Buckelinsomniac
insomniac 时间:2021-03-17 阅读:()
>>Forrelatedonlinecontent,seetheSciencePodcast,p.
311305CONTENTSCONTENTScontinued>>DEPARTMENTS311ScienceOnline313ThisWeekinScience318Editors'Choice320ContactScience321RandomSamples323Newsmakers423NewProducts424ScienceCareersCOVERAnartist'sconceptionoftheantibioticpenicillinandsomeofthebacteriathathavedevelopedresistancetovariousantibiotics.
Aspecialsectionbeginningonpage355explorestheriseandspreadofso-calledbadbugsandpossibleinterventions.
Illustration:ChrisBickel/ScienceEDITORIAL317EngagingRussianScientistsbyGlennSchweitzer355NEWSOFTHEWEEKBushTakesaFinalSwipe,andSalute,atCO2324EmissionCurbsOldSamplesTripUpTokyoTeam324NewPolicyTriestoEaseSecurityRestrictions325StalledTrialforAutismHighlightsDilemmaof326AlternativeTreatmentsCaribbeanMegaeruptionsDroveaGlobalOceanCrisis327SCIENCESCOPE327TwoU.
S.
LabsVieforLong-DelayedExotic328NucleiSourceSurveyFindsCitationsGrowingNarrowerasJournals329MoveOnline>>Reportp.
395NEWSFOCUSReinventingRicetoFeedtheWorld330SowingtheSeedsofExpertiseSimpleSleepers334>>ResearchArticlep.
372Acoustics'08Meeting338SoundScienceMapsVenetianCanalsandPeruvianRuinsUltrasoundUsesinMedicineHeatUpListeningtoDistantIceCrackSnapshotsFromtheMeetingVolume321,Issue5887INTRODUCTIONDeadlyDefiance355NEWSTheBacteriaFightBack356CollateralDamage:TheRiseofResistantC.
difficileTrenchWarfareinaBattleWithTB362Anti-TBDrugs:AndThenThereWereNonePERSPECTIVESAntibioticsandAntibioticResistanceGenesin365NaturalEnvironmentsJ.
L.
MartínezOutwittingMultidrugResistancetoAntifungals367B.
C.
MonkandA.
GoffeauSPECIALSECTIONDrugResistancewww.
sciencemag.
orgSCIENCEVOL32118JULY2008330PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008307CONTENTScontinued>>SCIENCEEXPRESSwww.
sciencexpress.
orgPLANTSCIENCEPlantImmunityRequiresConformationalChangesofNPR1viaS-NitrosylationandThioredoxinsY.
Tadaetal.
Afterapathogeninvadesaplant,aprotein,usuallykeptinamultimericstatebyS-nitrosylation,isdissociatedbythioredoxin,freeingthemonomersfordefenseresponses.
10.
1126/science.
1156970GEOCHEMISTRYFerruginousConditionsDominatedLaterNeoproterozoicDeep-WaterChemistryD.
E.
Canfieldetal.
Lowsulfurinputcausedthedeeperoceantobecomeanoxicandrichinferrousiron750millionyearsago,areversalfromthemoreoxidizingconditionsoftheprevious1billionyears.
10.
1126/science.
1154499CELLBIOLOGYEssentialCytoplasmicTranslocationofaCytokineReceptor–AssembledSignalingComplexA.
Matsuzawaetal.
Degradationofonememberofaproteincomplexthatformswhenacytokinereceptorisactivatedcausesthecomplextomovetothecytoplasm,triggeringthedownstreampathway.
10.
1126/science.
1157340CONTENTSLETTERSTheCostofConservationM.
Bodeetal.
340ConservationwithCaveatsB.
W.
T.
CoetzeeResponseC.
Kremenetal.
CORRECTIONSANDCLARIFICATIONS342BOOKSETAL.
Insomniac343G.
Greene,reviewedbyM.
L.
PerlisRe-EngineeringPhilosophyforLimitedBeings344PiecewiseApproximationstoRealityW.
C.
Wimsatt,reviewedbyK.
SterelnyPOLICYFORUMAssistedColonizationandRapidClimateChange345O.
Hoegh-Guldbergetal.
PERSPECTIVESVertebrateVocalizations347D.
MargoliashandM.
E.
Hale>>Reportp.
417WastheYoungerDryasGlobal348T.
V.
LowellandM.
A.
Kelly>>Reportp.
392TrackingCorrosionCracking349A.
Stierle>>Reportp.
382GraspingLimbPatterning350C.
J.
TabinandA.
P.
McMahonFocusonX-rayDiffraction352H.
N.
Chapman>>Reportp.
379AHotterGreenhouse353M.
HuberTECHNICALCOMMENTABSTRACTSMICROBIOLOGYCommenton"A3-Hydroxypropionate/3424-HydroxybutyrateAutotrophicCarbonDioxideAssimilationPathwayinArchaea"T.
J.
G.
EttemaandS.
G.
E.
