yearadmit

admit  时间:2021-01-25  阅读:()
GeertMeyfroidtPierre-EdouardBollaertPaulE.
MarikAcuteischemicstrokeintheICU:toadmitornottoadmitReceived:1April2014Accepted:1April2014Publishedonline:8April2014Springer-VerlagBerlinHeidelbergandESICM2014G.
Meyfroidt())IntensiveCareMedicine,KULeuven,Line1:UZLeuven,3000Louvain,Belgiume-mail:geert.
meyfroidt@uzleuven.
beP.
-E.
BollaertServicedeReanimationMedicale,CHUdeNancy,Nancy,FranceP.
E.
MarikEasternVirginiaMedicalSchool,Norfolk,VA,USAAcuteischemicstroke(AIS)isanimportanthealth-careproblemworldwide,andasignicantcauseofdisabilityaswellasmortality.
TheincidenceofAISisexpectedtoincreaseinthefuture,becausethemajorityofAISarecausedbycardio-embolicdisordersandatherosclerosis,typicalfortheageingpopulation.
OnlytwointerventionsinsmallsubsetsofpatientshavebeendemonstratedtoimprovetheoutcomeofAISpatients.
ThesinglemostimportantinterventiontoalterthenaturalhistoryofAISandimprovethepatients'functionaloutcomeisthetimelyadministrationofathrombolyticagent(intra-venousrt-PA)intheappropriatepatientwithinthenarrow4.
5-hwindow[1].
Endovasculartherapyrepresentsanalternativetherapytointravenousrt-PAinthosewhoarenotcandidatesforintravenousrt-PA,buthasnoadvantageoverintravenousrt-PA[2].
Hemisphericdecompressioninpatientslessthan60yearsofagewithmalignantmiddlecerebralarteryterritory(MCA)infarctionandspace-occu-pyingbrainoedemahasbeendemonstratedtoimproveoutcome.
Thisresultwasconrmedinanindividualpatientmeta-analysis,demonstratingamarkedimprovementinneurologicalrecoveryandsurvival[3].
Fortheagegroupolderthan60yearsofagewithmalignantMCAinfarction,whoareover-representedintheAISpatientgroup,therecentlypublishedDESTINYIItrialwasabletodemon-stratethatdecompressionwasalsoabletoreducemortality,butnotinuencetheproportionofpatientswithseveredisability[4].
Despiteinitialpromise,neuroprotectiveagentshavefailedtoshowabenetinthemanagementofAIS[5],ashavetightglycaemiccontrol[6],highdosealbumin[7]andtheuseofanti-hypertensiveagents[8,9].
Today,increasingnumbersofpatientswithAISareadmittedtoanintensivecareunit(ICU)forvariousindi-cations.
InthisissueofIntensiveCareMedicine,Kirkmanetal.
presentastateoftheartreviewoftheICUmanage-mentofpatientswithAIS[10].
Theirreviewisverythoroughandprovideskeyrecommendationsontheaforementionedinterventions.
Unfortunately,theywerenotabletoprovidemuchevidence-basedguidanceastowhichpatientsshouldbeadmittedtotheICU,andwhichsubgroupsofAISpatientscouldactuallybenetfromICUmanagement.
TheguidelinesoftheSocietyofCriticalCareMedicinestatethat''ingeneralICUsshouldbereservedforthosepatentswithreversiblemedicalconditionswhohaveareasonableprospectofsubstantialrecovery''[11].
InherentinthisguidelineasitappliestotheAISpatient,istheassumptionthattheintensivisthasanarsenaloftherapeuticinterventionswhichwillalterthecourseofthepatient'sstrokeandthattheseinterventionswillimprovethepatient'soutcome.
IfwetakealookatthedataonmechanicalventilationinAISpatients,probablyoneofthemainindicationsforreferraltoanICU,notsurprisingly,therequirementformechanicalventilationinitselfappearstobeassociatedwithbothahighershort-andlong-termmortality.
Usingalargeadministrativedatabasecovering93countiesintheeasternhalfoftheUSA,Golestanianetal.
[12]evaluatedtheoutcomesof31,301AISpatients.
The30-dayand1-yearmortalitywas64%and81%respec-tivelyinthosepatientswhorequiredmechanicalventilationcomparedto16%and35%inthosepatientswhodidnotrequiremechanicalventilation.
Anumberofsmallerstud-ies(lessthan100patientseach)haveaddressedthisquestionaswell.
ThesestudiesconrmedtheobservedhighIntensiveCareMed(2014)40:749–751DOI10.
