Buckelinsomniac
insomniac 时间:2021-03-17 阅读:()
>>Forrelatedonlinecontent,seetheSciencePodcast,p.
311305CONTENTSCONTENTScontinued>>DEPARTMENTS311ScienceOnline313ThisWeekinScience318Editors'Choice320ContactScience321RandomSamples323Newsmakers423NewProducts424ScienceCareersCOVERAnartist'sconceptionoftheantibioticpenicillinandsomeofthebacteriathathavedevelopedresistancetovariousantibiotics.
Aspecialsectionbeginningonpage355explorestheriseandspreadofso-calledbadbugsandpossibleinterventions.
Illustration:ChrisBickel/ScienceEDITORIAL317EngagingRussianScientistsbyGlennSchweitzer355NEWSOFTHEWEEKBushTakesaFinalSwipe,andSalute,atCO2324EmissionCurbsOldSamplesTripUpTokyoTeam324NewPolicyTriestoEaseSecurityRestrictions325StalledTrialforAutismHighlightsDilemmaof326AlternativeTreatmentsCaribbeanMegaeruptionsDroveaGlobalOceanCrisis327SCIENCESCOPE327TwoU.
S.
LabsVieforLong-DelayedExotic328NucleiSourceSurveyFindsCitationsGrowingNarrowerasJournals329MoveOnline>>Reportp.
395NEWSFOCUSReinventingRicetoFeedtheWorld330SowingtheSeedsofExpertiseSimpleSleepers334>>ResearchArticlep.
372Acoustics'08Meeting338SoundScienceMapsVenetianCanalsandPeruvianRuinsUltrasoundUsesinMedicineHeatUpListeningtoDistantIceCrackSnapshotsFromtheMeetingVolume321,Issue5887INTRODUCTIONDeadlyDefiance355NEWSTheBacteriaFightBack356CollateralDamage:TheRiseofResistantC.
difficileTrenchWarfareinaBattleWithTB362Anti-TBDrugs:AndThenThereWereNonePERSPECTIVESAntibioticsandAntibioticResistanceGenesin365NaturalEnvironmentsJ.
L.
MartínezOutwittingMultidrugResistancetoAntifungals367B.
C.
MonkandA.
GoffeauSPECIALSECTIONDrugResistancewww.
sciencemag.
orgSCIENCEVOL32118JULY2008330PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008307CONTENTScontinued>>SCIENCEEXPRESSwww.
sciencexpress.
orgPLANTSCIENCEPlantImmunityRequiresConformationalChangesofNPR1viaS-NitrosylationandThioredoxinsY.
Tadaetal.
Afterapathogeninvadesaplant,aprotein,usuallykeptinamultimericstatebyS-nitrosylation,isdissociatedbythioredoxin,freeingthemonomersfordefenseresponses.
10.
1126/science.
1156970GEOCHEMISTRYFerruginousConditionsDominatedLaterNeoproterozoicDeep-WaterChemistryD.
E.
Canfieldetal.
Lowsulfurinputcausedthedeeperoceantobecomeanoxicandrichinferrousiron750millionyearsago,areversalfromthemoreoxidizingconditionsoftheprevious1billionyears.
10.
1126/science.
1154499CELLBIOLOGYEssentialCytoplasmicTranslocationofaCytokineReceptor–AssembledSignalingComplexA.
Matsuzawaetal.
Degradationofonememberofaproteincomplexthatformswhenacytokinereceptorisactivatedcausesthecomplextomovetothecytoplasm,triggeringthedownstreampathway.
10.
1126/science.
1157340CONTENTSLETTERSTheCostofConservationM.
Bodeetal.
340ConservationwithCaveatsB.
W.
T.
CoetzeeResponseC.
Kremenetal.
CORRECTIONSANDCLARIFICATIONS342BOOKSETAL.
Insomniac343G.
Greene,reviewedbyM.
L.
PerlisRe-EngineeringPhilosophyforLimitedBeings344PiecewiseApproximationstoRealityW.
C.
Wimsatt,reviewedbyK.
SterelnyPOLICYFORUMAssistedColonizationandRapidClimateChange345O.
Hoegh-Guldbergetal.
PERSPECTIVESVertebrateVocalizations347D.
MargoliashandM.
E.
Hale>>Reportp.
417WastheYoungerDryasGlobal348T.
V.
LowellandM.
A.
Kelly>>Reportp.
392TrackingCorrosionCracking349A.
Stierle>>Reportp.
382GraspingLimbPatterning350C.
J.
TabinandA.
P.
McMahonFocusonX-rayDiffraction352H.
N.
Chapman>>Reportp.
379AHotterGreenhouse353M.
HuberTECHNICALCOMMENTABSTRACTSMICROBIOLOGYCommenton"A3-Hydroxypropionate/3424-HydroxybutyrateAutotrophicCarbonDioxideAssimilationPathwayinArchaea"T.
J.
G.
EttemaandS.
G.
E.