Anderssonfulltextatwww.
sciencemag.
org/cgi/content/full/321/5887/342bResponsetoCommenton"A3-Hydroxypropionate/4-HydroxybutyrateAutotrophicCarbonDioxideAssimilationPathwayinArchaea"I.
A.
Berg,D.
Kockelkorn,W.
Buckel,G.
Fuchsfulltextatwww.
sciencemag.
org/cgi/content/full/321/5887/342cBREVIAOCEANSCIENCEIceScourDisturbanceinAntarcticWaters371D.
A.
Smaleetal.
IcebergshaveincreasinglyscouredthecoastlinesalongtheWestAntarcticPeninsulaasitsiceshelvesandglaciershavewaned,affectingbenthicmarinecommunities.
RESEARCHARTICLENEUROSCIENCEIdentificationofSLEEPLESS,aSleep-PromotingFactor372K.
Kohetal.
AsearchforgeneticmodulatorsofsleepinDrosophilaidentifiedageneencodingabrainproteinthatislikelysecretedandisrequiredforrecoveryfromsleepdeprivation.
>>Newsstoryp.
334REPORTSASTRONOMYPropertiesofGamma-RayBurstProgenitorStars376P.
Kumar,R.
Narayan,J.
L.
JohnsonAnalysisofthex-rayafterglowofintensegamma-rayburstsshowsthattheburstsresultfromconsumptionoftheouterpartofadensestaranddefinethestar'srotationrate.
347&417PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008309CONTENTSCONTENTScontinued>>REPORTSCONTINUED.
.
.
APPLIEDPHYSICSHigh-ResolutionScanningX-rayDiffractionMicroscopy379P.
Thibaultetal.
Analysisofdifferencesindiffractionpatternsateachpointalonganx-rayscanofamaterialallowsimagingofaburiedstructurewitharesolutionof50nanometers.
>>Perspectivep.
352MATERIALSSCIENCEObservationsofIntergranularStressCorrosion382CrackinginaGrain-MappedPolycrystalA.
Kingetal.
Tomographicimagingrevealsthatsomegrainboundariesinstainlesssteelareresistanttostresscorrosioncracking,whichleadstosuddenbrittlefailure.
>>Perspectivep.
349MATERIALSSCIENCEMeasurementoftheElasticPropertiesand385IntrinsicStrengthofMonolayerGrapheneC.
Lee,X.
Wei,J.
W.
Kysar,J.
HoneMeasurementsoftheelasticpropertiesofgrapheneagreewithcalculationsforadefect-freematerialandshowthatitisindeedstrongerthanothermaterials.
CHEMISTRYMeasurementoftheDistributionofSite388EnhancementsinSurface-EnhancedRamanScatteringY.
Fang,N.
-H.
Seong,D.
D.
DlottThedistributionofelectricfield–enhancingsitesonananostructuredsubstrateismeasuredbyusingtheenhancedfieldtodamagethosesites.
CLIMATECHANGEPatagonianGlacierResponseDuringtheLate392Glacial–HoloceneTransitionR.
P.
AckertJr.
etal.
DatingofaglacialmoraineinsouthernPatagoniaimpliesthatincreasedprecipitationcausedglaciergrowthafteraperiodofNorthernHemispherecooling11,000yearsago.
>>Perspectivep.
348SOCIOLOGYElectronicPublicationandtheNarrowingof395ScienceandScholarshipJ.
A.
EvansAsjournalsbecomeavailableelectronically,scientistsandscholarshavemorearticlesattheirfingertipsbutciterelativelyfewer,andthesetendtobemorerecent.
>>Newsstoryp.
329EVOLUTIONTheEvolutionandDistributionofSpeciesBodySize399A.
ClausetandD.
H.
ErwinAmodelofevolutionarybody-sizechangesthataccountsforphysicalconstraintsandextinctionriskreproducesthesizedistributionoflandmammalsfromtheQuaternary.
CELLBIOLOGYFour-jointedIsaGolgiKinaseThatPhosphorylates401aSubsetofCadherinDomainsH.
O.
Ishikawaetal.
AnewlydescribedtypeofproteinkinasefoundintheGolgiphosphorylatessignalingproteinsonaminoacidsthataredestinedtobewithinextracellulardomains.
352&379CELLBIOLOGYSignal-MediatedDynamicRetentionof404GlycosyltransferasesintheGolgiL.
Tu,W.
C.
S.
Tai,L.
Chen,D.
K.
BanfieldGlycosyltransferaseenzymesstayintheGolgiinthefaceofcontinuingmembranetrafficbecauseareceptorlinkstheircytoplasmictailstoarecyclingcoatedvesicle.
IMMUNOLOGYAnomalousType17ResponsetoViralInfectionby408CD8+TCellsLackingT-betandEomesoderminA.
M.
Intlekoferetal.
TwotranscriptionfactorscooperatetoensurethecorrectfunctioningofCD8+Tcellsduringtheresponsetoinfection.
