hilum77ququ.com
77ququ.com 时间:2021-03-23 阅读:()
CASEREPORTOpenAccessArarepresentationofPulmonaryLymphangiticCarcinomatosisinCancerofLip:CaseReportSajithBabu1*,SatheeshanB1,GeethaM2andSurijSalih1AbstractSquamouscellcarcinomaoflipisacommonmalignancyinIndiansubcontinent.
Metastaticspreadisinfrequent.
Althoughadvancedtumoursspreadtolymphnodesintheneck,itdoesnottypicallypresentwithlungmetastasisorwithlymphangiticcarcinomatosis.
Wedescribeapatientwhodevelopedcoughandincreasingdyspnoeawhileontreatmentforcarcinomaoflip.
Chestx-rayandcomputedtomographywereconsistentwithlymphangiticcarcinomatosis.
Lymphangiticcarcinomatosisoccurswithmanydifferentprimarytumoursandcanrarelyoccurinoralcancers.
Thisisthefirstreportfromcarcinomaoflip.
BackgroundThecommonsiteofmetastasisfrommostofthesolidmalignanciesislung.
Theyusuallyappearasnodularlesionsinradiologicimages.
Insomepatients,metastasispresentswithinterstitialspreadanditisreferredtoasPulmonaryLymphangiticCarcinomatosis(PLC).
HeadandneckcancersveryrarelyhavelungmetastasisintheformofPLC.
Oropharyngealandhypopharyngealcan-cershavebeenreportedtohavesuchtypeofmetastasis[1].
CanceroflipisacommonmalignancyinIndiansubcontinentmainlyduetotobaccochewingandthatthesecancersaredetectedinearlystagesduetoitsvisi-blelocation,aspreadtolungisrareandtheyareoftypicalnodularmetastases.
PLChasnotbeenreportedtilldatefromlipcancersinEnglishliterature.
HerewereportacaseofPLCarisingfromcancerofthelowerlip.
CasePresentation60yearoldgentlemanwithnocomorbidillness,pre-sentedwithasquamouscellcarcinomaoflowerlip.
Afterevaluation,thiswasstagedasT4N2aM0,stageIVandwasmoderatelydifferentiatedsquamouscellcar-cinoma.
TheX-rayofthechestwaswithinnormallim-its.
Wideexcisionofthelesionandreconstructionwithadeltopectoralflapandaradicalneckdissectiononipsilateralsidewasdone.
Postoperativehistopathologywasmoderatelydifferentiatedsquamouscellcarcinoma(pT4N2a).
After4weeks,postoperativeadjuvantcon-currentchemoradiationwasstartedwithCisplatinandradiotherapyin2Gyperfraction.
Whileonradiother-apy,thepatientdevelopedseveredyspnoeaofacuteonset.
Therewasnohistoryofsimilarepisodeinthepastandhewasnotaknownpatientofchronicobstructivepulmonarydisease.
Hewasafebrileandtherewasnocoughorexpectoration.
Basichaematologi-calstudyrevealednormalhaemogram.
Clinicallyhewasdyspnoeic,tachypnoeicandwithtachycardia.
Onauscul-tationofthechest,therewasscatteredcracklesandoccasionalronchi.
Airentrywasequalonbothsides.
Hewasputonsymptomaticcareintheformofbronchodi-lators,antibioticsandnasaloxygen.
Possibilitiesconsid-eredwereacutebronchopneumoniaandPLC.
Chestradiographrevealedinterstitiallinearpatternfromthehilumtotheouterlungfields(Figure1)andKerley'sBlinesinbothlungssuggestingPLC.
AcomputerizedtomographywastakenwhichshowednodularseptalthickeninganditstronglysuggestedthediagnosisofPLC(Figure2).
PatientwasgivenfurthercoursesofchemotherapywithCisplatin,butwithnoimprovement.
Thepatientsuccumbedtodiseaseoneighteenthdayafterthestartofpulmonarysymptoms.
DiscussionLungmetastasisfrommalignanttumoursusuallypre-sentasnodularlesionsandrarelyasPulmonaryLym-phangiticCarcinomatosis(PLC).
PLCischaracterisedbydiffusespreadofmalignancyinthelung,causinginflam-mationofthelymphvessels.
Thefirstreportedcaseof*Correspondence:drsajith@gmail.
com1DepartmentofSurgicalOncology,MalabarCancerCentre,Thalassery,KeralaFulllistofauthorinformationisavailableattheendofthearticleBabuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77WORLDJOURNALOFSURGICALONCOLOGY2011Babuetal;licenseeBioMedCentralLtd.
ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(http://creativecommons.
org/licenses/by/2.
0),whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.
PLCwasbyGabrielAndralin1829[2].
ThediffuselyinfiltratingpatternofmetastasisasseeninPLCoccursin6-8%oflungmetastases[3].
80%ofthemarefromadenocarcinomas.
ThecommonsitesofprimaryfromwhichPLCoccursarecancersofbreast,bronchus,andstomach[4,5].
TheotherdescribedsiteswithPLCarecancersfromcolon,pancreas,kidney,cervix,thyroid,larynxandhypopharynx[6-8].
Thecancersofheadandneckrarelyshowthistypeofmetastasis.
Theexactreasonisunknown.
Thedescribedsitesinheadandneckregionarelarynx,hypopharynxandthyroid.
Metastasistolymphnodesfromadvancedcancersoflipisseeninabout44%.
Metastasistolungisreportedtobeverylow.
ThereisnoavailablereportsuggestingaPLCfromoralcancers.
PLCasmetastaticfeatureasseeninthecasedescribedinthismanuscriptisanextremelyrarepresentation.
Thepathophysiologyisthatthetumoursspreadbyhaematogenousroutetothelungandthenthroughthelymphaticswithinthelung.
Thelymphaticsinthelungareseenintheperibronchovascular,centrilobular,inter-lobularandsubpleuralregions.
Thetumourobstructstheselymphaticchannels.
Thedilatedlymphaticvesselsduetooedemafluid,tumoursecretionandthedesmo-plasticreactionbythetumourcells,producesinterstitialthickeningwhichisseenasstreaksinimagingstudies.
Thenodularpatternisduetothespreadoftumourintothelungparenchymaasseeninusuallungmetastases.
TheclinicalfeaturesofPLCaredyspnoeaandnonpro-ductivecoughwithcrepitationsandwithoutfeaturesofconsolidation.
ChestX-rayshowsseptallines(KerleyAandBlines).
Thedifferentialdiagnosisisinterstitiallungdisease,primarymalignancyinthelung,pulmonarysar-coidosisandhypersensitivitypneumonitis.
HRCTisthemodalityofchoiceforconfirmationofthediagnosis.
ThefindingsinCTscanare-thickeningofinterlobularsepta,fissuresandbronchovascularbundles.
Thesefind-ingsmaybeseenaslimitedordiffuseandmayinvolveunilateralorbilaterallungs.
Theradiologicpicturemaybesymmetricorasymmetricinbothlungs.
Theotherfindingsarenodularityinpleuraandgroundglassopa-city[9].
Thepossibilityofinterstitiallungdiseaseistobeconsideredandruledout.
PrakashPetaldescribedtheuseofPET/CTindiagnosingPLC.
Inastudyof35,theyfoundthatPET/CThashighspecificityindetectionofpulmonarylymphangiticcarcinomatosis[10].
Histopathologicalexaminationsshowinterstitialoedemaandfibrosisalongwithmalignantcellsandarefoundusuallyonpostmortembiopsy.
Sincetheradiolo-gicalfindinginapatientwithmalignantdiseaseelse-whereissuggestive,abiopsyofthelungisnotmandatory.
PLCoftenpresentsinthelatestagesofmalignancyanditindicatespoorprognosis.
ThetreatmentoptioninPLCiswithchemotherapy.
Cisplatinhavebeenfoundtobeeffective[11].
ConclusionPulmonaryLymphangiticCarcinomatosismayalsooccurrarelyinpatientswithoralcancersasseeninourpatientanditsprognosisisverypoorevenwithtreat-mentwithchemotherapy.
Figure1CXR:ChestRadiographshowingseptallines.
Figure2CTScan:CTscanofthoraxshowingdiffuseandbilateralfindings.
Babuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77Page2of3ConsentWritteninformedconsentwasobtainedfromthepatientforpublicationofthiscasereportandaccompanyingimages.
AcopyofthewrittenconsentisavailableforreviewbytheEditor-in-Chiefofthisjournal.
Authordetails1DepartmentofSurgicalOncology,MalabarCancerCentre,Thalassery,Kerala.
2DepartmentofRadiationOncology,MalabarCancerCentre,Thalassery,Kerala.
Authors'contributionsSBpreparedthemanuscriptandtheliteraturesearch,GMreviewedandeditedthemanuscript,STcorrectedandrevisedthemanuscript,SS:reviewedthemanuscript.