Anderssonfulltextatwww.
sciencemag.
org/cgi/content/full/321/5887/342bResponsetoCommenton"A3-Hydroxypropionate/4-HydroxybutyrateAutotrophicCarbonDioxideAssimilationPathwayinArchaea"I.
A.
Berg,D.
Kockelkorn,W.
Buckel,G.
Fuchsfulltextatwww.
sciencemag.
org/cgi/content/full/321/5887/342cBREVIAOCEANSCIENCEIceScourDisturbanceinAntarcticWaters371D.
A.
Smaleetal.
IcebergshaveincreasinglyscouredthecoastlinesalongtheWestAntarcticPeninsulaasitsiceshelvesandglaciershavewaned,affectingbenthicmarinecommunities.
RESEARCHARTICLENEUROSCIENCEIdentificationofSLEEPLESS,aSleep-PromotingFactor372K.
Kohetal.
AsearchforgeneticmodulatorsofsleepinDrosophilaidentifiedageneencodingabrainproteinthatislikelysecretedandisrequiredforrecoveryfromsleepdeprivation.
>>Newsstoryp.
334REPORTSASTRONOMYPropertiesofGamma-RayBurstProgenitorStars376P.
Kumar,R.
Narayan,J.
L.
JohnsonAnalysisofthex-rayafterglowofintensegamma-rayburstsshowsthattheburstsresultfromconsumptionoftheouterpartofadensestaranddefinethestar'srotationrate.
347&417PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008309CONTENTSCONTENTScontinued>>REPORTSCONTINUED.
.
.
APPLIEDPHYSICSHigh-ResolutionScanningX-rayDiffractionMicroscopy379P.
Thibaultetal.
Analysisofdifferencesindiffractionpatternsateachpointalonganx-rayscanofamaterialallowsimagingofaburiedstructurewitharesolutionof50nanometers.
>>Perspectivep.
352MATERIALSSCIENCEObservationsofIntergranularStressCorrosion382CrackinginaGrain-MappedPolycrystalA.
Kingetal.
Tomographicimagingrevealsthatsomegrainboundariesinstainlesssteelareresistanttostresscorrosioncracking,whichleadstosuddenbrittlefailure.
>>Perspectivep.
349MATERIALSSCIENCEMeasurementoftheElasticPropertiesand385IntrinsicStrengthofMonolayerGrapheneC.
Lee,X.
Wei,J.
W.
Kysar,J.
HoneMeasurementsoftheelasticpropertiesofgrapheneagreewithcalculationsforadefect-freematerialandshowthatitisindeedstrongerthanothermaterials.
CHEMISTRYMeasurementoftheDistributionofSite388EnhancementsinSurface-EnhancedRamanScatteringY.
Fang,N.
-H.
Seong,D.
D.
DlottThedistributionofelectricfield–enhancingsitesonananostructuredsubstrateismeasuredbyusingtheenhancedfieldtodamagethosesites.
CLIMATECHANGEPatagonianGlacierResponseDuringtheLate392Glacial–HoloceneTransitionR.
P.
AckertJr.
etal.
DatingofaglacialmoraineinsouthernPatagoniaimpliesthatincreasedprecipitationcausedglaciergrowthafteraperiodofNorthernHemispherecooling11,000yearsago.
>>Perspectivep.
348SOCIOLOGYElectronicPublicationandtheNarrowingof395ScienceandScholarshipJ.
A.
EvansAsjournalsbecomeavailableelectronically,scientistsandscholarshavemorearticlesattheirfingertipsbutciterelativelyfewer,andthesetendtobemorerecent.
>>Newsstoryp.
329EVOLUTIONTheEvolutionandDistributionofSpeciesBodySize399A.
ClausetandD.
H.
ErwinAmodelofevolutionarybody-sizechangesthataccountsforphysicalconstraintsandextinctionriskreproducesthesizedistributionoflandmammalsfromtheQuaternary.
CELLBIOLOGYFour-jointedIsaGolgiKinaseThatPhosphorylates401aSubsetofCadherinDomainsH.
O.
Ishikawaetal.
AnewlydescribedtypeofproteinkinasefoundintheGolgiphosphorylatessignalingproteinsonaminoacidsthataredestinedtobewithinextracellulardomains.
352&379CELLBIOLOGYSignal-MediatedDynamicRetentionof404GlycosyltransferasesintheGolgiL.
Tu,W.
C.
S.
Tai,L.
Chen,D.
K.
BanfieldGlycosyltransferaseenzymesstayintheGolgiinthefaceofcontinuingmembranetrafficbecauseareceptorlinkstheircytoplasmictailstoarecyclingcoatedvesicle.
IMMUNOLOGYAnomalousType17ResponsetoViralInfectionby408CD8+TCellsLackingT-betandEomesoderminA.
M.
Intlekoferetal.
TwotranscriptionfactorscooperatetoensurethecorrectfunctioningofCD8+Tcellsduringtheresponsetoinfection.