CELLSIGNALINGRiboswitchesinEubacteriaSensetheSecond411MessengerCyclicDi-GMPN.
Sudarsanetal.
Thebacterialsecondmessengercyclicdi–guanosinemonophosphatecontrolsawidevarietyofcellularfunctionsbyactingonariboswitchmotifinnumerousmessengerRNAs.
NEUROSCIENCEBottom-UpDependentGatingofFrontalSignalsin414EarlyVisualCortexL.
B.
Ekstrometal.
Higherbraincenterscanmodulateactivityinthecorticalregionsthatdirectlyreceivevisualinput,butonlywhenavisualstimulusispresent.
NEUROSCIENCEEvolutionaryOriginsforSocialVocalizationina417VertebrateHindbrain–SpinalCompartmentA.
H.
Bass,E.
H.
Gilland,R.
BakerTheconservedneuralcircuitryforvocalcommunicationinfishandothertetrapodssuggeststhatthisfunctionmayhaveoriginatedpriortotheevolutionofbonyvertebrates.
>>Perspectivep.
347NEUROSCIENCEOrbitofrontalDysfunctioninPatientswith421Obsessive-CompulsiveDisorderandTheirUnaffectedRelativesS.
R.
Chamberlainetal.
Theabnormallylowactivationinthefrontalcortexofindividualswithobsessivecompulsivedisorderandtheircloserelativesmayconferariskforthedisease.
SCIENCE(ISSN0036-8075)ispublishedweeklyonFriday,exceptthelastweekinDecember,bytheAmericanAssociationfortheAdvancementofScience,1200NewYorkAvenue,NW,Washington,DC20005.
PeriodicalsMailpostage(publicationNo.
484460)paidatWashington,DC,andadditionalmailingoffices.
Copyright2008bytheAmericanAssociationfortheAdvancementofScience.
ThetitleSCIENCEisaregisteredtrademarkoftheAAAS.
Domesticindividualmembershipandsubscription(51issues):$144($74allocatedtosubscription).
Domesticinstitutionalsubscription(51issues):$770;Foreignpostageextra:Mexico,Caribbean(surfacemail)$55;othercountries(airassistdelivery)$85.
Firstclass,airmail,student,andemeritusratesonrequest.
CanadianrateswithGSTavailableuponrequest,GST#125488122.
PublicationsMailAgreementNumber1069624.
PrintedintheU.
S.
A.
Changeofaddress:Allow4weeks,givingoldandnewaddressesand8-digitaccountnumber.
Postmaster:SendchangeofaddresstoAAAS,P.
O.
Box96178,Washington,DC20090–6178.
Single-copysales:$10.
00currentissue,$15.
00backissueprepaidincludessurfacepostage;bulkratesonrequest.
AuthorizationtophotocopymaterialforinternalorpersonaluseundercircumstancesnotfallingwithinthefairuseprovisionsoftheCopyrightActisgrantedbyAAAStolibrariesandotherusersregisteredwiththeCopyrightClearanceCenter(CCC)TransactionalReportingService,providedthat$20.
00perarticleispaiddirectlytoCCC,222RosewoodDrive,Danvers,MA01923.
TheidentificationcodeforScienceis0036-8075.
ScienceisindexedintheReader'sGuidetoPeriodicalLiteratureandinseveralspecializedindexes.
SCIENCE(ISSN0036-8075)ispublishedweeklyonFriday,exceptthelastweekinDecember,bytheAmericanAssociationfortheAdvancementofScience,1200NewYorkAvenue,NW,Washington,DC20005.
PeriodicalsMailpostage(publicationNo.
484460)paidatWashington,DC,andadditionalmailingoffices.
Copyright2008bytheAmericanAssociationfortheAdvancementofScience.
ThetitleSCIENCEisaregisteredtrademarkoftheAAAS.
Domesticindividualmembershipandsubscription(51issues):$144($74allocatedtosubscription).
Domesticinstitutionalsubscription(51issues):$770;Foreignpostageextra:Mexico,Caribbean(surfacemail)$55;othercountries(airassistdelivery)$85.
Firstclass,airmail,student,andemeritusratesonrequest.
CanadianrateswithGSTavailableuponrequest,GST#125488122.
PublicationsMailAgreementNumber1069624.
PrintedintheU.
S.
A.
Changeofaddress:Allow4weeks,givingoldandnewaddressesand8-digitaccountnumber.
Postmaster:SendchangeofaddresstoAAAS,P.
O.
Box96178,Washington,DC20090–6178.
Single-copysales:$10.
00currentissue,$15.
00backissueprepaidincludessurfacepostage;bulkratesonrequest.
AuthorizationtophotocopymaterialforinternalorpersonaluseundercircumstancesnotfallingwithinthefairuseprovisionsoftheCopyrightActisgrantedbyAAAStolibrariesandotherusersregisteredwiththeCopyrightClearanceCenter(CCC)TransactionalReportingService,providedthat$20.
