hilum77ququ.com
77ququ.com 时间:2021-03-23 阅读:()
CASEREPORTOpenAccessArarepresentationofPulmonaryLymphangiticCarcinomatosisinCancerofLip:CaseReportSajithBabu1*,SatheeshanB1,GeethaM2andSurijSalih1AbstractSquamouscellcarcinomaoflipisacommonmalignancyinIndiansubcontinent.
Metastaticspreadisinfrequent.
Althoughadvancedtumoursspreadtolymphnodesintheneck,itdoesnottypicallypresentwithlungmetastasisorwithlymphangiticcarcinomatosis.
Wedescribeapatientwhodevelopedcoughandincreasingdyspnoeawhileontreatmentforcarcinomaoflip.
Chestx-rayandcomputedtomographywereconsistentwithlymphangiticcarcinomatosis.
Lymphangiticcarcinomatosisoccurswithmanydifferentprimarytumoursandcanrarelyoccurinoralcancers.
Thisisthefirstreportfromcarcinomaoflip.
BackgroundThecommonsiteofmetastasisfrommostofthesolidmalignanciesislung.
Theyusuallyappearasnodularlesionsinradiologicimages.
Insomepatients,metastasispresentswithinterstitialspreadanditisreferredtoasPulmonaryLymphangiticCarcinomatosis(PLC).
HeadandneckcancersveryrarelyhavelungmetastasisintheformofPLC.
Oropharyngealandhypopharyngealcan-cershavebeenreportedtohavesuchtypeofmetastasis[1].
CanceroflipisacommonmalignancyinIndiansubcontinentmainlyduetotobaccochewingandthatthesecancersaredetectedinearlystagesduetoitsvisi-blelocation,aspreadtolungisrareandtheyareoftypicalnodularmetastases.
PLChasnotbeenreportedtilldatefromlipcancersinEnglishliterature.
HerewereportacaseofPLCarisingfromcancerofthelowerlip.
CasePresentation60yearoldgentlemanwithnocomorbidillness,pre-sentedwithasquamouscellcarcinomaoflowerlip.
Afterevaluation,thiswasstagedasT4N2aM0,stageIVandwasmoderatelydifferentiatedsquamouscellcar-cinoma.
TheX-rayofthechestwaswithinnormallim-its.
Wideexcisionofthelesionandreconstructionwithadeltopectoralflapandaradicalneckdissectiononipsilateralsidewasdone.
Postoperativehistopathologywasmoderatelydifferentiatedsquamouscellcarcinoma(pT4N2a).
After4weeks,postoperativeadjuvantcon-currentchemoradiationwasstartedwithCisplatinandradiotherapyin2Gyperfraction.
Whileonradiother-apy,thepatientdevelopedseveredyspnoeaofacuteonset.
Therewasnohistoryofsimilarepisodeinthepastandhewasnotaknownpatientofchronicobstructivepulmonarydisease.
Hewasafebrileandtherewasnocoughorexpectoration.
Basichaematologi-calstudyrevealednormalhaemogram.
Clinicallyhewasdyspnoeic,tachypnoeicandwithtachycardia.
Onauscul-tationofthechest,therewasscatteredcracklesandoccasionalronchi.
Airentrywasequalonbothsides.
Hewasputonsymptomaticcareintheformofbronchodi-lators,antibioticsandnasaloxygen.
Possibilitiesconsid-eredwereacutebronchopneumoniaandPLC.
Chestradiographrevealedinterstitiallinearpatternfromthehilumtotheouterlungfields(Figure1)andKerley'sBlinesinbothlungssuggestingPLC.
AcomputerizedtomographywastakenwhichshowednodularseptalthickeninganditstronglysuggestedthediagnosisofPLC(Figure2).
PatientwasgivenfurthercoursesofchemotherapywithCisplatin,butwithnoimprovement.
Thepatientsuccumbedtodiseaseoneighteenthdayafterthestartofpulmonarysymptoms.
DiscussionLungmetastasisfrommalignanttumoursusuallypre-sentasnodularlesionsandrarelyasPulmonaryLym-phangiticCarcinomatosis(PLC).
PLCischaracterisedbydiffusespreadofmalignancyinthelung,causinginflam-mationofthelymphvessels.
Thefirstreportedcaseof*Correspondence:drsajith@gmail.
com1DepartmentofSurgicalOncology,MalabarCancerCentre,Thalassery,KeralaFulllistofauthorinformationisavailableattheendofthearticleBabuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77WORLDJOURNALOFSURGICALONCOLOGY2011Babuetal;licenseeBioMedCentralLtd.
ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(http://creativecommons.
org/licenses/by/2.
0),whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.
PLCwasbyGabrielAndralin1829[2].
ThediffuselyinfiltratingpatternofmetastasisasseeninPLCoccursin6-8%oflungmetastases[3].
80%ofthemarefromadenocarcinomas.
ThecommonsitesofprimaryfromwhichPLCoccursarecancersofbreast,bronchus,andstomach[4,5].
TheotherdescribedsiteswithPLCarecancersfromcolon,pancreas,kidney,cervix,thyroid,larynxandhypopharynx[6-8].
Thecancersofheadandneckrarelyshowthistypeofmetastasis.
Theexactreasonisunknown.
Thedescribedsitesinheadandneckregionarelarynx,hypopharynxandthyroid.
Metastasistolymphnodesfromadvancedcancersoflipisseeninabout44%.
Metastasistolungisreportedtobeverylow.
ThereisnoavailablereportsuggestingaPLCfromoralcancers.
PLCasmetastaticfeatureasseeninthecasedescribedinthismanuscriptisanextremelyrarepresentation.
Thepathophysiologyisthatthetumoursspreadbyhaematogenousroutetothelungandthenthroughthelymphaticswithinthelung.
Thelymphaticsinthelungareseenintheperibronchovascular,centrilobular,inter-lobularandsubpleuralregions.
Thetumourobstructstheselymphaticchannels.
Thedilatedlymphaticvesselsduetooedemafluid,tumoursecretionandthedesmo-plasticreactionbythetumourcells,producesinterstitialthickeningwhichisseenasstreaksinimagingstudies.
Thenodularpatternisduetothespreadoftumourintothelungparenchymaasseeninusuallungmetastases.
TheclinicalfeaturesofPLCaredyspnoeaandnonpro-ductivecoughwithcrepitationsandwithoutfeaturesofconsolidation.
ChestX-rayshowsseptallines(KerleyAandBlines).
Thedifferentialdiagnosisisinterstitiallungdisease,primarymalignancyinthelung,pulmonarysar-coidosisandhypersensitivitypneumonitis.
HRCTisthemodalityofchoiceforconfirmationofthediagnosis.
ThefindingsinCTscanare-thickeningofinterlobularsepta,fissuresandbronchovascularbundles.
Thesefind-ingsmaybeseenaslimitedordiffuseandmayinvolveunilateralorbilaterallungs.
Theradiologicpicturemaybesymmetricorasymmetricinbothlungs.
Theotherfindingsarenodularityinpleuraandgroundglassopa-city[9].
Thepossibilityofinterstitiallungdiseaseistobeconsideredandruledout.
PrakashPetaldescribedtheuseofPET/CTindiagnosingPLC.
Inastudyof35,theyfoundthatPET/CThashighspecificityindetectionofpulmonarylymphangiticcarcinomatosis[10].
Histopathologicalexaminationsshowinterstitialoedemaandfibrosisalongwithmalignantcellsandarefoundusuallyonpostmortembiopsy.
Sincetheradiolo-gicalfindinginapatientwithmalignantdiseaseelse-whereissuggestive,abiopsyofthelungisnotmandatory.
PLCoftenpresentsinthelatestagesofmalignancyanditindicatespoorprognosis.
ThetreatmentoptioninPLCiswithchemotherapy.
Cisplatinhavebeenfoundtobeeffective[11].
ConclusionPulmonaryLymphangiticCarcinomatosismayalsooccurrarelyinpatientswithoralcancersasseeninourpatientanditsprognosisisverypoorevenwithtreat-mentwithchemotherapy.
Figure1CXR:ChestRadiographshowingseptallines.
Figure2CTScan:CTscanofthoraxshowingdiffuseandbilateralfindings.
Babuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77Page2of3ConsentWritteninformedconsentwasobtainedfromthepatientforpublicationofthiscasereportandaccompanyingimages.
AcopyofthewrittenconsentisavailableforreviewbytheEditor-in-Chiefofthisjournal.
Authordetails1DepartmentofSurgicalOncology,MalabarCancerCentre,Thalassery,Kerala.
2DepartmentofRadiationOncology,MalabarCancerCentre,Thalassery,Kerala.
Authors'contributionsSBpreparedthemanuscriptandtheliteraturesearch,GMreviewedandeditedthemanuscript,STcorrectedandrevisedthemanuscript,SS:reviewedthemanuscript.