1007/s00134-014-3289-5EDITORIAL1-yearmortalityforpatientsrequiringmechanicalventi-lation,37–87%,withnoclearevidenceofimprovementovertime[13–18].
Furthermore,severedisabilitywasobservedin20–45%ofsurvivors.
InthisdiscussiononthebenetofmechanicalventilationfortheoutcomeofAIS,thereasonwhymechanicalventilationwasinitiatedmightbeimportant.
Unfortunately,thiswasonlyassessedinfourofthesestudies(Fig.
1)[13–16].
Althoughthepopulationsamplesincludedinthelatterstudiesweresmall,thesedatasuggestthatthosepatientsintubatedandventilatedforcomaorneurologicdeteriorationmaynotbenetfrommechanicalventilation.
Thelackofdataontheoutcomebenetofspecicther-apeuticinterventionstoimprovetheoutcomeofthemajorityofpatientssufferingfromAIScertainlydoesnotimplythatphysiciansshouldadoptafatalisticapproachwhenmanag-ingthesepatients.
Anumberofwell-conductedclinicaltrialshavedemonstratedthatthemortalityandfunctionalrecoveryofpatientsfollowingastrokearesignicantlyimprovedwhenthesepatientsarecaredforinaspecializedstrokeunitascomparedtoageneralmedicalward[19,20].
Theseunitsprovidespecializednursingcareandawell-organizedmul-tidisciplinaryrehabilitationprogram.
Strokeunitcarereducesthemedicalcomplicationsinthesepatientsandallowsforearlierandmoreintenserehabilitation.
Incontrasttothis,specicstrokeICUswereaban-donedinthe1970safteritwasdemonstratedthatsuchunitshadverylittleimpactontheoutcomeofpatientsfollowingastroke.
Nevertheless,aproportionofpatientswhosufferfromstrokemaybenetfromadmissiontotheICU.
Endotrachealintubationandmechanicalventilationshouldbereservedforpatientswithreversiblerespiratoryfailurewhoarelikelytohaveagoodprognosisforafunctionalrecovery,e.
g.
inthetreatmentandpreventionofaspirationpneumoniaduetotemporallossofbulbarfunction,occurringin37–78%ofstrokepatients[21].
LargeMCAstrokeswhomayrequiredecompressivecraniectomy,regardlessoftheirage[3,4],andspace-occupyingcerebellarinfarctionsaccessibletoapromptsurgicaldecompression[22]areaclearindicationforICUadmission.
Insomecases,themanagementofbloodpressure,orseizures,mightnecessitateanICUadmission.
FurtherresearchshouldfocusontheuseofvalidatedstrokeseverityscoringsystemssuchastheNIHStrokeScale(NIHSS)ortheTriageStrokePanel(MMX),takingintoaccounttheinitialclinicalevolutionofthesepatients[23],toidentifythosepatientswhowillbenetfromICUreferral.
Itisclearthataggressivemedicalmeasuresindeeplycomatosepatients,withalowprobabilityofafavourableoutcomeareaformofnon-benecialcare,whichwillonlyincreasetheburdenonpatients,familiesandthehealth-caresystem.
Theparadigmof''lessmaybemore''wouldappeartobeappropriateforthesepatients[24].
References1.
LeesKR,BluhmkiE,vonKR,BrottTG,ToniD,GrottaJC,AlbersGW,KasteM,MarlerJR,HamiltonSA,TilleyBC,DavisSM,DonnanGA,HackeW(2010)Timetotreatmentwithintravenousalteplaseandoutcomeinstroke:anupdatedpooledanalysisofECASS,ATLANTIS,NINDS,andEPITHETtrials.
Lancet375:1695–17032.
CicconeA,ValvassoriL,NichelattiM,SgoifoA,PonzioM,SterziR,BoccardiE(2013)Endovasculartreatmentforacuteischemicstroke.
NEnglJMed368:904–9133.
VahediK,HofmeijerJ,JuettlerE,VicautE,GeorgeB,AlgraA,AmelinkGJ,SchmiedeckP,SchwabS,RothwellPM,BousserMG,vanderWorpHB,HackeW(2007)Earlydecompressivesurgeryinmalignantinfarctionofthemiddlecerebralartery:apooledanalysisofthreerandomisedcontrolledtrials.
LancetNeurol6:215–2220102030405060708090100Burtinetal.
Wijdicksetal.
Steineretal.
Lekeretal.
ComaConvulsionsElectiveResp.
failure%1-yearmortalityFig.
1One-yearmortalityinstrokepatientsaccordingtothecauseofmechanicalventilation7504.