00perarticleispaiddirectlytoCCC,222RosewoodDrive,Danvers,MA01923.
TheidentificationcodeforScienceis0036-8075.
ScienceisindexedintheReader'sGuidetoPeriodicalLiteratureandinseveralspecializedindexes.
PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008311CREDITS:(SCIENCENOW)MENNAJONES;(SCIENCECAREERS)NSF/WILLIAMA.
MITCHELL;(SCIENCESIGNALING)PHOTOTAKE,INC.
/ALAMYONLINESCIENCESIGNALINGwww.
sciencesignaling.
orgTHESIGNALTRANSDUCTIONKNOWLEDGEENVIRONMENTREVIEW:Host-DirectedDrugTargetingofFactorsHijackedbyPathogensA.
SchwegmannandF.
BrombacherAnewdrugdiscoveryparadigmfocusesonidentifyingandtargetingcellularelementsofthehostthatareexploitedbypathogens.
GLOSSARYFindoutwhatDILP,HRE,andOGTmeanintheworldofcellsignaling.
EVENTSCheckoutthemorethan50cellsignaling–relatedmeetingshappeninginthesecondhalfof2008.
SCIENCENOWwww.
sciencenow.
orgHIGHLIGHTSFROMOURDAILYNEWSCOVERAGEToughTimesfortheTazResearchersdebatetheevolutionaryimpactofadeadlycancerinTasmaniandevils.
AnswertoCarbonEmissionsMayLieUndertheSeaResearchersproposeinjectinggreenhousegasnearvolcanicrockontheoceanbottom.
"BabyBoom"inaStellarNurseryAstronomersdiscoveranancientgalacticstarfactoryonoverdrive.
SCIENCECAREERSwww.
sciencecareers.
org/career_developmentFREECAREERRESOURCESFORSCIENTISTSDoYouWannaBeaVAPL.
MalisheskiAvisitingassistantprofessorpositioncanbeastepforwardonsomecareerpaths.
ToolingUp:ReviewYourCareerD.
JensenItmaybetimetoshakethingsupwithacareerreview.
DesigningfortheNextQuakeA.
SainiEarthquakeengineersstudyhowtoavoidseismicdestruction.
ScienceCareersSeeksBloggersJ.
AustinWearelookingforafewpeoplewithinterestingthingstosayabouttheircareersinscience.
Engineeringtominimizeearthquakedamage.
Separateindividualorinstitutionalsubscriptionstotheseproductsmayberequiredforfull-textaccess.
www.
sciencemag.
orgDownloadthe18JulySciencePodcasttohearaboutpathogenicfungi,resistancegenesinnaturalenvironments,extremelymultidrug-resistantbacteria,andmore.
>>DrugResistancesectionp.
355SCIENCEPODCASTwww.
sciencemag.
org/multimedia/podcastFREEWEEKLYSHOWListeria,ahumanpathogen.
Devildestroyer.
PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfrom321(5887)(5887),313-423.
321ScienceARTICLETOOLShttp://science.
sciencemag.
org/content/321/5887PERMISSIONShttp://www.
sciencemag.
org/help/reprints-and-permissionsTermsofServiceUseofthisarticleissubjecttotheisaregisteredtrademarkofAAAS.
ScienceScience,1200NewYorkAvenueNW,Washington,DC20005.
Thetitle(printISSN0036-8075;onlineISSN1095-9203)ispublishedbytheAmericanAssociationfortheAdvancementofScienceScience.
NoclaimtooriginalU.
S.
GovernmentWorks.
Copyright2008TheAuthors,somerightsreserved;exclusivelicenseeAmericanAssociationfortheAdvancementofonMarch8,2021http://science.
sciencemag.
org/Downloadedfrom
311305CONTENTSCONTENTScontinued>>DEPARTMENTS311ScienceOnline313ThisWeekinScience318Editors'Choice320ContactScience321RandomSamples323Newsmakers423NewProducts424ScienceCareersCOVERAnartist'sconceptionoftheantibioticpenicillinandsomeofthebacteriathathavedevelopedresistancetovariousantibiotics.
Aspecialsectionbeginningonpage355explorestheriseandspreadofso-calledbadbugsandpossibleinterventions.
Illustration:ChrisBickel/ScienceEDITORIAL317EngagingRussianScientistsbyGlennSchweitzer355NEWSOFTHEWEEKBushTakesaFinalSwipe,andSalute,atCO2324EmissionCurbsOldSamplesTripUpTokyoTeam324NewPolicyTriestoEaseSecurityRestrictions325StalledTrialforAutismHighlightsDilemmaof326AlternativeTreatmentsCaribbeanMegaeruptionsDroveaGlobalOceanCrisis327SCIENCESCOPE327TwoU.
S.
LabsVieforLong-DelayedExotic328NucleiSourceSurveyFindsCitationsGrowingNarrowerasJournals329MoveOnline>>Reportp.
395NEWSFOCUSReinventingRicetoFeedtheWorld330SowingtheSeedsofExpertiseSimpleSleepers334>>ResearchArticlep.