Allauthorsreadandapprovedthefinalmanuscript.
CompetinginterestsTheauthorsdeclarethattheyhavenocompetinginterests.
Received:8March2011Accepted:14July2011Published:14July2011References1.
ZieskeLA,MyersEN,BrownBM:Pulmonarylymphangiticcarcinomatosisfromhypopharyngealadenosquamouscarcinoma.
HeadNeckSurg1988,10(3):195-8.
2.
DoyleL:GabrielAndral(1797-1876)andthefirstreportsoflymphangitiscarcinomatosa.
JRSocMed1989,82(8):491-3.
3.
BruceDM,HeysSD,EreminO:Lymphangitiscarcinomatosa:aliteraturereview.
JRCollSurgEdinb1996,41(1):7-13.
4.
YamagishiY,AkibaY,IzumiyaM,HiguchiH,IizukaH,TakaishiH,NagataH,HibiT:[AcaseofadvancedgastriccancerwithlymphangitiscarcinomatosaafteroperationofKrukenbergtumortreatedbyTS-1plusCPT-11asthird-linechemotherapy].
GanToKagakuRyoho2005,32(8):1167-70.
5.
GuptaPR,JoshiN,MeenaRC,AliM:Asymptomaticlymphangitiscarcinomatosisduetosquamouscelllungcarcinoma.
IndianJChestDisAlliedSci2005,47(2):121-3.
6.
ThomasA,LenoxR:Pulmonarylymphangiticcarcinomatosisasaprimarymanifestationofcoloncancerinayoungadult.
CMAJ2008,179(4):338-40.
7.
KirkJE,KumaranM:Lymphangitiscarcinomatosaasanunusualpresentationofrenalcellcarcinoma:acasereport.
JMedCaseReports2008,2:19.
8.
YangSP,LinCC:[Pulmonarylymphangiticcarcinomatosis].
TaiwanYiXueHuiZaZhi1968,67(9):361-74.
9.
ZhangK,HuangY:[Clinicalfeaturesanddiagnosisofpulmonarylymphangiticcarcinomatosis].
AiZheng2006,25(9):1127-30.
10.
PrakashP,KalraMK,SharmaA,ShepardJA,DigumarthySR:FDGPET/CTinAssessmentofPulmonaryLymphangiticCarcinomatosis.
AJRAmJRoentgenol2010,194(1):231-6.
11.
KikuchiN,ShiozawaT,IshiiY,SatohH,NoguchiM,OhtsukaM:ApatientwithpulmonarylymphangiticcarcinomatosissuccessfullytreatedwithTS-1andcisplatin.
InternMed2007,46(8):491-4.
doi:10.
1186/1477-7819-9-77Citethisarticleas:Babuetal.
:ArarepresentationofPulmonaryLymphangiticCarcinomatosisinCancerofLip:CaseReport.
WorldJournalofSurgicalOncology20119:77.
SubmityournextmanuscripttoBioMedCentralandtakefulladvantageof:ConvenientonlinesubmissionThoroughpeerreviewNospaceconstraintsorcolorgurechargesImmediatepublicationonacceptanceInclusioninPubMed,CAS,ScopusandGoogleScholarResearchwhichisfreelyavailableforredistributionSubmityourmanuscriptatwww.
biomedcentral.
com/submitBabuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77Page3of3
Metastaticspreadisinfrequent.
Althoughadvancedtumoursspreadtolymphnodesintheneck,itdoesnottypicallypresentwithlungmetastasisorwithlymphangiticcarcinomatosis.
Wedescribeapatientwhodevelopedcoughandincreasingdyspnoeawhileontreatmentforcarcinomaoflip.
Chestx-rayandcomputedtomographywereconsistentwithlymphangiticcarcinomatosis.
Lymphangiticcarcinomatosisoccurswithmanydifferentprimarytumoursandcanrarelyoccurinoralcancers.
Thisisthefirstreportfromcarcinomaoflip.
BackgroundThecommonsiteofmetastasisfrommostofthesolidmalignanciesislung.
Theyusuallyappearasnodularlesionsinradiologicimages.
Insomepatients,metastasispresentswithinterstitialspreadanditisreferredtoasPulmonaryLymphangiticCarcinomatosis(PLC).
HeadandneckcancersveryrarelyhavelungmetastasisintheformofPLC.
Oropharyngealandhypopharyngealcan-cershavebeenreportedtohavesuchtypeofmetastasis[1].