CELLSIGNALINGRiboswitchesinEubacteriaSensetheSecond411MessengerCyclicDi-GMPN.
Sudarsanetal.
Thebacterialsecondmessengercyclicdi–guanosinemonophosphatecontrolsawidevarietyofcellularfunctionsbyactingonariboswitchmotifinnumerousmessengerRNAs.
NEUROSCIENCEBottom-UpDependentGatingofFrontalSignalsin414EarlyVisualCortexL.
B.
Ekstrometal.
Higherbraincenterscanmodulateactivityinthecorticalregionsthatdirectlyreceivevisualinput,butonlywhenavisualstimulusispresent.
NEUROSCIENCEEvolutionaryOriginsforSocialVocalizationina417VertebrateHindbrain–SpinalCompartmentA.
H.
Bass,E.
H.
Gilland,R.
BakerTheconservedneuralcircuitryforvocalcommunicationinfishandothertetrapodssuggeststhatthisfunctionmayhaveoriginatedpriortotheevolutionofbonyvertebrates.
>>Perspectivep.
347NEUROSCIENCEOrbitofrontalDysfunctioninPatientswith421Obsessive-CompulsiveDisorderandTheirUnaffectedRelativesS.
R.
Chamberlainetal.
Theabnormallylowactivationinthefrontalcortexofindividualswithobsessivecompulsivedisorderandtheircloserelativesmayconferariskforthedisease.
SCIENCE(ISSN0036-8075)ispublishedweeklyonFriday,exceptthelastweekinDecember,bytheAmericanAssociationfortheAdvancementofScience,1200NewYorkAvenue,NW,Washington,DC20005.
PeriodicalsMailpostage(publicationNo.
484460)paidatWashington,DC,andadditionalmailingoffices.
Copyright2008bytheAmericanAssociationfortheAdvancementofScience.
ThetitleSCIENCEisaregisteredtrademarkoftheAAAS.
Domesticindividualmembershipandsubscription(51issues):$144($74allocatedtosubscription).
Domesticinstitutionalsubscription(51issues):$770;Foreignpostageextra:Mexico,Caribbean(surfacemail)$55;othercountries(airassistdelivery)$85.
Firstclass,airmail,student,andemeritusratesonrequest.
CanadianrateswithGSTavailableuponrequest,GST#125488122.
PublicationsMailAgreementNumber1069624.
PrintedintheU.
S.
A.
Changeofaddress:Allow4weeks,givingoldandnewaddressesand8-digitaccountnumber.
Postmaster:SendchangeofaddresstoAAAS,P.
O.
Box96178,Washington,DC20090–6178.
Single-copysales:$10.
00currentissue,$15.
00backissueprepaidincludessurfacepostage;bulkratesonrequest.
AuthorizationtophotocopymaterialforinternalorpersonaluseundercircumstancesnotfallingwithinthefairuseprovisionsoftheCopyrightActisgrantedbyAAAStolibrariesandotherusersregisteredwiththeCopyrightClearanceCenter(CCC)TransactionalReportingService,providedthat$20.
00perarticleispaiddirectlytoCCC,222RosewoodDrive,Danvers,MA01923.
TheidentificationcodeforScienceis0036-8075.
ScienceisindexedintheReader'sGuidetoPeriodicalLiteratureandinseveralspecializedindexes.
SCIENCE(ISSN0036-8075)ispublishedweeklyonFriday,exceptthelastweekinDecember,bytheAmericanAssociationfortheAdvancementofScience,1200NewYorkAvenue,NW,Washington,DC20005.
PeriodicalsMailpostage(publicationNo.
484460)paidatWashington,DC,andadditionalmailingoffices.
Copyright2008bytheAmericanAssociationfortheAdvancementofScience.
ThetitleSCIENCEisaregisteredtrademarkoftheAAAS.
Domesticindividualmembershipandsubscription(51issues):$144($74allocatedtosubscription).
Domesticinstitutionalsubscription(51issues):$770;Foreignpostageextra:Mexico,Caribbean(surfacemail)$55;othercountries(airassistdelivery)$85.
Firstclass,airmail,student,andemeritusratesonrequest.
CanadianrateswithGSTavailableuponrequest,GST#125488122.
PublicationsMailAgreementNumber1069624.
PrintedintheU.
S.
A.
Changeofaddress:Allow4weeks,givingoldandnewaddressesand8-digitaccountnumber.
Postmaster:SendchangeofaddresstoAAAS,P.
O.
Box96178,Washington,DC20090–6178.
Single-copysales:$10.
00currentissue,$15.
00backissueprepaidincludessurfacepostage;bulkratesonrequest.
AuthorizationtophotocopymaterialforinternalorpersonaluseundercircumstancesnotfallingwithinthefairuseprovisionsoftheCopyrightActisgrantedbyAAAStolibrariesandotherusersregisteredwiththeCopyrightClearanceCenter(CCC)TransactionalReportingService,providedthat$20.
00perarticleispaiddirectlytoCCC,222RosewoodDrive,Danvers,MA01923.
