-gliarespondrapidlytoneurotransmissionviatheirsynapticconnectionswithneuronsandtheirrepertoireofneurotransmitterreceptorsandionchannels.
BidirectionalinteractionsbetweenNG2-gliaandneuronsarealsoimportantforsynapticfunctionandneuronalintegrity.
NG2-gliarespondtomostneuropathologiesbyincreasedproliferationanddifferentiationintooligodendrocytes,whichiscriticalforreplacingdamagedmyelinafterinjuryandindemyelinatingdiseases,suchasmultiplesclerosis.
ThereisalsoevidenceNG2-gliaarecapableofgeneratingastrocytesandneuronsundersomecircumstances.
ThefullcapacityofNG2-gliaisnotyetclear,buttheirkeyfunctionisthelifelonggenerationofoligodendrocytes,whichisabsolutelycriticalforCNSfunctionandintegrity.
""4","9781615047321","9781615047338","MolecularMechanismsofBodyWaterHomeostasis","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","100","11-09-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00144ED1V01Y201610ISP067","10.
4199/C00144ED1V01Y201610ISP067","Thisbookdiscussesourintimaterelationshipwithanddependenceonwater,howthebodyregulatesitswaterlevels,andvariouspathophysiologicalstatesassociatedwithimpairmentsinbodywaterhomeostasis.
Thehumanbodyconsistsof70–80%water.
Therefore,concisecontrolofwaterhomeostasisisessentialtosurvivalandinvolvescoordinationofseveralsystems,butprimarilythebrainandkidneysystems.
Waterrequirementsoftheaveragehealthyhumanrangebetween2–4L/d,andamajorportionofthiscancomefromfoodsources.
Themajorhormonalregulatorofwaterbalanceistheanti-diuretichormone,vasopressin.
Vasopressin,a9–aminoacidpeptide,isproducedinthehypothalamus,storedintheposteriorpituitary,andsecretedwhenplasmaosmolalityrises.
Vasopressinactsonthekidneytoconservewater.
Thekidneysfilter180Lofbloodperday,consistingofabout50–65%water,andreabsorbaround99%ofthisintheproximaltubule,distaltubule,andcollectingduct,producingonly1–2Lofurine.
Thevasopressin-sensitivedistaltubuleandcollectingductareresponsibleforfine-tuningwaterreabsorption.
Conditionsexist,however,whereurinecannotbeconcentratedeffectively.
Thisisknownasdiabetesinsipidusandcanleadtodehydrationandfailuretothrive.
Attheotherextreme,hyponatremia(lowserumsodium)istheinabilitytoadequatelydiluteurineorgetridoffreebodywaterinexcessofbodyneeds,aseriousandsometimesfatalcondition.
""4","9781615047345","9781615047352","RegulationofGastrointestinalMucosalGrowth,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","132","11-23-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00145ED2V01Y201610ISP068","10.
4199/C00145ED2V01Y201610ISP068","Themammaliangastrointestinalmucosaisarapidlyself-renewingtissueinthebody,anditshomeostasisispreservedthroughthestrictregulationofepithelialcellproliferation,growtharrest,andapoptosis.
Thecontrolofthegrowthofgastrointestinalmucosaisuniqueand,comparedwithmostothertissueinthebody,complex.
Mucosalgrowthisregulatedbythesamehormonesthataltermetabolisminothertissues,butthegastrointestinalmucosaalsorespondstohosteventstriggeredbytheingestionandpresenceoffoodwithinthedigestivetract.
Theseguthormonesandpeptidesregulatethegrowthoftheexocrinepancreas,gallbladderepithelium,andthemucosaoftheoxynticglandregionofthestomachandthesmallandlargeintestines.
Luminalfactors,includingnutrientsorotherdietaryfactors,secretions,andmicrobesthatoccurwithinthelumenanddistributeoveraproximal-to-distalgradient,arealsocrucialformaintenanceofnormalgutmucosalregenerationandcouldexplainthevillous-height-crypt-depthgradientandvarietyofadaptation,sincethesefactorsarediluted,absorbed,anddestroyedastheypassdownthedigestivetract.