Allauthorsreadandapprovedthefinalmanuscript.
CompetinginterestsTheauthorsdeclarethattheyhavenocompetinginterests.
Received:8March2011Accepted:14July2011Published:14July2011References1.
ZieskeLA,MyersEN,BrownBM:Pulmonarylymphangiticcarcinomatosisfromhypopharyngealadenosquamouscarcinoma.
HeadNeckSurg1988,10(3):195-8.
2.
DoyleL:GabrielAndral(1797-1876)andthefirstreportsoflymphangitiscarcinomatosa.
JRSocMed1989,82(8):491-3.
3.
BruceDM,HeysSD,EreminO:Lymphangitiscarcinomatosa:aliteraturereview.
JRCollSurgEdinb1996,41(1):7-13.
4.
YamagishiY,AkibaY,IzumiyaM,HiguchiH,IizukaH,TakaishiH,NagataH,HibiT:[AcaseofadvancedgastriccancerwithlymphangitiscarcinomatosaafteroperationofKrukenbergtumortreatedbyTS-1plusCPT-11asthird-linechemotherapy].
GanToKagakuRyoho2005,32(8):1167-70.
5.
GuptaPR,JoshiN,MeenaRC,AliM:Asymptomaticlymphangitiscarcinomatosisduetosquamouscelllungcarcinoma.
IndianJChestDisAlliedSci2005,47(2):121-3.
6.
ThomasA,LenoxR:Pulmonarylymphangiticcarcinomatosisasaprimarymanifestationofcoloncancerinayoungadult.
CMAJ2008,179(4):338-40.
7.
KirkJE,KumaranM:Lymphangitiscarcinomatosaasanunusualpresentationofrenalcellcarcinoma:acasereport.
JMedCaseReports2008,2:19.
8.
YangSP,LinCC:[Pulmonarylymphangiticcarcinomatosis].
TaiwanYiXueHuiZaZhi1968,67(9):361-74.
9.
ZhangK,HuangY:[Clinicalfeaturesanddiagnosisofpulmonarylymphangiticcarcinomatosis].
AiZheng2006,25(9):1127-30.
10.
PrakashP,KalraMK,SharmaA,ShepardJA,DigumarthySR:FDGPET/CTinAssessmentofPulmonaryLymphangiticCarcinomatosis.
AJRAmJRoentgenol2010,194(1):231-6.
11.
KikuchiN,ShiozawaT,IshiiY,SatohH,NoguchiM,OhtsukaM:ApatientwithpulmonarylymphangiticcarcinomatosissuccessfullytreatedwithTS-1andcisplatin.
InternMed2007,46(8):491-4.
doi:10.
1186/1477-7819-9-77Citethisarticleas:Babuetal.
:ArarepresentationofPulmonaryLymphangiticCarcinomatosisinCancerofLip:CaseReport.
WorldJournalofSurgicalOncology20119:77.
SubmityournextmanuscripttoBioMedCentralandtakefulladvantageof:ConvenientonlinesubmissionThoroughpeerreviewNospaceconstraintsorcolorgurechargesImmediatepublicationonacceptanceInclusioninPubMed,CAS,ScopusandGoogleScholarResearchwhichisfreelyavailableforredistributionSubmityourmanuscriptatwww.
biomedcentral.
com/submitBabuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77Page3of3
Metastaticspreadisinfrequent.
Althoughadvancedtumoursspreadtolymphnodesintheneck,itdoesnottypicallypresentwithlungmetastasisorwithlymphangiticcarcinomatosis.
Wedescribeapatientwhodevelopedcoughandincreasingdyspnoeawhileontreatmentforcarcinomaoflip.
Chestx-rayandcomputedtomographywereconsistentwithlymphangiticcarcinomatosis.
Lymphangiticcarcinomatosisoccurswithmanydifferentprimarytumoursandcanrarelyoccurinoralcancers.
Thisisthefirstreportfromcarcinomaoflip.
BackgroundThecommonsiteofmetastasisfrommostofthesolidmalignanciesislung.
Theyusuallyappearasnodularlesionsinradiologicimages.
Insomepatients,metastasispresentswithinterstitialspreadanditisreferredtoasPulmonaryLymphangiticCarcinomatosis(PLC).
HeadandneckcancersveryrarelyhavelungmetastasisintheformofPLC.
Oropharyngealandhypopharyngealcan-cershavebeenreportedtohavesuchtypeofmetastasis[1].