CanceroflipisacommonmalignancyinIndiansubcontinentmainlyduetotobaccochewingandthatthesecancersaredetectedinearlystagesduetoitsvisi-blelocation,aspreadtolungisrareandtheyareoftypicalnodularmetastases.
PLChasnotbeenreportedtilldatefromlipcancersinEnglishliterature.
HerewereportacaseofPLCarisingfromcancerofthelowerlip.
CasePresentation60yearoldgentlemanwithnocomorbidillness,pre-sentedwithasquamouscellcarcinomaoflowerlip.
Afterevaluation,thiswasstagedasT4N2aM0,stageIVandwasmoderatelydifferentiatedsquamouscellcar-cinoma.
TheX-rayofthechestwaswithinnormallim-its.
Wideexcisionofthelesionandreconstructionwithadeltopectoralflapandaradicalneckdissectiononipsilateralsidewasdone.
Postoperativehistopathologywasmoderatelydifferentiatedsquamouscellcarcinoma(pT4N2a).
After4weeks,postoperativeadjuvantcon-currentchemoradiationwasstartedwithCisplatinandradiotherapyin2Gyperfraction.
Whileonradiother-apy,thepatientdevelopedseveredyspnoeaofacuteonset.
Therewasnohistoryofsimilarepisodeinthepastandhewasnotaknownpatientofchronicobstructivepulmonarydisease.
Hewasafebrileandtherewasnocoughorexpectoration.
Basichaematologi-calstudyrevealednormalhaemogram.
Clinicallyhewasdyspnoeic,tachypnoeicandwithtachycardia.
Onauscul-tationofthechest,therewasscatteredcracklesandoccasionalronchi.
Airentrywasequalonbothsides.
Hewasputonsymptomaticcareintheformofbronchodi-lators,antibioticsandnasaloxygen.
Possibilitiesconsid-eredwereacutebronchopneumoniaandPLC.
Chestradiographrevealedinterstitiallinearpatternfromthehilumtotheouterlungfields(Figure1)andKerley'sBlinesinbothlungssuggestingPLC.
AcomputerizedtomographywastakenwhichshowednodularseptalthickeninganditstronglysuggestedthediagnosisofPLC(Figure2).
PatientwasgivenfurthercoursesofchemotherapywithCisplatin,butwithnoimprovement.
Thepatientsuccumbedtodiseaseoneighteenthdayafterthestartofpulmonarysymptoms.
DiscussionLungmetastasisfrommalignanttumoursusuallypre-sentasnodularlesionsandrarelyasPulmonaryLym-phangiticCarcinomatosis(PLC).
PLCischaracterisedbydiffusespreadofmalignancyinthelung,causinginflam-mationofthelymphvessels.
Thefirstreportedcaseof*Correspondence:drsajith@gmail.
com1DepartmentofSurgicalOncology,MalabarCancerCentre,Thalassery,KeralaFulllistofauthorinformationisavailableattheendofthearticleBabuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77WORLDJOURNALOFSURGICALONCOLOGY2011Babuetal;licenseeBioMedCentralLtd.
ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(http://creativecommons.
org/licenses/by/2.
0),whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.
PLCwasbyGabrielAndralin1829[2].
ThediffuselyinfiltratingpatternofmetastasisasseeninPLCoccursin6-8%oflungmetastases[3].
80%ofthemarefromadenocarcinomas.
ThecommonsitesofprimaryfromwhichPLCoccursarecancersofbreast,bronchus,andstomach[4,5].
TheotherdescribedsiteswithPLCarecancersfromcolon,pancreas,kidney,cervix,thyroid,larynxandhypopharynx[6-8].
Thecancersofheadandneckrarelyshowthistypeofmetastasis.
Theexactreasonisunknown.
Thedescribedsitesinheadandneckregionarelarynx,hypopharynxandthyroid.
Metastasistolymphnodesfromadvancedcancersoflipisseeninabout44%.
Metastasistolungisreportedtobeverylow.
ThereisnoavailablereportsuggestingaPLCfromoralcancers.
PLCasmetastaticfeatureasseeninthecasedescribedinthismanuscriptisanextremelyrarepresentation.
Thepathophysiologyisthatthetumoursspreadbyhaematogenousroutetothelungandthenthroughthelymphaticswithinthelung.
Thelymphaticsinthelungareseenintheperibronchovascular,centrilobular,inter-lobularandsubpleuralregions.
Thetumourobstructstheselymphaticchannels.