TheidentificationcodeforScienceis0036-8075.
ScienceisindexedintheReader'sGuidetoPeriodicalLiteratureandinseveralspecializedindexes.
PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008311CREDITS:(SCIENCENOW)MENNAJONES;(SCIENCECAREERS)NSF/WILLIAMA.
MITCHELL;(SCIENCESIGNALING)PHOTOTAKE,INC.
/ALAMYONLINESCIENCESIGNALINGwww.
sciencesignaling.
orgTHESIGNALTRANSDUCTIONKNOWLEDGEENVIRONMENTREVIEW:Host-DirectedDrugTargetingofFactorsHijackedbyPathogensA.
SchwegmannandF.
BrombacherAnewdrugdiscoveryparadigmfocusesonidentifyingandtargetingcellularelementsofthehostthatareexploitedbypathogens.
GLOSSARYFindoutwhatDILP,HRE,andOGTmeanintheworldofcellsignaling.
EVENTSCheckoutthemorethan50cellsignaling–relatedmeetingshappeninginthesecondhalfof2008.
SCIENCENOWwww.
sciencenow.
orgHIGHLIGHTSFROMOURDAILYNEWSCOVERAGEToughTimesfortheTazResearchersdebatetheevolutionaryimpactofadeadlycancerinTasmaniandevils.
AnswertoCarbonEmissionsMayLieUndertheSeaResearchersproposeinjectinggreenhousegasnearvolcanicrockontheoceanbottom.
"BabyBoom"inaStellarNurseryAstronomersdiscoveranancientgalacticstarfactoryonoverdrive.
SCIENCECAREERSwww.
sciencecareers.
org/career_developmentFREECAREERRESOURCESFORSCIENTISTSDoYouWannaBeaVAPL.
MalisheskiAvisitingassistantprofessorpositioncanbeastepforwardonsomecareerpaths.
ToolingUp:ReviewYourCareerD.
JensenItmaybetimetoshakethingsupwithacareerreview.
DesigningfortheNextQuakeA.
SainiEarthquakeengineersstudyhowtoavoidseismicdestruction.
ScienceCareersSeeksBloggersJ.
AustinWearelookingforafewpeoplewithinterestingthingstosayabouttheircareersinscience.
Engineeringtominimizeearthquakedamage.
Separateindividualorinstitutionalsubscriptionstotheseproductsmayberequiredforfull-textaccess.
www.
sciencemag.
orgDownloadthe18JulySciencePodcasttohearaboutpathogenicfungi,resistancegenesinnaturalenvironments,extremelymultidrug-resistantbacteria,andmore.
>>DrugResistancesectionp.
355SCIENCEPODCASTwww.
sciencemag.
org/multimedia/podcastFREEWEEKLYSHOWListeria,ahumanpathogen.
Devildestroyer.
PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfrom321(5887)(5887),313-423.
321ScienceARTICLETOOLShttp://science.
sciencemag.
org/content/321/5887PERMISSIONShttp://www.
sciencemag.
org/help/reprints-and-permissionsTermsofServiceUseofthisarticleissubjecttotheisaregisteredtrademarkofAAAS.
ScienceScience,1200NewYorkAvenueNW,Washington,DC20005.
Thetitle(printISSN0036-8075;onlineISSN1095-9203)ispublishedbytheAmericanAssociationfortheAdvancementofScienceScience.
NoclaimtooriginalU.
S.
GovernmentWorks.
Copyright2008TheAuthors,somerightsreserved;exclusivelicenseeAmericanAssociationfortheAdvancementofonMarch8,2021http://science.
sciencemag.
org/Downloadedfrom
311305CONTENTSCONTENTScontinued>>DEPARTMENTS311ScienceOnline313ThisWeekinScience318Editors'Choice320ContactScience321RandomSamples323Newsmakers423NewProducts424ScienceCareersCOVERAnartist'sconceptionoftheantibioticpenicillinandsomeofthebacteriathathavedevelopedresistancetovariousantibiotics.
Aspecialsectionbeginningonpage355explorestheriseandspreadofso-calledbadbugsandpossibleinterventions.
Illustration:ChrisBickel/ScienceEDITORIAL317EngagingRussianScientistsbyGlennSchweitzer355NEWSOFTHEWEEKBushTakesaFinalSwipe,andSalute,atCO2324EmissionCurbsOldSamplesTripUpTokyoTeam324NewPolicyTriestoEaseSecurityRestrictions325StalledTrialforAutismHighlightsDilemmaof326AlternativeTreatmentsCaribbeanMegaeruptionsDroveaGlobalOceanCrisis327SCIENCESCOPE327TwoU.
S.
LabsVieforLong-DelayedExotic328NucleiSourceSurveyFindsCitationsGrowingNarrowerasJournals329MoveOnline>>Reportp.
395NEWSFOCUSReinventingRicetoFeedtheWorld330SowingtheSeedsofExpertiseSimpleSleepers334>>ResearchArticlep.