CanceroflipisacommonmalignancyinIndiansubcontinentmainlyduetotobaccochewingandthatthesecancersaredetectedinearlystagesduetoitsvisi-blelocation,aspreadtolungisrareandtheyareoftypicalnodularmetastases.
PLChasnotbeenreportedtilldatefromlipcancersinEnglishliterature.
HerewereportacaseofPLCarisingfromcancerofthelowerlip.
CasePresentation60yearoldgentlemanwithnocomorbidillness,pre-sentedwithasquamouscellcarcinomaoflowerlip.
Afterevaluation,thiswasstagedasT4N2aM0,stageIVandwasmoderatelydifferentiatedsquamouscellcar-cinoma.
TheX-rayofthechestwaswithinnormallim-its.
Wideexcisionofthelesionandreconstructionwithadeltopectoralflapandaradicalneckdissectiononipsilateralsidewasdone.
Postoperativehistopathologywasmoderatelydifferentiatedsquamouscellcarcinoma(pT4N2a).
After4weeks,postoperativeadjuvantcon-currentchemoradiationwasstartedwithCisplatinandradiotherapyin2Gyperfraction.
Whileonradiother-apy,thepatientdevelopedseveredyspnoeaofacuteonset.
Therewasnohistoryofsimilarepisodeinthepastandhewasnotaknownpatientofchronicobstructivepulmonarydisease.
Hewasafebrileandtherewasnocoughorexpectoration.
Basichaematologi-calstudyrevealednormalhaemogram.
Clinicallyhewasdyspnoeic,tachypnoeicandwithtachycardia.
Onauscul-tationofthechest,therewasscatteredcracklesandoccasionalronchi.
Airentrywasequalonbothsides.
Hewasputonsymptomaticcareintheformofbronchodi-lators,antibioticsandnasaloxygen.
Possibilitiesconsid-eredwereacutebronchopneumoniaandPLC.
Chestradiographrevealedinterstitiallinearpatternfromthehilumtotheouterlungfields(Figure1)andKerley'sBlinesinbothlungssuggestingPLC.
AcomputerizedtomographywastakenwhichshowednodularseptalthickeninganditstronglysuggestedthediagnosisofPLC(Figure2).
PatientwasgivenfurthercoursesofchemotherapywithCisplatin,butwithnoimprovement.
Thepatientsuccumbedtodiseaseoneighteenthdayafterthestartofpulmonarysymptoms.
DiscussionLungmetastasisfrommalignanttumoursusuallypre-sentasnodularlesionsandrarelyasPulmonaryLym-phangiticCarcinomatosis(PLC).
PLCischaracterisedbydiffusespreadofmalignancyinthelung,causinginflam-mationofthelymphvessels.
Thefirstreportedcaseof*Correspondence:drsajith@gmail.
com1DepartmentofSurgicalOncology,MalabarCancerCentre,Thalassery,KeralaFulllistofauthorinformationisavailableattheendofthearticleBabuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77WORLDJOURNALOFSURGICALONCOLOGY2011Babuetal;licenseeBioMedCentralLtd.
ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(http://creativecommons.
org/licenses/by/2.
0),whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.
PLCwasbyGabrielAndralin1829[2].
ThediffuselyinfiltratingpatternofmetastasisasseeninPLCoccursin6-8%oflungmetastases[3].
80%ofthemarefromadenocarcinomas.
ThecommonsitesofprimaryfromwhichPLCoccursarecancersofbreast,bronchus,andstomach[4,5].
TheotherdescribedsiteswithPLCarecancersfromcolon,pancreas,kidney,cervix,thyroid,larynxandhypopharynx[6-8].
Thecancersofheadandneckrarelyshowthistypeofmetastasis.
Theexactreasonisunknown.
Thedescribedsitesinheadandneckregionarelarynx,hypopharynxandthyroid.
Metastasistolymphnodesfromadvancedcancersoflipisseeninabout44%.
Metastasistolungisreportedtobeverylow.
ThereisnoavailablereportsuggestingaPLCfromoralcancers.
PLCasmetastaticfeatureasseeninthecasedescribedinthismanuscriptisanextremelyrarepresentation.
Thepathophysiologyisthatthetumoursspreadbyhaematogenousroutetothelungandthenthroughthelymphaticswithinthelung.
Thelymphaticsinthelungareseenintheperibronchovascular,centrilobular,inter-lobularandsubpleuralregions.
Thetumourobstructstheselymphaticchannels.
Thedilatedlymphaticvesselsduetooedemafluid,tumoursecretionandthedesmo-plasticreactionbythetumourcells,producesinterstitialthickeningwhichisseenasstreaksinimagingstudies.