Thedilatedlymphaticvesselsduetooedemafluid,tumoursecretionandthedesmo-plasticreactionbythetumourcells,producesinterstitialthickeningwhichisseenasstreaksinimagingstudies.
Thenodularpatternisduetothespreadoftumourintothelungparenchymaasseeninusuallungmetastases.
TheclinicalfeaturesofPLCaredyspnoeaandnonpro-ductivecoughwithcrepitationsandwithoutfeaturesofconsolidation.
ChestX-rayshowsseptallines(KerleyAandBlines).
Thedifferentialdiagnosisisinterstitiallungdisease,primarymalignancyinthelung,pulmonarysar-coidosisandhypersensitivitypneumonitis.
HRCTisthemodalityofchoiceforconfirmationofthediagnosis.
ThefindingsinCTscanare-thickeningofinterlobularsepta,fissuresandbronchovascularbundles.
Thesefind-ingsmaybeseenaslimitedordiffuseandmayinvolveunilateralorbilaterallungs.
Theradiologicpicturemaybesymmetricorasymmetricinbothlungs.
Theotherfindingsarenodularityinpleuraandgroundglassopa-city[9].
Thepossibilityofinterstitiallungdiseaseistobeconsideredandruledout.
PrakashPetaldescribedtheuseofPET/CTindiagnosingPLC.
Inastudyof35,theyfoundthatPET/CThashighspecificityindetectionofpulmonarylymphangiticcarcinomatosis[10].
Histopathologicalexaminationsshowinterstitialoedemaandfibrosisalongwithmalignantcellsandarefoundusuallyonpostmortembiopsy.
Sincetheradiolo-gicalfindinginapatientwithmalignantdiseaseelse-whereissuggestive,abiopsyofthelungisnotmandatory.
PLCoftenpresentsinthelatestagesofmalignancyanditindicatespoorprognosis.
ThetreatmentoptioninPLCiswithchemotherapy.
Cisplatinhavebeenfoundtobeeffective[11].
ConclusionPulmonaryLymphangiticCarcinomatosismayalsooccurrarelyinpatientswithoralcancersasseeninourpatientanditsprognosisisverypoorevenwithtreat-mentwithchemotherapy.
Figure1CXR:ChestRadiographshowingseptallines.
Figure2CTScan:CTscanofthoraxshowingdiffuseandbilateralfindings.
Babuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77Page2of3ConsentWritteninformedconsentwasobtainedfromthepatientforpublicationofthiscasereportandaccompanyingimages.
AcopyofthewrittenconsentisavailableforreviewbytheEditor-in-Chiefofthisjournal.
Authordetails1DepartmentofSurgicalOncology,MalabarCancerCentre,Thalassery,Kerala.
2DepartmentofRadiationOncology,MalabarCancerCentre,Thalassery,Kerala.
Authors'contributionsSBpreparedthemanuscriptandtheliteraturesearch,GMreviewedandeditedthemanuscript,STcorrectedandrevisedthemanuscript,SS:reviewedthemanuscript.
Allauthorsreadandapprovedthefinalmanuscript.
CompetinginterestsTheauthorsdeclarethattheyhavenocompetinginterests.
Received:8March2011Accepted:14July2011Published:14July2011References1.
ZieskeLA,MyersEN,BrownBM:Pulmonarylymphangiticcarcinomatosisfromhypopharyngealadenosquamouscarcinoma.
HeadNeckSurg1988,10(3):195-8.
2.
DoyleL:GabrielAndral(1797-1876)andthefirstreportsoflymphangitiscarcinomatosa.
JRSocMed1989,82(8):491-3.
3.
BruceDM,HeysSD,EreminO:Lymphangitiscarcinomatosa:aliteraturereview.
JRCollSurgEdinb1996,41(1):7-13.
4.
YamagishiY,AkibaY,IzumiyaM,HiguchiH,IizukaH,TakaishiH,NagataH,HibiT:[AcaseofadvancedgastriccancerwithlymphangitiscarcinomatosaafteroperationofKrukenbergtumortreatedbyTS-1plusCPT-11asthird-linechemotherapy].
GanToKagakuRyoho2005,32(8):1167-70.
5.
GuptaPR,JoshiN,MeenaRC,AliM:Asymptomaticlymphangitiscarcinomatosisduetosquamouscelllungcarcinoma.
IndianJChestDisAlliedSci2005,47(2):121-3.
6.
ThomasA,LenoxR:Pulmonarylymphangiticcarcinomatosisasaprimarymanifestationofcoloncancerinayoungadult.