372Acoustics'08Meeting338SoundScienceMapsVenetianCanalsandPeruvianRuinsUltrasoundUsesinMedicineHeatUpListeningtoDistantIceCrackSnapshotsFromtheMeetingVolume321,Issue5887INTRODUCTIONDeadlyDefiance355NEWSTheBacteriaFightBack356CollateralDamage:TheRiseofResistantC.
difficileTrenchWarfareinaBattleWithTB362Anti-TBDrugs:AndThenThereWereNonePERSPECTIVESAntibioticsandAntibioticResistanceGenesin365NaturalEnvironmentsJ.
L.
MartínezOutwittingMultidrugResistancetoAntifungals367B.
C.
MonkandA.
GoffeauSPECIALSECTIONDrugResistancewww.
sciencemag.
orgSCIENCEVOL32118JULY2008330PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008307CONTENTScontinued>>SCIENCEEXPRESSwww.
sciencexpress.
orgPLANTSCIENCEPlantImmunityRequiresConformationalChangesofNPR1viaS-NitrosylationandThioredoxinsY.
Tadaetal.
Afterapathogeninvadesaplant,aprotein,usuallykeptinamultimericstatebyS-nitrosylation,isdissociatedbythioredoxin,freeingthemonomersfordefenseresponses.
10.
1126/science.
1156970GEOCHEMISTRYFerruginousConditionsDominatedLaterNeoproterozoicDeep-WaterChemistryD.
E.
Canfieldetal.
Lowsulfurinputcausedthedeeperoceantobecomeanoxicandrichinferrousiron750millionyearsago,areversalfromthemoreoxidizingconditionsoftheprevious1billionyears.
10.
1126/science.
1154499CELLBIOLOGYEssentialCytoplasmicTranslocationofaCytokineReceptor–AssembledSignalingComplexA.
Matsuzawaetal.
Degradationofonememberofaproteincomplexthatformswhenacytokinereceptorisactivatedcausesthecomplextomovetothecytoplasm,triggeringthedownstreampathway.
10.
1126/science.
1157340CONTENTSLETTERSTheCostofConservationM.
Bodeetal.
340ConservationwithCaveatsB.
W.
T.
CoetzeeResponseC.
Kremenetal.
CORRECTIONSANDCLARIFICATIONS342BOOKSETAL.
Insomniac343G.
Greene,reviewedbyM.
L.
PerlisRe-EngineeringPhilosophyforLimitedBeings344PiecewiseApproximationstoRealityW.
C.
Wimsatt,reviewedbyK.
SterelnyPOLICYFORUMAssistedColonizationandRapidClimateChange345O.
Hoegh-Guldbergetal.
PERSPECTIVESVertebrateVocalizations347D.
MargoliashandM.
E.
Hale>>Reportp.
417WastheYoungerDryasGlobal348T.
V.
LowellandM.
A.
Kelly>>Reportp.
392TrackingCorrosionCracking349A.
Stierle>>Reportp.
382GraspingLimbPatterning350C.
J.
TabinandA.
P.
McMahonFocusonX-rayDiffraction352H.
N.
Chapman>>Reportp.
379AHotterGreenhouse353M.
HuberTECHNICALCOMMENTABSTRACTSMICROBIOLOGYCommenton"A3-Hydroxypropionate/3424-HydroxybutyrateAutotrophicCarbonDioxideAssimilationPathwayinArchaea"T.
J.
G.
EttemaandS.
G.
E.
Anderssonfulltextatwww.
sciencemag.
org/cgi/content/full/321/5887/342bResponsetoCommenton"A3-Hydroxypropionate/4-HydroxybutyrateAutotrophicCarbonDioxideAssimilationPathwayinArchaea"I.
A.
Berg,D.
Kockelkorn,W.
Buckel,G.
Fuchsfulltextatwww.
sciencemag.
org/cgi/content/full/321/5887/342cBREVIAOCEANSCIENCEIceScourDisturbanceinAntarcticWaters371D.
A.
Smaleetal.
IcebergshaveincreasinglyscouredthecoastlinesalongtheWestAntarcticPeninsulaasitsiceshelvesandglaciershavewaned,affectingbenthicmarinecommunities.
RESEARCHARTICLENEUROSCIENCEIdentificationofSLEEPLESS,aSleep-PromotingFactor372K.
Kohetal.
AsearchforgeneticmodulatorsofsleepinDrosophilaidentifiedageneencodingabrainproteinthatislikelysecretedandisrequiredforrecoveryfromsleepdeprivation.
>>Newsstoryp.
334REPORTSASTRONOMYPropertiesofGamma-RayBurstProgenitorStars376P.
Kumar,R.
Narayan,J.
L.
JohnsonAnalysisofthex-rayafterglowofintensegamma-rayburstsshowsthattheburstsresultfromconsumptionoftheouterpartofadensestaranddefinethestar'srotationrate.