372Acoustics'08Meeting338SoundScienceMapsVenetianCanalsandPeruvianRuinsUltrasoundUsesinMedicineHeatUpListeningtoDistantIceCrackSnapshotsFromtheMeetingVolume321,Issue5887INTRODUCTIONDeadlyDefiance355NEWSTheBacteriaFightBack356CollateralDamage:TheRiseofResistantC.
difficileTrenchWarfareinaBattleWithTB362Anti-TBDrugs:AndThenThereWereNonePERSPECTIVESAntibioticsandAntibioticResistanceGenesin365NaturalEnvironmentsJ.
L.
MartínezOutwittingMultidrugResistancetoAntifungals367B.
C.
MonkandA.
GoffeauSPECIALSECTIONDrugResistancewww.
sciencemag.
orgSCIENCEVOL32118JULY2008330PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008307CONTENTScontinued>>SCIENCEEXPRESSwww.
sciencexpress.
orgPLANTSCIENCEPlantImmunityRequiresConformationalChangesofNPR1viaS-NitrosylationandThioredoxinsY.
Tadaetal.
Afterapathogeninvadesaplant,aprotein,usuallykeptinamultimericstatebyS-nitrosylation,isdissociatedbythioredoxin,freeingthemonomersfordefenseresponses.
10.
1126/science.
1156970GEOCHEMISTRYFerruginousConditionsDominatedLaterNeoproterozoicDeep-WaterChemistryD.
E.
Canfieldetal.
Lowsulfurinputcausedthedeeperoceantobecomeanoxicandrichinferrousiron750millionyearsago,areversalfromthemoreoxidizingconditionsoftheprevious1billionyears.
10.
1126/science.
1154499CELLBIOLOGYEssentialCytoplasmicTranslocationofaCytokineReceptor–AssembledSignalingComplexA.
Matsuzawaetal.
Degradationofonememberofaproteincomplexthatformswhenacytokinereceptorisactivatedcausesthecomplextomovetothecytoplasm,triggeringthedownstreampathway.
10.
1126/science.
1157340CONTENTSLETTERSTheCostofConservationM.
Bodeetal.
340ConservationwithCaveatsB.
W.
T.
CoetzeeResponseC.
Kremenetal.
CORRECTIONSANDCLARIFICATIONS342BOOKSETAL.
Insomniac343G.
Greene,reviewedbyM.
L.
PerlisRe-EngineeringPhilosophyforLimitedBeings344PiecewiseApproximationstoRealityW.
C.
Wimsatt,reviewedbyK.
SterelnyPOLICYFORUMAssistedColonizationandRapidClimateChange345O.
Hoegh-Guldbergetal.
PERSPECTIVESVertebrateVocalizations347D.
MargoliashandM.
E.
Hale>>Reportp.
417WastheYoungerDryasGlobal348T.
V.
LowellandM.
A.
Kelly>>Reportp.
392TrackingCorrosionCracking349A.
Stierle>>Reportp.
382GraspingLimbPatterning350C.
J.
TabinandA.
P.
McMahonFocusonX-rayDiffraction352H.
N.
Chapman>>Reportp.
379AHotterGreenhouse353M.
HuberTECHNICALCOMMENTABSTRACTSMICROBIOLOGYCommenton"A3-Hydroxypropionate/3424-HydroxybutyrateAutotrophicCarbonDioxideAssimilationPathwayinArchaea"T.
J.
G.
EttemaandS.
G.
E.
Anderssonfulltextatwww.
sciencemag.
org/cgi/content/full/321/5887/342bResponsetoCommenton"A3-Hydroxypropionate/4-HydroxybutyrateAutotrophicCarbonDioxideAssimilationPathwayinArchaea"I.
A.
Berg,D.
Kockelkorn,W.
Buckel,G.
Fuchsfulltextatwww.
sciencemag.
org/cgi/content/full/321/5887/342cBREVIAOCEANSCIENCEIceScourDisturbanceinAntarcticWaters371D.
A.
Smaleetal.
IcebergshaveincreasinglyscouredthecoastlinesalongtheWestAntarcticPeninsulaasitsiceshelvesandglaciershavewaned,affectingbenthicmarinecommunities.
RESEARCHARTICLENEUROSCIENCEIdentificationofSLEEPLESS,aSleep-PromotingFactor372K.
Kohetal.
AsearchforgeneticmodulatorsofsleepinDrosophilaidentifiedageneencodingabrainproteinthatislikelysecretedandisrequiredforrecoveryfromsleepdeprivation.
>>Newsstoryp.
334REPORTSASTRONOMYPropertiesofGamma-RayBurstProgenitorStars376P.
Kumar,R.
Narayan,J.
L.
JohnsonAnalysisofthex-rayafterglowofintensegamma-rayburstsshowsthattheburstsresultfromconsumptionoftheouterpartofadensestaranddefinethestar'srotationrate.
347&417PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008309CONTENTSCONTENTScontinued>>REPORTSCONTINUED.