CMAJ2008,179(4):338-40.
7.
KirkJE,KumaranM:Lymphangitiscarcinomatosaasanunusualpresentationofrenalcellcarcinoma:acasereport.
JMedCaseReports2008,2:19.
8.
YangSP,LinCC:[Pulmonarylymphangiticcarcinomatosis].
TaiwanYiXueHuiZaZhi1968,67(9):361-74.
9.
ZhangK,HuangY:[Clinicalfeaturesanddiagnosisofpulmonarylymphangiticcarcinomatosis].
AiZheng2006,25(9):1127-30.
10.
PrakashP,KalraMK,SharmaA,ShepardJA,DigumarthySR:FDGPET/CTinAssessmentofPulmonaryLymphangiticCarcinomatosis.
AJRAmJRoentgenol2010,194(1):231-6.
11.
KikuchiN,ShiozawaT,IshiiY,SatohH,NoguchiM,OhtsukaM:ApatientwithpulmonarylymphangiticcarcinomatosissuccessfullytreatedwithTS-1andcisplatin.
InternMed2007,46(8):491-4.
doi:10.
1186/1477-7819-9-77Citethisarticleas:Babuetal.
:ArarepresentationofPulmonaryLymphangiticCarcinomatosisinCancerofLip:CaseReport.
WorldJournalofSurgicalOncology20119:77.
SubmityournextmanuscripttoBioMedCentralandtakefulladvantageof:ConvenientonlinesubmissionThoroughpeerreviewNospaceconstraintsorcolorgurechargesImmediatepublicationonacceptanceInclusioninPubMed,CAS,ScopusandGoogleScholarResearchwhichisfreelyavailableforredistributionSubmityourmanuscriptatwww.
biomedcentral.
com/submitBabuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77Page3of3
- hilum77ququ.com相关文档
- ,,,,"新兴产业周报",,,,,,"09-06-15",,"第(26)期",,,,,,
- Southampton77ququ.com
- 模块77ququ.com
- 化合物77ququ.com
- Nujol77ququ.com
- apsi77ququ.com
TmhHost 全场八折优惠且充值返10% 多款CN2线路
TmhHost 商家是一家成立于2019年的国人主机品牌。目前主营的是美国VPS以及美国、香港、韩国、菲律宾的独立服务器等，其中VPS业务涵盖香港CN2、香港NTT、美国CN2回程高防、美国CN2 GIA、日本软银、韩国cn2等,均为亚太中国直连优质线路，TmhHost提供全中文界面，支持支付宝付款。 TmhHost黑五优惠活动发布了，全场云服务器、独立服务器提供8折，另有充值返现、特价服务器促销...
raksmart：香港机房服务器实测评数据分享，告诉你raksmart服务器怎么样
raksmart作为一家老牌美国机房总是被很多人问到raksmart香港服务器怎么样、raksmart好不好？其实，这也好理解。香港服务器离大陆最近、理论上是不需要备案的服务器里面速度最快的，被过多关注也就在情理之中了。本着为大家趟雷就是本站的光荣这一理念，拿了一台raksmart的香港独立服务器，简单做个测评，分享下实测的数据，仅供参考！官方网站：https://www.raksmart.com...
HostYun（22元/月）全场88折优惠香港原生IP大带宽
在之前的一些文章中有提到HostYun商家的信息，这个商家源头是比较老的，这两年有更换新的品牌域名。在陆续的有新增机房，价格上还是走的低价格路线，所以平时的折扣力度已经是比较低的。在前面我也有介绍到提供九折优惠，这个品牌商家就是走的低价量大为主。中秋节即将到，商家也有推出稍微更低的88折。全场88折优惠码：moon88这里，整理部分HostYun商家的套餐。所有的价格目前都是原价，我们需要用折扣码...
77ququ.com为你推荐
-
网络访问怎样设置Internet网络连接共享？AsgardiaCONSTANTIA 1685（2017年）红酒多少一瓶？工信部约谈电信去工信部网站投诉电信是否有效乐划锁屏乐视屏幕手机解锁忘记但是指纹可以解开怎么办？外挂购买什么外挂网好点www.983mm.comwww.47683.com比肩工场命比肩多 是什么意思啊？嘀动网手机一键通用来干嘛呢？杰景新特杰德特这个英雄怎么样8090lu.com8090向前冲电影 8090向前冲清晰版 8090向前冲在线观看 8090向前冲播放 8090向前冲视频下载地址？？