Ju¨ttlerE,UnterbergA,WoitzikJ,Bo¨selJ,AmiriH,SakowitzOW,GondanM,SchillerP,LimprechtR,LuntzS,SchneiderH,PinzerT,HobohmC,MeixensbergerJ(2014)HackeWfortheDESTINYIIInvestigators.
Hemicraniectomyinolderpatientswithextensivemiddlecerebralarterystroke.
NEngJMed370:1091–11005.
GinsbergMD(2008)Neuroprotectionforischemicstroke:past,presentandfuture.
Neuropharmacology55:363–3896.
RossoC,CorvolJC,PiresC,CrozierS,AttalY,JacqueminetS,DeltourS,MultluG,LegerA,MeresseI,PayanC,DormontD,SamsonY(2012)Intensiveversussubcutaneousinsulininpatientswithhyperacutestroke:resultsfromtherandomizedINSULINFARCTtrial.
Stroke43:2343–23497.
GinsbergMD,PaleschYY,HillMD,MartinRH,MoyCS,BarsanWG,WaldmanBD,TamarizD,RyckborstKJ(2013)High-dosealbumintreatmentforacuteischaemicstroke(ALIAS)part2:arandomised,double-blind,phase3,placebo-controlledtrial.
LancetNeurol12:1049–10588.
HeJ,ZhangY,XuT,ZhaoQ,WangD,ChenCS,TongW,LiuC,XuT,JuZ(2014)Effectofimmediatebloodpressurereductionondeathandmajordisabilityinpatientswithacuteischemicstroke:theCATISrandomizedclinicaltrial.
JAMA311:479–4899.
HankeyGJ(2011)Loweringbloodpressureinacutestroke:theSCASTtrial.
Lancet377:696–69810.
KirkmanMA,CiterioG,SmithM(2014).
Theintensivecaremanagementofacuteischemicstroke:anoverview.
IntensiveCareMed.
doi:10.
1007/s00134-014-3266-z11.
TaskForceoftheAmericanCollegeofCriticalCareMedicine,SocietyofCriticalCareMedicine(1999)Guidelinesforintensivecareunitadmission,discharge,andtriage.
CritCareMed27:633–63812.
GolestanianE,LiouJI,SmithMA(2009)Long-termsurvivalinoldercriticallyillpatientswithacuteischemicstroke.
CritCareMed37:3107–311313.
BurtinP,BollaertPE,FeldmannL,NaceL,LelargeP,BauerP,LarcanA(1994)Prognosisofstrokepatientsundergoingmechanicalventilation.
IntensiveCareMed20:32–3614.
SteinerT,MendozaG,DeGeorgiaM,SchellingerP,HolleR,HackeW(1997)Prognosisofstrokepatientsrequiringmechanicalventilationinaneurologicalcriticalcareunit.
Stroke28:711–71515.
WijdicksEF,ScottJP(1997)Causesandoutcomeofmechanicalventilationinpatientswithhemisphericischemicstroke.
MayoClinProc72:210–21316.
LekerRR,Ben-HurT(2000)Prognosticfactorsinarticiallyventilatedstrokepatients.
JNeurolSci176:83–8717.
SantoliF,DeJB,HayonJ,TranB,PiperaudM,MerrerJ,OutinH(2001)Mechanicalventilationinpatientswithacuteischemicstroke:survivalandoutcomeatoneyear.
IntensiveCareMed27:1141–114618.
Navarrete-NavarroP,Rivera-FernandezR,Lopez-MutuberriaMT,GalindoI,MurilloF,DominguezJM,MunozA,Jimenez-MoragasJM,NacleB,Vazquez-MataG(2003)Outcomepredictionintermsoffunctionaldisabilityandmortalityat1yearamongICU-admittedseverestrokepatients:aprospectiveepidemiologicalstudyinthesouthoftheEuropeanUnion(EvascanProject,Andalusia,Spain).
IntensiveCareMed29:1237–124419.
StrokeUnitTrialists'Collaboration(2013)Organisedinpatient(strokeunit)careforstroke.
CochraneDatabaseSystRev9:CD00019720.
LanghorneP,deVilliersL,PandianJD(2012)Applicabilityofstroke-unitcaretolow-incomeandmiddle-incomecountries.
LancetNeurol11:341–34821.
MartinoR,FoleyN,BhogalS,DiamantN,SpeechleyM,TeasellR(2005)Dysphagiaafterstroke:incidence,diagnosisandpulmonarycomplications.
Stroke36:2756–276322.
JuttlerE,SchweickertS,RinglebPA,HuttnerHB,KohrmannM,AschoffA(2009)Long-termoutcomeaftersurgicaltreatmentforspace-occupyingcerebellarinfarction:experiencein56patients.
Stroke40:3060–306623.
BrounsR,SheorajpandayR,KunnenJ,DeSurgelooseD,DeDeynPP(2009)Clinical,biochemicalandneuroimagingparametersafterthrombolytictherapypredictlong-termstrokeoutcome.
EurNeurol62(1):9–1524.
KnoxM,PickkersP(2013)''Lessismore''incriticallyillpatients:nottoointensive.
JAMAInternMed173:1369–1372751