Recently,intestinalstemcells,cellularpolyamines,andnoncodingRNAsareshowntoplayanimportantroleintheregulationofgastrointestinalmucosalgrowthunderphysiologicalandvariouspathologicalconditions.
Inthisbook,wehighlightkeyissuesandfactorsthatcontrolgastrointestinalmucosalgrowthandhomeostasis,withspecialemphasisonthemechanismsthroughwhichepithelialrenewalandapoptosisareregulatedatthecellularandmolecularlevels.
""4","9781615047260","9781615047277","CardiovascularResponsestoExercise,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","122","12-02-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00146ED2V01Y201610ISP069","10.
4199/C00146ED2V01Y201610ISP069","Exerciseistheactofincreasingmetabolicrateforthepurposeofenhancingphysicalfitness.
Exercisecanbeoneofthemoststressfulphysiologicalresponsesthatthebodyundertakes.
Withexercise,thereareincreasesinmetabolicrate,heartrate,bloodflow(hyperemia),respiration,andheatproduction.
Theincreasedmetabolicrequirementduringexerciseiswellmetbyanincreasedbloodflow(functionalhyperemia)andoxygensupplytotheexercisingtissue,whichisregulatedbymultiplelocalandsystemicmechanisms.
Thelocalmechanisms(factors)areresponsibleformediatingthemusclehomeostasisandvascularconductancetomatchtheincreasedmetabolicrequirement,whereasthesystemicmechanismsareresponsibleforthemaintenanceofbloodpressureandglobalcardiovascularhomeostasis,includingtheincreaseinandredistributionofcardiacoutput,whichismainlymediatedbysympatheticactivation.
Forinstance,thesubstantialdecreasesinvascularresistanceandresultantlargeincreaseinbloodflowduringexerciserequirehigherbloodpressureandmorecardiacoutput,suchthatthemetabolicallyactivemusclecanbeperfusedwithadequatebloodflow.
Thisbookwillprovideanoverviewofthecardiovascularresponsestoexerciseunderphysiologicalconditionsaswellassomepathologicalcircumstances.
""4","9781615047376","9781615047383","TheBiliarySystem,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","178","12-16-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00147ED2V01Y201611ISP071","10.
4199/C00147ED2V01Y201611ISP071","Theliverisavitalorganinvolvedinnumerousmetabolicprocessessuchascholesterolandbileacidmetabolism,biliarylipidsecretion,andbileformation.
CholesterolbalanceacrosstheliverhasacrucialeffectoninfluencingplasmatotalandLDLcholesterollevelsandbiliarycholesterolconcentrations.
Cholesterolandbileacidbiosynthesesareprimarilymodulatedbynegativefeedbackregulatorymechanismsthroughthesterolregulatoryelement-bindingproteinisoform2(SREBP-2)andthefarnesoidXreceptor(FXR)pathways,respectively.
Theconversionofcholesteroltobileacidsinthelivercanbalancethefecalexcretionofbileacids,whichisanimportantroutefortheremovalofcholesterolfromthebody.
Bileformationbeginsinthebilecanaliculi,andmaintenanceoftheenterohepaticcirculationofbileacidsresultsinacontinuoussecretionofbile.
HepaticsecretionofbiliarylipidsisdeterminedmainlybyagroupofATP-bindingcassette(ABC)transportersthatarelocatedonthecanalicularmembraneofhepatocytes,whichareregulatedbyvariousnuclearreceptors.
Bileacidspromotebileflowbytheirosmoticeffects.
Also,theyareessentialfortheintestinalabsorptionofcholesterol,fattyacids,andfat-solublevitaminsandplayanimportantroleinaidingthedigestionofdietaryfat.
Bileacidsfunctionassignalingmoleculesandanti-inflammatoryagentstoregulatelipid,glucose,andenergymetabolismbyrapidlyactivatingnuclearreceptorsandcellsignalingpathways.
ThiseBooksummarizestheprogressinthemolecularandcellularmechanismsofcholesterolandbileacidmetabolismandthephysical-chemistryofbiliarylipids,withemphasisonbiliarylipidmetabolismthatisregulatedbynuclearreceptorsinthehepatobiliarysystem.
""4","9781615047390","9781615047406","TheBlood-BrainBarrierinHealthandDisease","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","67","12-16-20","2154-560X","2154-5626","https://doi.
org/10.