Thenodularpatternisduetothespreadoftumourintothelungparenchymaasseeninusuallungmetastases.
TheclinicalfeaturesofPLCaredyspnoeaandnonpro-ductivecoughwithcrepitationsandwithoutfeaturesofconsolidation.
ChestX-rayshowsseptallines(KerleyAandBlines).
Thedifferentialdiagnosisisinterstitiallungdisease,primarymalignancyinthelung,pulmonarysar-coidosisandhypersensitivitypneumonitis.
HRCTisthemodalityofchoiceforconfirmationofthediagnosis.
ThefindingsinCTscanare-thickeningofinterlobularsepta,fissuresandbronchovascularbundles.
Thesefind-ingsmaybeseenaslimitedordiffuseandmayinvolveunilateralorbilaterallungs.
Theradiologicpicturemaybesymmetricorasymmetricinbothlungs.
Theotherfindingsarenodularityinpleuraandgroundglassopa-city[9].
Thepossibilityofinterstitiallungdiseaseistobeconsideredandruledout.
PrakashPetaldescribedtheuseofPET/CTindiagnosingPLC.
Inastudyof35,theyfoundthatPET/CThashighspecificityindetectionofpulmonarylymphangiticcarcinomatosis[10].
Histopathologicalexaminationsshowinterstitialoedemaandfibrosisalongwithmalignantcellsandarefoundusuallyonpostmortembiopsy.
Sincetheradiolo-gicalfindinginapatientwithmalignantdiseaseelse-whereissuggestive,abiopsyofthelungisnotmandatory.
PLCoftenpresentsinthelatestagesofmalignancyanditindicatespoorprognosis.
ThetreatmentoptioninPLCiswithchemotherapy.
Cisplatinhavebeenfoundtobeeffective[11].
ConclusionPulmonaryLymphangiticCarcinomatosismayalsooccurrarelyinpatientswithoralcancersasseeninourpatientanditsprognosisisverypoorevenwithtreat-mentwithchemotherapy.
Figure1CXR:ChestRadiographshowingseptallines.
Figure2CTScan:CTscanofthoraxshowingdiffuseandbilateralfindings.
Babuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77Page2of3ConsentWritteninformedconsentwasobtainedfromthepatientforpublicationofthiscasereportandaccompanyingimages.
AcopyofthewrittenconsentisavailableforreviewbytheEditor-in-Chiefofthisjournal.
Authordetails1DepartmentofSurgicalOncology,MalabarCancerCentre,Thalassery,Kerala.
2DepartmentofRadiationOncology,MalabarCancerCentre,Thalassery,Kerala.
Authors'contributionsSBpreparedthemanuscriptandtheliteraturesearch,GMreviewedandeditedthemanuscript,STcorrectedandrevisedthemanuscript,SS:reviewedthemanuscript.
Allauthorsreadandapprovedthefinalmanuscript.
CompetinginterestsTheauthorsdeclarethattheyhavenocompetinginterests.
Received:8March2011Accepted:14July2011Published:14July2011References1.
ZieskeLA,MyersEN,BrownBM:Pulmonarylymphangiticcarcinomatosisfromhypopharyngealadenosquamouscarcinoma.
HeadNeckSurg1988,10(3):195-8.
2.
DoyleL:GabrielAndral(1797-1876)andthefirstreportsoflymphangitiscarcinomatosa.
JRSocMed1989,82(8):491-3.
3.
BruceDM,HeysSD,EreminO:Lymphangitiscarcinomatosa:aliteraturereview.
JRCollSurgEdinb1996,41(1):7-13.
4.
YamagishiY,AkibaY,IzumiyaM,HiguchiH,IizukaH,TakaishiH,NagataH,HibiT:[AcaseofadvancedgastriccancerwithlymphangitiscarcinomatosaafteroperationofKrukenbergtumortreatedbyTS-1plusCPT-11asthird-linechemotherapy].
GanToKagakuRyoho2005,32(8):1167-70.
5.
GuptaPR,JoshiN,MeenaRC,AliM:Asymptomaticlymphangitiscarcinomatosisduetosquamouscelllungcarcinoma.
IndianJChestDisAlliedSci2005,47(2):121-3.
6.
ThomasA,LenoxR:Pulmonarylymphangiticcarcinomatosisasaprimarymanifestationofcoloncancerinayoungadult.
CMAJ2008,179(4):338-40.
7.