.
.
APPLIEDPHYSICSHigh-ResolutionScanningX-rayDiffractionMicroscopy379P.
Thibaultetal.
Analysisofdifferencesindiffractionpatternsateachpointalonganx-rayscanofamaterialallowsimagingofaburiedstructurewitharesolutionof50nanometers.
>>Perspectivep.
352MATERIALSSCIENCEObservationsofIntergranularStressCorrosion382CrackinginaGrain-MappedPolycrystalA.
Kingetal.
Tomographicimagingrevealsthatsomegrainboundariesinstainlesssteelareresistanttostresscorrosioncracking,whichleadstosuddenbrittlefailure.
>>Perspectivep.
349MATERIALSSCIENCEMeasurementoftheElasticPropertiesand385IntrinsicStrengthofMonolayerGrapheneC.
Lee,X.
Wei,J.
W.
Kysar,J.
HoneMeasurementsoftheelasticpropertiesofgrapheneagreewithcalculationsforadefect-freematerialandshowthatitisindeedstrongerthanothermaterials.
CHEMISTRYMeasurementoftheDistributionofSite388EnhancementsinSurface-EnhancedRamanScatteringY.
Fang,N.
-H.
Seong,D.
D.
DlottThedistributionofelectricfield–enhancingsitesonananostructuredsubstrateismeasuredbyusingtheenhancedfieldtodamagethosesites.
CLIMATECHANGEPatagonianGlacierResponseDuringtheLate392Glacial–HoloceneTransitionR.
P.
AckertJr.
etal.
DatingofaglacialmoraineinsouthernPatagoniaimpliesthatincreasedprecipitationcausedglaciergrowthafteraperiodofNorthernHemispherecooling11,000yearsago.
>>Perspectivep.
348SOCIOLOGYElectronicPublicationandtheNarrowingof395ScienceandScholarshipJ.
A.
EvansAsjournalsbecomeavailableelectronically,scientistsandscholarshavemorearticlesattheirfingertipsbutciterelativelyfewer,andthesetendtobemorerecent.
>>Newsstoryp.
329EVOLUTIONTheEvolutionandDistributionofSpeciesBodySize399A.
ClausetandD.
H.
ErwinAmodelofevolutionarybody-sizechangesthataccountsforphysicalconstraintsandextinctionriskreproducesthesizedistributionoflandmammalsfromtheQuaternary.
CELLBIOLOGYFour-jointedIsaGolgiKinaseThatPhosphorylates401aSubsetofCadherinDomainsH.
O.
Ishikawaetal.
AnewlydescribedtypeofproteinkinasefoundintheGolgiphosphorylatessignalingproteinsonaminoacidsthataredestinedtobewithinextracellulardomains.
352&379CELLBIOLOGYSignal-MediatedDynamicRetentionof404GlycosyltransferasesintheGolgiL.
Tu,W.
C.
S.
Tai,L.
Chen,D.
K.
BanfieldGlycosyltransferaseenzymesstayintheGolgiinthefaceofcontinuingmembranetrafficbecauseareceptorlinkstheircytoplasmictailstoarecyclingcoatedvesicle.
IMMUNOLOGYAnomalousType17ResponsetoViralInfectionby408CD8+TCellsLackingT-betandEomesoderminA.
M.
Intlekoferetal.
TwotranscriptionfactorscooperatetoensurethecorrectfunctioningofCD8+Tcellsduringtheresponsetoinfection.
CELLSIGNALINGRiboswitchesinEubacteriaSensetheSecond411MessengerCyclicDi-GMPN.
Sudarsanetal.
Thebacterialsecondmessengercyclicdi–guanosinemonophosphatecontrolsawidevarietyofcellularfunctionsbyactingonariboswitchmotifinnumerousmessengerRNAs.
NEUROSCIENCEBottom-UpDependentGatingofFrontalSignalsin414EarlyVisualCortexL.
B.
Ekstrometal.
Higherbraincenterscanmodulateactivityinthecorticalregionsthatdirectlyreceivevisualinput,butonlywhenavisualstimulusispresent.
NEUROSCIENCEEvolutionaryOriginsforSocialVocalizationina417VertebrateHindbrain–SpinalCompartmentA.
H.
Bass,E.
H.
Gilland,R.
BakerTheconservedneuralcircuitryforvocalcommunicationinfishandothertetrapodssuggeststhatthisfunctionmayhaveoriginatedpriortotheevolutionofbonyvertebrates.
>>Perspectivep.
347NEUROSCIENCEOrbitofrontalDysfunctioninPatientswith421Obsessive-CompulsiveDisorderandTheirUnaffectedRelativesS.
R.
Chamberlainetal.
Theabnormallylowactivationinthefrontalcortexofindividualswithobsessivecompulsivedisorderandtheircloserelativesmayconferariskforthedisease.
SCIENCE(ISSN0036-8075)ispublishedweeklyonFriday,exceptthelastweekinDecember,bytheAmericanAssociationfortheAdvancementofScience,1200NewYorkAvenue,NW,Washington,DC20005.