4199/C00148ED1V01Y201612ISP072","10.
4199/C00148ED1V01Y201612ISP072","Theblood-brainbarrier(BBB)isacomplexanddynamicstructurethatprotectsthebrainfromcellswithinthevasculature,fromtheimmunesystemandfrompathogens.
Thisbarrierispresentinarterioles,capillariesandvenulesandisformedatthelevelofadjacentendothelialcells,whicharecoupledtoastrocytes,microglia,neuronsandpericytes.
Thestructureofthisendothelialbarrierisuniqueamongendotheliaofotherorgansystemsandiscomposedofcomplexesmadeupoftight,gapandadherensjunctions.
Inaddition,itistheresponsibilityofthesurroundingcellularelementstomaintaintheintegrityofthejunctionalcomplexesandrestricttheentryofsubstancesfromthebloodintothebrain.
ChangesinpermeabilityoftheBBBduringphysiologicandpathophysiologicconditionsinvolvealterationsinspecifictransportersattheleveloftheendothelium,activationofspecificcellularsecondmessengerpathwaysand/orthedissolutionofthejunctionalcomplexescomposingtheBBB.
ThisbookfocusesonvariousaspectsthataccountfortheformationandmaintenanceoftheBBB,andondiseasestatesthatcompromisethisbarrier.
""4","9781615047468","9781615047475","PolycysticKidneyDisease","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","47","01-25-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00150ED1V01Y201612ISP073","10.
4199/C00150ED1V01Y201612ISP073","Thisbookreviewsimportantaspectsofpolycystickidneydiseases,thelatestscientificunderstandingofthediseasesandsyndromes,alongwiththetherapiesbeingdeveloped.
Cystickidneydiseasescompriseaspectrumofgeneticsyndromesdefinedbyrenalcystformationandexpansionwithvariableextrarenalmanifestations.
Themostprevalentdisorderistheautosomaldominantpolycystickidneydisease(ADPKD).
Itisthemostcommonmonogeneticdisorderinhumansandaccountsfor4.
4%ofend-stagerenaldisease(ESRD)casesintheU.
S.
PatientsinevitablyprogresstoESRDandrequirerenalreplacementtherapyintheformofdialysisortransplantation.
Throughadvancementsingenomicsandproteomicsapproaches,novelgenesresponsibleforcysticdiseaseshavebeenidentified,furtherexpandingourunderstandingofbasicmechanismsofdiseasepathogenesis.
Thehallmarkamongallcysticgeneticsyndromesistheformationandgrowthoffluid-filledcysts,whichoriginatefromtubularepitheliaofnephronsegments.
Cystsarethedisease,andtreatmentstrategiesarebeingdevelopedtotargetpreventionordelayofcystformationandexpansionatanearlystage,howevernosuchtherapyiscurrentlyapproved.
""4","9781615047444","9781615047451","ClinicalandMolecularHeterogeneityofOsteogenesisImperfecta","ColloquiumSeriesonGenomicandMolecularMedicine","63","01-30-21","2167-7840","2167-7859","https://doi.
org/10.
4199/C00149ED1V01Y201612GMM008","10.
4199/C00149ED1V01Y201612GMM008","Osteogenesisimperfecta(OI)isadiseaseencompassingagroupofdisordersmainlycharacterizedbybonefragilityandisthecommonestformofheritablebonefragility.
Inthisbook,theclinicalpresentationswithparticularemphasisonrarephenotypesassociatedwithOIarediscussedtogetherwithmolecularadvancesindiagnosisandtreatmentofOI.
ThereisabroadspectrumofclinicalseverityinOI,rangingfrommultiplefracturesinuteroandperinataldeath,tonear-normaladultstatureandlowfractureincidence.
Facialdysmorphismhasbeennoted,butisnotwelldescribed,norisitaninvariablefeature.
Sillenceetal.
,in1979,providedtheclinicalclassification,whichhasbeenfurtherexpanded.
Geneticdefectsintype1collagencanbeidentifiedin85%ofpatientswithaclinicaldiagnosisofOI,thatis,mutationsinCOL1A1/COL1A2,whichfollowsanautosomaldominantpatternofinheritance.