KirkJE,KumaranM:Lymphangitiscarcinomatosaasanunusualpresentationofrenalcellcarcinoma:acasereport.
JMedCaseReports2008,2:19.
8.
YangSP,LinCC:[Pulmonarylymphangiticcarcinomatosis].
TaiwanYiXueHuiZaZhi1968,67(9):361-74.
9.
ZhangK,HuangY:[Clinicalfeaturesanddiagnosisofpulmonarylymphangiticcarcinomatosis].
AiZheng2006,25(9):1127-30.
10.
PrakashP,KalraMK,SharmaA,ShepardJA,DigumarthySR:FDGPET/CTinAssessmentofPulmonaryLymphangiticCarcinomatosis.
AJRAmJRoentgenol2010,194(1):231-6.
11.
KikuchiN,ShiozawaT,IshiiY,SatohH,NoguchiM,OhtsukaM:ApatientwithpulmonarylymphangiticcarcinomatosissuccessfullytreatedwithTS-1andcisplatin.
InternMed2007,46(8):491-4.
doi:10.
1186/1477-7819-9-77Citethisarticleas:Babuetal.
:ArarepresentationofPulmonaryLymphangiticCarcinomatosisinCancerofLip:CaseReport.
WorldJournalofSurgicalOncology20119:77.
SubmityournextmanuscripttoBioMedCentralandtakefulladvantageof:ConvenientonlinesubmissionThoroughpeerreviewNospaceconstraintsorcolorgurechargesImmediatepublicationonacceptanceInclusioninPubMed,CAS,ScopusandGoogleScholarResearchwhichisfreelyavailableforredistributionSubmityourmanuscriptatwww.
biomedcentral.
com/submitBabuetal.
WorldJournalofSurgicalOncology2011,9:77http://www.
wjso.
com/content/9/1/77Page3of3
- hilum77ququ.com相关文档
- ,,,,"新兴产业周报",,,,,,"09-06-15",,"第(26)期",,,,,,
- Southampton77ququ.com
- 模块77ququ.com
- 化合物77ququ.com
- Nujol77ququ.com
- apsi77ququ.com
EtherNetservers年付仅10美元，美国洛杉矶VPS/1核512M内存10GB硬盘1Gpbs端口月流量500GB/2个IP
EtherNetservers是一家成立于2013年的英国主机商，提供基于OpenVZ和KVM架构的VPS，数据中心包括美国洛杉矶、新泽西和杰克逊维尔，商家支持使用PayPal、支付宝等付款方式，提供 60 天退款保证，这在IDC行业来说很少见，也可见商家对自家产品很有信心。有需要便宜VPS、多IP VPS的朋友可以关注一下。优惠码SUMMER-VPS-15 （终身 15% 的折扣）SUMMER-...
星梦云：四川100G高防4H4G10M月付仅60元
星梦云怎么样?星梦云资质齐全，IDC/ISP均有，从星梦云这边租的服务器均可以备案，属于一手资源，高防机柜、大带宽、高防IP业务，一手整C IP段，四川电信，星梦云专注四川高防服务器,成都服务器,雅安服务器。星梦云目前夏日云服务器促销,四川100G高防4H4G10M月付仅60元;西南高防月付特价活动，续费同价，买到就是赚到!点击进入：星梦云官方网站地址1、成都电信年中活动机(成都电信优化线路，封锁...
台湾云服务器整理推荐UCloud/易探云！
台湾云服务器去哪里买?国内有没有哪里的台湾云服务器这块做的比较好的?有很多用户想用台湾云服务器，那么判断哪家台湾云服务器好，不是按照最便宜或最贵的选择，而是根据您的实际使用目的选择服务器，只有最适合您的才是最好的。总体而言，台湾云服务器的稳定性确实要好于大陆。今天，云服务器网(yuntue.com)小编来介绍一下台湾云服务器哪里买和一年需要多少钱！一、UCloud台湾云服务器UCloud上市云商,...
77ququ.com为你推荐
-
vc组合洛天依的组合都有谁同ip域名不同域名解析到同一个IP是否有影响同一ip网站同一个IP不同的30个网站，是不是在一个服务器上呢？百度关键词工具百度有关键字分析工具吗？Google AdWords有的8090lu.com8090lu.com怎么样了?工程有进展吗？杨丽晓博客杨丽晓是如何进入娱乐圈的?杨丽晓博客杨丽晓哪一年出生的？广告法中华人民共和国广告法中,有哪些广告不得发布?www.ca800.comPLC好学吗sodu.tw台湾的可以看小说的网站