PeriodicalsMailpostage(publicationNo.
484460)paidatWashington,DC,andadditionalmailingoffices.
Copyright2008bytheAmericanAssociationfortheAdvancementofScience.
ThetitleSCIENCEisaregisteredtrademarkoftheAAAS.
Domesticindividualmembershipandsubscription(51issues):$144($74allocatedtosubscription).
Domesticinstitutionalsubscription(51issues):$770;Foreignpostageextra:Mexico,Caribbean(surfacemail)$55;othercountries(airassistdelivery)$85.
Firstclass,airmail,student,andemeritusratesonrequest.
CanadianrateswithGSTavailableuponrequest,GST#125488122.
PublicationsMailAgreementNumber1069624.
PrintedintheU.
S.
A.
Changeofaddress:Allow4weeks,givingoldandnewaddressesand8-digitaccountnumber.
Postmaster:SendchangeofaddresstoAAAS,P.
O.
Box96178,Washington,DC20090–6178.
Single-copysales:$10.
00currentissue,$15.
00backissueprepaidincludessurfacepostage;bulkratesonrequest.
AuthorizationtophotocopymaterialforinternalorpersonaluseundercircumstancesnotfallingwithinthefairuseprovisionsoftheCopyrightActisgrantedbyAAAStolibrariesandotherusersregisteredwiththeCopyrightClearanceCenter(CCC)TransactionalReportingService,providedthat$20.
00perarticleispaiddirectlytoCCC,222RosewoodDrive,Danvers,MA01923.
TheidentificationcodeforScienceis0036-8075.
ScienceisindexedintheReader'sGuidetoPeriodicalLiteratureandinseveralspecializedindexes.
SCIENCE(ISSN0036-8075)ispublishedweeklyonFriday,exceptthelastweekinDecember,bytheAmericanAssociationfortheAdvancementofScience,1200NewYorkAvenue,NW,Washington,DC20005.
PeriodicalsMailpostage(publicationNo.
484460)paidatWashington,DC,andadditionalmailingoffices.
Copyright2008bytheAmericanAssociationfortheAdvancementofScience.
ThetitleSCIENCEisaregisteredtrademarkoftheAAAS.
Domesticindividualmembershipandsubscription(51issues):$144($74allocatedtosubscription).
Domesticinstitutionalsubscription(51issues):$770;Foreignpostageextra:Mexico,Caribbean(surfacemail)$55;othercountries(airassistdelivery)$85.
Firstclass,airmail,student,andemeritusratesonrequest.
CanadianrateswithGSTavailableuponrequest,GST#125488122.
PublicationsMailAgreementNumber1069624.
PrintedintheU.
S.
A.
Changeofaddress:Allow4weeks,givingoldandnewaddressesand8-digitaccountnumber.
Postmaster:SendchangeofaddresstoAAAS,P.
O.
Box96178,Washington,DC20090–6178.
Single-copysales:$10.
00currentissue,$15.
00backissueprepaidincludessurfacepostage;bulkratesonrequest.
AuthorizationtophotocopymaterialforinternalorpersonaluseundercircumstancesnotfallingwithinthefairuseprovisionsoftheCopyrightActisgrantedbyAAAStolibrariesandotherusersregisteredwiththeCopyrightClearanceCenter(CCC)TransactionalReportingService,providedthat$20.
00perarticleispaiddirectlytoCCC,222RosewoodDrive,Danvers,MA01923.
TheidentificationcodeforScienceis0036-8075.
ScienceisindexedintheReader'sGuidetoPeriodicalLiteratureandinseveralspecializedindexes.
PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfromwww.
sciencemag.
orgSCIENCEVOL32118JULY2008311CREDITS:(SCIENCENOW)MENNAJONES;(SCIENCECAREERS)NSF/WILLIAMA.
MITCHELL;(SCIENCESIGNALING)PHOTOTAKE,INC.
/ALAMYONLINESCIENCESIGNALINGwww.
sciencesignaling.
orgTHESIGNALTRANSDUCTIONKNOWLEDGEENVIRONMENTREVIEW:Host-DirectedDrugTargetingofFactorsHijackedbyPathogensA.
SchwegmannandF.
BrombacherAnewdrugdiscoveryparadigmfocusesonidentifyingandtargetingcellularelementsofthehostthatareexploitedbypathogens.
GLOSSARYFindoutwhatDILP,HRE,andOGTmeanintheworldofcellsignaling.
EVENTSCheckoutthemorethan50cellsignaling–relatedmeetingshappeninginthesecondhalfof2008.
SCIENCENOWwww.
sciencenow.
orgHIGHLIGHTSFROMOURDAILYNEWSCOVERAGEToughTimesfortheTazResearchersdebatetheevolutionaryimpactofadeadlycancerinTasmaniandevils.