SeveralgeneshavenowbeenimplicatedinautosomalrecessiveformsofOIandX-linkedosteoporosis.
GiventhepossibleantenatalpresentationandprognosisassociatedwithOI,itisimportanttomakethisdiagnosisearlyandbeabletodistinguishthisfromotherlethalskeletaldysplasias.
Itisalsoimportanttodistinguishnonaccidentalinjuryfromapathologicalcauseoffractures,suchasOI,anddiagnosethispromptlyinthesesituations.
However,thisisnotalwayspossibleduetovariabilityinpresentationandinabilitytopinpointtheprecisegeneticetiologydespiteextensivegenetictesting.
OIisonesuchraregeneticconditionwheretreatmentisavailableintheformofbisphosphonates,whichhasahugeimpactonqualityoflife.
Despiteadvancesinmedicaltherapy,multidisciplinarymanagementincludingphysiotherapyremainsthemainstayoftreatmentandimprovedoutcomesinOI.
""4","9781615047482","9781615047499","TheEndocannabinoidSysteminLocalandSystemicInflammation","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","192","03-28-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00151ED1V01Y201702ISP074","10.
4199/C00151ED1V01Y201702ISP074","Thisbookfocusesontheroleoftheendocannabinoidsysteminlocalandsystemicinflammation,withindividualchapterswrittenbyexpertsinthefieldofcannabinoidresearchandmedicine.
Thetopicsexploretheactionsoftheendocannabinoidsystemontheimmunesystem,includingneuroinflammationinautoimmunedisorderssuchasmultiplesclerosis,andinneurodegenerativedisorderssuchasHuntington'sandAlzheimer's,aswellaslocalandsystemicinflammatoryconditionsaffectingorgansincludingtheeye(uveitisandcornealinflammation),thebladder(interstitialcystitis),pancreas(diabetes),cardiovascularsystem(stroke),joints(arthritis),andsepsis.
Theobjectiveofthisbookistoprovideknowledgetransferontheuseofcannabinoidsininflammatorydiseasebycriticallyexaminingpreclinicalandclinicalresearchontheimmunomodulatoryactionsoftheendocannabinoidsystem,withspecificemphasisontheactionsofcannabinoidsindiseaseswhereinflammationisaprominentcomponent.
Bydrawingtheseresultstogether,weseektoprovidefurtherunderstandingofthecomplexitiesofendocannabinoidsystemmodulationofimmunefunctionandidentifypotentialusesandlimitationsforcannabinoid-basedtherapeutics.
""4","9781615047505","9781615047512","VascularBiologyofthePlacenta,SecondEdition","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","113","06-24-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00153ED1V01Y201704ISP075","10.
4199/C00153ED1V01Y201704ISP075","Theplacentaisanorganthatconnectsthedevelopingfetustotheuterinewall,therebyallowingnutrientuptake,wasteelimination,andgasexchangeviathemother'sbloodsupply.
Propervasculardevelopmentintheplacentaisfundamentaltoensuringahealthyfetusandsuccessfulpregnancy.
Thisbookprovidesanup-to-datesummaryandsynthesisofknowledgeregardingplacentalvascularbiologyanddiscussestherelevanceofthisvascularbedtothefunctionsofthehumanplacenta.
""4","9781615046683","9781615046690","IntroductiontoQuantitativeCellBiology","ColloquiumSeriesonQuantitativeCellBiology","50","07-21-21","2375-7744","2375-7752","https://doi.
org/10.
4199/C00121ED1V01Y201409QCB002","10.
4199/C00121ED1V01Y201409QCB002","Forthepastdecadeormore,muchofcellbiologyresearchhasbeenfocusedondeterminingthekeymoleculesinvolvedindifferentcellularprocesses,ananalyticalproblemthathasbeenamenabletobiochemicalandgeneticapproaches.
Now,wefaceanintegrativeproblemofunderstandinghowallofthesemoleculesworktogethertoproducelivingcells,achallengethatrequiresusingquantitativeapproachestomodelthecomplexinteractionswithinacell,andtestingthosemodelswithcarefulquantitativemeasurements.