347&417PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008309CONTENTSCONTENTScontinued>>REPORTSCONTINUED.
.
.
APPLIEDPHYSICSHigh-ResolutionScanningX-rayDiffractionMicroscopy379P.
Thibaultetal.
Analysisofdifferencesindiffractionpatternsateachpointalonganx-rayscanofamaterialallowsimagingofaburiedstructurewitharesolutionof50nanometers.
>>Perspectivep.
352MATERIALSSCIENCEObservationsofIntergranularStressCorrosion382CrackinginaGrain-MappedPolycrystalA.
Kingetal.
Tomographicimagingrevealsthatsomegrainboundariesinstainlesssteelareresistanttostresscorrosioncracking,whichleadstosuddenbrittlefailure.
>>Perspectivep.
349MATERIALSSCIENCEMeasurementoftheElasticPropertiesand385IntrinsicStrengthofMonolayerGrapheneC.
Lee,X.
Wei,J.
W.
Kysar,J.
HoneMeasurementsoftheelasticpropertiesofgrapheneagreewithcalculationsforadefect-freematerialandshowthatitisindeedstrongerthanothermaterials.
CHEMISTRYMeasurementoftheDistributionofSite388EnhancementsinSurface-EnhancedRamanScatteringY.
Fang,N.
-H.
Seong,D.
D.
DlottThedistributionofelectricfield–enhancingsitesonananostructuredsubstrateismeasuredbyusingtheenhancedfieldtodamagethosesites.
CLIMATECHANGEPatagonianGlacierResponseDuringtheLate392Glacial–HoloceneTransitionR.
P.
AckertJr.
etal.
DatingofaglacialmoraineinsouthernPatagoniaimpliesthatincreasedprecipitationcausedglaciergrowthafteraperiodofNorthernHemispherecooling11,000yearsago.
>>Perspectivep.
348SOCIOLOGYElectronicPublicationandtheNarrowingof395ScienceandScholarshipJ.
A.
EvansAsjournalsbecomeavailableelectronically,scientistsandscholarshavemorearticlesattheirfingertipsbutciterelativelyfewer,andthesetendtobemorerecent.
>>Newsstoryp.
329EVOLUTIONTheEvolutionandDistributionofSpeciesBodySize399A.
ClausetandD.
H.
ErwinAmodelofevolutionarybody-sizechangesthataccountsforphysicalconstraintsandextinctionriskreproducesthesizedistributionoflandmammalsfromtheQuaternary.
CELLBIOLOGYFour-jointedIsaGolgiKinaseThatPhosphorylates401aSubsetofCadherinDomainsH.
O.
Ishikawaetal.
AnewlydescribedtypeofproteinkinasefoundintheGolgiphosphorylatessignalingproteinsonaminoacidsthataredestinedtobewithinextracellulardomains.
352&379CELLBIOLOGYSignal-MediatedDynamicRetentionof404GlycosyltransferasesintheGolgiL.
Tu,W.
C.
S.
Tai,L.
Chen,D.
K.
BanfieldGlycosyltransferaseenzymesstayintheGolgiinthefaceofcontinuingmembranetrafficbecauseareceptorlinkstheircytoplasmictailstoarecyclingcoatedvesicle.
IMMUNOLOGYAnomalousType17ResponsetoViralInfectionby408CD8+TCellsLackingT-betandEomesoderminA.
M.
Intlekoferetal.
TwotranscriptionfactorscooperatetoensurethecorrectfunctioningofCD8+Tcellsduringtheresponsetoinfection.
CELLSIGNALINGRiboswitchesinEubacteriaSensetheSecond411MessengerCyclicDi-GMPN.
Sudarsanetal.
Thebacterialsecondmessengercyclicdi–guanosinemonophosphatecontrolsawidevarietyofcellularfunctionsbyactingonariboswitchmotifinnumerousmessengerRNAs.
NEUROSCIENCEBottom-UpDependentGatingofFrontalSignalsin414EarlyVisualCortexL.
B.
Ekstrometal.
Higherbraincenterscanmodulateactivityinthecorticalregionsthatdirectlyreceivevisualinput,butonlywhenavisualstimulusispresent.
NEUROSCIENCEEvolutionaryOriginsforSocialVocalizationina417VertebrateHindbrain–SpinalCompartmentA.
H.
Bass,E.
H.
Gilland,R.
BakerTheconservedneuralcircuitryforvocalcommunicationinfishandothertetrapodssuggeststhatthisfunctionmayhaveoriginatedpriortotheevolutionofbonyvertebrates.
>>Perspectivep.
347NEUROSCIENCEOrbitofrontalDysfunctioninPatientswith421Obsessive-CompulsiveDisorderandTheirUnaffectedRelativesS.
R.
Chamberlainetal.
Theabnormallylowactivationinthefrontalcortexofindividualswithobsessivecompulsivedisorderandtheircloserelativesmayconferariskforthedisease.