AnswertoCarbonEmissionsMayLieUndertheSeaResearchersproposeinjectinggreenhousegasnearvolcanicrockontheoceanbottom.
"BabyBoom"inaStellarNurseryAstronomersdiscoveranancientgalacticstarfactoryonoverdrive.
SCIENCECAREERSwww.
sciencecareers.
org/career_developmentFREECAREERRESOURCESFORSCIENTISTSDoYouWannaBeaVAPL.
MalisheskiAvisitingassistantprofessorpositioncanbeastepforwardonsomecareerpaths.
ToolingUp:ReviewYourCareerD.
JensenItmaybetimetoshakethingsupwithacareerreview.
DesigningfortheNextQuakeA.
SainiEarthquakeengineersstudyhowtoavoidseismicdestruction.
ScienceCareersSeeksBloggersJ.
AustinWearelookingforafewpeoplewithinterestingthingstosayabouttheircareersinscience.
Engineeringtominimizeearthquakedamage.
Separateindividualorinstitutionalsubscriptionstotheseproductsmayberequiredforfull-textaccess.
www.
sciencemag.
orgDownloadthe18JulySciencePodcasttohearaboutpathogenicfungi,resistancegenesinnaturalenvironments,extremelymultidrug-resistantbacteria,andmore.
>>DrugResistancesectionp.
355SCIENCEPODCASTwww.
sciencemag.
org/multimedia/podcastFREEWEEKLYSHOWListeria,ahumanpathogen.
Devildestroyer.
PublishedbyAAASonMarch8,2021http://science.
sciencemag.
org/Downloadedfrom321(5887)(5887),313-423.
321ScienceARTICLETOOLShttp://science.
sciencemag.
org/content/321/5887PERMISSIONShttp://www.
sciencemag.
org/help/reprints-and-permissionsTermsofServiceUseofthisarticleissubjecttotheisaregisteredtrademarkofAAAS.
ScienceScience,1200NewYorkAvenueNW,Washington,DC20005.
Thetitle(printISSN0036-8075;onlineISSN1095-9203)ispublishedbytheAmericanAssociationfortheAdvancementofScienceScience.
NoclaimtooriginalU.
S.
GovernmentWorks.
Copyright2008TheAuthors,somerightsreserved;exclusivelicenseeAmericanAssociationfortheAdvancementofonMarch8,2021http://science.
sciencemag.
org/Downloadedfrom
- Buckelinsomniac相关文档
- readinginsomniac
- 宰制insomniac
- "赠送全新西数或希捷硬盘,三年保修,拷满高品质无损APE格式音乐!",,
- revelationinsomniac
- incidenceinsomniac
- convergeinsomniac
瓜云互联-美国洛杉矶高防CN2高防云服务器，新老用户均可9折促销！低至32.4元/月！
瓜云互联一直主打超高性价比的海外vps产品，主要以美国cn2、香港cn2线路为主，100M以内高宽带，非常适合个人使用、企业等等！安全防护体系 弹性灵活，能为提供简单、 高效、智能、快速、低成本的云防护，帮助个人、企业从实现网络攻击防御，同时也承诺产品24H支持退换，不喜欢可以找客服退现,诚信自由交易！官方网站：点击访问瓜云互联官网活动方案：打折优惠策略：新老用户购买服务器统统9折优惠预存返款活动...
阿里云服务器绑定域名的几个流程整理
今天遇到一个网友，他之前一直在用阿里云虚拟主机，我们知道虚拟主机绑定域名是直接在面板上绑定的。这里由于他的网站项目流量比较大，虚拟主机是不够的，而且我看他虚拟主机已经有升级过。这里要说的是，用过阿里云虚拟主机的朋友可能会比较一下价格，实际上虚拟主机价格比云服务器还贵。所以，基于成本和性能的考虑，建议他选择云服务器。毕竟他的备案都接入在阿里云。这里在选择阿里云服务器后，他就蒙圈不知道如何绑定域名。这...
妮妮云，美国cera CN2线路，VPS享3折优惠
近期联通CUVIP的线路（AS4837线路）非常火热，妮妮云也推出了这类线路的套餐以及优惠，目前到国内优质线路排行大致如下：电信CN2 GIA>联通AS9929>联通AS4837>电信CN2 GT>普通线路，AS4837线路比起前两的优势就是带宽比较大，相对便宜一些，所以大家才能看到这个线路的带宽都非常高。妮妮云互联目前云服务器开放抽奖活动，每天开通前10台享3折优惠，另外...
insomniac为你推荐
-
刘祚天还有DJ网么?rawtoolsRAW是什么衣服牌子51sese.com谁有免费看电影的网站？javmoo.com找下载JAV软件格式的网站www.kanav001.com长虹V001手机小游戏下载的网址是什么www.hhh258comwww.tx88d.com 有这个网站吗？www.kaspersky.com.cn现在网上又有病毒了？yinrentangweichentang万艾可正品的作用真的不错吗干支论坛干支计时的干支计时邯郸纠风网河北邯郸有几个县个名单非法集资