Thisbookisanintroductoryoverviewofthevariousapproaches,methods,techniques,andmodelsemployedinquantitativecellbiology,whicharereviewedingreaterdetailintheothervolumesinthise-bookseries.
Particularemphasisisplacedonthegoalsandpurposeofquantitativeanalysisandmodeling,andthespecialchallengesthatcellbiologyholdsforunderstandinglifeatthephysicallevel.
""4","9781615047284","9781615047291","SexandtheDevelopingBrain,SecondEdition","ColloquiumSeriesonTheDevelopingBrain","141","09-01-21","2159-5194","2159-5208","https://doi.
org/10.
4199/C00152ED1V01Y201703DBR014","10.
4199/C00152ED1V01Y201703DBR014","Thebrainsofmalesandfemales,menandwomen,aredifferent,thatisafact.
Whatisdebatedishowdifferentandhowimportantarethosedifferences.
Sexdifferencesinthebrainaredeterminedbygenetics,hormones,andexperience,whichinhumansincludesculture,society,andparentalandpeerexpectations.
Theimportanceofnonbiologicalvariablestosexdifferencesinhumansisparamount,makingitdifficultifnotimpossibletoparseoutthosecontributionsthataretrulybiological.
Thestudyofanimalsprovidesustheopportunitytounderstandthemagnitudeandscopeofbiologicallybasedsexdifferencesinthebrain,andunderstandingthecellularmechanismsprovidesusinsightintonovelsourcesofbrainplasticity.
Manysexdifferencesareestablishedduringadevelopmentalsensitivewindowbydifferencesinthehormonalmilieuofmalesversusfemales.
Theneonataltestisproduceslargeamountsoftestosteronewhichgainsaccesstothebrainandisfurthermetabolizedintoactiveandrogensandestrogenswhichmodifybraindevelopment.
Majorparametersthatareinfluencedbyhormonesincludeneurogenesis,celldeath,neurochemicalphenotype,axonalanddendriticgrowth,andsynaptogenesis.
Varianceintheseparametersresultsinsexdifferencesinthesizeofparticularbrainregions,theprojectionsbetweenbrainregions,andthenumberandtypeofsynapseswithinparticularbrainregions.
Thecellularmechanismsarebothregionandendpointspecificandinvokemanysurprisingsystemssuchasprostaglandins,endocannabinoids,andcelldeathproteins.
Epigeneticmodificationstothegenomebothestablishandmaintainsexdifferencesinthebrainandbehavior.
Byunderstandingwhen,why,andhowsexdifferencesinthebrainareestablished,wemayalsolearnthesourceofstronggenderbiasesintherelativeriskandseverityofnumerousneurologicaldiseasesanddisordersofmentalhealth.
Boysaremuchmorelikelytobediagnosedwithautismspectrumorattentionandhyperactivitydisorders,aswellasspeechandlanguagedeficits,comparedtogirls.
Bycontrast,womenaremorelikelytosufferfromaffectivedisorders,suchasdepression,anxiety,compulsion,andeatingdisordersandmorelikelytoexperienceautoimmuneandneurodegenerativedisorders.
Schizophreniawithanearlyonsetismorecommoninmalesbutalate-onsetversionismarkedlymorefrequentinfemales.
Malebiaseddisordershaveoriginsindevelopmentwhilefemalebiaseddisordersarealmostexclusivelypost-puberty.
Thisremarkableshiftindiseaseriskdemandsourattention.
Novelinsightsintothebiologicaloriginsofdiseasearealsogainedbycomparingandcontrastingthesameprocessesindifferentsexes.
""4","9781615047567","9781615047574","Sepsis:StagingandPotentialFutureTherapies","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","91","09-12-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00157ED1V01Y201708ISP077","10.
4199/C00157ED1V01Y201708ISP077","Sepsisisalife-threateningorgandysfunctioncausedbyadysregulatedhostresponsetoinfection.
Variabilityinpathogenesisandcomplexpathophysiologyoftendelaydiagnosisandcreatesignificantchallengesforclinicalstudiesinthisgroupofcriticallyillpatients.
Mainlyforthosereasons,thereisnotherapyapprovedsofartoovercometheunderlyingimmunedysregulation.