SCIENCE(ISSN0036-8075)ispublishedweeklyonFriday,exceptthelastweekinDecember,bytheAmericanAssociationfortheAdvancementofScience,1200NewYorkAvenue,NW,Washington,DC20005.
PeriodicalsMailpostage(publicationNo.
484460)paidatWashington,DC,andadditionalmailingoffices.
Copyright2008bytheAmericanAssociationfortheAdvancementofScience.
ThetitleSCIENCEisaregisteredtrademarkoftheAAAS.
Domesticindividualmembershipandsubscription(51issues):$144($74allocatedtosubscription).
Domesticinstitutionalsubscription(51issues):$770;Foreignpostageextra:Mexico,Caribbean(surfacemail)$55;othercountries(airassistdelivery)$85.
Firstclass,airmail,student,andemeritusratesonrequest.
CanadianrateswithGSTavailableuponrequest,GST#125488122.
PublicationsMailAgreementNumber1069624.
PrintedintheU.
S.
A.
Changeofaddress:Allow4weeks,givingoldandnewaddressesand8-digitaccountnumber.
Postmaster:SendchangeofaddresstoAAAS,P.
O.
Box96178,Washington,DC20090–6178.
Single-copysales:$10.
00currentissue,$15.
00backissueprepaidincludessurfacepostage;bulkratesonrequest.
AuthorizationtophotocopymaterialforinternalorpersonaluseundercircumstancesnotfallingwithinthefairuseprovisionsoftheCopyrightActisgrantedbyAAAStolibrariesandotherusersregisteredwiththeCopyrightClearanceCenter(CCC)TransactionalReportingService,providedthat$20.
00perarticleispaiddirectlytoCCC,222RosewoodDrive,Danvers,MA01923.
TheidentificationcodeforScienceis0036-8075.
ScienceisindexedintheReader'sGuidetoPeriodicalLiteratureandinseveralspecializedindexes.
SCIENCE(ISSN0036-8075)ispublishedweeklyonFriday,exceptthelastweekinDecember,bytheAmericanAssociationfortheAdvancementofScience,1200NewYorkAvenue,NW,Washington,DC20005.
PeriodicalsMailpostage(publicationNo.
484460)paidatWashington,DC,andadditionalmailingoffices.
Copyright2008bytheAmericanAssociationfortheAdvancementofScience.
ThetitleSCIENCEisaregisteredtrademarkoftheAAAS.
Domesticindividualmembershipandsubscription(51issues):$144($74allocatedtosubscription).
Domesticinstitutionalsubscription(51issues):$770;Foreignpostageextra:Mexico,Caribbean(surfacemail)$55;othercountries(airassistdelivery)$85.
Firstclass,airmail,student,andemeritusratesonrequest.
CanadianrateswithGSTavailableuponrequest,GST#125488122.
PublicationsMailAgreementNumber1069624.
PrintedintheU.
S.
A.
Changeofaddress:Allow4weeks,givingoldandnewaddressesand8-digitaccountnumber.
Postmaster:SendchangeofaddresstoAAAS,P.
O.
Box96178,Washington,DC20090–6178.
Single-copysales:$10.
00currentissue,$15.
00backissueprepaidincludessurfacepostage;bulkratesonrequest.
AuthorizationtophotocopymaterialforinternalorpersonaluseundercircumstancesnotfallingwithinthefairuseprovisionsoftheCopyrightActisgrantedbyAAAStolibrariesandotherusersregisteredwiththeCopyrightClearanceCenter(CCC)TransactionalReportingService,providedthat$20.
00perarticleispaiddirectlytoCCC,222RosewoodDrive,Danvers,MA01923.
TheidentificationcodeforScienceis0036-8075.
ScienceisindexedintheReader'sGuidetoPeriodicalLiteratureandinseveralspecializedindexes.
PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008311CREDITS:(SCIENCENOW)MENNAJONES;(SCIENCECAREERS)NSF/WILLIAMA.
MITCHELL;(SCIENCESIGNALING)PHOTOTAKE,INC.
/ALAMYONLINESCIENCESIGNALINGwww.
sciencesignaling.
orgTHESIGNALTRANSDUCTIONKNOWLEDGEENVIRONMENTREVIEW:Host-DirectedDrugTargetingofFactorsHijackedbyPathogensA.
SchwegmannandF.
BrombacherAnewdrugdiscoveryparadigmfocusesonidentifyingandtargetingcellularelementsofthehostthatareexploitedbypathogens.
GLOSSARYFindoutwhatDILP,HRE,andOGTmeanintheworldofcellsignaling.
EVENTSCheckoutthemorethan50cellsignaling–relatedmeetingshappeninginthesecondhalfof2008.
SCIENCENOWwww.
sciencenow.
orgHIGHLIGHTSFROMOURDAILYNEWSCOVERAGEToughTimesfortheTazResearchersdebatetheevolutionaryimpactofadeadlycancerinTasmaniandevils.
AnswertoCarbonEmissionsMayLieUndertheSeaResearchersproposeinjectinggreenhousegasnearvolcanicrockontheoceanbottom.