易探云:香港CN2云服务器低至18元/月起,183.60元/年

易探云怎么样?易探云最早是主攻香港云服务器的品牌商家,由于之前香港云服务器性价比高、稳定性不错获得了不少用户的支持。易探云推出大量香港云服务器,采用BGP、CN2线路,机房有香港九龙、香港新界、香港沙田、香港葵湾等,香港1核1G低至18元/月,183.60元/年,老站长建站推荐香港2核4G5M+10G数据盘仅799元/年,性价比超强,关键是延迟全球为50ms左右,适合国内境外外贸行业网站等,如果需...

【IT狗】在线ping,在线tcping,路由追踪

IT狗为用户提供 在线ping、在线tcping、在线路由追踪、域名被墙检测、域名被污染检测 等实用工具。【工具地址】https://www.itdog.cn/【工具特色】1、目前同类网站中,在线ping 仅支持1次或少量次数的测试,无法客观的展现目标服务器一段时间的网络状况,IT狗Ping工具可持续的进行一段时间的ping测试,并生成更为直观的网络质量柱状图,让用户更容易掌握服务器在各地区、各线...

inux国外美老牌PhotonVPS月$2.5 ,Linux系统首月半价

PhotonVPS 服务商我们是不是已经很久没有见过?曾经也是相当的火爆的,我们中文习惯称作为饭桶VPS主机商。翻看之前的文章,在2015年之前也有较多商家的活动分享的,这几年由于服务商太多,乃至于有一些老牌的服务商都逐渐淡忘。这不有看到PhotonVPS商家发布促销活动。PhotonVPS 商家七月份推出首月半价Linux系统VPS主机,首月低至2.5美元,有洛杉矶、达拉斯、阿什本机房,除提供普...

admit为你推荐
金士顿内存卡价格金士顿的手机内存卡多少钱聚酯纤维和棉哪个好聚酯纤维和纯棉的相比,哪个好?骁龙750g和765g哪个好骁龙768g什么水平骁龙750g和765g哪个好麒麟970跟骁龙730哪个更好法兰绒和珊瑚绒哪个好珊瑚绒和法兰绒哪个暖和江门旅游景点哪个好玩的地方江门有什么地方好玩的?唱K 行街 免答石英表和机械表哪个好石英表好还是机械表好?浮动利率和固定利率哪个好贷款选择浮动利率还是固定利率浮动利率和固定利率哪个好对于企业来说固定利率贷款与浮动利率贷款优缺点各是什么?谢谢了。网页传奇哪个好玩传奇网页游戏哪个好玩的最新相关信息
深圳主机租用 域名交易网 42u标准机柜尺寸 12306抢票助手 新站长网 网盘申请 中国特价网 最好看的qq空间 七夕快乐英文 免费活动 metalink 彩虹云 免费邮件服务器 网站加速软件 免费asp空间 监控服务器 德隆中文网 全能空间 个人免费邮箱 godaddy空间 更多