Thisbookprovidesanoverviewaboutthestateoftheartofsepsisdiagnosticsandpotentialfuturetherapies.
Chapter1focusesontheimmunologicstagingofsepsis—thekeyforsuccessfultreatmentofthedysregulatedhotresponse.
Chapter2revealssimilaritiesintheimmuneresponseinsepsisandcancer—openingnewavenuesfornoveltherapies.
Chapter3introducesanimportantmodulatoroftheimmuneresponse—theendogenouscannabinoidsystemandelucidatesitsroleinorgandysfunctioninsepsis.
Facingtheincreasingbacterialresistancetoclassicalantibiotics,Chapter4discussestwouniquemechanismstotreatinfectionandinflammationinsepsis:ironchelation,andthesphingosinepathway.
Theauthors,allexpertsinexperimentalandclinicalsepsisresearch,seektoprovidefurtherunderstandingofthecomplexitiesoftheimmuneresponseasthephysiologicalbasisforthedevelopmentofnewtherapeuticsinsepsis.
""4","9781615047529","9781615047536","FromGenetoTherapy:UnderstandingHumanDiseasethroughGenetics","ColloquiumSeriesonTheGeneticBasisofHumanDisease","89","09-13-21","2168-4006","2168-4022","https://doi.
org/10.
4199/C00154ED1V01Y201707GBD008","10.
4199/C00154ED1V01Y201707GBD008","ThisColloquiumLectureprovidesanoverviewoftheprogressmadeinmolecularmedicineapplyinggeneticsandgenomicstotheunderstanding,diagnosis,andtreatmentofhumandiseases.
Specifically,themethodsforidentifyinggenesinvolvedinhumandiseasesaredescribed.
Examplesfrom10genesanddiseaseswillbeprovided,drawingontheauthor'sresearch.
TopicsincludeexamplesfromsimpleMendeliandiseases,suchascysticfibrosis,inheritedcancers,oncogenesactivatedbychromosomaltranslocations,hostgenesinvolvedininfectiousdisease,genesidentifiedviagenomewideassociationstudies,pathogenscausingcancer,andgenefamiliescontributingtomultiplediseases.
Foreachexample,historicaldetailswillbeprovidedasbackgroundforreaderstounderstandthecontextandprocessofthediscoveries,technologiesexplained,andcurrentunderstandingandtreatmentimplicationsdetailed.
""4","9781615047543","9781615047550","EndothelialLuminalMembrane-Glycocalyx:FunctionalitiesinHealthandDisease","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","159","11-03-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00155ED1V01Y201708ISP076","10.
4199/C00155ED1V01Y201708ISP076","Thisbookfocusesonthestructural,biochemical,anddiversefunctionalpropertiesoftheendothelialluminalmembraneglycocalyx(ELMG),anorganellewhichconstitutestheendothelialcell"membrane.
"Itisintendedtoprovidethenewcomerwithabroad,basic,andbriefperspectiveoftheluminalendothelialvascularmembrane,andforthemoreestablishedinvestigator,abasicoverviewandintegratedperspectiveofthe"universe"weexplore.
Theendotheliumisanassortmentofheterogeneousregulatorycellswhosecytoplasmandcellmembranesarejoined,formingfunctionalunits.
Thereisatremendousamountofliteratureontheendothelialcell,constitutingseeminglyisolatedanddistinctfieldsofencapsulatedresearch.
However,themultifunctionalpropertiesofsomemoleculesgiverisetoanoverlapoffindings,frequentlyignoredbetweenthedifferentfields.
Thebookisdividedintothreeparts.
ThefirstpartconcentratesonthestructureoftheELMG,withemphasisonmorphologicalandbiochemicalcomposition.
TheimportanceofthechemicalcompositiontothephysiologicalfunctionsoftheELMG,suchassievingproperties,pharmacology,andflowsensing,isthefocusofthesecondpartofthebook.
Finally,someofthepathologiesassociatedwithELMGdysfunctionareexploredinthelastsection.
Theaimistoprovidebasicandwell-establishedknowledgeinthevariousindividualfields,identifythecurrentconceptsineacharea,anddiscusstheirrespectivestrengthsandweaknesses(includinghiddenproblems).