"BabyBoom"inaStellarNurseryAstronomersdiscoveranancientgalacticstarfactoryonoverdrive.
SCIENCECAREERSwww.
sciencecareers.
org/career_developmentFREECAREERRESOURCESFORSCIENTISTSDoYouWannaBeaVAPL.
MalisheskiAvisitingassistantprofessorpositioncanbeastepforwardonsomecareerpaths.
ToolingUp:ReviewYourCareerD.
JensenItmaybetimetoshakethingsupwithacareerreview.
DesigningfortheNextQuakeA.
SainiEarthquakeengineersstudyhowtoavoidseismicdestruction.
ScienceCareersSeeksBloggersJ.
AustinWearelookingforafewpeoplewithinterestingthingstosayabouttheircareersinscience.
Engineeringtominimizeearthquakedamage.
Separateindividualorinstitutionalsubscriptionstotheseproductsmayberequiredforfull-textaccess.
www.
sciencemag.
orgDownloadthe18JulySciencePodcasttohearaboutpathogenicfungi,resistancegenesinnaturalenvironments,extremelymultidrug-resistantbacteria,andmore.
>>DrugResistancesectionp.
355SCIENCEPODCASTwww.
sciencemag.
org/multimedia/podcastFREEWEEKLYSHOWListeria,ahumanpathogen.
Devildestroyer.
PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfrom321(5887)(5887),313-423.
321ScienceARTICLETOOLShttp://science.
sciencemag.
org/content/321/5887PERMISSIONShttp://www.
sciencemag.
org/help/reprints-and-permissionsTermsofServiceUseofthisarticleissubjecttotheisaregisteredtrademarkofAAAS.
ScienceScience,1200NewYorkAvenueNW,Washington,DC20005.
Thetitle(printISSN0036-8075;onlineISSN1095-9203)ispublishedbytheAmericanAssociationfortheAdvancementofScienceScience.
NoclaimtooriginalU.
S.
GovernmentWorks.
Copyright2008TheAuthors,somerightsreserved;exclusivelicenseeAmericanAssociationfortheAdvancementofonMarch8,2021http://science.
sciencemag.
org/Downloadedfrom
- Buckelinsomniac相关文档
- readinginsomniac
- 宰制insomniac
- "赠送全新西数或希捷硬盘,三年保修,拷满高品质无损APE格式音乐!",,
- revelationinsomniac
- incidenceinsomniac
- convergeinsomniac
buyvm迈阿密机房VPS国内首发测评，高性能平台：AMD Ryzen 9 3900x+DDR4+NVMe+1Gbps带宽不限流量
buyvm的第四个数据中心上线了，位于美国东南沿海的迈阿密市。迈阿密的VPS依旧和buyvm其他机房的一样，KVM虚拟，Ryzen 9 3900x、DDR4、NVMe、1Gbps带宽、不限流量。目前还没有看见buyvm上架迈阿密的block storage，估计不久也会有的。 官方网站：https://my.frantech.ca/cart.php?gid=48 加密货币、信用卡、PayPal、...
Dynadot COM特价新注册48元
想必我们有一些朋友应该陆续收到国内和国外的域名注册商关于域名即将涨价的信息。大概的意思是说从9月1日开始，.COM域名会涨价一点点，大约需要单个9.99美元左右一个。其实对于大部分用户来说也没多大的影响，毕竟如今什么都涨价，域名涨一点点也不要紧。如果是域名较多的话，确实增加续费成本和注册成本。今天整理看到Dynadot有发布新的八月份域名优惠活动，.COM首年注册依然是仅需48元，本次优惠活动截止...
创梦网络-江苏宿迁BGP云服务器100G高防资源,全程ceph集群存储,安全可靠,数据有保证,防护真实,现在购买7折促销,续费同价！
官方网站：点击访问创梦网络宿迁BGP高防活动方案：机房CPU内存硬盘带宽IP防护流量原价活动价开通方式宿迁BGP4vCPU4G40G+50G20Mbps1个100G不限流量299元/月 209.3元/月点击自助购买成都电信优化线路8vCPU8G40G+50G20Mbps1个100G不限流量399元/月 279.3元/月点击自助购买成都电信优化线路8vCPU16G40G+50G2...
insomniac为你推荐
-
怎么查询商标怎样查询商标有没有被注册方法有哪些？安徽汽车网中国汽车十大品牌103838.com39052.com这电影网支持网页观看吗？www.mywife.ccmywife哪部最经典javbibi日文里的bibi是什么意思lcoc.toptop weenie 是什么？www.36ybyb.com有什么网址有很多动漫可以看的啊?我知道的有www.hnnn.net.很多好看的！但是．．．都看了！我想看些别人哦！还有优酷网也不错．．．baqizi.cc誰知道，最近有什麼好看的電視劇机器蜘蛛有谁知道猎人的机械蜘蛛在哪捉的www.1diaocha.com手机网赚是真的吗