Finally,theoverallgoalistointegrateareaswhereoverlapisclearlyindicated,bringingthemalltogethertoprovidethefirsteverbasic,integrative,panoramicbird's-eyeviewofthefield.
""4","9781615047581","9781615047598","AlexanderDisease:AGuideforPatientsandFamilies","ColloquiumSeriesonNeurogliainBiologyandMedicine:FromPhysiologytoDisease","96","11-15-21","2375-9933","2375-9917","https://doi.
org/10.
4199/C00156ED1V01Y201708NGL010","10.
4199/C00156ED1V01Y201708NGL010","ThisbookoffersacomprehensiveoverviewofAlexanderdisease,arareanddevastatingneurologicaldisorderthatoftenaffectsthewhitematterofthebrainandspinalcord.
ItsdistinctiveneuropathologyconsistsofabundantRosenthalfiberswithinastrocytes(oneofthefourmajorcelltypesofthecentralnervoussystem).
NearlyallcasesarecausedbyvariantsinthegeneencodingtheintermediatefilamentproteinGFAP,buthowthesechangesinGFAPleadtothewidespreadmanifestationsofdiseaseispoorlyunderstood.
Astrocytes,whilediscoveredoveracenturyago,arethemselvesstillmuchofamystery.
Theyexhibitconsiderablediversity,defyprecisedefinition,andyetactivelyregulatemanyaspectsofnervoussystemfunctioning.
WealsohaveincompleteunderstandingofRosenthalfibers,oddstructuresthatcontainGFAPasjustoneofmanycomponents.
Whethertheyaretoxicorprotectiveisunknown.
Moreover,RosenthalfibersarenotabsolutelyuniquetoAlexanderdisease,andareseensporadicallyinawidevarietyofotherconditions,includingbraintumorsandmultiplesclerosis.
GFAPisthethirdunknown.
Itisanancientprotein,arisingearlyintheevolutionofvertebrates,butitsroleinnormalbiologyisstillamatterofdebate.
YetAlexanderdiseaseshows,withoutadoubt,thatchangingjustasingleofits432aminoacidscanleadtocatastrophe,notjustintheastrocyteswhereGFAPisproducedbutalsointheothercellswithwhichastrocytesinteract.
Despitealloftheunknowns,muchhasbeenlearnedinthepast20years,anditistimetosharethisknowledge.
Thisbookisintendedforrecentlydiagnosedpatientsandfamilies,aswellasnon-specialistresearchersinterestedinthisneurologicaldisease.
Itcovershistoricalorigins,thestateofcurrentknowledge,andprospectsforwhatliesahead,withcitationstotheprimaryliteraturegiventhroughout.
""4","9781615047604","9781615047611","PathophysiologyofPulmonaryHypertension","ColloquiumSeriesonIntegratedSystemsPhysiology:FromMoleculetoFunction","104","11-23-21","2154-560X","2154-5626","https://doi.
org/10.
4199/C00158ED1V01Y201710ISP078","10.
4199/C00158ED1V01Y201710ISP078","Pulmonaryhypertensionisalife-threateningdiseasewithnoknowncure.
Hereweprovideaconciseyetcomprehensivereviewofthecurrentknowledgeaboutthepathophysiologyofpulmonaryhypertension(PH).
Theunderlyingsignalingmechanismsinvolvedinpulmonaryvascularremodelingandtheexaggeratedvascularcontractility,twocharacteristicfeaturesofpulmonaryhypertension,arediscussedindepth.
Therolesofinflammation,immunity,andrightventricularfunctioninthepathobiologyofpulmonaryhypertensionarediscussed.
Theepidemiologyofthefivegroupsofpulmonaryhypertension(WorldHealthOrganizationclassification;Nice,2013)isalsobrieflydescribed.
AclearunderstandingofourcurrentknowledgeaboutthepathogenesisofPHisessentialforfurtherexplorationoftheunderlyingmechanismsinvolvedinthisdiseaseandforthedevelopmentofnewtherapeuticmodalities.
Thisbookshouldbeofinteresttoresearchersandgraduatestudents,bothinbasicresearchandinclinicalsettings,inthefieldsofpulmonaryvascularbiologyandpulmonaryhypertension.
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